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Impact of Yeast-Derived β-Glucans on the Porcine Gut Microbiota and Immune System in Early Life.
Hugo de Vries, Mirelle Geervliet, Christine A Jansen, Victor PMG Rutten, Hubèrt van Hees, Natalie Groothuis, Jerry M Wells, Huub FJ Savelkoul, Edwin Tijhaar, Hauke Smidt
Jan 11, 2021
Piglets are susceptible to infections in early life and around weaning due to rapid environmental and dietary changes. A compelling target to improve pig health in early life is diet, as it constitutes a pivotal determinant of...
Age-associated Impairment of the Mucus Barrier Function is Associated with Profound Changes in Microbiota and Immunity.
Bruno Sovran, Floor Hugenholtz, Marlies Elderman, Adriaan A Van Beek, Katrine Graversen, Myrte Huijskes, Mark V Boekschoten, Huub FJ Savelkoul, Paul De Vos, Jan Dekker, Jerry M Wells
Jul 16, 2019
Aging significantly increases the vulnerability to gastrointestinal (GI) disorders but there are few studies investigating the key factors in aging that affect the GI tract. To address this knowledge gap, we used 10-week- and...
Planar cell polarity
Adrià Chorro, Bhavna Verma, Maylin Homfeldt, Beatríz Ibáñez, Peter A Lawrence, José Casal
Jan 07, 2023
The slope of a supracellular molecular gradient has long been thought to orient and coordinate planar cell polarity (PCP). Here we demonstrate and measure that gradient. Dachsous (Ds) is a conserved and elemental molecule of...
Gene expression regulation by the Chromodomain helicase DNA-binding protein 9 (CHD9) chromatin remodeler is dispensable for murine development.
Andrej Alendar, Jan-Paul Lambooij, Rajith Bhaskaran, Cesare Lancini, Ji-Ying Song, Huub van Vugt, Margriet Snoek, Anton Berns
May 26, 2020
Chromodomain helicase DNA-binding (CHD) chromatin remodelers regulate transcription and DNA repair. They govern cell-fate decisions during embryonic development and are often deregulated in human pathologies. Chd1-8 show upon...
Ten lessons of leadership
FJ Gilbert
Jul 27, 2020
The defining qualities and characteristics of a good leader - visionary, decisive, clear communicator, honesty and integrity, commitment and passion, being inspirational, accountable, well organised with the ability to delegate...
Comparative evaluation of linear and exponential amplification techniques for expression profiling at the single-cell level
Background: Single-cell microarray expression profiling requires 10(8)-10(9)-fold amplification of the picogram amounts of total RNA typically found in eukaryotic cells. Several methods for RNA amplification are in general use...
Artificial intelligence in clinical imaging
The development and application of artificial intelligence (AI) to radiology requires an approach that encompasses a health system. The UK government and National Health Service (NHS) are creating an ecosystem to facilitate...
The shape of trees
1. How ecologists think about aboveground forest structure and dynamics is fundamentally shaped by the data we can collect. This has historically been limited to what is possible with simple equipment such as a tape measure...
Personalised screening
Screening with mammography has been implemented in many countries across the world with most offering 2-yearly examinations between the ages of 50-69 years. Robust modelling tools that include breast density and single...
Microstructural alterations in the onychomycotic and psoriatic nail
E Cutrin Gomez, S. Anguiano Igea, Maria Delgado-Charro, JL Gomez Amoza, FJ Otero Espinar
Jul 31, 2018
Despite the important nail alterations caused by onychomycosis and psoriasis few studies have characterized the microstructure of the diseased nail plate and the diffusion and penetration of drugs through this altered...
Ciclopirox Clobetasol propionate Nail onychomycosis Porosity psoriasis /dk/atira/pure/subjectarea/asjc/1300/1305 name=Biotechnology /dk/atira/pure/subjectarea/asjc/3000/3003 name=Pharmaceutical Science /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
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