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Results: 122
Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes.
Johnny Habchi, Sean Chia, Céline Galvagnion, Thomas CT Michaels, Mathias MJ Bellaiche, Francesco Simone Ruggeri, Michele Sanguanini, Ilaria Idini, Janet R Kumita, Emma Sparr, Sara Linse, Christopher M Dobson, Tuomas PJ Knowles, Michele Vendruscolo
Dec 03, 2020
Alzheimer's disease is a neurodegenerative disorder associated with the aberrant aggregation of the amyloid-β peptide. Although increasing evidence implicates cholesterol in the pathogenesis of Alzheimer's disease, the detailed...
Assessment of trends in hydrological extremes using regional magnification factors
Detection and attribution of trends in individual at-site series of hydrological extremes is routinely undertaken using simple linear regression-based models. However, the available records are often too short to allow a...
Reassessing flood frequency for the Sussex Ouse, Lewes
The application of historical flood information as a tool for augmenting instrumental flood data is increasingly recognised as a valuable tool. Most previous studies have focused on large catchments with historic settlements...
Assessing the element of surprise of record-breaking flood events
The occurrence of record-breaking flood events continues to cause damage and disruption despite significant investments in flood defences, suggesting that these events are in some sense surprising. This study develops a new...
Non-stationarity in annual and seasonal series of peak flow and precipitation in the UK
When designing or maintaining an hydraulic structure, an estimate of the frequency and magnitude of extreme events is required. The most common methods to obtain such estimates rely on the assumption of stationarity, i.e. the...
Statistical distributions for monthly aggregations of precipitation and streamflow in drought indicator applications
Drought indicators are used as triggers for action and so are the foundation of drought monitoring and early warning. The computation of drought indicators like the standardized precipitation index (SPI) and standardized...
Assessment of trends in hydrological extremes using regional magnification factors
Detection and attribution of trends in individual at-site series of hydrological extremes is routinely undertaken using simple linear regression-based models. However, the available records are often too short to allow a...
A bivariate trend analysis to investigate the effect of increasing urbanisation on flood characteristics
Flood frequency analyses are usually based on the assumption of stationarity, which might be unrealistic if changes in climate, land uses or urbanisation impact the study catchment. Moreover, most non-stationarity studies only...
Non-stationarity in annual and seasonal series of peak flow and precipitation in the UK
When designing or maintaining an hydraulic structure, an estimate of the frequency and magnitude of extreme events is required. The most common methods to obtain such estimates rely on the assumption of stationarity, i.e. the...
A depth-duration-frequency analysis for short-duration rainfall events in England and Wales.
This study presents a depth–duration–frequency (DDF) model, which is applied to the annual maxima of sub-hourly rainfall totals of selected stations in England and Wales. The proposed DDF model follows from the standard...
A depth-duration-frequency analysis for short-duration rainfall events in England and Wales.
This study presents a depth–duration–frequency (DDF) model, which is applied to the annual maxima of sub-hourly rainfall totals of selected stations in England and Wales. The proposed DDF model follows from the standard...
On the use of a four-parameter kappa distribution in regional frequency analysis
New developments are presented enabling the using a four-parameter kappa distribution with the widely used regional goodness-of-fit methods as part of an index flood regional frequency analysis based on the method of L-moments....
Assessing the element of surprise of record-breaking flood events
The occurrence of record-breaking flood events continues to cause damage and disruption despite significant investments in flood defences, suggesting that these events are in some sense surprising. This study develops a new...
Reassessing flood frequency for the Sussex Ouse, Lewes
The application of historical flood information as a tool for augmenting instrumental flood data is increasingly recognised as a valuable tool. Most previous studies have focused on large catchments with historic settlements...
A bivariate extension of the Hosking and Wallis goodness-of-fit measure for regional distributions
This study presents a bivariate extension of the goodness-of-fit measure for regional frequency distributions developed by Hosking and Wallis [1993] for use with the method of L-moments. Utilising the approximate joint normal...
A bivariate extension of the Hosking and Wallis goodness-of-fit measure for regional distributions
This study presents a bivariate extension of the goodness-of-fit measure for regional frequency distributions developed by Hosking and Wallis [1993] for use with the method of L-moments. Utilising the approximate joint normal...
Developing drought impact functions for drought risk management
Drought management frameworks are dependent on methods for monitoring and prediction, but quantifying the hazard alone is arguably not sufficient; the negative consequences that may arise from a lack of precipitation must also...
On the use of a four-parameter kappa distribution in regional frequency analysis
New developments are presented enabling the using a four-parameter kappa distribution with the widely used regional goodness-of-fit methods as part of an index flood regional frequency analysis based on the method of L-moments....
Areal models for spatially coherent trend detection
Ilaria Prosdocimi, Emiko Dupont, Nicole Augustin, Thomas Kjeldsen, Dan Simpson, Theresa Smith
Nov 28, 2019
With increasing concerns on the impacts of climate change, there is wide interest in understanding whether hydrometric and environmental series display any sort of trend. Many studies however, focus on the analysis of highly...
Great Britain areal models flood frequency analysis Floods statistics trend detection /dk/atira/pure/subjectarea/asjc/1900/1908 name=Geophysics /dk/atira/pure/subjectarea/asjc/1900/1900 name=General Earth and Planetary Sciences /dk/atira/pure/sustainabledevelopmentgoals/climate_action name=SDG 13 - Climate Action
Influence of pile driving on the clearance rate of the blue mussel, Mytilus edulis (L.)
Underwater pile driving is typically undertaken during construction of offshore oil and gas platforms and wind farms and harbours. These structures generally need solid foundations - provided by large steel piles - that are...
Influence of pile driving on the clearance rate of the blue mussel, Mytilus edulis (L.)
Underwater pile driving is typically undertaken during construction of offshore oil and gas platforms and wind farms and harbours. These structures generally need solid foundations - provided by large steel piles - that are...
Statistical distributions for monthly aggregations of precipitation and streamflow in drought indicator applications
Drought indicators are used as triggers for action and so are the foundation of drought monitoring and early warning. The computation of drought indicators like the standardized precipitation index (SPI) and standardized...
Increased platelet adhesion and thrombus formation in a mouse model of Alzheimer's disease
Ilaria Canobbio, Caterina Visconte, Barbara Oliviero, Gianni Guidetti, Marta Zara, Giordano Pula, Mauro Torti
Dec 01, 2016
Vascular dysfunctions and Alzheimer's disease show significant similarities and overlaps. Cardiovascular risk factors (hypercholesterolemia, hypertension, obesity, atherosclerosis and diabetes) increase the risk of vascular...
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