Modeling Parkinson's Disease Neuropathology and Symptoms by Intranigral Inoculation of Preformed Human α-Synuclein Oligomers.
Laura Boi,
Augusta Pisanu,
Maria Francesca Palmas,
Giuliana Fusco,
Ezio Carboni,
Maria Antonietta Casu,
Valentina Satta,
Maria Scherma,
Elzbieta Janda,
Ignazia Mocci,
Giovanna Mulas,
Anna Ena,
Saturnino Spiga,
Paola Fadda,
Alfonso De Simone,
Anna R Carta
Nov 13, 2020
The accumulation of aggregated α-synuclein (αSyn) is a hallmark of Parkinson's disease (PD). Current evidence indicates that small soluble αSyn oligomers (αSynOs) are the most toxic species among the forms of αSyn aggregates...