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Letter from Editor
Connie Shen
Jan 01, 0001
This is the introductory letter from Assistant Editor Connie Shen.
Anthology Winthrop Literary Journal Arts Journal Arts Magazine Literary Magazine Magazine art poetry prose Creative Writing Nonfiction
Published by: Winthrop University
Reasoning about privacy in mobile application install decisions
Data sharing has become prevalent with the rapid growth of mobile technologies. A lack of awareness and understanding of privacy practices often results in the installation of privacy-invasive applications (apps) which could...
Effect of Graphite on Copper Bioleaching from Waste Printed Circuit Boards
The efficient extraction of copper as a valuable metal from waste printed circuit boards (WPCBs) is currently attracting growing interest. Here, we systematically investigated the impact of bacteria on the efficiency of copper...
HIF-1-Independent Mechanisms Regulating Metabolic Adaptation in Hypoxic Cancer Cells.
In solid tumours, cancer cells exist within hypoxic microenvironments, and their metabolic adaptation to this hypoxia is driven by HIF-1 transcription factor, which is overexpressed in a broad range of human cancers. HIF...
Hypoxia Myc Lipid Metabolism Glycolysis cancer metabolism Glutamine metabolism AMP-activated protein kinase (AMPK) 2-Hydroxyglutarate phosphatidylinositol 3-kinase (PI3K) hypoxia-inducible factor-1 (HIF-1) creatine metabolism
Published by: Cells
How and Why Are Cancers Acidic? Carbonic Anhydrase IX and the Homeostatic Control of Tumour Extracellular pH
The acidic tumour microenvironment is now recognized as a tumour phenotype that drives cancer somatic evolution and disease progression, causing cancer cells to become more invasive and to metastasise. This property of solid...
Epstein-Barr-Virus-Induced One-Carbon Metabolism Drives B Cell Transformation.
Liang Wei Wang, Hongying Shen, Luis Nobre, Ina Ersing, Joao A Paulo, Stephen Trudeau, Zhonghao Wang, Nicholas A Smith, Yijie Ma, Bryn Reinstadler, Jason Nomburg, Thomas Sommermann, Ellen Cahir-McFarland, Steven P Gygi, Vamsi K Mootha, Michael P Weekes, Benjamin E Gewurz
Jun 05, 2019
Epstein-Barr virus (EBV) causes Burkitt, Hodgkin, and post-transplant B cell lymphomas. How EBV remodels metabolic pathways to support rapid B cell outgrowth remains largely unknown. To gain insights, primary human B cells were...
B-cell activation de novo serine synthesis folate isotope tracing metabolic remodeling mitochondrial one-carbon metabolism quantitative proteomics tandem mass tag tumor virus virus oncoprotein Aminohydrolases B-Lymphocytes Cell Transformation Viral Epstein-Barr Virus Infections Epstein-Barr Virus Nuclear Antigens Female Folic Acid Glycolysis HEK293 Cells Herpesvirus 4 Human Humans Lymphocyte Activation Methylenetetrahydrofolate Dehydrogenase (NADP) Mitochondria Multifunctional Enzymes NADP Oxidation-Reduction Proteome Proto-Oncogene Proteins c-myc Serine
Reasoning about privacy in mobile application install decisions
Data sharing has become prevalent with the rapid growth of mobile technologies. A lack of awareness and understanding of privacy practices often results in the installation of privacy-invasive applications (apps) which could...
How and Why Are Cancers Acidic? Carbonic Anhydrase IX and the Homeostatic Control of Tumour Extracellular pH.
The acidic tumour microenvironment is now recognized as a tumour phenotype that drives cancer somatic evolution and disease progression, causing cancer cells to become more invasive and to metastasise. This property of solid...
HIF-1-Independent Mechanisms Regulating Metabolic Adaptation in Hypoxic Cancer Cells.
In solid tumours, cancer cells exist within hypoxic microenvironments, and their metabolic adaptation to this hypoxia is driven by HIF-1 transcription factor, which is overexpressed in a broad range of human cancers. HIF...
2-Hydroxyglutarate AMP-activated protein kinase (AMPK) Myc cancer metabolism creatine metabolism Glutamine metabolism Glycolysis Hypoxia hypoxia-inducible factor-1 (HIF-1) Lipid Metabolism phosphatidylinositol 3-kinase (PI3K) Adaptation Physiological Animals Cell Hypoxia Humans Hypoxia-Inducible Factor 1 Neoplasms Signal Transduction
Structures of apo Cas12a and its complex with crRNA and DNA reveal the dynamics of ternary complex formation and target DNA cleavage.
Li Jianwei, Chacko Jobichen, Satoru Machida, Sun Meng, Randy J Read, Chen Hongying, Shi Jian, Yuren Adam Yuan, J Sivaraman
Apr 14, 2023
Cas12a is a programmable nuclease for adaptive immunity against invading nucleic acids in CRISPR-Cas systems. Here, we report the crystal structures of apo Cas12a from Lachnospiraceae bacterium MA2020 (Lb2) and the...
Published by: PLoS biology
HIF-1-Independent Mechanisms Regulating Metabolic Adaptation in Hypoxic Cancer Cells
In solid tumours, cancer cells exist within hypoxic microenvironments, and their metabolic adaptation to this hypoxia is driven by HIF-1 transcription factor, which is overexpressed in a broad range of human cancers. HIF...
Impact of infant 13-valent pneumococcal conjugate vaccine on serotypes in adult pneumonia.
Chamira Rodrigo, Thomas Bewick, Carmen Sheppard, Sonia Greenwood, Tricia M Mckeever, Caroline L Trotter, Mary Slack, Robert George, Wei Shen Lim
Mar 03, 2015
ATP-dependent substrate transport by the ABC transporter MsbA is proton-coupled.
Himansha Singh, Saroj Velamakanni, Michael J Deery, Julie Howard, Shen L Wei, Hendrik W van Veen
Jul 28, 2016
Quantifying wind-induced impacts on particulate Cu footprint in the Yangtze Estuary.
Zeng Yichuan, Wang Hua, Liang Dongfang, Yuan Weihao, Li Bao, Zhuang Wei, John Paul Kaisam, Shen Wenbo
Oct 06, 2020
Under two wind conditions, a polar coordinated segmented quantification method (PCSQM) taking the easternmost point of Chongming Island (121°59'20″E, 31°29'38″N) as the origin of the coordinate was proposed to quantify...
Carbonic anhydrase IX is a pH-stat that sets an acidic tumour extracellular pH in vivo
John Richard Griffiths, Shen-Han Lee, Dominick McIntyre, Davina Honess, Alzbeta Hulikova, Jesus Pacheco-Torres, Sebastian Cerdan, Adrian L Harris
Dec 18, 2018
Jiejie
Connie Shen
Jan 01, 0001
A prose story
Anthology Winthrop Literary Journal Arts Journal Arts Magazine Literary Magazine Magazine art poetry prose Creative Writing fiction
Published by: Winthrop University
Investigating the modulation of active preparation and passive dissipation on inhibitory control processes in the language switching paradigm.
Qinfang Shen
Feb 10, 2023
Semantic models for texturing volume objects
P Y Shen
Oct 01, 2007
Published by: Department of Computer Science, University of Bath
Effectiveness of the 23-valent pneumococcal polysaccharide vaccine against vaccine serotype pneumococcal pneumonia in adults
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