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Results: 4
GKAP Acts as a Genetic Modulator of NMDAR Signaling to Govern Invasive Tumor Growth.
Leanne Li, Qiqun Zeng, Arjun Bhutkar, José A Galván, Eva Karamitopoulou, Daan Noordermeer, Mei-Wen Peng, Alessandra Piersigilli, Aurel Perren, Inti Zlobec, Hugh Robinson, M Luisa Iruela-Arispe, Douglas Hanahan
Jun 28, 2018
Genetic linkage analysis previously suggested that GKAP, a scaffold protein of the N-methyl-D-aspartate receptor (NMDAR), was a potential modifier of invasion in a mouse model of pancreatic neuroendocrine tumor (PanNET). Here...
FMRP GKAP/Dlgap1 GluN2b/NR2b/Grin2b HSF1 MK801 NMDAR RIP1Tag2 cancer modifier glutamate receptor Memantine pancreatic ductal adenocarcinoma (PDAC) Animals Antineoplastic Agents Carcinoma Neuroendocrine Carcinoma Pancreatic Ductal Cell Line Tumor Fragile X Mental Retardation Protein Gene Expression Profiling Gene Expression Regulation Neoplastic Heat Shock Transcription Factors Humans Mice Neoplasm Invasiveness Neoplasm Transplantation Pancreatic Neoplasms Prognosis Receptors N-Methyl-D-Aspartate SAP90-PSD95 Associated Proteins Sequence Analysis RNA Signal Transduction Survival Analysis
Synaptic proximity enables NMDAR signalling to promote brain metastasis.
Qiqun Zeng, Iacovos P Michael, Peng Zhang, Sadegh Saghafinia, Graham Knott, Wei Jiao, Brian D McCabe, José A Galván, Hugh PC Robinson, Inti Zlobec, Giovanni Ciriello, Douglas Hanahan
Dec 23, 2020
Impaired Punishment Learning in Conduct Disorder
Erik M. Elster, Ruth Pauli, Sarah Baumann, Stephane A. De Brito, Graeme Fairchild, Christine M. Freitag, Kerstin Konrad, Veit Roessner, Inti A. Brazil, Patricia L. Lockwood, Gregor Kohls
Apr 30, 2024
Objective: Conduct disorder (CD) has been associated with deficits in the use of punishment to guide reinforcement learning (RL) and decision making. This may explain the poorly planned and often impulsive antisocial and...
computational modeling Conduct Disorder Decision Making Punishment Reinforcement /dk/atira/pure/subjectarea/asjc/3200/3204 name=Developmental and Educational Psychology /dk/atira/pure/subjectarea/asjc/2700/2738 name=Psychiatry and Mental health /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Impaired Punishment Learning in Conduct Disorder
Erik M. Elster, Ruth Pauli, Sarah Baumann, Stephane A. De Brito, Graeme Fairchild, Christine M. Freitag, Kerstin Konrad, Veit Roessner, Inti A. Brazil, Patricia L. Lockwood, Gregor Kohls
Apr 30, 2024
Objective: Conduct disorder (CD) has been associated with deficits in the use of punishment to guide reinforcement learning (RL) and decision making. This may explain the poorly planned and often impulsive antisocial and...
computational modeling Conduct Disorder Decision Making Punishment Reinforcement /dk/atira/pure/subjectarea/asjc/3200/3204 name=Developmental and Educational Psychology /dk/atira/pure/subjectarea/asjc/2700/2738 name=Psychiatry and Mental health /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being