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IPR Policy Brief - The global auction for high skilled work
It is commonly assumed that in the global knowledge economy there is a straightforward relationship between learning and earning. The key finding of research conducted by Phillip Brown (Cardiff University), Hugh Lauder...
Published by: University of Bath
IPR Policy Brief - The global auction for high skilled work
It is commonly assumed that in the global knowledge economy there is a straightforward relationship between learning and earning. The key finding of research conducted by Phillip Brown (Cardiff University), Hugh Lauder...
Published by: University of Bath
Functional interplay of Epstein-Barr virus oncoproteins in a mouse model of B cell lymphomagenesis.
Thomas Sommermann, Tomoharu Yasuda, Jonathan Ronen, Tristan Wirtz, Timm Weber, Ulrike Sack, Rebecca Caeser, Jingwei Zhang, Xun Li, Van Trung Chu, Anna Jauch, Kristian Unger, Daniel J Hodson, Altuna Akalin, Klaus Rajewsky
Jun 15, 2020
Epstein-Barr virus (EBV) is a B cell transforming virus that causes B cell malignancies under conditions of immune suppression. EBV orchestrates B cell transformation through its latent membrane proteins (LMPs) and Epstein-Barr...
B cell lymphomagenesis EBNA Epstein-Barr virus LMP1 plasma cell differentiation Animals Cell Differentiation Cell Line Tumor Cell Transformation Viral DNA-Binding Proteins Disease Models Animal Epstein-Barr Virus Infections Epstein-Barr Virus Nuclear Antigens FIBROBLASTS Herpesvirus 4 Human Humans Lymphoma B-Cell Mice Mice Knockout Plasma Cells Primary Cell Culture Trans-Activators Viral Matrix Proteins Viral Proteins
Epstein-Barr virus subverts mevalonate and fatty acid pathways to promote infected B-cell proliferation and survival.
Liang Wei Wang, Zhonghao Wang, Ina Ersing, Luis Nobre, Rui Guo, Sizun Jiang, Stephen Trudeau, Bo Zhao, Michael P Weekes, Benjamin E Gewurz
Aug 19, 2019
Epstein-Barr virus (EBV) causes infectious mononucleosis and is associated with multiple human malignancies. EBV drives B-cell proliferation, which contributes to the pathogenesis of multiple lymphomas. Yet, knowledge of how EBV...
Alkyl and Aryl Transferases B-Lymphocytes Cell Proliferation Cell Survival Cholesterol Epstein-Barr Virus Infections Epstein-Barr Virus Nuclear Antigens Fatty Acids Herpesvirus 4 Human Host Microbial Interactions Humans Metabolic Networks and Pathways Mevalonic Acid Proto-Oncogene Proteins c-myc Sterol Regulatory Element Binding Protein 2 Viral Proteins rab GTP-Binding Proteins
Dendritic Cells Initiate Immune Control of Epstein-Barr Virus Transformation of B Lymphocytes in Vitro
The initiation of cell-mediated immunity to Epstein-Barr virus (EBV) has been analyzed with cells from EBV-seronegative blood donors in culture. The addition of dendritic cells (DCs) is essential to prime naive T cells that...
Published by: Rockefeller University
A Temporal Proteomic Map of Epstein-Barr Virus Lytic Replication in B Cells
I Ersing, L Nobre, LW Wang, L Soday, Y Ma, JA Paulo, Y Narita, CW Ashbaugh, C Jiang, NE Grayson, E Kieff, SP Gygi, MP Weekes, BE Gewurz
Jul 04, 2017
Epstein-Barr virus (EBV) replication contributes to multiple human diseases, including infectious mononucleosis, nasopharyngeal carcinoma, B cell lymphomas, and oral hairy leukoplakia. We performed systematic quantitative...
A recombinant modified vaccinia Ankara vaccine encoding Epstein-Barr virus (EBV) target antigens
Graham S. Taylor, Hui Jia, Kevin Harrington, Lip Wai Lee, James E Turner, Kristin Ladell, David A. Price, Manjit Tanday, Jen Matthews, Claudia Roberts, Ceri Edwards, Lesley McGuigan, Andrew Hartley, Steve Wilson, Edwin P. Hui, Anthony T. C. Chan, Alan B. Rickinson, Neil M. Steven
Oct 01, 2014
Purpose: Epstein-Barr virus (EBV) is associated with several cancers in which the tumour cells express EBV antigens EBNA1 and LMP2. A therapeutic vaccine comprising a recombinant vaccinia virus, MVA-EL, was designed to boost...
Epstein-Barr-virus-positive large B-cell lymphoma associated with breast implants
L Jeffrey Medeiros, Mario L Marques-Piubelli, Valentina FI Sangiorgio, Roberto Ruiz-Cordero, Francisco Vega, Andrew L Feldman, Jennifer R Chapman, Mark W Clemens, Kelly K Hunt, Mark G Evans, Christine Khoo, Stephen Lade, Mark Silberman, Jerzy Morkowski, Edward M Pina, Daniel C Mills, Christopher M Bates, Winston B Magno, Aliyah R Sohani, Beth A Sieling, Joseph M O'Donoghue, Chris M Bacon, Neill Patani, Despina Televantou, Suzanne D Turner, Laura Johnson, Fiona MacNeill, Andrew C Wotherspoon, Swaminathan P Iyer, Luis E Malpica, Keyur P Patel, Jie Xu, Roberto N Miranda
Jun 21, 2021
Breast implant anaplastic large cell lymphoma (ALCL) is a T-cell neoplasm arising around textured breast implants that was recognized recently as a distinct entity by the World Health Organization. Rarely, other types of...
Human CD4+ T lymphocytes consistently respond to the latent Epstein- Barr virus nuclear antigen EBNA1
The Epstein-Barr virus (EBV)-encoded nuclear antigen EBNA1 is critical for the persistence of the viral episome in replicating EBV-transformed human B cells. Therefore, all EBV-induced tumors express this foreign antigen....
Published by: Rockefeller University
What to give the patient who has everything? A qualitative study of prescribing for multimorbidity in primary care.
BACKGROUND: Using clinical guidelines in the management of patients with multimorbidity can lead to the prescription of multiple and sometimes conflicting medications. AIM: To explore how GPs make decisions when prescribing for...
Chronic Disease Decision Making General Practice Medication Therapy Management physician’s practice patterns qualitative research Chronic Disease communication Comorbidity Decision Making Evidence-Based Medicine general practitioners Humans Ireland Medication Therapy Management Physician-Patient Relations Practice Guidelines as Topic Practice Patterns Physicians' qualitative research
Of Mice and Men: Studying Innate and Adaptive Immunity Against the Epstein-Barr Virus
Till Strowig
Jan 01, 0001
The Epstein-Barr virus (EBV) is a lymphotropic ?-herpes virus infecting over 90% of the human adult population. A striking feature that the virus shares with other ?-herpes viruses is its oncogenic potential. This transforming...
Published by: Rockefeller University
Rock Hill Man Charged with Five Burglaries of Campus Buildings
Winthrop University
Jan 01, 0001
Zedric Barr, 24, arrested for trespassing and now charged with several burglaries. Campus Police charged a second man for possessing property from the burglaries.
Published by: Winthrop University
MLOps
Companies are moving from a cottage industry to a factory approach to analytics, especially in regard to machine learning (ML) models. This change is motivating companies to adopt ML operations (MLOps) as a methodology for the...
Published by: IGI Global Scientific Publishing
Epstein-Barr-Virus-Induced One-Carbon Metabolism Drives B Cell Transformation.
Liang Wei Wang, Hongying Shen, Luis Nobre, Ina Ersing, Joao A Paulo, Stephen Trudeau, Zhonghao Wang, Nicholas A Smith, Yijie Ma, Bryn Reinstadler, Jason Nomburg, Thomas Sommermann, Ellen Cahir-McFarland, Steven P Gygi, Vamsi K Mootha, Michael P Weekes, Benjamin E Gewurz
Jun 05, 2019
Epstein-Barr virus (EBV) causes Burkitt, Hodgkin, and post-transplant B cell lymphomas. How EBV remodels metabolic pathways to support rapid B cell outgrowth remains largely unknown. To gain insights, primary human B cells were...
B-cell activation de novo serine synthesis folate isotope tracing metabolic remodeling mitochondrial one-carbon metabolism quantitative proteomics tandem mass tag tumor virus virus oncoprotein Aminohydrolases B-Lymphocytes Cell Transformation Viral Epstein-Barr Virus Infections Epstein-Barr Virus Nuclear Antigens Female Folic Acid Glycolysis HEK293 Cells Herpesvirus 4 Human Humans Lymphocyte Activation Methylenetetrahydrofolate Dehydrogenase (NADP) Mitochondria Multifunctional Enzymes NADP Oxidation-Reduction Proteome Proto-Oncogene Proteins c-myc Serine
Host genetic variants and gene expression patterns associated with Epstein-Barr virus copy number in lymphoblastoid cell lines.
Charlotte J Houldcroft, Velislava Petrova, Jimmy Z Liu, Dan Frampton, Carl A Anderson, Astrid Gall, Paul Kellam
Nov 30, 2018
Lymphoblastoid cell lines (LCLs) are commonly used in molecular genetics, supplying DNA for the HapMap and 1000 Genomes Projects, used to test chemotherapeutic agents, and informing the basis of a number of population genetics...
GPs' perspectives on the management of patients with multimorbidity
OBJECTIVE: To synthesise the existing published literature on the perceptions of general practitioners (GPs) or their equivalent on the clinical management of multimorbidity and determine targets for future research that aims to...
Epstein-Barr virus nuclear antigen EBNA-LP is essential for transforming naïve B cells, and facilitates recruitment of transcription factors to the viral genome.
Agnieszka Szymula, Richard D Palermo, Amr Bayoumy, Ian J Groves, Mohammed Ba Abdullah, Beth Holder, Robert E White
Jul 31, 2018
The Epstein-Barr virus (EBV) nuclear antigen leader protein (EBNA-LP) is the first viral latency-associated protein produced after EBV infection of resting B cells. Its role in B cell transformation is poorly defined, but it has...
Adult B-Lymphocytes Cell Transformation Viral Cells Cultured Epstein-Barr Virus Infections Female Gene Expression Regulation Viral Genome Viral HEK293 Cells Herpesvirus 4 Human Humans Infant Newborn Leukemia B-Cell Pregnancy Promoter Regions Genetic Protein Binding Transcription Factors Viral Proteins
A recombinant modified vaccinia Ankara vaccine encoding Epstein-Barr virus (EBV) target antigens
Graham S. Taylor, Hui Jia, Kevin Harrington, Lip Wai Lee, James E Turner, Kristin Ladell, David A. Price, Manjit Tanday, Jen Matthews, Claudia Roberts, Ceri Edwards, Lesley McGuigan, Andrew Hartley, Steve Wilson, Edwin P. Hui, Anthony T. C. Chan, Alan B. Rickinson, Neil M. Steven
Oct 01, 2014
Purpose: Epstein-Barr virus (EBV) is associated with several cancers in which the tumour cells express EBV antigens EBNA1 and LMP2. A therapeutic vaccine comprising a recombinant vaccinia virus, MVA-EL, was designed to boost...
EBNA1-specific CD4+ T cells in healthy carriers of Epstein-Barr virus are primarily Th1 in function
The Epstein-Barr virus (EBV) nuclear antigen-1 (EBNA1) maintains the viral episome in all host cells infected with EBV. Recently, EBNA1 was found to be the main EBV latency antigen for CD4+ T cells and could be recognized in...
cell isolation Epstein Barr virus nasopharynx carcinoma T lymphocyte subpopulation virus carcinogenesis
Published by: Rockefeller University
Thinking About Globalizaton as an Integration Process
For a long time, many studies have been involved with the globalization research among academia, business practitioners, and policy analysts. It is highly controversial on what globalization is about. Scholars and experts...
Published by: IGI Global Scientific Publishing
Distinct Roles of Extracellular Domains in the Epstein-Barr Virus-Encoded BILF1 Receptor for Signaling and Major Histocompatibility Complex Class I Downregulation.
Suzan Fares, Katja Spiess, Emma TB Olesen, Jianmin Zuo, Sarah Jackson, Thomas N Kledal, Mark R Wills, Mette M Rosenkilde
Feb 07, 2019
The Epstein-Barr virus (EBV) BILF1 gene encodes a constitutively active G protein-coupled receptor (GPCR) that downregulates major histocompatibility complex (MHC) class I and induces signaling-dependent tumorigenesis. Different...
Dendritic cells cross-present latency gene products from Epstein-Barr virus-transformed B cells and expand tumor-reactive CD8+ killer T cells
Dendritic cells (DCs) are not targets for infection by the transforming Epstein-Barr virus (EBV). To test if the adjuvant role of DCs could be harnessed against EBV latency genes by cross-presentation, DCs were allowed to...
Published by: Rockefeller University
Commencement Highlights Include Photography Major's Finish and Honorary Degrees
Winthrop University
Jan 01, 0001
Austin Harmon is one of more than 310 students receiving their undergraduate degrees on Saturday at 11 a.m. at the Winthrop Coliseum. President Anthony DiGiorgio also will present honorary degrees to S.C. State Senator Hugh...
Published by: Winthrop University
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