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An endogenous nanomineral chaperones luminal antigen and peptidoglycan to intestinal immune cells.
Jonathan J Powell, Emma Thomas-McKay, Vinay Thoree, Jack Robertson, Rachel E Hewitt, Jeremy N Skepper, Andy Brown, Juan Carlos Hernandez-Garrido, Paul A Midgley, Inmaculada Gomez-Morilla, Geoffrey W Grime, Karen J Kirkby, Neil A Mabbott, David S Donaldson, Ifor R Williams, Daniel Rios, Stephen E Girardin, Carolin T Haas, Sylvaine FA Bruggraber, Jon D Laman, Yakup Tanriver, Giovanna Lombardi, Robert Lechler, Richard PH Thompson, Laetitia C Pele
Aug 08, 2017
In humans and other mammals it is known that calcium and phosphate ions are secreted from the distal small intestine into the lumen. However, why this secretion occurs is unclear. Here, we show that the process leads to the...
Unbinned multivariate observables for global SMEFT analyses from machine learning
Abstract
Theoretical interpretations of particle physics data, such as the determination of the Wilson coefficients of the Standard Model Effective Field...
The Grizzly, December 8, 1992
Tom Wilusz, Sarah Starr, Sara Jacobson, Hope Rinehimer, Audra Boettcher, Denise Moretz, Megan Mendte, Christian P. Sockel, Jeff Eckerson, Betsy Laskowski, Ellen Cosgrove, Harley David Rubin, Richard P. Richter, Mark Leiser, Melissa Chido, David Van Benthuysen
Jan 01, 0001
Gomez Speaks on Gildah Stories Wellness Center Confusion Greek Service Projects How To Handle Holiday Dysfunction Senior Profile: Tina Moukoulis Wismer's Christmas Dinner Russian Rock With Yuri Exam Schedule Standards A...
Ursinus College Collegeville Pennsylvania newspaper Basketball ADA compliance Condoms AIDS Christmas Yuri Naumov Tina Moukoulis Jewelle Gomez Gay and Lesbian Alliance sororities fraternities wellness fee cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Distinctive Frontal and Occipitotemporal Surface Features in Neglectful Parenting
Inmaculada León, María José Rodrigo, Ileana Quiñones, Juan Andrés Hernández-Cabrera, Lorna García-Pentón
Mar 20, 2021
Although the brain signatures of adaptive human parenting are well documented, the cortical features associated with maladaptive caregiving are underexplored. We investigated whether cortical thickness and surface area vary in a...
Minimal Design Principles for Icosahedral Virus Capsids.
The geometrical structures of single- and multiple-shell icosahedral virus capsids are reproduced as the targets that minimize the cost corresponding to relatively simple design functions. Capsid subunits are first identified as...
Distinctive Frontal and Occipitotemporal Surface Features in Neglectful Parenting.
Inmaculada León, María José Rodrigo, Ileana Quiñones, Juan Andrés Hernández-Cabrera, Lorna García-Pentón
Jun 04, 2021
Although the brain signatures of adaptive human parenting are well documented, the cortical features associated with maladaptive caregiving are underexplored. We investigated whether cortical thickness and surface area vary in a...
Microstructural alterations in the onychomycotic and psoriatic nail
E Cutrin Gomez, S. Anguiano Igea, Maria Delgado-Charro, JL Gomez Amoza, FJ Otero Espinar
Jul 31, 2018
Despite the important nail alterations caused by onychomycosis and psoriasis few studies have characterized the microstructure of the diseased nail plate and the diffusion and penetration of drugs through this altered...
Microstructural alterations in the onychomycotic and psoriatic nail
E Cutrin Gomez, S. Anguiano Igea, Maria Delgado-Charro, JL Gomez Amoza, FJ Otero Espinar
Jul 31, 2018
Despite the important nail alterations caused by onychomycosis and psoriasis few studies have characterized the microstructure of the diseased nail plate and the diffusion and penetration of drugs through this altered...
Growth Models and Their Stability Analysis for Populations of a Single Species
Understanding the patterns of population growth for human beings or other animals is important for effective society and resource management. We study several population growth models for a single species to exhibit how the...
Published by: Digital Commons @ Texas A&M University-San Antonio
Characterisation of microRNA expression in post-natal mouse mammary gland development.
Practical Considerations for Continuous Time-Domain Cerebrovascular Reactivity Indices in Traumatic Brain Injury
Literature pertaining to traumatic brain injury care involves the mediation and control of secondary brain injury mechanisms, chief among these is cerebral autoregulation. Cerebral autoregulation is frequently assessed through...
Traumatic brain injury cerebral autoregulation Linearity continuous monitoring Cerebrovascular Reactivity (Cvrx)
Published by: Frontiers in neurology
Notch after cleavage.
The discovery that Notch activation involves a proteolytic cleavage to release the intracellular domain (NICD) revolutionized the field of Notch signaling. It resulted in a simple model whereby the cleaved NICD enters the...
Population mixing promotes arms race host–parasite coevolution
The consequences of host–parasite coevolution are highly contingent on the qualitative coevolutionary dynamics: whether selection fluctuates (fluctuating selection dynamic; FSD), or is directional towards increasing...
The Effect of Monitoring
BACKGROUND: The impact of surveying on individuals’ behavior and decision making has been widely studied in academic literature on market research but not so much the impact of monitoring on economic development interventions. ...
Microtubule organization is determined by the shape of epithelial cells.
Animals Cadherins Cell Shape Drosophila Proteins Drosophila melanogaster Embryo Nonmammalian Epithelial Cells Gene Expression Regulation Developmental Genes Reporter Green Fluorescent Proteins Interphase Larva Luminescent Proteins Membrane Glycoproteins Microtubules Morphogenesis Optical Imaging Pupa Zygote
Measuring single cell divisions in human tissues from multi-region sequencing data.
Benjamin Werner, Jack Case, Marc J Williams, Ketevan Chkhaidze, Daniel Temko, Javier Fernández-Mateos, George D Cresswell, Daniel Nichol, William Cross, Inmaculada Spiteri, Weini Huang, Ian PM Tomlinson, Chris P Barnes, Trevor A Graham, Andrea Sottoriva
Feb 24, 2021
Both normal tissue development and cancer growth are driven by a branching process of cell division and mutation accumulation that leads to intra-tissue genetic heterogeneity. However, quantifying somatic evolution in humans...
Delving Into the IT Governance-Management Communication Interface
This work is devoted to addressing the IT governance - management communication aspects, considering that their responsibilities are different, but complementary, in developing an IT governance framework. Our research question...
Published by: IGI Global Scientific Publishing
Association of Age and Sex With Multi-Modal Cerebral Physiology in Adult Moderate/Severe Traumatic Brain Injury
The impact of age and biological sex on outcome in moderate/severe traumatic brain injury (TBI) has been documented in large cohort studies, with advanced age and male sex linked to worse long-term outcomes. However, the...
Stable Pyrrole-Linked Bioconjugates through Tetrazine-Triggered Azanorbornadiene Fragmentation.
Enrique Gil de Montes, Alena Istrate, Claudio D Navo, Ester Jiménez-Moreno, Emily A Hoyt, Francisco Corzana, Inmaculada Robina, Gonzalo Jiménez-Osés, Antonio J Moreno-Vargas, Gonçalo JL Bernardes
Jan 31, 2020
An azanorbornadiene bromovinyl sulfone reagent for cysteine-selective bioconjugation has been developed. Subsequent reaction with dipyridyl tetrazine leads to bond cleavage and formation of a pyrrole-linked conjugate. The latter...
Azabicyclic vinyl sulfones for residue-specific dual protein labelling.
Enrique Gil de Montes, Ester Jiménez-Moreno, Bruno L Oliveira, Claudio D Navo, Pedro MSD Cal, Gonzalo Jiménez-Osés, Inmaculada Robina, Antonio J Moreno-Vargas, Gonçalo JL Bernardes
Mar 28, 2019
We have developed [2.2.1]azabicyclic vinyl sulfone reagents that simultaneously enable cysteine-selective protein modification and introduce a handle for further bioorthogonal ligation. The reaction is fast and selective for...
Activin/nodal signaling and NANOG orchestrate human embryonic stem cell fate decisions by controlling the H3K4me3 chromatin mark.
Alessandro Bertero, Pedro Madrigal, Antonella Galli, Nina C Hubner, Inmaculada Moreno, Deborah Burks, Stephanie Brown, Roger A Pedersen, Daniel Gaffney, Sasha Mendjan, Siim Pauklin, Ludovic Vallier
May 21, 2015
DPY30 H3K4me3 NANOG hESCs Activins Animals Cell Differentiation Cells Cultured Chromatin Embryo Mammalian Embryonic Stem Cells Epigenesis Genetic Histone Methyltransferases Histone-Lysine N-Methyltransferase Histones Homeodomain Proteins Humans Mice Nanog Homeobox Protein Nodal Protein Signal Transduction Smad2 Protein Smad3 Protein
Metal-organic frameworks post-synthetically modified with ferrocenyl groups
Metal-organic framework (MOF) materials based on zinc(II) and aluminium(III) dicarboxylate frameworks with covalently attached ferrocene functional redox groups were synthesised by post-synthetic modification and investigated by...
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