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Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant
Relative to several other toll-like receptor (TLR) agonists, we found polyinosinic:polycytidylic acid (poly IC) to be the most effective adjuvant for Th1 CD4+ T cell responses to a dendritic cell (DC)-targeted HIV gag protein...
Published by: Rockefeller University
Low-Temperature Direct Bonding of 3D-IC Packages and Power IC Modules Using Ag Nanotwinned Thin Films
Ag has the lowest stacking fault energy of all metals, which allows twin formation to occur more easily. The (111)-preferred orientation Ag nanotwinned films is fabricated by either sputtering or evaporation method exhibit...
Published by: IGI Global Scientific Publishing
Inhibitory control and problem solving in early childhood
Alexandra Hendry, Mary A Agyapong, Hana D'Souza, Matilda A Frick, Ana Maria Portugal, Linn Andersson Konke, Hamish Cloke, Rachael Bedford, Tim J Smith, Annette Karmiloff-Smith, Emily JH Jones, Tony Charman, Karin C Brocki
Sep 18, 2022
Low inhibitory control (IC) is sometimes associated with enhanced problem-solving amongst adults, yet for young children high IC is primarily framed as inherently better than low IC. Here, we explore associations between IC and...
Glacier characteristics and retreat between 1991 and 2014 in the Ladakh Range, Jammu and Kashmir
Glaciers in the Ladakh Range lie between the Himalaya, a monsoon-forced region of glacier retreat, and the Karakoram, a region of anomalous glacier stability driven by mid-latitude westerlies. Given this context, glaciers might...
Bromodomain Inhibitors Modulate FcγR-Mediated Mononuclear Phagocyte Activation and Chemotaxis.
Gemma D Banham, Colin YC Lee, John R Ferdinand, Rebeccah J Matthews, Chenzhi Jing, Nicholas Smithers, Rab K Prinjha, Menna R Clatworthy
May 24, 2022
IgG antibodies form immune complexes (IC) that propagate inflammation and tissue damage in autoimmune diseases such as systemic lupus erythematosus. IgG IC engage Fcγ receptors (FcγR) on mononuclear phagocytes (MNP), leading to...
The role of knowledge and medical involvement in the context of informed consent
Caterina Milo
Mar 03, 2023
Informed consent (IC) is a key patients' right. It gives patients the opportunity to access relevant information/knowledge and to support their decision-making role in partnership with clinicians. Despite this promising account...
Emergence of biaxial nematic phases in solutions of semiflexible dimers.
We investigate the isotropic, uniaxial nematic and biaxial nematic phases, and the transitions between them, for a model lyotropic mixture of flexible molecules consisting of two rigid rods connected by a spacer with variable...
Treatment outcomes among adults with HIV/non-communicable disease multimorbidity attending integrated care clubs in Cape Town, South Africa.
BACKGROUND: The growing burden of the HIV and non-communicable disease (NCD) syndemic in Sub- Saharan Africa has necessitated introduction of integrated models of care in order to leverage existing HIV care infrastructure for...
The role of knowledge and medical involvement in the context of informed consent
Caterina Milo
Dec 08, 2022
Informed consent (IC) is a key patients' right. It gives patients the opportunity to access relevant information/knowledge and to support their decision-making role in partnership with clinicians. Despite this promising account...
Direct Type I IFN but Not MDA5/TLR3 Activation of Dendritic Cells Is Required for Maturation and Metabolic Shift to Glycolysis after Poly IC Stimulation
Type I interferons (IFNs) play an important role in direct antiviral defense as well as linking the innate and adaptive immune responses. On dendritic cells (DCs), IFNs facilitate their activation and contribute to CD8+ and CD4+...
Published by: Rockefeller University
Informed consent
Informed consent (IC), as the process of sharing information between patients and clinicians before undertaking a medical treatment, signals a number of ‘good intentions’. IC, in its theoretical formulation, can be seen...
C Milo
Sep 11, 2022
Development of directed global inhibition, competitive inhibition and behavioural inhibition during the transition between infancy and toddlerhood.
Alexandra Hendry, Isobel Greenhalgh, Rhiannon Bailey, Abigail Fiske, Henrik Dvergsdal, Karla Holmboe
Dec 24, 2021
Inhibitory control (IC) is a core executive function integral to self-regulation and cognitive control, yet is itself multi-componential. Directed global inhibition entails stopping an action on demand. Competitive inhibition is...
Single-cell transcriptome analysis of fish immune cells provides insight into the evolution of vertebrate immune cell types
SJ Carmona, SA Teichmann, L Ferreira, IC Macaulay, MJT Stubbington, A Cvejic, D Gfeller
Mar 29, 2017
Experimental and Simulation Study of Resistive Helical HTS Fault Current Limiters
Wenjuan Song, Xiaoze Pei, Hamoud Alafnan, Jiawen Xi, Xianwu Zeng, Mohammad Yazdani Asrami, Bin Xiang, Zhiyuan Liu
Feb 24, 2021
Resistive type fault current limiters (SFCLs) have attracted lots of attention from research interests and engineering applications, due to their self-triggering, fast and effective fault current limitation ability. Fast...
Increasing University Entrepreneurialism
Purpose: Successful promotion of academic entrepreneurship is a determining factor in the pursuit of university entrepreneurialism. This paper aims to illustrate how qualitative data on the performance of the technology...
Academic entrepreneurship Entrepreneurial university Intellectual capital Performance measurement technology transfer office /dk/atira/pure/subjectarea/asjc/1400/1400 name=General Business,Management and Accounting /dk/atira/pure/subjectarea/asjc/1400/1407 name=Organizational Behavior and Human Resource Management /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Maternal obesity causes fetal hypothalamic insulin resistance and disrupts development of hypothalamic feeding pathways.
Hypothalamus Insulin Maternal obesity Neurogenesis Notch Animals Arcuate Nucleus of Hypothalamus Body Weight Brain Diet High-Fat Feeding Behavior Female Fetus Gene Expression Gene Expression Regulation Developmental Hypothalamus Insulin Insulin Resistance Male Maternal-Fetal Exchange Mice Mice Inbred C57BL Neural Stem Cells Neurons obesity obesity Maternal Pregnancy prenatal exposure delayed effects Weight Gain
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