A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization.
Anand D Jeyasekharan,
Yang Liu,
Hiroyoshi Hattori,
Venkat Pisupati,
Asta Bjork Jonsdottir,
Eeson Rajendra,
MiYoung Lee,
Elayanambi Sundaramoorthy,
Simon Schlachter,
Clemens F Kaminski,
Yaara Ofir-Rosenfeld,
Ko Sato,
Jane Savill,
Nabieh Ayoub,
Ashok R Venkitaraman
Feb 13, 2020
Germline missense mutations affecting a single BRCA2 allele predispose humans to cancer. Here we identify a protein-targeting mechanism that is disrupted by the cancer-associated mutation, BRCA2(D2723H), and that controls the...