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Microbial stimulation fully differentiates monocytes to DC-SIGN/CD209 + dendritic cells for immune T cell areas
Dendritic cells (DCs), critical antigen-presenting cells for immune control, normally derive from bone marrow precursors distinct from monocytes. It is not yet established if the large reservoir of monocytes can develop into...
Published by: Rockefeller University
Targeting Leishmania major Antigens to Dendritic Cells In Vivo Induces Protective Immunity
Efficient vaccination against the parasite Leishmania major, the causative agent of human cutaneous leishmaniasis, requires development of type 1 T-helper (Th1) CD4+ T cell immunity. Because of their unique capacity to initiate...
CD4+ T lymphocyte dendritic cell Genetic Engineering Immunization protozoal protein tumor necrosis factor Leishmania major
Published by: Rockefeller University
A Novel Adaptive Genetic Algorithm for Dynamic Vehicle Routing Problem With Backhaul and Two-Dimensional Loading Constraints
In this paper, we consider an extension of the Dynamic Vehicle Routing Problem with Backhauls integrated with two-dimensional loading problem called DVRPB with 2D loading constraints (2L-DVRPB). In the VRPB, a vehicle can...
Published by: IGI Global Scientific Publishing
Trends in therapeutic drug conjugates for bacterial diseases
INTRODUCTION: Drug conjugates are trend topics in Chemical Biology. These entities are an emerging class of highly potent biopharmaceutical drugs, best known in the field of oncology, that have been also designed as a targeted...
Building a Document-Oriented Warehouse Using NoSQL
The traditional data warehousing approaches should adapt to take into consideration novel needs and data structures. In this context, NoSQL technology is progressively gaining a place in the research and industry domains. This...
Published by: IGI Global Scientific Publishing
Development of vocal emotion recognition in school-age children
Leanne Nagels, Etienne Gaudrain, Deborah Vickers, Marta Matos Lopes, Petra Hendriks, Deniz Başkent
May 11, 2020
Traditionally, emotion recognition research has primarily used pictures and videos, while audio test materials are not always readily available or are not of good quality, which may be particularly important for studies with...
Published by: PeerJ
Rewiring Meiosis for Crop Improvement.
Meiosis is a specialized cell division that contributes to halve the genome content and reshuffle allelic combinations between generations in sexually reproducing eukaryotes. During meiosis, a large number of programmed DNA...
Rewiring Meiosis for Crop Improvement
Meiosis is a specialized cell division that contributes to halve the genome content and reshuffle allelic combinations between generations in sexually reproducing eukaryotes. During meiosis, a large number of programmed DNA...
A thioether-directed palladium-cleavable linker for targeted bioorthogonal drug decaging.
Benjamin J Stenton, Bruno L Oliveira, Maria J Matos, Laura Sinatra, Gonçalo JL Bernardes
Jul 02, 2018
We describe the development of a bifunctional linker that simultaneously allows site-specific protein modification and palladium-mediated bioorthogonal decaging. This was enabled by a thioether binding motif in the propargyl...
Fuzzy Logic for Solving the Water-Energy Management Problem in Standalone Water Desalination Systems
This work investigates an important topic of energy and water security (water-energy nexus). For this purpose, Water-Energy Management Strategy (W-EMS) for a standalone water desalination system powered by PV-Wind source is...
Published by: IGI Global Scientific Publishing
Facilitating permeability of landscapes impacted by roads for protected amphibians
Amphibian populations are highly vulnerable to road mortality and habitat fragmentation caused by road networks. Wildlife road tunnels are considered the most promising road mitigation measure for amphibians yet generally remain...
Synthesis and Biological Evaluation of Homogeneous Thiol-Linked NHC*-Au-Albumin and -Trastuzumab Bioconjugates.
Maria J Matos, Carlos Labão-Almeida, Claire Sayers, Oyinlola Dada, Matthias Tacke, Gonçalo JL Bernardes
Sep 05, 2018
Targeted delivery of potent cytotoxic drugs to cancer cells minimizes systemic toxicity and several side effects. NHC*-Au-Cl has already been proven to be a potent anticancer agent. In this study, we explore a strategy based on...
Development of vocal emotion recognition in school-age children
Leanne Nagels, Etienne Gaudrain, Deborah Vickers, Marta Matos Lopes, Petra Hendriks, Deniz Başkent
May 14, 2020
Traditionally, emotion recognition research has primarily used pictures and videos, while audio test materials are not always readily available or are not of good quality, which may be particularly important for studies with...
User preferences and water use savings owing to washbasin taps retrofit
During the last decades, achieving water efficiency in buildings has increasingly become an important challenge in the scope of sustainability. Water consumption is directly related to individual conduct. Despite the various...
The effect of increasing Women's autonomy on primary and repeated caesarean sections in Brazil.
Caesarean section (C-section) rates continue to rise globally. Yet, there is little consensus about the key determinants of rising C-section rates and the sources of variation in C-section rates across the world. While...
Anterior mitral valve leaflet length in cats with hypertrophic cardiomyopathy.
INTRODUCTION: Anterior mitral valve leaflet (AMVL) elongation is a recognised feature of hypertrophic cardiomyopathy (HCM). However, whether AMVL elongation precedes left ventricular hypertrophy in cats is currently unknown. The...
Sequential dual site-selective protein labelling enabled by lysine modification.
Maria J Matos, Libby Brown, Barbara Bernardim, Ana Guerreiro, Gonzalo Jiménez-Osés, Gonçalo JL Bernardes
Sep 25, 2020
Methods that allow for chemical site-selective dual protein modification are scarce. Here, we provide proof-of-concept for the orthogonality and compatibility of a method for regioselective lysine modification with strategies...
Comparison of Normalization Techniques on Data Sets With Outliers
With the fast growth of data-rich systems, dealing with complex decision problems with skewed input data sets and respective outliers is unavoidable. Generally, data skewness refers to a non-uniform distribution in a dataset...
Published by: IGI Global Scientific Publishing
Temperature response of an all-solid photonic bandgap fiber for sensing applications
The spectral shift due to temperature in the photonic bandgap (PBG) of an all-solid PBG fiber is investigated, aiming at discrete and distributed temperature sensing. A temperature rise induces a red shift in the bandgap...
Changes in the quantity and quality of time use during the COVID-19 lockdowns in the UK
We investigated changes in the quantity and quality of time spent on various activities in response to the COVID-19-induced national lockdowns in the UK. We examined effects both in the first national lockdown (May 2020) and the...
User preferences and water use savings owing to washbasin taps retrofit
During the last decades, achieving water efficiency in buildings has increasingly become an important challenge in the scope of sustainability. Water consumption is directly related to individual conduct. Despite the various...
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