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Hypoxic microenvironment shapes HIV-1 replication and latency.
Xiaodong Zhuang, Isabela Pedroza-Pacheco, Isabel Nawroth, Anna E Kliszczak, Andrea Magri, Wayne Paes, Claudia Orbegozo Rubio, Hongbing Yang, Margaret Ashcroft, David Mole, Peter Balfe, Persephone Borrow, Jane A McKeating
Jul 16, 2020
Viral replication is defined by the cellular microenvironment and one key factor is local oxygen tension, where hypoxia inducible factors (HIFs) regulate the cellular response to oxygen. Human immunodeficiency virus (HIV)...
Hypoxic microenvironment shapes HIV-1 replication and latency
Xiaodong Zhuang, Isabela Pedroza-Pacheco, Isabel Nawroth, Anna E. Kliszczak, Andrea Magri, Wayne Paes, Claudia Orbegozo Rubio, Hongbing Yang, Margaret Ashcroft, David Mole, Peter Balfe, Persephone Borrow, Jane A. McKeating
Feb 18, 2021
Abstract: Viral replication is defined by the cellular microenvironment and one key factor is local oxygen tension, where hypoxia inducible factors (HIFs) regulate the cellular response to oxygen. Human immunodeficiency virus...
Hypoxic microenvironment shapes HIV-1 replication and latency
Xiaodong Zhuang, Isabela Pedroza-Pacheco, Isabel Nawroth, Anna E. Kliszczak, Andrea Magri, Wayne Paes, Claudia Orbegozo Rubio, Hongbing Yang, Margaret Ashcroft, David Mole, Peter Balfe, Persephone Borrow, Jane A. McKeating
Jul 14, 2020
Abstract: Viral replication is defined by the cellular microenvironment and one key factor is local oxygen tension, where hypoxia inducible factors (HIFs) regulate the cellular response to oxygen. Human immunodeficiency virus...
Hypoxic microenvironment shapes HIV-1 replication and latency
Xiaodong Zhuang, Isabela Pedroza-Pacheco, Isabel Nawroth, Anna E. Kliszczak, Andrea Magri, Wayne Paes, Claudia Orbegozo Rubio, Hongbing Yang, Margaret Ashcroft, David Mole, Peter Balfe, Persephone Borrow, Jane A. McKeating
Jul 28, 2021
Abstract: Viral replication is defined by the cellular microenvironment and one key factor is local oxygen tension, where hypoxia inducible factors (HIFs) regulate the cellular response to oxygen. Human immunodeficiency virus...
The Difficulty With Introducing Project Management Techniques in Digital Startups
Isabela Mantilla
Jan 01, 0001
Digital startups face complex issues when it comes to accurately using project management techniques because of the startup's scarcity of resources and the governance of projects , such as having different stages of growth and...
project management in startups digital startups and project management difficulties project management difficulties in startups digital startups Business Administration, Management, and Operations Entrepreneurial and Small Business Operations Management Information Systems Marketing Operations and Supply Chain Management Technology and Innovation
Published by: Harrisburg University of Science and Technology
Multidrug resistant enteric fever in South Asia
Christopher M Parry, Isabela Ribeiro, Kamini Walia, Priscilla Rupali, Stephen Baker, Buddha Basnyat
Apr 10, 2019
Investments in newer diagnostics and antimicrobial treatments are critical to improve management of enteric fever in South Asia, say Christopher Parry and colleagues
A New Learning Path Model for E-Learning Systems
This work presents a new approach to the learning path model in e-learning systems. The model uses data from the database records from an e-learning system and uses graphs as representation. In this work, the authors show how...
Published by: IGI Global Scientific Publishing
Identification of functional long non-coding RNAs in C. elegans.
Alper Akay, David Jordan, Isabela Cunha Navarro, Tomasz Wrzesinski, Chris P Ponting, Eric A Miska, Wilfried Haerty
May 09, 2019
BACKGROUND: Functional characterisation of the compact genome of the model organism Caenorhabditis elegans remains incomplete despite its sequencing 20 years ago. The last decade of research has seen a tremendous increase in the...
Translational adaptation to heat stress is mediated by RNA 5-methylcytosine in Caenorhabditis elegans.
Isabela Cunha Navarro, Francesca Tuorto, David Jordan, Carine Legrand, Jonathan Price, Fabian Braukmann, Alan G Hendrick, Alper Akay, Annika Kotter, Mark Helm, Frank Lyko, Eric A Miska
Nov 12, 2020
Methylation of carbon-5 of cytosines (m5 C) is a post-transcriptional nucleotide modification of RNA found in all kingdoms of life. While individual m5 C-methyltransferases have been studied, the impact of the global cytosine-5...
Caenorhabditis elegans 5-Methylcytosine NSUN RNA modifications translation efficiency 5-Methylcytosine Adaptation Physiological Animals CRISPR-Cas Systems Caenorhabditis elegans Cytosine Gene Editing Heat-Shock Response Hot Temperature Leucine Methyltransferases Mitochondria Proline Protein Biosynthesis RNA RNA processing Post-Transcriptional Ribosomes
Is temporary employment a cause or consequence of poor mental health? A panel data analysis
Mental health status has an association with labour market outcomes. If people in temporary employment have poorer mental health than those in permanent employment then it is consistent with two mutually inclusive possibilities...
Is temporary employment a cause or consequence of poor mental health? A panel data analysis
Mental health status has an association with labour market outcomes. If people in temporary employment have poorer mental health than those in permanent employment then it is consistent with two mutually inclusive possibilities...
Automated Markov state models for molecular dynamics simulations of aggregation and self-assembly.
Markov state models have become popular in the computational biochemistry and biophysics communities as a technique for identifying stationary and kinetic information of protein dynamics from molecular dynamics simulation data....
A Secreted RNA Binding Protein Forms RNA-Stabilizing Granules in the Honeybee Royal Jelly.
Eyal Maori, Isabela Cunha Navarro, Humberto Boncristiani, David J Seilly, Konrad Ludwig Moritz Rudolph, Alexandra Sapetschnig, Chi-Chuan Lin, John Edward Ladbury, Jay Daniel Evans, Jonathan Luke Heeney, Eric Alexander Miska
Apr 26, 2019
The RNA polymerase II subunit RPB-9 recruits the integrator complex to terminate Caenorhabditis elegans piRNA transcription.
Ahmet C Berkyurek, Giulia Furlan, Lisa Lampersberger, Toni Beltran, Eva-Maria Weick, Emily Nischwitz, Isabela Cunha Navarro, Fabian Braukmann, Alper Akay, Jonathan Price, Falk Butter, Peter Sarkies, Eric A Miska
Mar 19, 2021
PIWI-interacting RNAs (piRNAs) are genome-encoded small RNAs that regulate germ cell development and maintain germline integrity in many animals. Mature piRNAs engage Piwi Argonaute proteins to silence complementary transcripts...
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