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Results: 7
A Restricted Role for FcγR in the Regulation of Adaptive Immunity.
Marieke F Fransen, Hreinn Benonisson, Wendy W van Maren, Heng Sheng Sow, Cor Breukel, Margot M Linssen, Jill WC Claassens, Conny Brouwers, Jos van der Kaa, Marcel Camps, Jan Willem Kleinovink, Kelly K Vonk, Sandra van Heiningen, Ngaisah Klar, Lianne van Beek, Vanessa van Harmelen, Lucia Daxinger, Kutty S Nandakumar, Rikard Holmdahl, Chris Coward, Qingshun Lin, Sachiko Hirose, Daniela Salvatori, Thorbald van Hall, Cees van Kooten, Piero Mastroeni, Ferry Ossendorp, J Sjef Verbeek
Sep 27, 2018
By their interaction with IgG immune complexes, FcγR and complement link innate and adaptive immunity, showing functional redundancy. In complement-deficient mice, IgG downstream effector functions are often impaired, as well as...
Large genome-wide association study identifies three novel risk variants for restless legs syndrome
Maria Didriksen, Muhammad Sulaman Nawaz, Joseph Dowsett, Steven Bell, Christian Erikstrup, Ole B. Pedersen, Erik Sørensen, Poul J. Jennum, Kristoffer S. Burgdorf, Brendan Burchell, Adam S. Butterworth, Nicole Soranzo, David B. Rye, Lynn Marie Trotti, Prabhjyot Saini, Lilja Stefansdottir, Sigurdur H. Magnusson, Gudmar Thorleifsson, Thordur Sigmundsson, Albert P. Sigurdsson, Katja van den Hurk, Franke Quee, Michael W. T. Tanck, Willem H. Ouwehand, David J. Roberts, Eric J. Earley, Michael P. Busch, Alan E. Mast, Grier P. Page, John Danesh, Emanuele Di Angelantonio, Hreinn Stefansson, Henrik Ullum, Kari Stefansson
Nov 25, 2020
A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis
Steven Bell, Andreas S. Rigas, Magnus K. Magnusson, Egil Ferkingstad, Elias Allara, Gyda Bjornsdottir, Anna Ramond, Erik Sørensen, Gisli H. Halldorsson, Dirk S. Paul, Kristoffer S. Burgdorf, Hannes P. Eggertsson, Joanna M. M. Howson, Lise W. Thørner, Snaedis Kristmundsdottir, William J. Astle, Christian Erikstrup, Jon K. Sigurdsson, Dragana Vuckovic, Khoa M. Dinh, Vinicius Tragante, Praveen Surendran, Ole B. Pedersen, Brynjar Vidarsson, Tao Jiang, Helene M. Paarup, Pall T. Onundarson, Parsa Akbari, Kaspar R. Nielsen, Sigrun H. Lund, Kristinn Juliusson, Magnus I. Magnusson, Michael L. Frigge, Asmundur Oddsson, Isleifur Olafsson, Stephen Kaptoge, Henrik Hjalgrim, Gudmundur Runarsson, Angela M. Wood, Ingileif Jonsdottir, Thomas F. Hansen, Olof Sigurdardottir, Hreinn Stefansson, David Rye, James E. Peters, David Westergaard, Hilma Holm, Nicole Soranzo, Karina Banasik, Gudmar Thorleifsson, Willem H. Ouwehand, Unnur Thorsteinsdottir, David J. Roberts, Patrick Sulem, Adam S. Butterworth, Daniel F. Gudbjartsson, John Danesh, Søren Brunak, Emanuele Di Angelantonio, Henrik Ullum, Kari Stefansson, Steffen Andersen, Kristoffer Burgdorf, Gregor Jemec, Poul Jennum, Pär Johansson, Kasper R. Nielsen, Mette Nyegaard, Mikkel Petersen, Thomas Werge, Hreinn Stefánsson, Unnur Thorsteinsdóttir
Feb 03, 2021
Abstract: Iron is essential for many biological functions and iron deficiency and overload have major health implications. We performed a meta-analysis of three genome-wide association studies from Iceland, the UK and Denmark of...
Identification of Common Genetic Variants Influencing Spontaneous Dizygotic Twinning and Female Fertility.
Hamdi Mbarek, Stacy Steinberg, Dale R Nyholt, Scott D Gordon, Michael B Miller, Allan F McRae, Jouke Jan Hottenga, Felix R Day, Gonneke Willemsen, Eco J de Geus, Gareth E Davies, Hilary C Martin, Brenda W Penninx, Rick Jansen, Kerrie McAloney, Jacqueline M Vink, Jaakko Kaprio, Robert Plomin, Tim D Spector, Patrik K Magnusson, Bruno Reversade, R Alan Harris, Kjersti Aagaard, Ragnar P Kristjansson, Isleifur Olafsson, Gudmundur Ingi Eyjolfsson, Olof Sigurdardottir, William G Iacono, Cornelis B Lambalk, Grant W Montgomery, Matt McGue, Ken K Ong, John RB Perry, Nicholas G Martin, Hreinn Stefánsson, Kari Stefánsson, Dorret I Boomsma
May 17, 2016
Large genome-wide association study identifies three novel risk variants for restless legs syndrome.
Maria Didriksen, Muhammad Sulaman Nawaz, Joseph Dowsett, Steven Bell, Christian Erikstrup, Ole B Pedersen, Erik Sørensen, Poul J Jennum, Kristoffer S Burgdorf, Brendan Burchell, Adam S Butterworth, Nicole Soranzo, David B Rye, Lynn Marie Trotti, Prabhjyot Saini, Lilja Stefansdottir, Sigurdur H Magnusson, Gudmar Thorleifsson, Thordur Sigmundsson, Albert P Sigurdsson, Katja van den Hurk, Franke Quee, Michael WT Tanck, Willem H Ouwehand, David J Roberts, Eric J Earley, Michael P Busch, Alan E Mast, Grier P Page, John Danesh, Emanuele Di Angelantonio, Hreinn Stefansson, Henrik Ullum, Kari Stefansson
Oct 27, 2020
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.
Iris E Jansen, Jeanne E Savage, Kyoko Watanabe, Julien Bryois, Dylan M Williams, Stacy Steinberg, Julia Sealock, Ida K Karlsson, Sara Hägg, Lavinia Athanasiu, Nicola Voyle, Petroula Proitsi, Aree Witoelar, Sven Stringer, Dag Aarsland, Ina S Almdahl, Fred Andersen, Sverre Bergh, Francesco Bettella, Sigurbjorn Bjornsson, Anne Brækhus, Geir Bråthen, Christiaan de Leeuw, Rahul S Desikan, Srdjan Djurovic, Logan Dumitrescu, Tormod Fladby, Timothy J Hohman, Palmi V Jonsson, Steven J Kiddle, Arvid Rongve, Ingvild Saltvedt, Sigrid B Sando, Geir Selbæk, Maryam Shoai, Nathan G Skene, Jon Snaedal, Eystein Stordal, Ingun D Ulstein, Yunpeng Wang, Linda R White, John Hardy, Jens Hjerling-Leffler, Patrick F Sullivan, Wiesje M van der Flier, Richard Dobson, Lea K Davis, Hreinn Stefansson, Kari Stefansson, Nancy L Pedersen, Stephan Ripke, Ole A Andreassen, Danielle Posthuma
Jan 17, 2019
Genome-wide association study identifies 48 common genetic variants associated with handedness.
Gabriel Cuellar-Partida, Joyce Y Tung, Nicholas Eriksson, Eva Albrecht, Fazil Aliev, Ole A Andreassen, Inês Barroso, Jacques S Beckmann, Marco P Boks, Dorret I Boomsma, Heather A Boyd, Monique MB Breteler, Harry Campbell, Daniel I Chasman, Lynn F Cherkas, Gail Davies, Eco JC de Geus, Ian J Deary, Panos Deloukas, Danielle M Dick, David L Duffy, Johan G Eriksson, Tõnu Esko, Bjarke Feenstra, Frank Geller, Christian Gieger, Ina Giegling, Scott D Gordon, Jiali Han, Thomas F Hansen, Annette M Hartmann, Caroline Hayward, Kauko Heikkilä, Andrew A Hicks, Joel N Hirschhorn, Jouke-Jan Hottenga, Jennifer E Huffman, Liang-Dar Hwang, M Arfan Ikram, Jaakko Kaprio, John P Kemp, Kay-Tee Khaw, Norman Klopp, Bettina Konte, Zoltan Kutalik, Jari Lahti, Xin Li, Ruth JF Loos, Michelle Luciano, Sigurdur H Magnusson, Massimo Mangino, Pedro Marques-Vidal, Nicholas G Martin, Wendy L McArdle, Mark I McCarthy, Carolina Medina-Gomez, Mads Melbye, Scott A Melville, Andres Metspalu, Lili Milani, Vincent Mooser, Mari Nelis, Dale R Nyholt, Kevin S O'Connell, Roel A Ophoff, Cameron Palmer, Aarno Palotie, Teemu Palviainen, Guillaume Pare, Lavinia Paternoster, Leena Peltonen, Brenda WJH Penninx, Ozren Polasek, Peter P Pramstaller, Inga Prokopenko, Katri Raikkonen, Samuli Ripatti, Fernando Rivadeneira, Igor Rudan, Dan Rujescu, Johannes H Smit, George Davey Smith, Jordan W Smoller, Nicole Soranzo, Tim D Spector, Beate St Pourcain, John M Starr, Hreinn Stefánsson, Stacy Steinberg, Maris Teder-Laving, Gudmar Thorleifsson, Kári Stefánsson, Nicholas J Timpson, André G Uitterlinden, Cornelia M van Duijn, Frank JA van Rooij, Jaqueline M Vink, Peter Vollenweider, Eero Vuoksimaa, Gérard Waeber, Nicholas J Wareham, Nicole Warrington, Dawn Waterworth, Thomas Werge, H-Erich Wichmann, Elisabeth Widen, Gonneke Willemsen, Alan F Wright, Margaret J Wright, Mousheng Xu, Jing Hua Zhao, Peter Kraft, David A Hinds, Cecilia M Lindgren, Reedik Mägi, Benjamin M Neale, David M Evans, Sarah E Medland
Aug 19, 2020
Handedness has been extensively studied because of its relationship with language and the over-representation of left-handers in some neurodevelopmental disorders. Using data from the UK Biobank, 23andMe and the International...