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Results: 18
Recall of facial expressions and simple orientations reveals competition for resources at multiple levels of the visual hierarchy.
Many studies of visual working memory have tested humans' ability to reproduce primary visual features of simple objects, such as the orientation of a grating or the hue of a color patch, following a delay. A consistent finding...
Epigenetic and Genetic Contributions to Adaptation in Chlamydomonas.
Epigenetic modifications, such as DNA methylation or histone modifications, can be transmitted between cellular or organismal generations. However, there are no experiments measuring their role in adaptation, so here we use...
Chlamydomonas adaptive walk Carbon Dioxide epigenetic mutation experimental evolution Methylation phosphate starvation salt tolerance Adaptation Biological Adaptation Physiological Chlamydomonas Chlamydomonas reinhardtii DNA Methylation Directed Molecular Evolution Environment Epigenesis Genetic Epigenomics genetic variation Mutation Salt Tolerance
Lower limb joint kinetics during the first stance phase in athletics sprinting
This study analysed the first stance phase joint kinetics of three elite sprinters to improve the understanding of technique and investigate how individual differences in technique could influence the resulting levels of...
Lower limb joint kinetics during the first stance phase in athletics sprinting
This study analysed the first stance phase joint kinetics of three elite sprinters to improve the understanding of technique and investigate how individual differences in technique could influence the resulting levels of...
Relationships between lower-limb kinematics and block phase performance in a cross section of sprinters
This study investigated lower-limb kinematics to explain the techniques used to achieve high levels of sprint start performance. A cross-sectional design was used to examine relationships between specific technique variables...
Relationships between lower-limb kinematics and block phase performance in a cross section of sprinters
This study investigated lower-limb kinematics to explain the techniques used to achieve high levels of sprint start performance. A cross-sectional design was used to examine relationships between specific technique variables...
Efficiently searching through large tACS parameter spaces using closed-loop Bayesian optimization.
Romy Lorenz, Laura E Simmons, Ricardo P Monti, Joy L Arthur, Severin Limal, Ilkka Laakso, Robert Leech, Ines R Violante
Aug 19, 2019
BACKGROUND: Selecting optimal stimulation parameters from numerous possibilities is a major obstacle for assessing the efficacy of non-invasive brain stimulation. OBJECTIVE: We demonstrate that Bayesian optimization can rapidly...
Combined effects of continuous exercise and intermittent active interruptions to prolonged sitting on postprandial glucose, insulin, and triglycerides in adults with obesity
Michael J Wheeler, Daniel J Green, Ester Cerin, Kathryn A Ellis, Ilkka Heinonen, Jaye Lewis, Louise H Naylor, Neale Cohen, Robyn Larsen, Paddy C Dempsey, Bronwyn A Kingwell, Neville Owen, David W Dunstan
Dec 22, 2020
BACKGROUND: Postprandial glucose, insulin, and triglyceride metabolism is impaired by prolonged sitting, but enhanced by exercise. The aim of this study was to assess the effects of a continuous exercise bout with and without...
Effectiveness of a Hospital-Based Computerized Decision Support System on Clinician Recommendations and Patient Outcomes
Lorenzo Moja, Hernan Polo Friz, Matteo Capobussi, Koren Kwag, Rita Banzi, Francesca Ruggiero, Marien González-Lorenzo, Elisa G Liberati, Massimo Mangia, Peter Nyberg, Ilkka Kunnamo, Claudio Cimminiello, Giuseppe Vighi, Jeremy M Grimshaw, Giovanni Delgrossi, Stefanos Bonovas
Sep 11, 2020
IMPORTANCE: Sophisticated evidence-based information resources can filter medical evidence from the literature, integrate it into electronic health records, and generate recommendations tailored to individual patients....
Implementing an evidence-based computerized decision support system linked to electronic health records to improve care for cancer patients
Lorenzo Moja, Alessandro Passardi, Matteo Capobussi, Rita Banzi, Francesca Ruggiero, Koren Kwag, Elisa Giulia Liberati, Massimo Mangia, Ilkka Kunnamo, Michela Cinquini, Roberto Vespignani, Americo Colamartini, Valentina Di Iorio, Ilaria Massa, Marien González-Lorenzo, Lorenzo Bertizzolo, Peter Nyberg, Jeremy Grimshaw, Stefanos Bonovas, Oriana Nanni
Jul 30, 2018
BACKGROUND: Computerized decision support systems (CDSSs) are computer programs that provide doctors with person-specific, actionable recommendations, or management options that are intelligently filtered or presented at...
Computerized decision support systems Electronic Health Records Electronic patient records Evidence-Based Medicine oncology Pragmatic trial Randomized controlled trial Reminder Systems Decision Support Systems clinical Electronic Health Records Evidence-Based Medicine Humans Neoplasms Randomized Controlled Trials as Topic Research Design
Individual patient data meta-analysis of self-monitoring of blood pressure (BP-SMART)
Katherine L Tucker, James P Sheppard, Richard Stevens, Hayden B Bosworth, Alfred Bove, Emma P Bray, Marshal Godwin, Beverly Green, Paul Hebert, FD Richard Hobbs, Ilkka Kantola, Sally Kerry, David J Magid, Jonathan Mant, Karen L Margolis, Brian McKinstry, Stefano Omboni, Olugbenga Ogedegbe, Gianfranco Parati, Nashat Qamar, Juha Varis, Willem Verberk, Bonnie J Wakefield, Richard J McManus
May 03, 2018
INTRODUCTION: Self-monitoring of blood pressure is effective in reducing blood pressure in hypertension. However previous meta-analyses have shown a considerable amount of heterogeneity between studies, only part of which can be...
Multivariate Genome-wide Association Analysis of a Cytokine Network Reveals Variants with Widespread Immune, Haematological, and Cardiometabolic Pleiotropy.
Artika P Nath, Scott C Ritchie, Nastasiya F Grinberg, Howard Ho-Fung Tang, Qin Qin Huang, Shu Mei Teo, Ari V Ahola-Olli, Peter Würtz, Aki S Havulinna, Kristiina Santalahti, Niina Pitkänen, Terho Lehtimäki, Mika Kähönen, Leo-Pekka Lyytikäinen, Emma Raitoharju, Ilkka Seppälä, Antti-Pekka Sarin, Samuli Ripatti, Aarno Palotie, Markus Perola, Jorma S Viikari, Sirpa Jalkanen, Mikael Maksimow, Marko Salmi, Chris Wallace, Olli T Raitakari, Veikko Salomaa, Gad Abraham, Johannes Kettunen, Michael Inouye
Oct 04, 2019
GWAS blood cell traits cardiometabolic diseases colocalisation analysis Cytokines eQTLs metabolites Multivariate Analysis protein QTLs Adolescent Adult Aged Biomarkers Blood Proteins Cardiovascular Diseases Child Cytokines Female Follow-Up Studies Gene Regulatory Networks Genetic Pleiotropy Genetic Predisposition to Disease Genome Human Genome-Wide Association Study Humans Longitudinal Studies Male Middle Aged Polymorphism Single Nucleotide Prognosis Prospective Studies Quantitative Trait Loci Young Adult
A genome-wide association study of total child psychiatric problems scores.
Alexander Neumann, Ilja M Nolte, Irene Pappa, Tarunveer S Ahluwalia, Erik Pettersson, Alina Rodriguez, Andrew Whitehouse, Catharina EM van Beijsterveldt, Beben Benyamin, Anke R Hammerschlag, Quinta Helmer, Ville Karhunen, Eva Krapohl, Yi Lu, Peter J van der Most, Teemu Palviainen, Beate St Pourcain, Ilkka Seppälä, Anna Suarez, Natalia Vilor-Tejedor, Carla MT Tiesler, Carol Wang, Amanda Wills, Ang Zhou, Silvia Alemany, Hans Bisgaard, Klaus Bønnelykke, Gareth E Davies, Christian Hakulinen, Anjali K Henders, Elina Hyppönen, Jakob Stokholm, Meike Bartels, Jouke-Jan Hottenga, Joachim Heinrich, John Hewitt, Liisa Keltikangas-Järvinen, Tellervo Korhonen, Jaakko Kaprio, Jari Lahti, Marius Lahti-Pulkkinen, Terho Lehtimäki, Christel M Middeldorp, Jackob M Najman, Craig Pennell, Chris Power, Albertine J Oldehinkel, Robert Plomin, Katri Räikkönen, Olli T Raitakari, Kaili Rimfeld, Lærke Sass, Harold Snieder, Marie Standl, Jordi Sunyer, Gail M Williams, Marian J Bakermans-Kranenburg, Dorret I Boomsma, Marinus H van IJzendoorn, Catharina A Hartman, Henning Tiemeier
Sep 22, 2022
Substantial genetic correlations have been reported across psychiatric disorders and numerous cross-disorder genetic variants have been detected. To identify the genetic variants underlying general psychopathology in childhood...
Self-monitoring of blood pressure in hypertension
Katherine L Tucker, James P Sheppard, Richard Stevens, Hayden B Bosworth, Alfred Bove, Emma P Bray, Kenneth Earle, Johnson George, Marshall Godwin, Beverly B Green, Paul Hebert, FD Richard Hobbs, Ilkka Kantola, Sally M Kerry, Alfonso Leiva, David J Magid, Jonathan Mant, Karen L Margolis, Brian McKinstry, Mary Ann McLaughlin, Stefano Omboni, Olugbenga Ogedegbe, Gianfranco Parati, Nashat Qamar, Bahman P Tabaei, Juha Varis, Willem J Verberk, Bonnie J Wakefield, Richard J McManus
May 01, 2018
BACKGROUND: Self-monitoring of blood pressure (BP) appears to reduce BP in hypertension but important questions remain regarding effective implementation and which groups may benefit most. This individual patient data (IPD)...
A genome-wide association study of total child psychiatric problems scores.
Alexander Neumann, Ilja M Nolte, Irene Pappa, Tarunveer S Ahluwalia, Erik Pettersson, Alina Rodriguez, Andrew Whitehouse, Catharina EM van Beijsterveldt, Beben Benyamin, Anke R Hammerschlag, Quinta Helmer, Ville Karhunen, Eva Krapohl, Yi Lu, Peter J van der Most, Teemu Palviainen, Beate St Pourcain, Ilkka Seppälä, Anna Suarez, Natalia Vilor-Tejedor, Carla MT Tiesler, Carol Wang, Amanda Wills, Ang Zhou, Silvia Alemany, Hans Bisgaard, Klaus Bønnelykke, Gareth E Davies, Christian Hakulinen, Anjali K Henders, Elina Hyppönen, Jakob Stokholm, Meike Bartels, Jouke-Jan Hottenga, Joachim Heinrich, John Hewitt, Liisa Keltikangas-Järvinen, Tellervo Korhonen, Jaakko Kaprio, Jari Lahti, Marius Lahti-Pulkkinen, Terho Lehtimäki, Christel M Middeldorp, Jackob M Najman, Craig Pennell, Chris Power, Albertine J Oldehinkel, Robert Plomin, Katri Räikkönen, Olli T Raitakari, Kaili Rimfeld, Lærke Sass, Harold Snieder, Marie Standl, Jordi Sunyer, Gail M Williams, Marian J Bakermans-Kranenburg, Dorret I Boomsma, Marinus H van IJzendoorn, Catharina A Hartman, Henning Tiemeier
Aug 22, 2022
Substantial genetic correlations have been reported across psychiatric disorders and numerous cross-disorder genetic variants have been detected. To identify the genetic variants underlying general psychopathology in childhood...
Genetic association study of childhood aggression across raters, instruments, and age.
Hill F Ip, Camiel M van der Laan, Eva M L Krapohl, Isabell Brikell, Cristina Sánchez-Mora, Ilja M Nolte, Beate St Pourcain, Koen Bolhuis, Teemu Palviainen, Hadi Zafarmand, Lucía Colodro-Conde, Scott Gordon, Tetyana Zayats, Fazil Aliev, Chang Jiang, Carol A Wang, Gretchen Saunders, Ville Karhunen, Anke R Hammerschlag, Daniel E Adkins, Richard Border, Roseann E Peterson, Joseph A Prinz, Elisabeth Thiering, Ilkka Seppälä, Natàlia Vilor-Tejedor, Tarunveer S Ahluwalia, Felix R Day, Jouke-Jan Hottenga, Andrea G Allegrini, Kaili Rimfeld, Qi Chen, Yi Lu, Joanna Martin, María Soler Artigas, Paula Rovira, Rosa Bosch, Gemma Español, Josep Antoni Ramos Quiroga, Alexander Neumann, Judith Ensink, Katrina Grasby, José J Morosoli, Xiaoran Tong, Shelby Marrington, Christel Middeldorp, James G Scott, Anna Vinkhuyzen, Andrey A Shabalin, Robin Corley, Luke M Evans, Karen Sugden, Silvia Alemany, Lærke Sass, Rebecca Vinding, Kate Ruth, Jess Tyrrell, Gareth E Davies, Erik A Ehli, Fiona A Hagenbeek, Eveline De Zeeuw, Toos C E M Van Beijsterveldt, Henrik Larsson, Harold Snieder, Frank C Verhulst, Najaf Amin, Alyce M Whipp, Tellervo Korhonen, Eero Vuoksimaa, Richard J Rose, André G Uitterlinden, Andrew C Heath, Pamela Madden, Jan Haavik, Jennifer R Harris, Øyvind Helgeland, Stefan Johansson, Gun Peggy S Knudsen, Pal Rasmus Njolstad, Qing Lu, Alina Rodriguez, Anjali K Henders, Abdullah Mamun, Jackob M Najman, Sandy Brown, Christian Hopfer, Kenneth Krauter, Chandra Reynolds, Andrew Smolen, Michael Stallings, Sally Wadsworth, Tamara L Wall, Judy L Silberg, Allison Miller, Liisa Keltikangas-Järvinen, Christian Hakulinen, Laura Pulkki-Råback, Alexandra Havdahl, Per Magnus, Olli T Raitakari, John R B Perry, Sabrina Llop, Maria-Jose Lopez-Espinosa, Klaus Bønnelykke, Hans Bisgaard, Jordi Sunyer, Terho Lehtimäki, Louise Arseneault, Marie Standl, Joachim Heinrich, Joseph Boden, John Pearson, L John Horwood, Martin Kennedy, Richie Poulton, Lindon J Eaves, Hermine H Maes, John Hewitt, William E Copeland, Elizabeth J Costello, Gail M Williams, Naomi Wray, Marjo-Riitta Järvelin, Matt McGue, William Iacono, Avshalom Caspi, Terrie E Moffitt, Andrew Whitehouse, Craig E Pennell, Kelly L Klump, S Alexandra Burt, Danielle M Dick, Ted Reichborn-Kjennerud, Nicholas G Martin, Sarah E Medland, Tanja Vrijkotte, Jaakko Kaprio, Henning Tiemeier, George Davey Smith, Catharina A Hartman, Albertine J Oldehinkel, Miquel Casas, Marta Ribasés, Paul Lichtenstein, Sebastian Lundström, Robert Plomin, Meike Bartels, Michel G Nivard, Dorret I Boomsma
Aug 31, 2021
Childhood aggressive behavior (AGG) has a substantial heritability of around 50%. Here we present a genome-wide association meta-analysis (GWAMA) of childhood AGG, in which all phenotype measures across childhood ages from...
Humans Retrospective Studies Aggression Mental Disorders Adolescent Child Child Preschool Infant Female Genome-Wide Association Study Genetic Association Studies
Published by: Translational psychiatry
Genetic association study of childhood aggression across raters, instruments, and age
Hill F. Ip, Camiel M. van der Laan, Eva M. L. Krapohl, Isabell Brikell, Cristina Sánchez-Mora, Ilja M. Nolte, Beate St Pourcain, Koen Bolhuis, Teemu Palviainen, Hadi Zafarmand, Lucía Colodro-Conde, Scott Gordon, Tetyana Zayats, Fazil Aliev, Chang Jiang, Carol A. Wang, Gretchen Saunders, Ville Karhunen, Anke R. Hammerschlag, Daniel E. Adkins, Richard Border, Roseann E. Peterson, Joseph A. Prinz, Elisabeth Thiering, Ilkka Seppälä, Natàlia Vilor-Tejedor, Tarunveer S. Ahluwalia, Felix R. Day, Jouke-Jan Hottenga, Andrea G. Allegrini, Kaili Rimfeld, Qi Chen, Yi Lu, Joanna Martin, María Soler Artigas, Paula Rovira, Rosa Bosch, Gemma Español, Josep Antoni Ramos Quiroga, Alexander Neumann, Judith Ensink, Katrina Grasby, José J. Morosoli, Xiaoran Tong, Shelby Marrington, Christel Middeldorp, James G. Scott, Anna Vinkhuyzen, Andrey A. Shabalin, Robin Corley, Luke M. Evans, Karen Sugden, Silvia Alemany, Lærke Sass, Rebecca Vinding, Kate Ruth, Jess Tyrrell, Gareth E. Davies, Erik A. Ehli, Fiona A. Hagenbeek, Eveline De Zeeuw, Toos C.E.M. Van Beijsterveldt, Henrik Larsson, Harold Snieder, Frank C. Verhulst, Najaf Amin, Alyce M. Whipp, Tellervo Korhonen, Eero Vuoksimaa, Richard J. Rose, André G. Uitterlinden, Andrew C. Heath, Pamela Madden, Jan Haavik, Jennifer R. Harris, Øyvind Helgeland, Stefan Johansson, Gun Peggy S. Knudsen, Pal Rasmus Njolstad, Qing Lu, Alina Rodriguez, Anjali K. Henders, Abdullah Mamun, Jackob M. Najman, Sandy Brown, Christian Hopfer, Kenneth Krauter, Chandra Reynolds, Andrew Smolen, Michael Stallings, Sally Wadsworth, Tamara L. Wall, Judy L. Silberg, Allison Miller, Liisa Keltikangas-Järvinen, Christian Hakulinen, Laura Pulkki-Råback, Alexandra Havdahl, Per Magnus, Olli T. Raitakari, John R. B. Perry, Sabrina Llop, Maria-Jose Lopez-Espinosa, Klaus Bønnelykke, Hans Bisgaard, Jordi Sunyer, Terho Lehtimäki, Louise Arseneault, Marie Standl, Joachim Heinrich, Joseph Boden, John Pearson, L. John Horwood, Martin Kennedy, Richie Poulton, Lindon J. Eaves, Hermine H. Maes, John Hewitt, William E. Copeland, Elizabeth J. Costello, Gail M. Williams, Naomi Wray, Marjo-Riitta Järvelin, Matt McGue, William Iacono, Avshalom Caspi, Terrie E. Moffitt, Andrew Whitehouse, Craig E. Pennell, Kelly L. Klump, S. Alexandra Burt, Danielle M. Dick, Ted Reichborn-Kjennerud, Nicholas G. Martin, Sarah E. Medland, Tanja Vrijkotte, Jaakko Kaprio, Henning Tiemeier, George Davey Smith, Catharina A. Hartman, Albertine J. Oldehinkel, Miquel Casas, Marta Ribasés, Paul Lichtenstein, Sebastian Lundström, Robert Plomin, Meike Bartels, Michel G. Nivard, Dorret I. Boomsma
Jul 30, 2021
Abstract: Childhood aggressive behavior (AGG) has a substantial heritability of around 50%. Here we present a genome-wide association meta-analysis (GWAMA) of childhood AGG, in which all phenotype measures across childhood ages...
Genetic association study of childhood aggression across raters, instruments, and age.
Hill F Ip, Camiel M van der Laan, Eva ML Krapohl, Isabell Brikell, Cristina Sánchez-Mora, Ilja M Nolte, Beate St Pourcain, Koen Bolhuis, Teemu Palviainen, Hadi Zafarmand, Lucía Colodro-Conde, Scott Gordon, Tetyana Zayats, Fazil Aliev, Chang Jiang, Carol A Wang, Gretchen Saunders, Ville Karhunen, Anke R Hammerschlag, Daniel E Adkins, Richard Border, Roseann E Peterson, Joseph A Prinz, Elisabeth Thiering, Ilkka Seppälä, Natàlia Vilor-Tejedor, Tarunveer S Ahluwalia, Felix R Day, Jouke-Jan Hottenga, Andrea G Allegrini, Kaili Rimfeld, Qi Chen, Yi Lu, Joanna Martin, María Soler Artigas, Paula Rovira, Rosa Bosch, Gemma Español, Josep Antoni Ramos Quiroga, Alexander Neumann, Judith Ensink, Katrina Grasby, José J Morosoli, Xiaoran Tong, Shelby Marrington, Christel Middeldorp, James G Scott, Anna Vinkhuyzen, Andrey A Shabalin, Robin Corley, Luke M Evans, Karen Sugden, Silvia Alemany, Lærke Sass, Rebecca Vinding, Kate Ruth, Jess Tyrrell, Gareth E Davies, Erik A Ehli, Fiona A Hagenbeek, Eveline De Zeeuw, Toos CEM Van Beijsterveldt, Henrik Larsson, Harold Snieder, Frank C Verhulst, Najaf Amin, Alyce M Whipp, Tellervo Korhonen, Eero Vuoksimaa, Richard J Rose, André G Uitterlinden, Andrew C Heath, Pamela Madden, Jan Haavik, Jennifer R Harris, Øyvind Helgeland, Stefan Johansson, Gun Peggy S Knudsen, Pal Rasmus Njolstad, Qing Lu, Alina Rodriguez, Anjali K Henders, Abdullah Mamun, Jackob M Najman, Sandy Brown, Christian Hopfer, Kenneth Krauter, Chandra Reynolds, Andrew Smolen, Michael Stallings, Sally Wadsworth, Tamara L Wall, Judy L Silberg, Allison Miller, Liisa Keltikangas-Järvinen, Christian Hakulinen, Laura Pulkki-Råback, Alexandra Havdahl, Per Magnus, Olli T Raitakari, John RB Perry, Sabrina Llop, Maria-Jose Lopez-Espinosa, Klaus Bønnelykke, Hans Bisgaard, Jordi Sunyer, Terho Lehtimäki, Louise Arseneault, Marie Standl, Joachim Heinrich, Joseph Boden, John Pearson, L John Horwood, Martin Kennedy, Richie Poulton, Lindon J Eaves, Hermine H Maes, John Hewitt, William E Copeland, Elizabeth J Costello, Gail M Williams, Naomi Wray, Marjo-Riitta Järvelin, Matt McGue, William Iacono, Avshalom Caspi, Terrie E Moffitt, Andrew Whitehouse, Craig E Pennell, Kelly L Klump, S Alexandra Burt, Danielle M Dick, Ted Reichborn-Kjennerud, Nicholas G Martin, Sarah E Medland, Tanja Vrijkotte, Jaakko Kaprio, Henning Tiemeier, George Davey Smith, Catharina A Hartman, Albertine J Oldehinkel, Miquel Casas, Marta Ribasés, Paul Lichtenstein, Sebastian Lundström, Robert Plomin, Meike Bartels, Michel G Nivard, Dorret I Boomsma
Aug 13, 2021
Childhood aggressive behavior (AGG) has a substantial heritability of around 50%. Here we present a genome-wide association meta-analysis (GWAMA) of childhood AGG, in which all phenotype measures across childhood ages from...