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Determinants of QuantiFERON Plus-diagnosed tuberculosis infection in adult Ugandan TB contacts
Jonathan Mayito, Adrian R Martineau, Divya Tiwari, Lydia Nakiyingi, David P Kateete, Stephen T Reece, Irene Andia Biraro
Apr 17, 2023
Background
The tuberculin skin test is commonly used to diagnose latent tuberculosis infection (LTBI) in resource-limited settings, but its specificity is limited by factors including cross-reactivity with BCG vaccine...
Humans Tuberculosis HIV Infections Tuberculin Test Cross-Sectional Studies Adult Uganda Female Male Latent Tuberculosis Interferon-gamma Release Tests
Published by: PLOS ONE
The Dog Ate My Homework
Claire Irene Bowley
Aug 22, 2017
To achieve individual and population health goals in Newfoundland and Labrador, people must have the capacity to take an active role in their personal nutritional health and wellbeing and to advocate for social, cultural...
Community Health; Nutrition and Dietetics food literacy; nutrition literacy; health promotion; education
Published by: Memorial University of Newfoundland
Internet Presence and Multilingual Dissemination in Corporate Websites
The development of Information and Communication Technologies has enabled companies to spread messages globally, allowing them to open new markets and reach international clients. In this sense, the multilingual dissemination of...
Published by: IGI Global
Inclusion of palliative and end of life care in health strategies aimed at integrated care: a documentary analysis [version 2; peer review
Rachel L Chambers, Sophie Pask, Irene J Higginson, Stephen Barclay, Fliss E M Murtagh, Katherine E Sleeman
Apr 17, 2023
Background
In England, Integrated Care Systems have been established to improve integration of care, as part of the NHS Long Term Plan. For people near the end of life, palliative care can improve integration of care. We...
Published by: AMRC open research
Provision of palliative and end-of-life care in UK care homes during the COVID-19 pandemic
Andy Bradshaw, Sophia Ostler, Claire Goodman, Izabele Batkovskyte, Clare Ellis-Smith, India Tunnard, Anna E Bone, Stephen Barclay, Martin Vernon, Irene J Higginson, Catherine J Evans, Katherine E Sleeman
Apr 17, 2023
Introduction
Little consideration has been given to how the provision of palliative and end-of-life care in care homes was affected by COVID-19. The aims of this study were to: (i) investigate the response of UK care...
Policy Palliative Care care homes end-of-life care mixed methods observational covid-19 Humans Terminal Care Cross-Sectional Studies Pandemics United Kingdom covid-19
Published by: Frontiers in public health
Breath Biopsy® to Identify Exhaled Volatile Organic Compounds Biomarkers for Liver Cirrhosis Detection.
Giuseppe Ferrandino, Giovanna De Palo, Antonio Murgia, Owen Birch, Ahmed Tawfike, Rob Smith, Irene Debiram-Beecham, Olga Gandelman, Graham Kibble, Anne Marie Lydon, Alice Groves, Agnieszka Smolinska, Max Allsworth, Billy Boyle, Marc P van der Schee, Michael Allison, Rebecca C Fitzgerald, Matthew Hoare, Victoria K Snowdon
Apr 17, 2023
BACKGROUND AND AIMS: The prevalence of chronic liver disease in adults exceeds 30% in some countries and there is significant interest in developing tests and treatments to help control disease progression and reduce healthcare...
Fumarate induces vesicular release of mtDNA to drive innate immunity.
Vincent Zecchini, Vincent Paupe, Irene Herranz-Montoya, Joëlle Janssen, Inge MN Wortel, Jordan L Morris, Ashley Ferguson, Suvagata Roy Chowdury, Marc Segarra-Mondejar, Ana SH Costa, Gonçalo C Pereira, Laura Tronci, Timothy Young, Efterpi Nikitopoulou, Ming Yang, Dóra Bihary, Federico Caicci, Shun Nagashima, Alyson Speed, Kalliopi Bokea, Zara Baig, Shamith Samarajiwa, Maxine Tran, Thomas Mitchell, Mark Johnson, Julien Prudent, Christian Frezza
Apr 08, 2023
Mutations in fumarate hydratase (FH) cause hereditary leiomyomatosis and renal cell carcinoma1. Loss of FH in the kidney elicits several oncogenic signalling cascades through the accumulation of the oncometabolite fumarate2....
In vivo interrogation of regulatory genomes reveals extensive quasi-insufficiency in cancer evolution.
Anja Fischer, Robert Lersch, Niklas de Andrade Krätzig, Alexander Strong, Mathias J Friedrich, Julia Weber, Thomas Engleitner, Rupert Öllinger, Hsi-Yu Yen, Ursula Kohlhofer, Irene Gonzalez-Menendez, David Sailer, Liz Kogan, Mari Lahnalampi, Saara Laukkanen, Thorsten Kaltenbacher, Christine Klement, Majdaddin Rezaei, Tim Ammon, Juan J Montero, Günter Schneider, Julia Mayerle, Mathias Heikenwälder, Marc Schmidt-Supprian, Leticia Quintanilla-Martinez, Katja Steiger, Pentao Liu, Juan Cadiñanos, George S Vassiliou, Dieter Saur, Olli Lohi, Merja Heinäniemi, Nathalie Conte, Allan Bradley, Lena Rad, Roland Rad
Apr 17, 2023
In contrast to mono- or biallelic loss of tumor-suppressor function, effects of discrete gene dysregulations, as caused by non-coding (epi)genome alterations, are poorly understood. Here, by perturbing the regulatory genome in...