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Role of amyloid peptides in vascular dysfunction and platelet dysregulation in Alzheimer’s disease

Alzheimer’s disease (AD) is the most common neurodegenerative cause of dementia in the elderly. AD is accompanied by the accumulation of amyloid peptides in the brain parenchyma and in the cerebral vessels. The sporadic form...

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Role of amyloid peptides in vascular dysfunction and platelet dysregulation in Alzheimer’s disease

Alzheimer’s disease (AD) is the most common neurodegenerative cause of dementia in the elderly. AD is accompanied by the accumulation of amyloid peptides in the brain parenchyma and in the cerebral vessels. The sporadic form...

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Increased platelet adhesion and thrombus formation in a mouse model of Alzheimer's disease
Vascular dysfunctions and Alzheimer's disease show significant similarities and overlaps. Cardiovascular risk factors (hypercholesterolemia, hypertension, obesity, atherosclerosis and diabetes) increase the risk of vascular...
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Increased platelet adhesion and thrombus formation in a mouse model of Alzheimer's disease
Vascular dysfunctions and Alzheimer's disease show significant similarities and overlaps. Cardiovascular risk factors (hypercholesterolemia, hypertension, obesity, atherosclerosis and diabetes) increase the risk of vascular...
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Assessment of trends in hydrological extremes using regional magnification factors

Detection and attribution of trends in individual at-site series of hydrological extremes is routinely undertaken using simple linear regression-based models. However, the available records are often too short to allow a...

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Amyloid β-peptide-dependent activation of human platelets

Alzheimer's disease is associated with the accumulation of Aβ (amyloid β)-peptides in the brain. Besides their cytotoxic effect on neurons, Aβ-peptides are thought to be responsible for the atherothrombotic complications...

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Amyloid β-peptide-dependent activation of human platelets

Alzheimer's disease is associated with the accumulation of Aβ (amyloid β)-peptides in the brain. Besides their cytotoxic effect on neurons, Aβ-peptides are thought to be responsible for the atherothrombotic complications...

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Reassessing flood frequency for the Sussex Ouse, Lewes
The application of historical flood information as a tool for augmenting instrumental flood data is increasingly recognised as a valuable tool. Most previous studies have focused on large catchments with historic settlements...
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Assessing the element of surprise of record-breaking flood events

The occurrence of record-breaking flood events continues to cause damage and disruption despite significant investments in flood defences, suggesting that these events are in some sense surprising. This study develops a new...

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Non-stationarity in annual and seasonal series of peak flow and precipitation in the UK
When designing or maintaining an hydraulic structure, an estimate of the frequency and magnitude of extreme events is required. The most common methods to obtain such estimates rely on the assumption of stationarity, i.e. the...
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Statistical distributions for monthly aggregations of precipitation and streamflow in drought indicator applications
Drought indicators are used as triggers for action and so are the foundation of drought monitoring and early warning. The computation of drought indicators like the standardized precipitation index (SPI) and standardized...
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Assessment of trends in hydrological extremes using regional magnification factors

Detection and attribution of trends in individual at-site series of hydrological extremes is routinely undertaken using simple linear regression-based models. However, the available records are often too short to allow a...

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A bivariate trend analysis to investigate the effect of increasing urbanisation on flood characteristics
Flood frequency analyses are usually based on the assumption of stationarity, which might be unrealistic if changes in climate, land uses or urbanisation impact the study catchment. Moreover, most non-stationarity studies only...
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Non-stationarity in annual and seasonal series of peak flow and precipitation in the UK
When designing or maintaining an hydraulic structure, an estimate of the frequency and magnitude of extreme events is required. The most common methods to obtain such estimates rely on the assumption of stationarity, i.e. the...
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A depth-duration-frequency analysis for short-duration rainfall events in England and Wales.
This study presents a depth–duration–frequency (DDF) model, which is applied to the annual maxima of sub-hourly rainfall totals of selected stations in England and Wales. The proposed DDF model follows from the standard...
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A depth-duration-frequency analysis for short-duration rainfall events in England and Wales.
This study presents a depth–duration–frequency (DDF) model, which is applied to the annual maxima of sub-hourly rainfall totals of selected stations in England and Wales. The proposed DDF model follows from the standard...
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On the use of a four-parameter kappa distribution in regional frequency analysis
New developments are presented enabling the using a four-parameter kappa distribution with the widely used regional goodness-of-fit methods as part of an index flood regional frequency analysis based on the method of L-moments....
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Assessing the element of surprise of record-breaking flood events

The occurrence of record-breaking flood events continues to cause damage and disruption despite significant investments in flood defences, suggesting that these events are in some sense surprising. This study develops a new...

Published by:
Reassessing flood frequency for the Sussex Ouse, Lewes
The application of historical flood information as a tool for augmenting instrumental flood data is increasingly recognised as a valuable tool. Most previous studies have focused on large catchments with historic settlements...
Published by:
A bivariate extension of the Hosking and Wallis goodness-of-fit measure for regional distributions
This study presents a bivariate extension of the goodness-of-fit measure for regional frequency distributions developed by Hosking and Wallis [1993] for use with the method of L-moments. Utilising the approximate joint normal...
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A bivariate extension of the Hosking and Wallis goodness-of-fit measure for regional distributions
This study presents a bivariate extension of the goodness-of-fit measure for regional frequency distributions developed by Hosking and Wallis [1993] for use with the method of L-moments. Utilising the approximate joint normal...
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Developing drought impact functions for drought risk management
Drought management frameworks are dependent on methods for monitoring and prediction, but quantifying the hazard alone is arguably not sufficient; the negative consequences that may arise from a lack of precipitation must also...
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On the use of a four-parameter kappa distribution in regional frequency analysis
New developments are presented enabling the using a four-parameter kappa distribution with the widely used regional goodness-of-fit methods as part of an index flood regional frequency analysis based on the method of L-moments....
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