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OMERACT Filter 2.1 Instrument Selection for Physical Function Domain in Psoriatic Arthritis

Ying-Ying Leung, Ana-Maria Orbai, Pil Hojgaard, Richard Holland, Ashish J Mathew, Niti Goel, Jeffrey Chau, William Tillett, Christine Lindsay, Alexis Ogdie, Laura C Coates, Dafna D Gladman, Robin Christensen, Philip Mease, Vibeke Strand

Oct 01, 2021

OBJECTIVES: Physical function is one of the core domains to be measured in all trials in psoriatic arthritis (PsA). We aimed to evaluate two instruments for physical function in PsA: The Health Assessment...

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OMERACT Filter 2.1 Instrument Selection for Physical Function Domain in Psoriatic Arthritis

Oct 01, 2021

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Increased ERK signalling promotes inflammatory signalling in primary airway epithelial cells expressing Z α1-antitrypsin.

Emily FA van 't Wout, Jennifer A Dickens, Annemarie van Schadewijk, Imran Haq, Hang Fai Kwok, Adriana Ordóñez, Gillian Murphy, Jan Stolk, David A Lomas, Pieter S Hiemstra, Stefan J Marciniak

May 18, 2018

Overexpression of Z α1-antitrypsin is known to induce polymer formation, prime the cells for endoplasmic reticulum stress and initiate nuclear factor kappa B (NF-κB) signalling. However, whether endogenous expression in primary...

ADAM Proteins ADAM17 Protein Cell Line Tumor Cytokines Endoplasmic reticulum stress Epithelial Cells ErbB Receptors Humans Inflammation Mediators Lung MAP Kinase Signaling System Mutation Missense NF-kappa B Primary Cell Culture Protein Multimerization Protein Processing Post-Translational Signal Transduction alpha 1-Antitrypsin

Cover Image for A single-chain variable fragment intrabody prevents intracellular polymerization of Z α1-antitrypsin while allowing its antiproteinase activity.

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A single-chain variable fragment intrabody prevents intracellular polymerization of Z α1-antitrypsin while allowing its antiproteinase activity.

Adriana Ordóñez, Juan Pérez, Lu Tan, Jennifer A Dickens, Neda Motamedi-Shad, James A Irving, Imran Haq, Ugo Ekeowa, Stefan J Marciniak, Elena Miranda, David A Lomas

May 18, 2018

Mutant Z α1-antitrypsin (E342K) accumulates as polymers within the endoplasmic reticulum (ER) of hepatocytes predisposing to liver disease, whereas low levels of circulating Z α1-antitrypsin lead to emphysema by loss of...

Liver Disease Monoclonal antibody scFv intrabody serpin polymer Animals Base Sequence COS Cells Chlorocebus aethiops Endoplasmic Reticulum Humans Immunoblotting Intracellular Space Kinetics Leukocyte Elastase Mice Inbred BALB C Molecular Sequence Data Mutation Polymerization Protease Inhibitors Single-Chain Antibodies alpha 1-Antitrypsin

Cover Image for Sterol metabolism regulates neuroserpin polymer degradation in the absence of the unfolded protein response in the dementia FENIB.

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Sterol metabolism regulates neuroserpin polymer degradation in the absence of the unfolded protein response in the dementia FENIB.

Benoit D Roussel, Timothy M Newton, Elke Malzer, Nikol Simecek, Imran Haq, Sally E Thomas, Marian L Burr, Paul J Lehner, Damian C Crowther, Stefan J Marciniak, David A Lomas

May 18, 2018

Mutants of neuroserpin are retained as polymers within the endoplasmic reticulum (ER) of neurones to cause the autosomal dominant dementia familial encephalopathy with neuroserpin inclusion bodies or FENIB. The cellular...

Animals Cells Cultured Cholesterol Disease Models Animal Drosophila melanogaster Endoplasmic Reticulum Epilepsies Myoclonic HeLa Cells Heredodegenerative Disorders Nervous System Humans Mice Mutant Proteins Neurons Neuropeptides Polymers Protein Unfolding Serpins Signal Transduction Ubiquitin-Conjugating Enzymes Ubiquitin-Protein Ligases Unfolded Protein Response

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Characterising the association of latency with α(1)-antitrypsin polymerisation using a novel monoclonal antibody.

Lu Tan, Juan Perez, Marianna Mela, Elena Miranda, Keith A Burling, Farshid N Rouhani, Dawn L DeMeo, Imran Haq, James A Irving, Adriana Ordóñez, Jennifer A Dickens, Mark Brantly, Stefan J Marciniak, Graeme JM Alexander, Bibek Gooptu, David A Lomas

May 18, 2018

α1-Antitrypsin is primarily synthesised in the liver, circulates to the lung and protects pulmonary tissues from proteolytic damage. The Z mutant (Glu342Lys) undergoes inactivating conformational change and polymerises. Polymers...

Augmentation therapy latency Monoclonal antibodies polymerisation α1-Antitrypsin Antibodies Monoclonal Endoplasmic Reticulum Kinetics Polymerization Protein Structure Secondary alpha 1-Antitrypsin

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Pelatihan Teknik Dasar Pembuatan Mahar di UPTD SPNF Ungaran

Arina Haq

Feb 11, 2025

One of the business opportunities that will always exist in the future is wedding dowry making services. SKB Ungaran has created a training program which will later be used as preparation for opening a business in the field of...

Dowry Folding technique creativity

Published by: Akademi Kesejahteraan Sosial Ibu Kartini Semarang

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Appraisal of candidate instruments for assessment of the physical function domain in patients with psoriatic arthritis

Ying Ying Leung, Ana Maria Orbai, Alexis Ogdie, Pil Hojgaard, Richard Holland, Niti Goel, Jeffrey Chau, Laura C. Coates, Vibeke Strand, Dafna D. Gladman, Philip J. Mease, Robin Christensen, William Tillett

Jan 01, 2021

Objective. Numerous patient-reported outcome measures (PROM) exist for the measurement of physical function for psoriatic arthritis (PsA), but only a few are validated comprehensively. The objective of this project was to...

outcome measures Physical function psoriasis psoriatic arthritis

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Clinical trial discrimination of physical function instruments for psoriatic arthritis

Ying-Ying Leung, Richard Holland, Ashish J Mathew, Christine Lindsay, Niti Goel, Alexis Ogdie, Ana-Maria Orbai, Pil Hojgaard, Jeffrey Chau, Laura C Coates, Vibeke Strand, Dafna D Gladman, Robin Christensen, William Tillett, Philip Mease

Oct 01, 2020

OBJECTIVES: Physical function (PF) is a core domain to be measured in randomized controlled trials (RCTs) of psoriatic arthritis (PsA), yet the discriminative performance of patient reported outcome measures (PROMs) for PF in...

Clinical Trials Physical function psoriatic arthritis Psychometric Responsiveness

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Rising to the challenge

Mark Lillicrap, Simon Otter, Inam Haq

Mar 29, 2016

attitude of health professionals education research health policies Medical Education outcome measures Clinical Competence Delivery of Health Care Education Medical Humans Patient Care Team Rheumatic Diseases Rheumatology Simulation Training

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Effect of coping strategies on patient and physician perceptions of disease severity and disability in systemic sclerosis

Dana D DiRenzo, Theresa R Smith, Tracy M Frech, Ami A Shah, John D Pauling

Oct 01, 2021

Objective. Systemic sclerosis (SSc) results in impaired function, disability, and reduced health-related quality of life. We investigated the effect of coping strategies on the patient global assessment of health (PtGA) and...

coping disability Pain Quality of life Scleroderma systemic sclerosis

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Effect of coping strategies on patient and physician perceptions of disease severity and disability in systemic sclerosis

Dana D DiRenzo, Theresa R Smith, Tracy M Frech, Ami A Shah, John D Pauling

Oct 01, 2021

coping disability Pain Quality of life Scleroderma systemic sclerosis

Cover Image for Evaluation of the Economic Burden of Psoriatic Arthritis and the Relationship Between Functional Status and Healthcare Costs

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Evaluation of the Economic Burden of Psoriatic Arthritis and the Relationship Between Functional Status and Healthcare Costs

Neil McHugh, Áine Maguire, Ian Handel, William Tillett, James Morris, Neil Hawkins, Charlotte Cavill, Eleanor Korendowych, Farhan Mughal

Aug 31, 2019

OBJECTIVE: This analysis aimed to evaluate the economic burden of patients with psoriatic arthritis (PsA) on the UK healthcare system and estimate the relationship between functional status and direct healthcare...

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Circulating polymers in α1-antitrypsin deficiency.

Lu Tan, Jennifer A Dickens, Dawn L DeMeo, Elena Miranda, Juan Perez, S Tamir Rashid, James Day, Adriana Ordoñez, Stefan J Marciniak, Imran Haq, Alan F Barker, Edward J Campbell, Edward Eden, Noel G McElvaney, Stephen I Rennard, Robert A Sandhaus, James M Stocks, James K Stoller, Charlie Strange, Gerard Turino, Farshid N Rouhani, Mark Brantly, David A Lomas

Feb 12, 2019

Alleles Biomarkers Biopsy Enzyme-Linked Immunosorbent Assay Humans Immunoprecipitation Inflammation Male Middle Aged Phenotype Polymers Sensitivity and Specificity alpha 1-Antitrypsin alpha 1-Antitrypsin Deficiency

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Evaluation of the Economic Burden of Psoriatic Arthritis and the Relationship Between Functional Status and Healthcare Costs

Neil McHugh, Áine Maguire, Ian Handel, William Tillett, James Morris, Neil Hawkins, Charlotte Cavill, Eleanor Korendowych, Farhan Mughal

Aug 31, 2019

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Appraisal of candidate instruments for assessment of the physical function domain in patients with psoriatic arthritis

Jan 01, 2021

outcome measures Physical function psoriasis psoriatic arthritis

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Clinical trial discrimination of physical function instruments for psoriatic arthritis

Oct 01, 2020

Clinical Trials Physical function psoriatic arthritis Psychometric Responsiveness

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The Meaning Of Ultra Qui Judicat Principle And The Validity Of The Verdict In Criminal Cases

Suwitno Y IMRAN, Sudarsono SUDARSONO, I Nyoman NURJAYA, Nurini APRILIANDA

Nov 30, 2022

The prohibition for judges to not sentence the defendant if the act is not described carefully, clearly and completely in the indictment of the public prosecutor, it turns out that in practice in court, there are judges who...

Ultra Qui Judicat Principle Verdict Judge Criminal Cases

Published by: Indonesia Strategic Sustainability

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Pelatihan Teknik Merangkai Hantaran Busana Lingerie Bagi Pengusaha Muda

Romadhona Chusna Tsani, Arina Haq

Feb 12, 2025

Training on techniques for assembling lingerie clothing gifts is one of the training in assembling gifts given to young entrepreneurs at community service activities at SKB Ungaran. This training aims to provide skills to young...

Training Stringing Techniques Wedding gift

Published by: Akademi Kesejahteraan Sosial Ibu Kartini Semarang

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Communicating risk in primary care

Alexandra Freeman, Martin Marshall, Julian Treadwell, David Spiegelhalter, Imran Rafi

Dec 06, 2017

In 2014, the National Institute for Health Care Excellence (NICE) changed its guidelines for offering statins to patients, reducing the threshold from 20% cardiovascular risk to 10%.1 This ignited a fervent debate about the...

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A Structural Break Approach to Analysing the Impact of the QE Portfolio Balance Channel on the US Stock Market

Imran H. Shah, Francesca Schmidt-Fischer, Issam Malki, Richard Hatfield

Jul 31, 2019

Following the 1929 Wall Street collapse, the initial response to the institutional failures and collapsing financial system was to allow the markets to self-correct, which led to a significant period of economic depression. In...

equity risk premium regime shifts quantitative easing portfolio balance channel equity returns US Treasuries.

Cover Image for Healthcare Access and Quality Index based on mortality from causes amenable to personal health care in 195 countries and territories, 1990-2015

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Healthcare Access and Quality Index based on mortality from causes amenable to personal health care in 195 countries and territories, 1990-2015

GBD 2015 Healthcare Access and Quality Collaborators. Electronic address: cjlm@uw.edu, GBD 2015 Healthcare Access and Quality Collaborators

Dec 12, 2017

BACKGROUND: National levels of personal health-care access and quality can be approximated by measuring mortality rates from causes that should not be fatal in the presence of effective medical care (ie, amenable mortality)....

Global Burden of Disease Health Services Accessibility Health Status Indicators Humans Mortality Quality of Health Care Risk Assessment Universal Health Insurance

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Avalanche criticality in LaAlO[Formula

John JR Scott, Blai Casals, King-Fa Luo, Atta Haq, Davide Mariotti, Ekhard KH Salje, Miryam Arredondo

Sep 02, 2022

Ferroic domain dynamics, as a function of external stimuli, can be collectively described as scale-invariant avalanches characterised by a critical exponent that are sensitive to the complexity of the domain microstructure. The...

article article

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How Do Oil Prices, Macroeconomic Factors and Policies Affect the Market for Renewable Energy?

Imran H. Shah, Charlie Hiles, Bruce Morley

Apr 01, 2018

The aim of this study is to determine the nature of any relationship between renewable energy investment, oil prices, GDP and the interest rate, using a time series approach. We concentrate on three countries with different...

Cover Image for Development of 3D boundary element method for the simulation of acoustic metamaterials/metasurfaces in mean flow for aerospace applications

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Development of 3D boundary element method for the simulation of acoustic metamaterials/metasurfaces in mean flow for aerospace applications

Imran Bashir, Michael Carley

Oct 01, 2020

Low-cost airlines have significantly increased air transport, thus an increase in aviation noise. Therefore, predicting aircraft noise is an important component for designing an aircraft to reduce its impact on environmental...

Boundary element method impedance mean flow Metamaterial noise attenuation