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Results: 33
Stable Pyrrole-Linked Bioconjugates through Tetrazine-Triggered Azanorbornadiene Fragmentation.
Enrique Gil de Montes, Alena Istrate, Claudio D Navo, Ester Jiménez-Moreno, Emily A Hoyt, Francisco Corzana, Inmaculada Robina, Gonzalo Jiménez-Osés, Antonio J Moreno-Vargas, Gonçalo JL Bernardes
Jan 31, 2020
An azanorbornadiene bromovinyl sulfone reagent for cysteine-selective bioconjugation has been developed. Subsequent reaction with dipyridyl tetrazine leads to bond cleavage and formation of a pyrrole-linked conjugate. The latter...
Azabicyclic vinyl sulfones for residue-specific dual protein labelling.
Enrique Gil de Montes, Ester Jiménez-Moreno, Bruno L Oliveira, Claudio D Navo, Pedro MSD Cal, Gonzalo Jiménez-Osés, Inmaculada Robina, Antonio J Moreno-Vargas, Gonçalo JL Bernardes
Mar 28, 2019
We have developed [2.2.1]azabicyclic vinyl sulfone reagents that simultaneously enable cysteine-selective protein modification and introduce a handle for further bioorthogonal ligation. The reaction is fast and selective for...
Synergistic effects of combining ultrasound with the Fenton process in the degradation of Reactive Blue 19
The decoloration of reactive dye C.I. Reactive Blue 19 (RB 19) using combined ultrasound with the Fenton process has been investigated. The effect of varying the concentrations of hydrogen peroxide and iron sulfate, initial...
Synergistic effects of combining ultrasound with the Fenton process in the degradation of Reactive Blue 19
The decoloration of reactive dye C.I. Reactive Blue 19 (RB 19) using combined ultrasound with the Fenton process has been investigated. The effect of varying the concentrations of hydrogen peroxide and iron sulfate, initial...
Distinctive Frontal and Occipitotemporal Surface Features in Neglectful Parenting
Inmaculada León, María José Rodrigo, Ileana Quiñones, Juan Andrés Hernández-Cabrera, Lorna García-Pentón
Mar 20, 2021
Although the brain signatures of adaptive human parenting are well documented, the cortical features associated with maladaptive caregiving are underexplored. We investigated whether cortical thickness and surface area vary in a...
Graphene nanoplatelets/CeO2 nanotiles nanocomposites as effective antibacterial material for multiple drug-resistant bacteria.
Saliha Ur Rehman, Robina Khan Niazi, M Zulqurnain, Qaisar Mansoor, Javed Iqbal, Aqsa Arshad
Apr 20, 2022
Antibacterial agents with low toxicity to normal cells, redox activity and free radical scavenging property are urgently needed to address the global health crisis. The phenomenal conducting nature of graphene is a best fit to...
Distinctive Frontal and Occipitotemporal Surface Features in Neglectful Parenting.
Inmaculada León, María José Rodrigo, Ileana Quiñones, Juan Andrés Hernández-Cabrera, Lorna García-Pentón
Jun 04, 2021
Although the brain signatures of adaptive human parenting are well documented, the cortical features associated with maladaptive caregiving are underexplored. We investigated whether cortical thickness and surface area vary in a...
Characterisation of microRNA expression in post-natal mouse mammary gland development.
Measuring single cell divisions in human tissues from multi-region sequencing data.
Benjamin Werner, Jack Case, Marc J Williams, Ketevan Chkhaidze, Daniel Temko, Javier Fernández-Mateos, George D Cresswell, Daniel Nichol, William Cross, Inmaculada Spiteri, Weini Huang, Ian PM Tomlinson, Chris P Barnes, Trevor A Graham, Andrea Sottoriva
Feb 24, 2021
Both normal tissue development and cancer growth are driven by a branching process of cell division and mutation accumulation that leads to intra-tissue genetic heterogeneity. However, quantifying somatic evolution in humans...
Activin/nodal signaling and NANOG orchestrate human embryonic stem cell fate decisions by controlling the H3K4me3 chromatin mark.
Alessandro Bertero, Pedro Madrigal, Antonella Galli, Nina C Hubner, Inmaculada Moreno, Deborah Burks, Stephanie Brown, Roger A Pedersen, Daniel Gaffney, Sasha Mendjan, Siim Pauklin, Ludovic Vallier
May 21, 2015
DPY30 H3K4me3 NANOG hESCs Activins Animals Cell Differentiation Cells Cultured Chromatin Embryo Mammalian Embryonic Stem Cells Epigenesis Genetic Histone Methyltransferases Histone-Lysine N-Methyltransferase Histones Homeodomain Proteins Humans Mice Nanog Homeobox Protein Nodal Protein Signal Transduction Smad2 Protein Smad3 Protein
Stigma mastery in people living with HIV
Charles Patrick Namisi, John C Munene, Rhoda K Wanyenze, Anne R Katahoire, Rosalinda M Parkes-Ratanshi, Stella Kentutsi, Maria M Nannyonga, Robina N Ssentongo, Mabel K Ogola, Maria Sarah Nabaggala, Geofrey Amanya, Agnes N Kiragga, Richard Batamwita, Nazarius M Tumwesigye
Nov 18, 2022
AIMS: This study aimed to determine the prevalence of, factors associated with, and to build a theoretical framework for understanding Internalsed HIV-related Stigma Mastery (IHSM). METHODS: A cross-sectional study nested within...
The effect of early life events on glucose levels in first-episode psychosis.
Clemente Garcia-Rizo, Bibiana Cabrera, Miquel Bioque, Gisela Mezquida, Antonio Lobo, Ana Gonzalez-Pinto, Covadonga M Diaz-Caneja, Iluminada Corripio, Eduard Vieta, Inmaculada Baeza, Maria Paz Garcia-Portilla, Miguel Gutierrez-Fraile, Roberto Rodriguez-Jimenez, Marina Garriga, Emilio Fernandez-Egea, Miguel bernardo, PEPs GROUP
Dec 19, 2022
The barley immune receptor Mla recognizes multiple pathogens and contributes to host range dynamics.
Jan Bettgenhaeuser, Inmaculada Hernández-Pinzón, Andrew M Dawson, Matthew Gardiner, Phon Green, Jodie Taylor, Matthew Smoker, John N Ferguson, Peter Emmrich, Amelia Hubbard, Rosemary Bayles, Robbie Waugh, Brian J Steffenson, Brande BH Wulff, Antonín Dreiseitl, Eric R Ward, Matthew J Moscou
Dec 15, 2021
Latent Cytomegalovirus-Driven Recruitment of Activated CD4+ T Cells Promotes Virus Reactivation.
Sarah E Jackson, Kevin C Chen, Ian J Groves, George X Sedikides, Amar Gandhi, Charlotte J Houldcroft, Emma L Poole, Inmaculada Montanuy, Gavin M Mason, Georgina Okecha, Matthew B Reeves, John H Sinclair, Mark R Wills
Mar 23, 2021
Human cytomegalovirus (HCMV) infection is not cleared by the initial immune response but persists for the lifetime of the host, in part due to its ability to establish a latent infection in cells of the myeloid lineage. HCMV has...
Latent Cytomegalovirus-Driven Recruitment of Activated CD4+ T Cells Promotes Virus Reactivation
Sarah E. Jackson, Kevin C. Chen, Ian J. Groves, George X. Sedikides, Amar Gandhi, Charlotte J. Houldcroft, Emma L. Poole, Inmaculada Montanuy, Gavin M. Mason, Georgina Okecha, Matthew B. Reeves, John H. Sinclair, Mark R. Wills
Apr 26, 2021
Human cytomegalovirus (HCMV) infection is not cleared by the initial immune response but persists for the lifetime of the host, in part due to its ability to establish a latent infection in cells of the myeloid lineage. HCMV has...
The barley immune receptor Mla recognizes multiple pathogens and contributes to host range dynamics.
Jan Bettgenhaeuser, Inmaculada Hernández-Pinzón, Andrew M Dawson, Matthew Gardiner, Phon Green, Jodie Taylor, Matthew Smoker, John N Ferguson, Peter Emmrich, Amelia Hubbard, Rosemary Bayles, Robbie Waugh, Brian J Steffenson, Brande BH Wulff, Antonín Dreiseitl, Eric R Ward, Matthew J Moscou
Jan 31, 2022
MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtype.
HES5 silencing is an early and recurrent change in prostate tumourigenesis.
Charles E Massie, Inmaculada Spiteri, Helen Ross-Adams, Hayley Luxton, Jonathan Kay, Hayley C Whitaker, Mark J Dunning, Alastair D Lamb, Antonio Ramos-Montoya, Daniel S Brewer, Colin S Cooper, Rosalind Eeles, UK Prostate ICGC Group, Anne Y Warren, Simon Tavaré, David E Neal, Andy G Lynch
Mar 12, 2015
AR ERG HES5 HES6 Notch epigenetics Methylation prostate cancer Basic Helix-Loop-Helix Transcription Factors Carcinogenesis Cell Line Tumor DNA Methylation Epigenesis Genetic Gene Expression Profiling Gene Expression Regulation Neoplastic Humans Male Promoter Regions Genetic Prostatic Neoplasms Repressor Proteins Trans-Activators Transcriptional Regulator ERG
The barley immune receptor Mla recognizes multiple pathogens and contributes to host range dynamics.
Jan Bettgenhaeuser, Inmaculada Hernández-Pinzón, Andrew M Dawson, Matthew Gardiner, Phon Green, Jodie Taylor, Matthew Smoker, John N Ferguson, Peter Emmrich, Amelia Hubbard, Rosemary Bayles, Robbie Waugh, Brian J Steffenson, Brande B H Wulff, Antonín Dreiseitl, Eric R Ward, Matthew J Moscou
Jan 07, 2022
Published by: Nature Communications
An endogenous nanomineral chaperones luminal antigen and peptidoglycan to intestinal immune cells.
Jonathan J Powell, Emma Thomas-McKay, Vinay Thoree, Jack Robertson, Rachel E Hewitt, Jeremy N Skepper, Andy Brown, Juan Carlos Hernandez-Garrido, Paul A Midgley, Inmaculada Gomez-Morilla, Geoffrey W Grime, Karen J Kirkby, Neil A Mabbott, David S Donaldson, Ifor R Williams, Daniel Rios, Stephen E Girardin, Carolin T Haas, Sylvaine FA Bruggraber, Jon D Laman, Yakup Tanriver, Giovanna Lombardi, Robert Lechler, Richard PH Thompson, Laetitia C Pele
Aug 08, 2017
In humans and other mammals it is known that calcium and phosphate ions are secreted from the distal small intestine into the lumen. However, why this secretion occurs is unclear. Here, we show that the process leads to the...
Outcome of Hospitalization for COVID-19 in Patients with Interstitial Lung Disease. An International Multicenter Study.
Thomas M Drake, Annemarie B Docherty, Ewen M Harrison, Jennifer K Quint, Huzaifa Adamali, Sarah Agnew, Suresh Babu, Christopher M Barber, Shaney Barratt, Elisabeth Bendstrup, Stephen Bianchi, Diego Castillo Villegas, Nazia Chaudhuri, Felix Chua, Robina Coker, William Chang, Anjali Crawshaw, Louise E Crowley, Davinder Dosanjh, Christine A Fiddler, Ian A Forrest, Peter M George, Michael A Gibbons, Katherine Groom, Sarah Haney, Simon P Hart, Emily Heiden, Michael Henry, Ling-Pei Ho, Rachel K Hoyles, John Hutchinson, Killian Hurley, Mark Jones, Steve Jones, Maria Kokosi, Michael Kreuter, Laura S MacKay, Siva Mahendran, George Margaritopoulos, Maria Molina-Molina, Philip L Molyneaux, Aiden O'Brien, Katherine O'Reilly, Alice Packham, Helen Parfrey, Venerino Poletti, Joanna C Porter, Elisabetta Renzoni, Pilar Rivera-Ortega, Anne-Marie Russell, Gauri Saini, Lisa G Spencer, Giulia M Stella, Helen Stone, Sharon Sturney, David Thickett, Muhunthan Thillai, Tim Wallis, Katie Ward, Athol U Wells, Alex West, Melissa Wickremasinghe, Felix Woodhead, Glenn Hearson, Lucy Howard, J Kenneth Baillie, Peter JM Openshaw, Malcolm G Semple, Iain Stewart, R Gisli Jenkins, ISARIC4C investigators
Jul 27, 2021
Rationale: The impact of coronavirus disease (COVID-19) on patients with interstitial lung disease (ILD) has not been established.Objectives: To assess outcomes in patients with ILD hospitalized for COVID-19 versus those without...
A cross-disease meta-GWAS identifies four new susceptibility loci shared between systemic sclerosis and Crohn’s disease
David González-Serna, Eguzkine Ochoa, Elena López-Isac, Antonio Julià, Frauke Degenhardt, Norberto Ortego-Centeno, Timothy R. D. J. Radstake, Andre Franke, Sara Marsal, Maureen D. Mayes, Javier Martín, Ana Márquez, Shervin Assassi, Xiaodong Zhou, Filemon K. Tan, Frank C. Arnett, John D. Reveille, Olga Gorlova, Wei V. Chen, Jun Ying, Peter K. Gregersen, Annette T. Lee, Alexandre E. Voskuyl, Jeska de Vries-Bouwstra, Cesar Magro-Checa, Jasper Broen, Bobby P. C. Koeleman, Carmen P. Simeón, Vicente Fonollosa, Alfredo Guillén, Patricia Carreira, Iván Castellví, Miguel A. González-Gay, Raquel Ríos, Jose Luis Callejas-Rubio, José A. Vargas-Hitos, Rosa García-Portales, María Teresa Camps, Antonio Fernández-Nebro, María F. González-Escribano, Francisco José García-Hernández, Ma. Jesús Castillo, Ma. Ángeles Aguirre, Inmaculada Gómez-Gracia, Luis Rodríguez-Rodríguez, Benjamín Fernández-Gutiérrez, Paloma García de la Peña, Esther Vicente, José Luis Andreu, Mónica Fernández de Castro, Francisco Javier López-Longo, Lina Martínez, Gerard Espinosa, Carlos Tolosa, Anna Pros, Mónica Rodríguez-Carballeira, Francisco Javier Narváez, Manel Rubio-Rivas, Vera Ortiz-Santamaría, Ana Belén Madroñero, Bernardino Díaz, Luis Trapiella, Adrián Sousa, María Victoria Egurbide, Patricia Fanlo-Mateo, Luis Sáez-Comet, Federico Díaz-González, Vanesa Hernández, Emma Beltrán, José Andrés Román-Ivorra, Elena Grau, Juan José Alegre-Sancho, Francisco J. Blanco-García, Natividad Oreiro, Mayka Freire, Alejandro Balsa, Ana M. Ortiz, Nicolas Hunzelmann, Gabriela Riemekasten, Jörg H. W. Distler, Torsten Witte, Paolo Airó, Lorenzo Beretta, Alessandro Santaniello, Chiara Bellocchi, Claudio Lunardi, Gianluca Moroncini, Armando Gabrielli
Feb 04, 2021
Abstract: Genome-wide association studies (GWASs) have identified a number of genetic risk loci associated with systemic sclerosis (SSc) and Crohn’s disease (CD), some of which confer susceptibility to both diseases. In order to...
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