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Results: 1093
Elevated homocysteine activates unfolded protein responses and causes aberrant trophoblast differentiation and mouse blastocyst development.
Regulation of AKT phosphorylation at Ser473 and Thr308 by endoplasmic reticulum stress modulates substrate specificity in a severity dependent manner.
Endoplasmic reticulum (ER) stress is a common factor in the pathophysiology of diverse human diseases that are characterised by contrasting cellular behaviours, from proliferation in cancer to apoptosis in neurodegenerative...
Morphological and molecular changes in the murine placenta exposed to normobaric hypoxia throughout pregnancy.
Hannah Matheson, Jan HW Veerbeek, D Stephen Charnock-Jones, Graham J Burton, Hong Wa Yung
Aug 11, 2015
Noncanonical mitochondrial unfolded protein response impairs placental oxidative phosphorylation in early-onset preeclampsia.
Hong Wa Yung, Francesca Colleoni, Emilie Dommett, Tereza Cindrova-Davies, John Kingdom, Andrew J Murray, Graham J Burton
Jul 31, 2019
Preeclampsia (PE) is a dangerous complication of pregnancy, especially when it presents at <34 wk of gestation (PE < 34 wk). It is a major cause of maternal and fetal morbidity and mortality and also increases the risk of...
Mitochondria Preeclampsia Unfolded Protein Response Activating Transcription Factors Chaperonin 60 Eukaryotic Initiation Factor-2 Female HSP70 Heat-Shock Proteins Humans Mitochondria Mitochondrial Proteins Oxidative Phosphorylation pre-eclampsia Pregnancy Trophoblasts Unfolded Protein Response eIF-2 Kinase
Excessive endoplasmic reticulum stress drives aberrant mouse trophoblast differentiation and placental development leading to pregnancy loss.
RNA-Seq reveals changes in human placental metabolism, transport and endocrinology across the first-second trimester transition.
Malwina Prater, Russell S Hamilton, Hong Wa Yung, Andrew M Sharkey, Paul Robson, N Erlyani Abd Hamid, Eric Jauniaux, D Stephen Charnock-Jones, Graham J Burton, Tereza Cindrova-Davies
Apr 14, 2021
Early placenta Human pregnancy metabolism Methylation Transcriptome Biomarkers Computational Biology Energy Metabolism Female Gene Expression Profiling Gene Expression Regulation Gene Ontology Humans Immunohistochemistry Molecular Sequence Annotation Placenta Pregnancy Pregnancy Trimester First Pregnancy Trimester Second RNA-seq
Defective folate metabolism causes germline epigenetic instability and distinguishes Hira as a phenotype inheritance biomarker.
Georgina E T Blake, Xiaohui Zhao, Hong Wa Yung, Graham J Burton, Anne C Ferguson-Smith, Russell S Hamilton, Erica D Watson
Jul 28, 2021
The mechanism behind transgenerational epigenetic inheritance is unclear, particularly through the maternal grandparental line. We previously showed that disruption of folate metabolism in mice by the Mtrr hypomorphic mutation...
Liver Germ Cells Spermatozoa Trophoblasts Animals Mice Inbred C57BL Mice Folic Acid Ferredoxin-NADP Reductase Cell Cycle Proteins Transcription Factors Pedigree DNA Methylation Epigenesis Genetic Heredity Inheritance Patterns Phenotype Polymorphism Single Nucleotide Female Male Embryo Mammalian Histone Chaperones Epigenomics Biomarkers Maternal Inheritance whole genome sequencing
Published by: Nature Communications
Role of Endoplasmic Reticulum Stress in Proinflammatory Cytokine-Mediated Inhibition of Trophoblast Invasion in Placenta-Related Complications of Pregnancy.
Cheuk-Lun Lee, Jan HW Veerbeek, Tirtha K Rana, Bas B van Rijn, Graham J Burton, Hong Wa Yung
Dec 09, 2018
Defective folate metabolism causes germline epigenetic instability and distinguishes Hira as a phenotype inheritance biomarker.
Georgina Et Blake, Xiaohui Zhao, Hong Wa Yung, Graham J Burton, Anne C Ferguson-Smith, Russell S Hamilton, Erica D Watson
Jun 02, 2021
Animals Biomarkers Cell Cycle Proteins DNA Methylation Embryo Mammalian Epigenesis Genetic Epigenomics Female Ferredoxin-NADP Reductase Folic Acid Germ Cells Heredity Histone Chaperones Inheritance Patterns Liver Male Maternal Inheritance Mice Mice Inbred C57BL Pedigree Phenotype Polymorphism Single Nucleotide Spermatozoa Transcription Factors Trophoblasts whole genome sequencing
Placental endoplasmic reticulum stress in gestational diabetes
Hong-Wa Yung, Patji Alnæs-Katjavivi, Carolyn JP Jones, Tatiana El-Bacha, Michaela Golic, Anne-Cathrine Staff, Graham J Burton
Jul 08, 2016
antioxidants chaperones Endoplasmic reticulum stress Gestational diabetes Metabolic acidosis Placenta trophoblast Unfolded Protein Response acidosis Adult antioxidants Ascorbic Acid Blood Glucose Blotting Western Cell Line Diabetes Gestational Endoplasmic reticulum stress Eukaryotic Initiation Factor-2 Female Glucose Humans Phenylbutyrates Phosphorylation Placenta Pregnancy Taurochenodeoxycholic Acid Unfolded Protein Response Vitamin E
RNA-Seq reveals changes in human placental metabolism, transport and endocrinology across the first-second trimester transition.
Malwina Prater, Russell S Hamilton, Hong Wa Yung, Andrew M Sharkey, Paul Robson, N Erlyani Abd Hamid, Eric Jauniaux, D Stephen Charnock-Jones, Graham J Burton, Tereza Cindrova-Davies
Jul 28, 2021
The human placenta is exposed to major environmental changes towards the end of the first trimester associated with full onset of the maternal arterial placental circulation. Changes include a switch from histotrophic to...
Published by: Biology open
Placental endoplasmic reticulum stress negatively regulates transcription of placental growth factor via ATF4 and ATF6β
Masahito Mizuuchi, Tereza Cindrova-Davies, Matts Olovsson, D Stephen Charnock-Jones, Graham J Burton, Hong Wa Yung
Dec 15, 2015
Endoplasmic reticulum stress Placenta placental growth factor pre-eclampsia pregnancy and reproduction Activating Transcription Factor 4 Activating Transcription Factor 6 Basic-Leucine Zipper Transcription Factors Endoplasmic reticulum stress Female Fetal Growth Retardation Humans Placenta Placenta Growth Factor Pregnancy Pregnancy Complications Pregnancy Proteins Unfolded Protein Response
Cantonese Children's Songs in Hong Kong
Lily Chen-Hafteck
Nov 19, 2013
A century of British colonial rule over a population of Chinese majority has resulted in a special culture of Hong Kong. While the local people have maintained a considerable amount of the traditional Chinese culture, a very...
Published by: Faculty of Education
Endoplasmic reticulum stress disrupts placental morphogenesis
Hong Wa Yung, Myriam Hemberger, Erica D Watson, Claire E Senner, Carolyn P Jones, Randal J Kaufman, D Stephen Charnock-Jones, Graham J Burton
Aug 10, 2020
We recently reported the first evidence of placental endoplasmic reticulum (ER) stress in the pathophysiology of human intrauterine growth restriction. Here, we used a mouse model to investigate potential underlying mechanisms....
Akt IGF2 Pdk1 Endoplasmic Reticulum intrauterine growth restriction mTOR placental morphogenesis Stress Animals Cell Differentiation Disease Models Animal Endoplasmic reticulum stress Eukaryotic Initiation Factor-2 Female Fetal Growth Retardation Glycoproteins Glycosylation Humans Mice Inbred C57BL Mice Mutant Strains Organ Size Placenta Placentation Pregnancy Protein Serine-Threonine Kinases Proto-Oncogene Proteins c-akt Pyruvate Dehydrogenase Acetyl-Transferring Kinase Signal Transduction TOR Serine-Threonine Kinases
Defective folate metabolism causes germline epigenetic instability and distinguishes Hira as a phenotype inheritance biomarker
Georgina E. T. Blake, Xiaohui Zhao, Hong Wa Yung, Graham J. Burton, Anne C. Ferguson-Smith, Russell S. Hamilton, Erica D. Watson
Jun 17, 2021
Analysis Of Eligibility, Contribution And Behavior Of Cloves Market In North Kulisusu District, North Buton Regency, Southeast Sulawesi
This research was conducted in Wa Ode Buri Village, North Kulisusu District, and North Buton Regency. The location determination was determined purposively. The objectives of this research are 1) to find out how much income...
Published by: Indonesia Strategic Sustainability
Cantonese Children's Songs in Hong Kong
Lily Chen-Hafteck
Nov 19, 2013
A century of British colonial rule over a population of Chinese majority has resulted in a special culture of Hong Kong. While the local people have maintained a considerable amount of the traditional Chinese culture, a very...
Published by: Faculty of Education
Loss sensitive investors and positively biased analysts in Hong Kong stock market
Taufiq Choudhry, Gishan Dissanaike, Ranadeva Jayasekera, Woo-Young Kang, Matthias Nnadi
Sep 22, 2021
Abstract: The Hong Kong stock market is known to be highly volatile. Professional investors have a strong demand for timely information because of the infrequent nature of Hong Kong analysts’ interim reports (Cheng et al....
The Residual Innate Lymphoid Cells in NFIL3-Deficient Mice Support Suboptimal Maternal Adaptations to Pregnancy.
Selma Boulenouar, Jean-Marc Doisne, Amanda Sferruzzi-Perri, Louise M Gaynor, Jens Kieckbusch, Elisa Balmas, Hong Wa Yung, Shagayegh Javadzadeh, Léa Volmer, Delia A Hawkes, Keli Phillips, Hugh JM Brady, Abigail L Fowden, Graham J Burton, Ashley Moffett, Francesco Colucci
Nov 01, 2018
Uterine NK cells are innate lymphoid cells (ILC) that populate the uterus and expand during pregnancy, regulating placental development and fetal growth in humans and mice. We have recently characterized the composition of...
Education for Justice-Oriented and Participatory Citizenship in a Politicized Era in Hong Kong
This chapter aims at introducing issues of citizenship education arising from the social, historical, and political context of Hong Kong before and after its handover from Britain to the People's Republic of China in 1997. It...
Civic Engagement & Social Justice Education Curriculum Development and Instructional Design Social Sciences and Humanities
Published by: IGI Global Scientific Publishing
English as a lingua franca communication between domestic helpers and employers in Hong Kong
This paper discusses an exploratory, small-scale study that investigated the use of English as a lingua franca in domestic workplaces in Hong Kong between Filipino employees and Hong Kongese employers. Through data collected...
Forecasting Migration to the United States from Hong Kong and India
Priyanka pkogta@my.harrisburgu
Jan 01, 0001
This study investigates the forecasting of migration from India and Hong Kong to the United States. To study this, quantitative design is employed so numerical data can be used. The proposed research strategy uses the...
Migration Forecasting Quantitative Design Descriptive Analyses Inferential Analyses United States india Hong Kong Computer and Systems Architecture Demography, Population, and Ecology Migration Studies
Published by: Harrisburg University of Science and Technology
English as a lingua franca communication between domestic helpers and employers in Hong Kong
This paper discusses an exploratory, small-scale study that investigated the use of English as a lingua franca in domestic workplaces in Hong Kong between Filipino employees and Hong Kongese employers. Through data collected...
Revealing the impacts of passive cooling techniques on building energy performance
Environmental concerns and growing energy costs raise the importance of sustainable development and energy conservation. The building sector accounts for a significant portion of total energy consumption. Passive cooling...
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