Search
Results: 55
Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans.
Andrew J Whittle, Meizi Jiang, Vivian Peirce, Joana Relat, Sam Virtue, Hiroyuki Ebinuma, Isamu Fukamachi, Takashi Yamaguchi, Mao Takahashi, Takeyoshi Murano, Ichiro Tatsuno, Masahiro Takeuchi, Chiaki Nakaseko, Wenlong Jin, Zhehu Jin, Mark Campbell, Wolfgang J Schneider, Antonio Vidal-Puig, Hideaki Bujo
Oct 30, 2015
Primate prefrontal neurons signal economic risk derived from the statistics of recent reward experience.
Risk derives from the variation of rewards and governs economic decisions, yet how the brain calculates risk from the frequency of experienced events, rather than from explicit risk-descriptive cues, remains unclear. Here, we...
Social inequality and the syndemic of chronic disease and COVID-19
Nazrul Islam, Ben Lacey, Sharmin Shabnam, A Mesut Erzurumluoglu, Hajira Dambha-Miller, Gerardo Chowell, Ichiro Kawachi, Michael Marmot
Jan 08, 2021
BACKGROUND: Given the effect of chronic diseases on risk of severe COVID-19 infection, the present pandemic may have a particularly profound impact on socially disadvantaged counties. METHODS: Counties in the USA were...
An Adaptive System for a Real-Time Matching Application
In order to enhance the customer experience, it is important not only to provide functions, but also to respond to changes in environments and requirements. It is a difficult task to evaluate and manage which function with...
Published by: IGI Global Scientific Publishing
Effects of covid-19 pandemic on life expectancy and premature mortality in 2020
Nazrul Islam, Dmitri A Jdanov, Vladimir M Shkolnikov, Kamlesh Khunti, Ichiro Kawachi, Martin White, Sarah Lewington, Ben Lacey
Nov 05, 2021
Abstract: Objective: To estimate the changes in life expectancy and years of life lost in 2020 associated with the covid-19 pandemic. Design: Time series analysis. Setting: 37 upper-middle and high income countries or regions...
Structure of KAP1 tripartite motif identifies molecular interfaces required for retroelement silencing.
Guido A Stoll, Shun-Ichiro Oda, Zheng-Shan Chong, Minmin Yu, Stephen H McLaughlin, Yorgo Modis
Jun 19, 2019
Endogenous retrovirus epigenetic silencing transcriptional repressor transposable element ubiquitin E3 ligase Amino Acid Sequence Binding Sites Chromatin Chromatin Assembly and Disassembly Cloning Molecular Crystallography X-Ray Epigenesis Genetic Escherichia coli Gene Expression Gene Silencing Genetic Vectors Humans Models Molecular Protein Binding Protein Conformation alpha-Helical Protein Conformation beta-Strand Protein Interaction Domains and Motifs Protein Multimerization Recombinant Proteins Repressor Proteins Retroelements Sequence Alignment Sequence Homology Amino Acid Transcription Genetic Tripartite Motif-Containing Protein 28
Effects of covid-19 pandemic on life expectancy and premature mortality in 2020
Nazrul Islam, Dmitri A Jdanov, Vladimir M Shkolnikov, Kamlesh Khunti, Ichiro Kawachi, Martin White, Sarah Lewington, Ben Lacey
Nov 04, 2021
Abstract: Objective: To estimate the changes in life expectancy and years of life lost in 2020 associated with the covid-19 pandemic. Design: Time series analysis. Setting: 37 upper-middle and high income countries or regions...
Effects of covid-19 pandemic on life expectancy and premature mortality in 2020
Nazrul Islam, Dmitri A Jdanov, Vladimir M Shkolnikov, Kamlesh Khunti, Ichiro Kawachi, Martin White, Sarah Lewington, Ben Lacey
Nov 05, 2021
OBJECTIVE: To estimate the changes in life expectancy and years of life lost in 2020 associated with the covid-19 pandemic. DESIGN: Time series analysis. SETTING: 37 upper-middle and high income countries or regions with...
Differential gene expression in the murine gastric fundus lacking interstitial cells of Cajal.
Yataro Daigo, Ichiro Takayama, Bruce AJ Ponder, Carlos Caldas, Sean M Ward, Kenton M Sanders, Masayuki A Fujino
Jun 16, 2011
BACKGROUND: The muscle layers of murine gastric fundus have no interstitial cells of Cajal at the level of the myenteric plexus and only possess intramuscular interstitial cells and this tissue does not generate electric slow...
Physical distancing interventions and incidence of coronavirus disease 2019
Nazrul Islam, Stephen J Sharp, Gerardo Chowell, Sharmin Shabnam, Ichiro Kawachi, Ben Lacey, Joseph M Massaro, Ralph B D’Agostino, Martin White
Jul 17, 2020
Abstract: Objective: To evaluate the association between physical distancing interventions and incidence of coronavirus disease 2019 (covid-19) globally. Design: Natural experiment using interrupted time series analysis, with...
Excess deaths associated with covid-19 pandemic in 2020
Nazrul Islam, Vladimir M Shkolnikov, Rolando J Acosta, Ilya Klimkin, Ichiro Kawachi, Rafael A Irizarry, Gianfranco Alicandro, Kamlesh Khunti, Tom Yates, Dmitri A Jdanov, Martin White, Sarah Lewington, Ben Lacey
May 03, 2021
Biocompatible fluorescent silicon nanocrystals for single-molecule tracking and fluorescence imaging.
Hirohito Nishimura, Ken Ritchie, Rinshi S Kasai, Miki Goto, Nobuhiro Morone, Hiroyuki Sugimura, Koichiro Tanaka, Ichiro Sase, Akihiko Yoshimura, Yoshitaro Nakano, Takahiro K Fujiwara, Akihiro Kusumi
May 28, 2019
Fluorescence microscopy is used extensively in cell-biological and biomedical research, but it is often plagued by three major problems with the presently available fluorescent probes: photobleaching, blinking, and large size....
Differential gene expression profile in the small intestines of mice lacking pacemaker interstitial cells of Cajal.
Yataro Daigo, Ichiro Takayama, Bruce AJ Ponder, Carlos Caldas, Sean M Ward, Kenton M Sanders, Masayuki A Fujino
Jun 16, 2011
Physical distancing interventions and incidence of coronavirus disease 2019
Nazrul Islam, Stephen J Sharp, Gerardo Chowell, Sharmin Shabnam, Ichiro Kawachi, Ben Lacey, Joseph M Massaro, Ralph B D'Agostino, Martin White
Jul 28, 2020
OBJECTIVE: To evaluate the association between physical distancing interventions and incidence of coronavirus disease 2019 (covid-19) globally. DESIGN: Natural experiment using interrupted time series analysis, with results...
Periphilin self-association underpins epigenetic silencing by the HUSH complex.
Daniil M Prigozhin, Christopher H Douse, Laura E Farleigh, Anna Albecka, Iva A Tchasovnikarova, Richard T Timms, Shun-Ichiro Oda, Frank Adolf, Stefan MV Freund, Sarah Maslen, Paul J Lehner, Yorgo Modis
Sep 08, 2020
Synthesis, conformational analysis and in vivo assays of an anti-cancer vaccine that features an unnatural antigen based on an sp2-iminosugar fragment.
Iris A Bermejo, Claudio D Navo, Jorge Castro-López, Ana Guerreiro, Ester Jiménez-Moreno, Elena M Sánchez Fernández, Fayna García-Martín, Hiroshi Hinou, Shin-Ichiro Nishimura, José M García Fernández, Carmen Ortiz Mellet, Alberto Avenoza, Jesús H Busto, Gonçalo JL Bernardes, Ramón Hurtado-Guerrero, Jesús M Peregrina, Francisco Corzana
Sep 15, 2020
The Tn antigen (GalNAc-α-1-O-Thr/Ser) is a well-known tumor-associated carbohydrate determinant. The use of glycopeptides that incorporate this structure has become a significant and promising niche of research owing to their...
Excess deaths associated with covid-19 pandemic in 2020
Nazrul Islam, Vladimir M Shkolnikov, Rolando J Acosta, Ilya Klimkin, Ichiro Kawachi, Rafael A Irizarry, Gianfranco Alicandro, Kamlesh Khunti, Tom Yates, Dmitri A Jdanov, Martin White, Sarah Lewington, Ben Lacey
May 21, 2021
Abstract: Objective: To estimate the direct and indirect effects of the covid-19 pandemic on mortality in 2020 in 29 high income countries with reliable and complete age and sex disaggregated mortality data. Design: Time series...
Primary functional brain connections associated with melancholic major depressive disorder and modulation by antidepressants.
Naho Ichikawa, Giuseppe Lisi, Noriaki Yahata, Go Okada, Masahiro Takamura, Ryu-Ichiro Hashimoto, Takashi Yamada, Makiko Yamada, Tetsuya Suhara, Sho Moriguchi, Masaru Mimura, Yujiro Yoshihara, Hidehiko Takahashi, Kiyoto Kasai, Nobumasa Kato, Shigeto Yamawaki, Ben Seymour, Mitsuo Kawato, Jun Morimoto, Yasumasa Okamoto
Mar 27, 2020
The limited efficacy of available antidepressant therapies may be due to how they affect the underlying brain network. The purpose of this study was to develop a melancholic MDD biomarker to identify critically important...
Synthesis, conformational analysis and <i>in vivo</i> assays of an anti-cancer vaccine that features an unnatural antigen based on an sp<sup>2</sup>-iminosugar fragment.
Iris A Bermejo, Claudio D Navo, Jorge Castro-López, Ana Guerreiro, Ester Jiménez-Moreno, Elena M Sánchez Fernández, Fayna García-Martín, Hiroshi Hinou, Shin-Ichiro Nishimura, José M García Fernández, Carmen Ortiz Mellet, Alberto Avenoza, Jesús H Busto, Gonçalo J L Bernardes, Ramón Hurtado-Guerrero, Jesús M Peregrina, Francisco Corzana
Jul 28, 2021
The Tn antigen (GalNAc-α-1-O-Thr/Ser) is a well-known tumor-associated carbohydrate determinant. The use of glycopeptides that incorporate this structure has become a significant and promising niche of research owing to...
Published by: Chemical science
Primary functional brain connections associated with melancholic major depressive disorder and modulation by antidepressants
Naho Ichikawa, Giuseppe Lisi, Noriaki Yahata, Go Okada, Masahiro Takamura, Ryu-Ichiro Hashimoto, Takashi Yamada, Makiko Yamada, Tetsuya Suhara, Sho Moriguchi, Masaru Mimura, Yujiro Yoshihara, Hidehiko Takahashi, Kiyoto Kasai, Nobumasa Kato, Shigeto Yamawaki, Ben Seymour, Mitsuo Kawato, Jun Morimoto, Yasumasa Okamoto
Aug 26, 2021
Abstract: The limited efficacy of available antidepressant therapies may be due to how they affect the underlying brain network. The purpose of this study was to develop a melancholic MDD biomarker to identify critically...
Primary functional brain connections associated with melancholic major depressive disorder and modulation by antidepressants
Naho Ichikawa, Giuseppe Lisi, Noriaki Yahata, Go Okada, Masahiro Takamura, Ryu-Ichiro Hashimoto, Takashi Yamada, Makiko Yamada, Tetsuya Suhara, Sho Moriguchi, Masaru Mimura, Yujiro Yoshihara, Hidehiko Takahashi, Kiyoto Kasai, Nobumasa Kato, Shigeto Yamawaki, Ben Seymour, Mitsuo Kawato, Jun Morimoto, Yasumasa Okamoto
Oct 14, 2020
Abstract: The limited efficacy of available antidepressant therapies may be due to how they affect the underlying brain network. The purpose of this study was to develop a melancholic MDD biomarker to identify critically...
HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity.
Hiroaki Semba, Norihiko Takeda, Takayuki Isagawa, Yuki Sugiura, Kurara Honda, Masaki Wake, Hidenobu Miyazawa, Yoshifumi Yamaguchi, Masayuki Miura, Dana MR Jenkins, Hyunsung Choi, Jung-Whan Kim, Masataka Asagiri, Andrew S Cowburn, Hajime Abe, Katsura Soma, Katsuhiro Koyama, Manami Katoh, Keimon Sayama, Nobuhito Goda, Randall S Johnson, Ichiro Manabe, Ryozo Nagai, Issei Komuro
May 04, 2018
In severely hypoxic condition, HIF-1α-mediated induction of Pdk1 was found to regulate glucose oxidation by preventing the entry of pyruvate into the tricarboxylic cycle. Monocyte-derived macrophages, however, encounter a...
Excess deaths associated with covid-19 pandemic in 2020
Nazrul Islam, Vladimir M Shkolnikov, Rolando J Acosta, Ilya Klimkin, Ichiro Kawachi, Rafael A Irizarry, Gianfranco Alicandro, Kamlesh Khunti, Tom Yates, Dmitri A Jdanov, Martin White, Sarah Lewington, Ben Lacey
Jun 21, 2021
Objective
To estimate the direct and indirect effects of the covid-19 pandemic on mortality in 2020 in 29 high income countries with reliable and complete age and sex disaggregated mortality data.Design
Time...
Humans Mortality Models Statistical Poisson Distribution Age Factors Sex Factors Developed Countries Adolescent Adult Aged Aged 80 and over Middle Aged Child Child Preschool Infant Infant Newborn United States Europe Female Male Young Adult Republic of Korea covid-19
Published by: BMJ (Clinical research ed.)
|
|< |
< |
1 |