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KIR Variation in Iranians Combines High Haplotype and Allotype Diversity With an Abundance of Functional Inhibitory Receptors.
Claudia Alicata, Elham Ashouri, Neda Nemat-Gorgani, Lisbeth A Guethlein, Wesley M Marin, Sudan Tao, Lorenzo Moretta, Jill A Hollenbach, John Trowsdale, James A Traherne, Abbas Ghaderi, Peter Parham, Paul J Norman
May 18, 2020
Natural killer (NK) cells are innate lymphocytes that eliminate infected and transformed cells. They discriminate healthy from diseased tissue through killer cell Ig-like receptor (KIR) recognition of HLA class I ligands....
Published by: Frontiers in immunology
KIR in Allogeneic Hematopoietic Stem Cell Transplantation
Adèle Dhuyser, Alice Aarnink, Michaël Pérès, Jyothi Jayaraman, Neda Nemat-Gorgani, Marie Thérèse Rubio, John Trowsdale, James Traherne
Mar 01, 2022
Allogeneic hematopoietic stem cell transplantation (aHSCT) is a lifesaving therapy for hematological malignancies. For years, a fully matched HLA donor was a requisite for the procedure. However, new immunosuppressive strategies...
KIR Variation in Iranians Combines High Haplotype and Allotype Diversity With an Abundance of Functional Inhibitory Receptors.
Claudia Alicata, Elham Ashouri, Neda Nemat-Gorgani, Lisbeth A Guethlein, Wesley M Marin, Sudan Tao, Lorenzo Moretta, Jill A Hollenbach, John Trowsdale, James A Traherne, Abbas Ghaderi, Peter Parham, Paul J Norman
May 29, 2020
Natural killer (NK) cells are innate lymphocytes that eliminate infected and transformed cells. They discriminate healthy from diseased tissue through killer cell Ig-like receptor (KIR) recognition of HLA class I ligands....
KIR Variation in Iranians Combines High Haplotype and Allotype Diversity With an Abundance of Functional Inhibitory Receptors
Claudia Alicata, Elham Ashouri, Neda Nemat-Gorgani, Lisbeth A. Guethlein, Wesley M. Marin, Sudan Tao, Lorenzo Moretta, Jill A. Hollenbach, John Trowsdale, James A. Traherne, Abbas Ghaderi, Peter Parham, Paul J. Norman
Apr 16, 2020
Natural killer (NK) cells are innate lymphocytes that eliminate infected and transformed cells. They discriminate healthy from diseased tissue through killer cell Ig-like receptor (KIR) recognition of HLA class I ligands....
Virtual Fly Brain-An interactive atlas of the Drosophila nervous system.
Diversity of KIR genes and their HLA-C ligands in Ugandan populations with historically varied malaria transmission intensity.
Stephen Tukwasibwe, James A Traherne, Olympe Chazara, Jyothi Jayaraman, John Trowsdale, Ashley Moffett, Wei Jiang, Joaniter I Nankabirwa, John Rek, Emmanuel Arinaitwe, Samuel L Nsobya, Maxine Atuheirwe, Mubiru Frank, Anguzu Godwin, Prasanna Jagannathan, Stephen Cose, Moses R Kamya, Grant Dorsey, Philip J Rosenthal, Francesco Colucci, Annettee Nakimuli
May 10, 2021
BACKGROUND: Malaria is one of the most serious infectious diseases in the world. The malaria burden is greatly affected by human immunity, and immune responses vary between populations. Genetic diversity in KIR and HLA-C genes...
Virtual Fly Brain-An interactive atlas of the Drosophila nervous system.
Robert Court, Marta Costa, Clare Pilgrim, Gillian Millburn, Alex Holmes, Alex McLachlan, Aoife Larkin, Nicolas Matentzoglu, Huseyin Kir, Helen Parkinson, Nicolas H Brown, Cahir J O'Kane, J Douglas Armstrong, Gregory SXE Jefferis, David Osumi-Sutherland
Mar 16, 2023
As a model organism, Drosophila is uniquely placed to contribute to our understanding of how brains control complex behavior. Not only does it have complex adaptive behaviors, but also a uniquely powerful genetic toolkit...
Introduction
The MHC controls specificity, to ensure that appropriate immune responses are mounted to invading pathogens whilst maintaining tolerance to the host. It encodes molecules that act as sentinels, providing a snapshot of the health...
Diversity of KIR genes and their HLA-C ligands in Ugandan populations with historically varied malaria transmission intensity
Stephen Tukwasibwe, James A. Traherne, Olympe Chazara, Jyothi Jayaraman, John Trowsdale, Ashley Moffett, Wei Jiang, Joaniter I. Nankabirwa, John Rek, Emmanuel Arinaitwe, Samuel L. Nsobya, Maxine Atuheirwe, Mubiru Frank, Anguzu Godwin, Prasanna Jagannathan, Stephen Cose, Moses R. Kamya, Grant Dorsey, Philip J. Rosenthal, Francesco Colucci, Annettee Nakimuli
Feb 25, 2021
Abstract: Background: Malaria is one of the most serious infectious diseases in the world. The malaria burden is greatly affected by human immunity, and immune responses vary between populations. Genetic diversity in KIR and...
Contribution of HLA and KIR Alleles to Systemic Sclerosis Susceptibility and Immunological and Clinical Disease Subtypes.
Aimee L Hanson, Joanne Sahhar, Gene-Siew Ngian, Janet Roddy, Jennifer Walker, Wendy Stevens, Mandana Nikpour, Shervin Assassi, Susanna Proudman, Maureen D Mayes, Tony J Kenna, Matthew A Brown
Jun 29, 2022
Systemic sclerosis (SSc) is an autoinflammatory, fibrotic condition of unknown aetiology. The presence of detectable autoantibodies against diverse nuclear antigens, as well as strong HLA associations with disease, suggest...
qKAT
Jyothi Jayaraman, Vitalina Kirgizova, Da Di, Christopher Johnson, Wei Jiang, James A Traherne
Oct 04, 2019
Killer cell immunoglobulin-like receptors (KIRs) are a set of inhibitory and activating immune receptors, on natural killer (NK) and T cells, encoded by a polymorphic cluster of genes on chromosome 19. Their best-characterized...
Segment-specific differences in the inward rectifier K<sup>+</sup> current along the renal interlobular artery.
Aims: We investigated the role of the inward rectifier K(+) channel (K(IR)) in the renal interlobular artery (ILA). The ILA supplies the afferent arteriole and ranges in diameter from >100 µm near its origin at the...
Segment-specific differences in the inward rectifier K<sup>+</sup> current along the renal interlobular artery.
Aims: We investigated the role of the inward rectifier K(+) channel (K(IR)) in the renal interlobular artery (ILA). The ILA supplies the afferent arteriole and ranges in diameter from >100 µm near its origin at the...
Distinctive phenotypes and functions of innate lymphoid cells in human decidua during early pregnancy.
Oisín Huhn, Martin A Ivarsson, Lucy Gardner, Mike Hollinshead, Jane C Stinchcombe, Puran Chen, Norman Shreeve, Olympe Chazara, Lydia E Farrell, Jakob Theorell, Hormas Ghadially, Peter Parham, Gillian Griffiths, Amir Horowitz, Ashley Moffett, Andrew M Sharkey, Francesco Colucci
Feb 21, 2020
During early pregnancy, decidual innate lymphoid cells (dILCs) interact with surrounding maternal cells and invading fetal extravillous trophoblasts (EVT). Here, using mass cytometry, we characterise five main dILC subsets...
Published by: Nature Communications
Polymorphism in killer cell immunoglobulin-like receptors and human leukocyte antigen-c and predisposition to preeclampsia in Ethiopian pregnant women population.
Tsehayneh Kelemu, Lena Erlandsson, Daniel Seifu, Eva Hansson, Markos Abebe, Sisay Teklu, Selfu Girma, James A Traherne, Ashley Moffett, Stefan R Hansson
Jun 26, 2020
INTRODUCTION: Preeclampsia (PE) is a human specific pregnancy-related syndrome of unknown etiology that affects 2-8 % of pregnancies. Polymorphism in maternal Killer Cell Immunoglobulin-like Receptors (KIRs) and the ligand fetal...
HLA KIR natural killer cell Preeclampsia Trophoblast cell Adolescent Adult Case-Control Studies Ethiopia Female Fetus Gene Frequency Genetic Predisposition to Disease HLA-C Antigens Humans Immune Tolerance Killer Cells Natural Polymorphism Single Nucleotide pre-eclampsia Pregnancy Protective factors Receptors KIR Young Adult
Distinctive phenotypes and functions of innate lymphoid cells in human decidua during early pregnancy
Oisín Huhn, Martin A. Ivarsson, Lucy Gardner, Mike Hollinshead, Jane C Stinchcombe, Puran Chen, Norman Shreeve, Olympe Chazara, Lydia E. Farrell, Jakob Theorell, Hormas Ghadially, Peter Parham, Gillian Griffiths, Amir Horowitz, Ashley Moffett, Andrew M. Sharkey, Francesco Colucci
Jan 19, 2021
Abstract: During early pregnancy, decidual innate lymphoid cells (dILCs) interact with surrounding maternal cells and invading fetal extravillous trophoblasts (EVT). Here, using mass cytometry, we characterise five main dILC...
Inhibitory killer cell immunoglobulin-like receptors strengthen CD8+ T cell-mediated control of HIV-1, HCV, and HTLV-1.
Lies Boelen, Bisrat Debebe, Marcos Silveira, Arafa Salam, Julia Makinde, Chrissy H Roberts, Eddie CY Wang, John Frater, Jill Gilmour, Katie Twigger, Kristin Ladell, Kelly L Miners, Jyothi Jayaraman, James A Traherne, David A Price, Ying Qi, Maureen P Martin, Derek C Macallan, Chloe L Thio, Jacquie Astemborski, Gregory Kirk, Sharyne M Donfield, Susan Buchbinder, Salim I Khakoo, James J Goedert, John Trowsdale, Mary Carrington, Simon Kollnberger, Becca Asquith
Dec 05, 2018
Killer cell immunoglobulin-like receptors (KIRs) are expressed predominantly on natural killer cells, where they play a key role in the regulation of innate immune responses. Recent studies show that inhibitory KIRs can also...
Enhanced Ceria Nanoflakes using Graphene Oxide as a Sacrificial Template for CO Oxidation and Dry Reforming of Methane
Shawn Rood, Huseyin Ahmet, Anais Gomez-Ramon, Laura Torrente-Murciano, Tomas Reina, Salvador Eslava
Mar 01, 2019
The development of novel fabrication methods to produce ceria catalysts with good high-temperature stability is critical for their implementation across a range of different applications. Herein, graphene oxide flakes are used...
Enhanced Ceria Nanoflakes using Graphene Oxide as a Sacrificial Template for CO Oxidation and Dry Reforming of Methane
Shawn Rood, Huseyin Ahmet, Anais Gomez-Ramon, Laura Torrente-Murciano, Tomas Reina, Salvador Eslava
Mar 01, 2019
The development of novel fabrication methods to produce ceria catalysts with good high-temperature stability is critical for their implementation across a range of different applications. Herein, graphene oxide flakes are used...
Ontology Development Kit
Nicolas Matentzoglu, Damien Goutte-Gattat, Shawn Zheng Kai Tan, James P Balhoff, Seth Carbon, Anita R Caron, William D Duncan, Joe E Flack, Melissa Haendel, Nomi L Harris, William R Hogan, Charles Tapley Hoyt, Rebecca C Jackson, HyeongSik Kim, Huseyin Kir, Martin Larralde, Julie A McMurry, James A Overton, Bjoern Peters, Clare Pilgrim, Ray Stefancsik, Sofia Mc Robb, Sabrina Toro, Nicole A Vasilevsky, Ramona Walls, Christopher J Mungall, David Osumi-Sutherland
Nov 08, 2022
Similar to managing software packages, managing the ontology life cycle involves multiple complex workflows such as preparing releases, continuous quality control checking and dependency management. To manage these processes, a...
NK cell allorecognition.
Ashley Moffett
Jul 19, 2019
My interest in uterine natural killer (NK) cells began in the early 1990s, when I and others described the striking accumulation of NK cells in the uterine mucosa during the establishment of the placenta. Whilst working as a...
Mouse fetal growth restriction through parental and fetal immune gene variation and intercellular communications cascade.
Gurman Kaur, Caroline BM Porter, Orr Ashenberg, Jack Lee, Samantha J Riesenfeld, Matan Hofree, Maria Aggelakopoulou, Ayshwarya Subramanian, Subita Balaram Kuttikkatte, Kathrine E Attfield, Christiane AE Desel, Jessica L Davies, Hayley G Evans, Inbal Avraham-Davidi, Lan T Nguyen, Danielle A Dionne, Anna E Neumann, Lise Torp Jensen, Thomas R Barber, Elizabeth Soilleux, Mary Carrington, Gil McVean, Orit Rozenblatt-Rosen, Aviv Regev, Lars Fugger
Jul 29, 2022
Fetal growth restriction (FGR) affects 5-10% of pregnancies, and can have serious consequences for both mother and child. Prevention and treatment are limited because FGR pathogenesis is poorly understood. Genetic studies...
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