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Wearable, Integrated EEG-fNIRS Technologies
There has been considerable interest in applying electroencephalography (EEG) and functional near-infrared spectroscopy (fNIRS) simultaneously for multimodal assessment of brain function. EEG-fNIRS can provide a comprehensive...
Structural and Functional Studies of Mycobacterial General Transcription Factors RbpA and CarD
Elizabeth Hubin
Jan 01, 0001
Gene expression in bacteria is highly regulated at the step of transcription initiation. For decades, the vast majority of biochemical and kinetic studies have used Escherichia coli (Eco) RNA polymerase (RNAP) as a model for...
Published by: Rockefeller University
Xenopus DPPA2 is a Direct Inhibitor of Microtubule Polymerization Required for Nuclear Assembly
John Zhao Xue
Jan 01, 0001
The eukaryotic nucleus mediates the genomic functions of information storage and gene expression, but must be completely rebuilt after every open mitosis as well as during fertilization. Nuclear abnormalities are observed in...
Published by: Rockefeller University
Variable Selection for a Categorical Varying-Coefficient Model with Identifications for Determinants of Body Mass Index
Obesity has become one of the major public health issues during the last three decades. A considerable number of determinants have been proposed for body mass index (BMI) by a large range of studies from multiple disciplines. In...
Variable Selection for a Categorical Varying-Coefficient Model with Identifications for Determinants of Body Mass Index
Obesity has become one of the major public health issues during the last three decades. A considerable number of determinants have been proposed for body mass index (BMI) by a large range of studies from multiple disciplines. In...
Human and mouse leukocytes
Simón Méndez-Ferrer
Mar 19, 2018
In this issue of Blood, Zhao et al use a humanized mouse model to investigate the mechanisms driving daily oscillations in circulating human and murine leukocytes.1 In the same mice, they find human and murine circulating...
Metabolically Specific In Situ Fluorescent Visualization of Bacterial Infection on Wound Tissues
Chen Jian Zhong, Xi Le Hu, Xiao Lan Yang, Hui Qi Gan, Kai Cheng Yan, Fu Ting Shu, Pei Wei, Teng Gong, Peng Fei Luo, Tony D. James, Zhao Hong Chen, Yong Jun Zheng, Xiao Peng He, Zhao Fan Xia
Sep 07, 2022
The ability to effectively detect bacterial infection in human tissues is important for the timely treatment of the infection. However, traditional techniques fail to visualize bacterial species adhered to host cells in situ...
Proline-Based Boronic Acid Receptors for Chiral Recognition of Glucose
Lin-E Guo, Yuan Hong, Shu-Ying Zhang, Miao Zhang, Xiao-Sheng Yan, Jin-Lian Cao, Zhao Li, Tony D James, Yun-Bao Jiang
Dec 21, 2018
Chiral recognition remains a major challenge in the area of molecular receptor design. With this research, we set out to explore the use of proline-based receptors for chiral recognition. Importantly, the proline structure...
Impact of Correlated Noise on the Mass Precision of Earth-analog Planets in Radial Velocity Surveys
Jacob K. Luhn, Eric B. Ford, Zhao Guo, Christian Gilbertson, Patrick Newman, Peter Plavchan, Jennifer A. Burt, Johanna Teske, Arvind F. Gupta
Feb 10, 2023
Characterizing the masses and orbits of near-Earth-mass planets is crucial for interpreting observations from future direct imaging missions (e.g., HabEx, LUVOIR). Therefore, the Exoplanet Science Strategy report recommended...
Published by: The American Astronomical Society
Metabolically Specific In Situ Fluorescent Visualization of Bacterial Infection on Wound Tissues
Chen Jian Zhong, Xi Le Hu, Xiao Lan Yang, Hui Qi Gan, Kai Cheng Yan, Fu Ting Shu, Pei Wei, Teng Gong, Peng Fei Luo, Tony D. James, Zhao Hong Chen, Yong Jun Zheng, Xiao Peng He, Zhao Fan Xia
Sep 07, 2022
The ability to effectively detect bacterial infection in human tissues is important for the timely treatment of the infection. However, traditional techniques fail to visualize bacterial species adhered to host cells in situ...
In situ structure of the AcrAB-TolC efflux pump at subnanometer resolution.
Muyuan Chen, Xiaodong Shi, Zhili Yu, Guizhen Fan, Irina I Serysheva, Matthew L Baker, Ben F Luisi, Steven J Ludtke, Zhao Wang
Sep 16, 2021
The tripartite AcrAB-TolC assembly, which spans both the inner and outer membranes in Gram-negative bacteria, is an efflux pump that contributes to multidrug resistance. Here, we present the in situ structure of full-length...
AcrAB-TolC cryo-ET in situ multidrug efflux pump subnanometer resolution Allosteric Regulation Bacterial Outer Membrane Proteins Carrier Proteins Cryoelectron Microscopy Electron Microscope Tomography Escherichia coli Escherichia coli Proteins Ligands Lipoproteins Membrane Transport Proteins Models Molecular Multidrug Resistance-Associated Proteins Protein Conformation
Proline-Based Boronic Acid Receptors for Chiral Recognition of Glucose
Lin-E Guo, Yuan Hong, Shu-Ying Zhang, Miao Zhang, Xiao-Sheng Yan, Jin-Lian Cao, Zhao Li, Tony D James, Yun-Bao Jiang
Dec 21, 2018
Chiral recognition remains a major challenge in the area of molecular receptor design. With this research, we set out to explore the use of proline-based receptors for chiral recognition. Importantly, the proline structure...
In situ structure and assembly of the multidrug efflux pump AcrAB-TolC.
Xiaodong Shi, Muyuan Chen, Zhili Yu, James M Bell, Hans Wang, Isaac Forrester, Heather Villarreal, Joanita Jakana, Dijun Du, Ben F Luisi, Steven J Ludtke, Zhao Wang
Jun 13, 2019
Anti-Bacterial Agents Bacterial Outer Membrane Proteins Carrier Proteins Cryoelectron Microscopy Drug Resistance Multiple Bacterial Electron Microscope Tomography Escherichia coli Escherichia coli Proteins Intravital Microscopy Lipoproteins Membrane Transport Proteins Multidrug Resistance-Associated Proteins Peptidoglycan Periplasm Protein Binding Protein Structure Quaternary
Two distinct β-sheet structures in Italian-mutant amyloid-beta fibrils
Ellen Hubin, Stéphanie Deroo, Gabriele Kaminksi Schierle, Clemens Kaminski, Louise Serpell, Vinod Subramaniam, Nico van Nuland, Kerensa Broersen, Vincent Raussens, Rabia Sarroukh
Feb 12, 2020
Most Alzheimer's disease (AD) cases are late-onset and characterized by the aggregation and deposition of the amyloid-beta (Aβ) peptide in extracellular plaques in the brain. However, a few rare and hereditary Aβ mutations, such...
An Organic–Inorganic Hybrid Exhibiting Electrical Conduction and Single‐Ion Magnetism
Yongbing Shen, Goulven Cosquer, Hiroshi Ito, David C Izuogu, Alex JW Thom, Toshiaki Ina, Tomoya Uruga, Takefumi Yoshida, Shinya Takaishi, Brian K Breedlove, Zhao‐Yang Li, Masahiro Yamashita
Jan 27, 2020
The first three–dimensional (3D) conductive single-ion magnet (SIM), (TTF)2[Co(pdms)2] (TTF =
tetrathiafulvalene and H2pdms = 1,2-bis(methanesulfonamido)benzene), was electrochemically
synthesized and investigated structurally...
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