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Results: 78784
Structural characterization of an unprecedented lectin-like antitumoral anti-MUC1 antibody.
Javier Macías-León, Iris A Bermejo, Alicia Asín, Ana García-García, Ismael Compañón, Ester Jiménez-Moreno, Helena Coelho, Vincenzo Mangini, Inês S Albuquerque, Filipa Marcelo, Juan L Asensio, Gonçalo JL Bernardes, Hiren J Joshi, Roberto Fiammengo, Ola Blixt, Ramón Hurtado-Guerrero, Francisco Corzana
Nov 13, 2020
The molecular basis of antibody 5E5, which recognizes the entire GalNAc unit as a primary epitope is disclosed. The antibody's contacts with the peptide are mostly limited to two residues, allowing it to show some degree of...
Synthesis, conformational analysis and <i>in vivo</i> assays of an anti-cancer vaccine that features an unnatural antigen based on an sp<sup>2</sup>-iminosugar fragment.
Iris A Bermejo, Claudio D Navo, Jorge Castro-López, Ana Guerreiro, Ester Jiménez-Moreno, Elena M Sánchez Fernández, Fayna García-Martín, Hiroshi Hinou, Shin-Ichiro Nishimura, José M García Fernández, Carmen Ortiz Mellet, Alberto Avenoza, Jesús H Busto, Gonçalo J L Bernardes, Ramón Hurtado-Guerrero, Jesús M Peregrina, Francisco Corzana
Jul 28, 2021
The Tn antigen (GalNAc-α-1-O-Thr/Ser) is a well-known tumor-associated carbohydrate determinant. The use of glycopeptides that incorporate this structure has become a significant and promising niche of research owing to...
Published by: Chemical science
Synthesis, conformational analysis and in vivo assays of an anti-cancer vaccine that features an unnatural antigen based on an sp2-iminosugar fragment.
Iris A Bermejo, Claudio D Navo, Jorge Castro-López, Ana Guerreiro, Ester Jiménez-Moreno, Elena M Sánchez Fernández, Fayna García-Martín, Hiroshi Hinou, Shin-Ichiro Nishimura, José M García Fernández, Carmen Ortiz Mellet, Alberto Avenoza, Jesús H Busto, Gonçalo JL Bernardes, Ramón Hurtado-Guerrero, Jesús M Peregrina, Francisco Corzana
Sep 15, 2020
The Tn antigen (GalNAc-α-1-O-Thr/Ser) is a well-known tumor-associated carbohydrate determinant. The use of glycopeptides that incorporate this structure has become a significant and promising niche of research owing to their...
High-flow nasal oxygen vs. standard oxygen therapy for patients undergoing transcatheter aortic valve replacement with conscious sedation
S Scheuermann, A Tan, P Govender, M Mckie, J Pack, G Martinez, F Falter, S George, A A. Klein
Apr 14, 2023
Growth Models and Their Stability Analysis for Populations of a Single Species
Understanding the patterns of population growth for human beings or other animals is important for effective society and resource management. We study several population growth models for a single species to exhibit how the...
Published by: Digital Commons @ Texas A&M University-San Antonio
Searching for doppelgängers
© The Institution of Engineering and Technology 2016. The authors generated 316,250 entire distributions of IrisCode impostor scores, each distribution obtained by comparing one iris against hundreds of thousands of others in a...
Young Alum Establishes Fund for Winthrop's Golf Program
Winthrop University
Jan 01, 0001
Chamberlin is currently the vice president for business development at IRIS Solutions, a Charlotte, N.C., based company providing integrated technology solutions for dental, medical and small businesses. In honor of his gift...
Published by: Winthrop University
Achieving robustness to aleatoric uncertainty with heteroscedastic Bayesian optimisation
Ryan-Rhys Griffiths, Alexander A Aldrick, Miguel Garcia-Ortegon, Vidhi Lalchand, Alpha A Lee
Nov 23, 2021
Abstract: Bayesian optimisation is a sample-efficient search methodology that holds great promise for accelerating drug and materials discovery programs. A frequently-overlooked modelling consideration in Bayesian optimisation...
Reflection impulsivity in binge drinking
Paula Banca, Iris Lange, Yulia Worbe, Nicholas A Howell, Michael Irvine, Neil A Harrison, Michael Moutoussis, Valerie Voon
Apr 01, 2015
Binge drinking Decision Making reflection impulsivity voxel-based morphometry Binge Drinking Case-Control Studies Computer Simulation Decision Making Delay Discounting Female Humans Impulsive Behavior Magnetic Resonance Imaging Male Neuropsychological Tests Organ Size Parietal Lobe Prefrontal Cortex Young Adult
Tablet in the Consultation Room and Physician Satisfaction
The purpose of the study is to investigate patient-physician interactions during a clinical encounter to ascertain the impact of tablet computing on physician satisfaction during a clinical encounter. This study was conducted at...
Published by: IGI Global Scientific Publishing
Multimodal signaling in the Small Torrent Frog (Micrixalus saxicola) in a complex acoustic environment.
Doris Preininger, Markus Boeckle, Anita Freudmann, Iris Starnberger, Marc Sztatecsny, Walter Hödl
Feb 06, 2019
Many animals use multimodal (both visual and acoustic) components in courtship signals. The acoustic communication of anuran amphibians can be masked by the presence of environmental background noise, and multimodal displays may...
A Model of Cloud Forensic Application With Assurance of Cloud Log
The key concepts of digital forensic investigation in cloud computing are examination and investigation. Cybercriminals target cloud-based web applications due to presence of vulnerabilities. Forensic investigation is a complex...
Published by: IGI Global Scientific Publishing
Depression amongst interns working in a tertiary care teaching Hospital in Maharashtra
Background: Internship is a crucial stage of medical school regarding student stress which can affect thepatient care negatively. Retrieving knowledge about presence of depression is therefore important in itself and iffound...
Published by: IJHS Medical Association
Depression amongst interns working in a tertiary care teaching Hospital in Maharashtra
Background: Internship is a crucial stage of medical school regarding student stress which can affect the patient care negatively. Retrieving knowledge about presence of depression is therefore important in itself and if found...
Published by: IJHS Medical Association
In situ magnetic separation of antibody fragments from Escherichia coli in complex media.
Martin Cerff, Alexander Scholz, Matthias Franzreb, Iris L Batalha, Ana Cecilia A Roque, Clemens Posten
Nov 29, 2017
BACKGROUND: In situ magnetic separation (ISMS) has emerged as a powerful tool to overcome process constraints such as product degradation or inhibition of target production. In the present work, an integrated ISMS process was...
Analysis of genetically determined gene expression suggests role of inflammatory processes in exfoliation syndrome.
Jibril B Hirbo, Francesca Pasutto, Eric R Gamazon, Patrick Evans, Priyanka Pawar, Daniel Berner, Julia Sealock, Ran Tao, Peter S Straub, Anuar I Konkashbaev, Max A Breyer, Ursula Schlötzer-Schrehardt, André Reis, Milam A Brantley, Chiea C Khor, Karen M Joos, Nancy J Cox
Feb 17, 2023
BACKGROUND: Exfoliation syndrome (XFS) is an age-related systemic disorder characterized by excessive production and progressive accumulation of abnormal extracellular material, with pathognomonic ocular manifestations. It is...
Western gorilla space use suggests territoriality.
The evolutionary origins of how modern humans share and use space are often modelled on the territorial-based violence of chimpanzees, with limited comparison to other apes. Gorillas are widely assumed to be non-territorial due...
Published by: Scientific reports
The effects of elevated CO2 and eutrophication on surface elevation gain in a European salt marsh.
Ruth Reef, Tom Spencer, Iris Mӧller, Catherine E Lovelock, Elizabeth K Christie, Anna L McIvor, Ben R Evans, James A Tempest
Jul 05, 2016
Knowledge and Attitude among High School Students towards HIV / AIDS in Rural areas of Belagavi–A Cross Sectional Study
Asha A. Bellad and Rajesh R Kulkarni
Mar 25, 2015
Introduction Since its emergence in 1981, the HIV/AIDS pandemic, which poses a serious challenge to mankind, without doubt, has become one of the most serious infectious diseases. Many adolescents around the world are sexually...
Published by: IJHS Medical Association
The Role of Parental Emotion Reactivity and Regulation in Child Maltreatment and Maltreatment Risk
The prevalence and impact of child maltreatment make the scientific investigation of this phenomenon a matter of vital importance. Prior research has examined associations between problematic patterns of parents’ emotion...
Sentiment Analysis on Movie Reviews Dataset Using Support Vector Machines and Ensemble Learning
The internet makes it easier for people to connect to each other and has become a platform to express ideas and share information with the world. The growth of the internet has indirectly led to the development of social...
Published by: IGI Global Scientific Publishing
Right sided eventration of diaphragm with clinodactyly
A. Sareen and K. Mahajan
Apr 21, 2015
Diaphragmatic hernia can be of two types-absence or deficiency of the diaphragm, or eventration resulting in elevation of a portion of the diaphragm as a result of incomplete muscularization. Complete eventration almost...
Published by: IJHS Medical Association
Knowledge and Attitude among High School Students towards HIV / AIDS in Rural areas of Belagavi–A Cross Sectional Study
Asha A. Bellad and Rajesh R Kulkarni
Mar 25, 2015
Introduction Since its emergence in 1981, the HIV/AIDS pandemic, which poses a serious challenge to mankind, without doubt, has become one of the most serious infectious diseases. Many adolescents around the world are sexually...
Published by: IJHS Medical Association
Splice-Modulating Oligonucleotide QR-110 Restores CEP290 mRNA and Function in Human c.2991+1655A>G LCA10 Models.
Kalyan Dulla, Monica Aguila, Amelia Lane, Katarina Jovanovic, David A Parfitt, Iris Schulkens, Hee Lam Chan, Iris Schmidt, Wouter Beumer, Lars Vorthoren, Rob WJ Collin, Alejandro Garanto, Lonneke Duijkers, Anna Brugulat-Panes, Ma'ayan Semo, Anthony A Vugler, Patricia Biasutto, Peter Adamson, Michael E Cheetham
Aug 07, 2019
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