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A high prevalence of blaOXA-48 in Klebsiella (Raoultella) ornithinolytica and related species in hospital wastewater in South West England
Marjorie J Gibbon, Natacha Couto, Sophia David, Ruth Barden, Richard Standerwick, Kishore Jagadeesan, Hollie Birkwood, Punyawee Dulyayangkul, Matthew B Avison, Andrew Kannan, Dan Kibbey, Tim Craft, Samia Habib, Harry A Thorpe, Jukka Corander, Barbara Kasprzyk-Hordern, Edward J Feil
Dec 31, 2021
Klebsiella species occupy a wide range of environmental and animal niches, and occasionally cause opportunistic infections that are resistant to multiple antibiotics. In particular, Klebsiella pneumoniae (Kpne) has gained...
'Our Learned Primate' and that 'Rare Treasurie'
The historical significance of Sir Robert Cotton's famous library of manuscripts is considered through the activities of James Ussher, Archbishop of Armagh, who used the library extensively in his work as Protestant...
Katherine Birkwood
Feb 23, 2012
A high prevalence of blaOXA-48 in Klebsiella (Raoultella) ornithinolytica and related species in hospital wastewater in South West England
Marjorie J Gibbon, Natacha Couto, Sophia David, Ruth Barden, Richard Standerwick, Kishore Jagadeesan, Hollie Birkwood, Punyawee Dulyayangkul, Matthew B Avison, Andrew Kannan, Dan Kibbey, Tim Craft, Samia Habib, Harry A Thorpe, Jukka Corander, Barbara Kasprzyk-Hordern, Edward J Feil
Dec 31, 2021
Klebsiella species occupy a wide range of environmental and animal niches, and occasionally cause opportunistic infections that are resistant to multiple antibiotics. In particular, Klebsiella pneumoniae (Kpne) has gained...
Fully automated real-time PCR for EGFR testing in non-small cell lung carcinoma.
Molecular testing for mutations in the EGFR gene is commonplace for patients with non-small cell lung cancer (NSCLC). These patients are often very sick and management decisions need to be made urgently. In many cases, the...
Development of an Infection-Responsive Fluorescent Sensor for the Early Detection of Urinary Catheter Blockage
Scarlet Milo, Florianne B. Acosta, Hollie J. Hathaway, Laura A. Wallace, Naing T. Thet, Andrew Jenkins
Mar 23, 2018
Formation of crystalline biofilms following infection by Proteus mirabilis can lead to encrustation and blockage of longterm indwelling catheters, with serious clinical consequences. We describe a simple sensor, placed within...
Proteus mirabilis Biofilms carboxyfluorescein Indwelling catheter sensor /dk/atira/pure/subjectarea/asjc/1500/1502 name=Bioengineering /dk/atira/pure/subjectarea/asjc/1500/1507 name=Fluid Flow and Transfer Processes /dk/atira/pure/subjectarea/asjc/1500/1508 name=Process Chemistry and Technology /dk/atira/pure/subjectarea/asjc/3100/3105 name=Instrumentation
Development of an Infection-Responsive Fluorescent Sensor for the Early Detection of Urinary Catheter Blockage
Scarlet Milo, Florianne B. Acosta, Hollie J. Hathaway, Laura A. Wallace, Naing T. Thet, Andrew Jenkins
Mar 23, 2018
Formation of crystalline biofilms following infection by Proteus mirabilis can lead to encrustation and blockage of longterm indwelling catheters, with serious clinical consequences. We describe a simple sensor, placed within...
Proteus mirabilis Biofilms carboxyfluorescein Indwelling catheter sensor /dk/atira/pure/subjectarea/asjc/1500/1502 name=Bioengineering /dk/atira/pure/subjectarea/asjc/1500/1507 name=Fluid Flow and Transfer Processes /dk/atira/pure/subjectarea/asjc/1500/1508 name=Process Chemistry and Technology /dk/atira/pure/subjectarea/asjc/3100/3105 name=Instrumentation
Recent advances in therapeutic delivery systems of bacteriophage and bacteriophage-encoded endolysins
Antibiotics have been the cornerstone of clinical management of bacterial infection since their discovery in the early 20th century. However, their widespread and often indiscriminate use has now led to reports of multidrug...
Prevention of Encrustation and Blockage of Urinary Catheters by Proteus mirabilis via pH-Triggered Release of Bacteriophage
Scarlet Milo, Hollie Hathaway, Jonathan Nzakizwanayo, Diana Alves, Patricia Pérez Esteban, Brian V. Jones, Andrew Jenkins
Jun 22, 2017
The crystalline biofilms of Proteus mirabilis can seriously complicate the careof patients undergoing long-term indwelling urinary catheterisation. Expression of bacterial urease causes a significant increase in urinary pH...
Recent advances in therapeutic delivery systems of bacteriophage and bacteriophage-encoded endolysins
Antibiotics have been the cornerstone of clinical management of bacterial infection since their discovery in the early 20th century. However, their widespread and often indiscriminate use has now led to reports of multidrug...
Emerging medical and engineering strategies for the prevention of long-term indwelling catheter blockage
Scarlet Milo, Jonathan Nzakizwanayo, Hollie J Hathaway, Brian V Jones, A Toby A Jenkins
Jan 01, 2019
Urinary catheters have been used on an intermittent or indwelling basis for centuries, in order to relieve urinary retention and incontinence. Nevertheless, the use of urinary catheters in the clinical setting is fraught with...
Emerging medical and engineering strategies for the prevention of long-term indwelling catheter blockage
Scarlet Milo, Jonathan Nzakizwanayo, Hollie J Hathaway, Brian V Jones, A Toby A Jenkins
Jan 01, 2019
Urinary catheters have been used on an intermittent or indwelling basis for centuries, in order to relieve urinary retention and incontinence. Nevertheless, the use of urinary catheters in the clinical setting is fraught with...
Prevention of Encrustation and Blockage of Urinary Catheters by Proteus mirabilis via pH-Triggered Release of Bacteriophage
Scarlet Milo, Hollie Hathaway, Jonathan Nzakizwanayo, Diana Alves, Patricia Pérez Esteban, Brian V. Jones, Andrew Jenkins
Jun 22, 2017
The crystalline biofilms of Proteus mirabilis can seriously complicate the careof patients undergoing long-term indwelling urinary catheterisation. Expression of bacterial urease causes a significant increase in urinary pH...
The systematic identification of content and delivery style of an exercise intervention
Fay E. Beck, Fiona B. Gillison, Miraslava D. Koseva, Martyn Standage, Jessica L. Brodrick, Claire Graham, Hollie Young
Jan 01, 0001
Objective: This study explored the utility of using behaviour change taxonomies and checklists to systematically assess the content and delivery of behavioural support for physical activity delivered through an established...
Zinc-Embedded Polyamide Fabrics Inactivate SARS-CoV-2 and Influenza A Virus.
Vikram Gopal, Benjamin E Nilsson-Payant, Hollie French, Jurre Y Siegers, Wai-Shing Yung, Matthew Hardwick, Aartjan JW Te Velthuis
Jul 29, 2021
Influenza A viruses (IAV) and SARS-CoV-2 can spread via liquid droplets and aerosols. Face masks and other personal protective equipment (PPE) can act as barriers that prevent the spread of these viruses. However, IAV and...
Transient RNA structures cause aberrant influenza virus replication and innate immune activation.
Hollie French, Emmanuelle Pitré, Michael S Oade, Elizaveta Elshina, Karishma Bisht, Alannah King, David LV Bauer, Aartjan JW Te Velthuis
Oct 10, 2022
During infection, the influenza A virus RNA polymerase produces both full-length and aberrant RNA molecules, such as defective viral genomes (DVGs) and mini viral RNAs (mvRNAs). Subsequent innate immune activation involves the...
The systematic identification of content and delivery style of an exercise intervention
Fay E. Beck, Fiona B. Gillison, Miraslava D. Koseva, Martyn Standage, Jessica L. Brodrick, Claire Graham, Hollie Young
Jan 01, 0001
Objective: This study explored the utility of using behaviour change taxonomies and checklists to systematically assess the content and delivery of behavioural support for physical activity delivered through an established...
Antidepressants for pain management in adults with chronic pain
Hollie Birkinshaw, Claire M. Friedrich, Peter Cole, Christopher Eccleston, Marc Serfaty, Gavin Stewart, Simon White, R. Andrew Moore, David Phillippo, Tamar Pincus
May 10, 2023
Background: Chronic pain is common in adults, and often has a detrimental impact upon physical ability, well-being, and quality of life. Previous reviews have shown that certain antidepressants may be effective in reducing...
Antidepressants for pain management in adults with chronic pain
Hollie Birkinshaw, Claire M. Friedrich, Peter Cole, Christopher Eccleston, Marc Serfaty, Gavin Stewart, Simon White, R. Andrew Moore, David Phillippo, Tamar Pincus
May 10, 2023
Background: Chronic pain is common in adults, and often has a detrimental impact upon physical ability, well-being, and quality of life. Previous reviews have shown that certain antidepressants may be effective in reducing...
Mini viral RNAs act as innate immune agonists during influenza virus infection.
Aartjan JW Te Velthuis, Joshua C Long, David LV Bauer, Rebecca LY Fan, Hui-Ling Yen, Jane Sharps, Jurre Y Siegers, Marian J Killip, Hollie French, Maria José Oliva-Martín, Richard E Randall, Emmie de Wit, Debby van Riel, Leo LM Poon, Ervin Fodor
Sep 08, 2018
The molecular processes that determine the outcome of influenza virus infection in humans are multifactorial and involve a complex interplay between host, viral and bacterial factors1. However, it is generally accepted that a...
Ruthenium‐Containing Linear Helicates and Mesocates with Tuneable p53‐Selective Cytotoxicity in Colorectal Cancer Cells
Simon J. Allison, David Cooke, Francesca S. Davidson, Paul I. P. Elliott, Robert A. Faulkner, Hollie B. S. Griffiths, Owen Harper, Omar Hussain, P. Jane Owen-Lynch, Roger M. Phillips, Craig R. Rice, Samantha L. Shepherd, Richard T. Wheelhouse
Jul 26, 2018
The ligands L1 and L2 both form separable dinuclear double‐stranded helicate and mesocate complexes with RuII. In contrast to clinically approved platinates, the helicate isomer of [Ru2(L1)2]4+ was preferentially cytotoxic to...
Ruthenium‐Containing Linear Helicates and Mesocates with Tuneable p53‐Selective Cytotoxicity in Colorectal Cancer Cells
Simon J. Allison, David Cooke, Francesca S. Davidson, Paul I. P. Elliott, Robert A. Faulkner, Hollie B. S. Griffiths, Owen Harper, Omar Hussain, P. Jane Owen-Lynch, Roger M. Phillips, Craig R. Rice, Samantha L. Shepherd, Richard T. Wheelhouse
Jul 26, 2018
The ligands L1 and L2 both form separable dinuclear double‐stranded helicate and mesocate complexes with RuII. In contrast to clinically approved platinates, the helicate isomer of [Ru2(L1)2]4+ was preferentially cytotoxic to...
Increased Seroprevalence and Improved Antibody Responses Following Third Primary SARS-CoV-2 Immunisation
Adrian M Shields, Sian E Faustini, Harriet J Hill, Saly Al-Taei, Chloe Tanner, Fiona Ashford, Sarita Workman, Fernando Moreira, Nisha Verma, Hollie Wagg, Gail Heritage, Naomi Campton, Zania Stamataki, Mark T Drayson, Paul Klenerman, James ED Thaventhiran, Shuayb Elkhalifa, Sarah Goddard, Sarah Johnston, Aarnoud Huissoon, Claire Bethune, Suzanne Elcombe, David M Lowe, Smita Y Patel, Sinisa Savic, Alex G Richter, Siobhan O Burns, COV-AD consortium
Jun 16, 2022
BACKGROUND: Patients with primary and secondary antibody deficiency are vulnerable to COVID-19 and demonstrate diminished responses following two-dose SARS-CoV-2 vaccine schedules. Third primary vaccinations have been deployed...
SARS-CoV-2 Vaccine Responses in Individuals with Antibody Deficiency
Adrian M Shields, Sian E Faustini, Harriet J Hill, Saly Al-Taei, Chloe Tanner, Fiona Ashford, Sarita Workman, Fernando Moreira, Nisha Verma, Hollie Wagg, Gail Heritage, Naomi Campton, Zania Stamataki, Paul Klenerman, James ED Thaventhiran, Sarah Goddard, Sarah Johnston, Aarnoud Huissoon, Claire Bethune, Suzanne Elcombe, David M Lowe, Smita Y Patel, Sinisa Savic, Siobhan O Burns, Alex G Richter, COV-AD consortium
Aug 25, 2022
BACKGROUND: Vaccination prevents severe morbidity and mortality from COVID-19 in the general population. The immunogenicity and efficacy of SARS-CoV-2 vaccines in patients with antibody deficiency is poorly understood....
Post COVID‐19
Silviu O. Petrovan, David C. Aldridge, Harriet Bartlett, Andrew J. Bladon, Hollie Booth, Steven Broad, Donald M. Broom, Neil D. Burgess, Sarah Cleaveland, Andrew A. Cunningham, Maurizio Ferri, Amy Hinsley, Fangyuan Hua, Alice C. Hughes, Kate Jones, Moira Kelly, George Mayes, Milorad Radakovic, Chinedu A. Ugwu, Nasir Uddin, Diogo Veríssimo, Christian Walzer, Thomas B. White, James L. Wood, William J. Sutherland
Jul 07, 2021
Post COVID-19
Silviu O Petrovan, David C Aldridge, Harriet Bartlett, Andrew J Bladon, Hollie Booth, Steven Broad, Donald M Broom, Neil D Burgess, Sarah Cleaveland, Andrew A Cunningham, Maurizio Ferri, Amy Hinsley, Fangyuan Hua, Alice C Hughes, Kate Jones, Moira Kelly, George Mayes, Milorad Radakovic, Chinedu A Ugwu, Nasir Uddin, Diogo Veríssimo, Christian Walzer, Thomas B White, James L Wood, William J Sutherland
Jun 24, 2021
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