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Results: 29
Epigenetic and Genetic Contributions to Adaptation in Chlamydomonas.
Epigenetic modifications, such as DNA methylation or histone modifications, can be transmitted between cellular or organismal generations. However, there are no experiments measuring their role in adaptation, so here we use...
Chlamydomonas adaptive walk Carbon Dioxide epigenetic mutation experimental evolution Methylation phosphate starvation salt tolerance Adaptation Biological Adaptation Physiological Chlamydomonas Chlamydomonas reinhardtii DNA Methylation Directed Molecular Evolution Environment Epigenesis Genetic Epigenomics genetic variation Mutation Salt Tolerance
Lower limb joint kinetics during the first stance phase in athletics sprinting
This study analysed the first stance phase joint kinetics of three elite sprinters to improve the understanding of technique and investigate how individual differences in technique could influence the resulting levels of...
Lower limb joint kinetics during the first stance phase in athletics sprinting
This study analysed the first stance phase joint kinetics of three elite sprinters to improve the understanding of technique and investigate how individual differences in technique could influence the resulting levels of...
Recall of facial expressions and simple orientations reveals competition for resources at multiple levels of the visual hierarchy.
Many studies of visual working memory have tested humans' ability to reproduce primary visual features of simple objects, such as the orientation of a grating or the hue of a color patch, following a delay. A consistent finding...
Relationships between lower-limb kinematics and block phase performance in a cross section of sprinters
This study investigated lower-limb kinematics to explain the techniques used to achieve high levels of sprint start performance. A cross-sectional design was used to examine relationships between specific technique variables...
Relationships between lower-limb kinematics and block phase performance in a cross section of sprinters
This study investigated lower-limb kinematics to explain the techniques used to achieve high levels of sprint start performance. A cross-sectional design was used to examine relationships between specific technique variables...
Promoting Mental Health and Psychological Thriving in University Students
Emma M Seppälä, Christina Bradley, Julia Moeller, Leilah Harouni, Dhruv Nandamudi, Marc A Brackett
Jul 29, 2020
This study aimed to address the decline in mental health on U.S. university campuses by examining the effects of three interventions. University students suffer from high levels of anxiety, depression, and suicide. Counseling...
Multivariate Genome-wide Association Analysis of a Cytokine Network Reveals Variants with Widespread Immune, Haematological, and Cardiometabolic Pleiotropy.
Artika P Nath, Scott C Ritchie, Nastasiya F Grinberg, Howard Ho-Fung Tang, Qin Qin Huang, Shu Mei Teo, Ari V Ahola-Olli, Peter Würtz, Aki S Havulinna, Kristiina Santalahti, Niina Pitkänen, Terho Lehtimäki, Mika Kähönen, Leo-Pekka Lyytikäinen, Emma Raitoharju, Ilkka Seppälä, Antti-Pekka Sarin, Samuli Ripatti, Aarno Palotie, Markus Perola, Jorma S Viikari, Sirpa Jalkanen, Mikael Maksimow, Marko Salmi, Chris Wallace, Olli T Raitakari, Veikko Salomaa, Gad Abraham, Johannes Kettunen, Michael Inouye
Oct 04, 2019
GWAS blood cell traits cardiometabolic diseases colocalisation analysis Cytokines eQTLs metabolites Multivariate Analysis protein QTLs Adolescent Adult Aged Biomarkers Blood Proteins Cardiovascular Diseases Child Cytokines Female Follow-Up Studies Gene Regulatory Networks Genetic Pleiotropy Genetic Predisposition to Disease Genome Human Genome-Wide Association Study Humans Longitudinal Studies Male Middle Aged Polymorphism Single Nucleotide Prognosis Prospective Studies Quantitative Trait Loci Young Adult
Efficiently searching through large tACS parameter spaces using closed-loop Bayesian optimization.
Romy Lorenz, Laura E Simmons, Ricardo P Monti, Joy L Arthur, Severin Limal, Ilkka Laakso, Robert Leech, Ines R Violante
Aug 19, 2019
BACKGROUND: Selecting optimal stimulation parameters from numerous possibilities is a major obstacle for assessing the efficacy of non-invasive brain stimulation. OBJECTIVE: We demonstrate that Bayesian optimization can rapidly...
Combined effects of continuous exercise and intermittent active interruptions to prolonged sitting on postprandial glucose, insulin, and triglycerides in adults with obesity
Michael J Wheeler, Daniel J Green, Ester Cerin, Kathryn A Ellis, Ilkka Heinonen, Jaye Lewis, Louise H Naylor, Neale Cohen, Robyn Larsen, Paddy C Dempsey, Bronwyn A Kingwell, Neville Owen, David W Dunstan
Dec 22, 2020
BACKGROUND: Postprandial glucose, insulin, and triglyceride metabolism is impaired by prolonged sitting, but enhanced by exercise. The aim of this study was to assess the effects of a continuous exercise bout with and without...
Effectiveness of a Hospital-Based Computerized Decision Support System on Clinician Recommendations and Patient Outcomes
Lorenzo Moja, Hernan Polo Friz, Matteo Capobussi, Koren Kwag, Rita Banzi, Francesca Ruggiero, Marien González-Lorenzo, Elisa G Liberati, Massimo Mangia, Peter Nyberg, Ilkka Kunnamo, Claudio Cimminiello, Giuseppe Vighi, Jeremy M Grimshaw, Giovanni Delgrossi, Stefanos Bonovas
Sep 11, 2020
IMPORTANCE: Sophisticated evidence-based information resources can filter medical evidence from the literature, integrate it into electronic health records, and generate recommendations tailored to individual patients....
Associations of physical activity, sedentary time, and cardiorespiratory fitness with heart rate variability in 6- to 9-year-old children
Associations of physical activity, sedentary time, and cardiorespiratory fitness with heart rate variability in 6- to 9-year-old children
Aapo Veijalainen, Eero A. Haapala, Juuso Väistö, Marja H. Leppänen, Niina Lintu, Tuomo Tompuri, Santeri Seppälä, Ulf Ekelund, Mika P. Tarvainen, Kate Westgate, Søren Brage, Timo A. Lakka
Sep 17, 2020
Abstract: Purpose: To study the associations of physical activity (PA), sedentary time (ST), and cardiorespiratory fitness (CRF) with heart rate variability (HRV) in children. Methods: The participants were a population sample...
Serum Metabolites Associated with Computed Tomography Findings after Traumatic Brain Injury.
Alex M Dickens, Jussi P Posti, Riikka SK Takala, Henna Ala-Seppälä, Ismo Mattila, Jonathan P Coles, Janek Frantzén, Peter J Hutchinson, Ari J Katila, Anna Kyllönen, Henna-Riikka Maanpää, Virginia Newcombe, Joanne Outtrim, Jussi Tallus, Keri LH Carpenter, David K Menon, Tuulia Hyötyläinen, Olli Tenovuo, Matej Orešic
Sep 27, 2018
Glial Fibrillary Acidic Protein and Ubiquitin C-Terminal Hydrolase-L1 Are Not Specific Biomarkers for Mild CT-Negative Traumatic Brain Injury.
A genome-wide association study of total child psychiatric problems scores.
Alexander Neumann, Ilja M Nolte, Irene Pappa, Tarunveer S Ahluwalia, Erik Pettersson, Alina Rodriguez, Andrew Whitehouse, Catharina EM van Beijsterveldt, Beben Benyamin, Anke R Hammerschlag, Quinta Helmer, Ville Karhunen, Eva Krapohl, Yi Lu, Peter J van der Most, Teemu Palviainen, Beate St Pourcain, Ilkka Seppälä, Anna Suarez, Natalia Vilor-Tejedor, Carla MT Tiesler, Carol Wang, Amanda Wills, Ang Zhou, Silvia Alemany, Hans Bisgaard, Klaus Bønnelykke, Gareth E Davies, Christian Hakulinen, Anjali K Henders, Elina Hyppönen, Jakob Stokholm, Meike Bartels, Jouke-Jan Hottenga, Joachim Heinrich, John Hewitt, Liisa Keltikangas-Järvinen, Tellervo Korhonen, Jaakko Kaprio, Jari Lahti, Marius Lahti-Pulkkinen, Terho Lehtimäki, Christel M Middeldorp, Jackob M Najman, Craig Pennell, Chris Power, Albertine J Oldehinkel, Robert Plomin, Katri Räikkönen, Olli T Raitakari, Kaili Rimfeld, Lærke Sass, Harold Snieder, Marie Standl, Jordi Sunyer, Gail M Williams, Marian J Bakermans-Kranenburg, Dorret I Boomsma, Marinus H van IJzendoorn, Catharina A Hartman, Henning Tiemeier
Sep 22, 2022
Substantial genetic correlations have been reported across psychiatric disorders and numerous cross-disorder genetic variants have been detected. To identify the genetic variants underlying general psychopathology in childhood...
Glial Fibrillary Acidic Protein and Ubiquitin C-Terminal Hydrolase-L1 as Outcome Predictors in Traumatic Brain Injury.
RSK Takala, JP Posti, H Runtti, VF Newcombe, JG Outtrim, AJ Katila, J Frantzén, H Ala-Seppälä, A Kyllönen, H-R Maanpää, J Tallus, MI Hossain, JP Coles, P Hutchinson, M van Gils, DK Menon, O Tenovuo
Dec 08, 2016
Biomarkers GFAP outcome Traumatic brain injury UCH-L1 Adolescent Adult Aged Area Under Curve Biomarkers Brain Injuries Female Glasgow Coma Scale Glial Fibrillary Acidic Protein Humans Injury Severity Score Logistic Models Male Middle Aged Predictive Value of Tests Prognosis Prospective Studies ROC Curve Ubiquitin Thiolesterase Young Adult
The Levels of Glial Fibrillary Acidic Protein and Ubiquitin C-Terminal Hydrolase-L1 During the First Week After a Traumatic Brain Injury
Jussi P Posti, Riikka SK Takala, Hilkka Runtti, Virginia F Newcombe, Joanne Outtrim, Ari J Katila, Janek Frantzén, Henna Ala-Seppälä, Jonathan P Coles, Md Iftakher Hossain, Anna Kyllönen, Henna-Riikka Maanpää, Jussi Tallus, Peter J Hutchinson, Mark van Gils, David K Menon, Olli Tenovuo
May 24, 2019
BACKGROUND: Glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase-L1 (UCH-L1) are promising biomarkers of traumatic brain injury (TBI). OBJECTIVE: We investigated the relation of the GFAP and UCH-L1 levels to...
A genome-wide association study of total child psychiatric problems scores.
Alexander Neumann, Ilja M Nolte, Irene Pappa, Tarunveer S Ahluwalia, Erik Pettersson, Alina Rodriguez, Andrew Whitehouse, Catharina EM van Beijsterveldt, Beben Benyamin, Anke R Hammerschlag, Quinta Helmer, Ville Karhunen, Eva Krapohl, Yi Lu, Peter J van der Most, Teemu Palviainen, Beate St Pourcain, Ilkka Seppälä, Anna Suarez, Natalia Vilor-Tejedor, Carla MT Tiesler, Carol Wang, Amanda Wills, Ang Zhou, Silvia Alemany, Hans Bisgaard, Klaus Bønnelykke, Gareth E Davies, Christian Hakulinen, Anjali K Henders, Elina Hyppönen, Jakob Stokholm, Meike Bartels, Jouke-Jan Hottenga, Joachim Heinrich, John Hewitt, Liisa Keltikangas-Järvinen, Tellervo Korhonen, Jaakko Kaprio, Jari Lahti, Marius Lahti-Pulkkinen, Terho Lehtimäki, Christel M Middeldorp, Jackob M Najman, Craig Pennell, Chris Power, Albertine J Oldehinkel, Robert Plomin, Katri Räikkönen, Olli T Raitakari, Kaili Rimfeld, Lærke Sass, Harold Snieder, Marie Standl, Jordi Sunyer, Gail M Williams, Marian J Bakermans-Kranenburg, Dorret I Boomsma, Marinus H van IJzendoorn, Catharina A Hartman, Henning Tiemeier
Aug 22, 2022
Substantial genetic correlations have been reported across psychiatric disorders and numerous cross-disorder genetic variants have been detected. To identify the genetic variants underlying general psychopathology in childhood...
Implementing an evidence-based computerized decision support system linked to electronic health records to improve care for cancer patients
Lorenzo Moja, Alessandro Passardi, Matteo Capobussi, Rita Banzi, Francesca Ruggiero, Koren Kwag, Elisa Giulia Liberati, Massimo Mangia, Ilkka Kunnamo, Michela Cinquini, Roberto Vespignani, Americo Colamartini, Valentina Di Iorio, Ilaria Massa, Marien González-Lorenzo, Lorenzo Bertizzolo, Peter Nyberg, Jeremy Grimshaw, Stefanos Bonovas, Oriana Nanni
Jul 30, 2018
BACKGROUND: Computerized decision support systems (CDSSs) are computer programs that provide doctors with person-specific, actionable recommendations, or management options that are intelligently filtered or presented at...
Computerized decision support systems Electronic Health Records Electronic patient records Evidence-Based Medicine oncology Pragmatic trial Randomized controlled trial Reminder Systems Decision Support Systems clinical Electronic Health Records Evidence-Based Medicine Humans Neoplasms Randomized Controlled Trials as Topic Research Design
Correlation of Blood Biomarkers and Biomarker Panels with Traumatic Findings on Computed Tomography after Traumatic Brain Injury.
Jussi P Posti, Riikka SK Takala, Linnéa Lagerstedt, Alex M Dickens, Iftakher Hossain, Mehrbod Mohammadian, Henna Ala-Seppälä, Janek Frantzén, Mark van Gils, Peter J Hutchinson, Ari J Katila, Henna-Riikka Maanpää, David K Menon, Virginia F Newcombe, Jussi Tallus, Kevin Hrusovsky, David H Wilson, Jessica Gill, Jean-Charles Sanchez, Olli Tenovuo, Henrik Zetterberg, Kaj Blennow
Feb 15, 2019
The aim of the study was to examine the ability of eight protein biomarkers and their combinations in discriminating computed tomography (CT)-negative and CT-positive patients with traumatic brain injury (TBI), utilizing highly...
Early Levels of Glial Fibrillary Acidic Protein and Neurofilament Light Protein in Predicting the Outcome of Mild Traumatic Brain Injury.
Iftakher Hossain, Mehrbod Mohammadian, Riikka SK Takala, Olli Tenovuo, Linnéa Lagerstedt, Henna Ala-Seppälä, Janek Frantzén, Mark van Gils, Peter Hutchinson, Ari J Katila, Henna-Riikka Maanpää, David K Menon, Virginia F Newcombe, Jussi Tallus, Kevin Hrusovsky, David H Wilson, Kaj Blennow, Jean-Charles Sanchez, Henrik Zetterberg, Jussi P Posti
Jan 09, 2019
The purpose of this study was to correlate the early levels of glial fibrillary acidic protein (GFAP) and neurofilament light protein (NF-L) with outcome in patients with mild traumatic brain injury (mTBI). A total of 107...
Individual patient data meta-analysis of self-monitoring of blood pressure (BP-SMART)
Katherine L Tucker, James P Sheppard, Richard Stevens, Hayden B Bosworth, Alfred Bove, Emma P Bray, Marshal Godwin, Beverly Green, Paul Hebert, FD Richard Hobbs, Ilkka Kantola, Sally Kerry, David J Magid, Jonathan Mant, Karen L Margolis, Brian McKinstry, Stefano Omboni, Olugbenga Ogedegbe, Gianfranco Parati, Nashat Qamar, Juha Varis, Willem Verberk, Bonnie J Wakefield, Richard J McManus
May 03, 2018
INTRODUCTION: Self-monitoring of blood pressure is effective in reducing blood pressure in hypertension. However previous meta-analyses have shown a considerable amount of heterogeneity between studies, only part of which can be...
A global analysis of the impact of COVID-19 stay-at-home restrictions on crime.
Amy E Nivette, Renee Zahnow, Raul Aguilar, Andri Ahven, Shai Amram, Barak Ariel, María José Arosemena Burbano, Roberta Astolfi, Dirk Baier, Hyung-Min Bark, Joris EH Beijers, Marcelo Bergman, Gregory Breetzke, I Alberto Concha-Eastman, Sophie Curtis-Ham, Ryan Davenport, Carlos Díaz, Diego Fleitas, Manne Gerell, Kwang-Ho Jang, Juha Kääriäinen, Tapio Lappi-Seppälä, Woon-Sik Lim, Rosa Loureiro Revilla, Lorraine Mazerolle, Gorazd Meško, Noemí Pereda, Maria FT Peres, Rubén Poblete-Cazenave, Simon Rose, Robert Svensson, Nico Trajtenberg, Tanja van der Lippe, Joran Veldkamp, Carlos J Vilalta Perdomo, Manuel P Eisner
Jun 22, 2021
Self-monitoring of blood pressure in hypertension
Katherine L Tucker, James P Sheppard, Richard Stevens, Hayden B Bosworth, Alfred Bove, Emma P Bray, Kenneth Earle, Johnson George, Marshall Godwin, Beverly B Green, Paul Hebert, FD Richard Hobbs, Ilkka Kantola, Sally M Kerry, Alfonso Leiva, David J Magid, Jonathan Mant, Karen L Margolis, Brian McKinstry, Mary Ann McLaughlin, Stefano Omboni, Olugbenga Ogedegbe, Gianfranco Parati, Nashat Qamar, Bahman P Tabaei, Juha Varis, Willem J Verberk, Bonnie J Wakefield, Richard J McManus
May 01, 2018
BACKGROUND: Self-monitoring of blood pressure (BP) appears to reduce BP in hypertension but important questions remain regarding effective implementation and which groups may benefit most. This individual patient data (IPD)...
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