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CH is the disproportionate clonal expansion of blood stem cells and their progeny driven by leukemia-associated somatic mutations and is associated with an increased risk of hematologic cancers and ischemic cardiovascular...
Triggers of the Postural Display of Courtship in Drosophila persimilis Flies.
D. persimilis courtship shows some flexibility and courting males sometimes perform an elaborate postural display in addition to the standard courtship behaviours shared by most Drosophila species. This postural display includes...
SWATH-MS dataset of heat-shock treated Drosophila melanogaster embryos.
Bertrand Fabre, Dagmara Korona, Daniel JH Nightingale, Steven Russell, Kathryn S Lilley
Nov 20, 2017
Data independent acquisition (DIA) has emerged as a promising mass spectrometry based approach, combining the advantages of shotgun and targeted proteomics. Here we applied a DIA approach (termed SWATH) to monitor the dynamics...
Substrate-borne vibratory communication during courtship in Drosophila melanogaster.
Caroline CG Fabre, Berthold Hedwig, Graham Conduit, Peter A Lawrence, Stephen F Goodwin, José Casal
Nov 18, 2020
Courtship in Drosophila melanogaster has become an iconic example of an innate and interactive series of behaviors. The female signals her acceptance of copulation by becoming immobile in response to a male's display of...
Characterisation of protein isoforms encoded by the Drosophila Glycogen Synthase Kinase 3 gene shaggy
Dagmara Korona, Daniel Nightingale, Bertrand Fabre, Michael Nelson, Bettina Fischer, Glynnis Johnson, Jonathan Lees, Simon Hubbard, Kathryn Lilley, Steven Russell
Aug 06, 2020
The Drosophila shaggy gene (sgg, GSK-3) encodes multiple protein isoforms with serine/threonine kinase activity and is a key player in diverse developmental signalling pathways. Currently it is unclear whether different Sgg...
Nationwide study in France investigating the impact of diabetes on mortality in patients undergoing abdominal aortic aneurysm repair.
Juliette Raffort, Fabien Lareyre, Roxane Fabre, Ziad Mallat, Christian Pradier, Laurent Bailly
Oct 01, 2021
The aim of this nationwide study was to analyze the impact of diabetes on post-operative mortality in patients undergoing AAA repair in France. This 10-year retrospective, multicenter study based on the French National...
Characterisation of protein isoforms encoded by the Drosophila Glycogen Synthase Kinase 3 gene shaggy.
Dagmara Korona, Daniel Nightingale, Bertrand Fabre, Michael Nelson, Bettina Fischer, Glynnis Johnson, Jonathan Lees, Simon Hubbard, Kathryn Lilley, Steven Russell
Jul 16, 2020
The Drosophila shaggy gene (sgg, GSK-3) encodes multiple protein isoforms with serine/threonine kinase activity and is a key player in diverse developmental signalling pathways. Currently it is unclear whether different Sgg...
Spectral Libraries for SWATH-MS Assays for Drosophila melanogaster and Solanum lycopersicum.
Bertrand Fabre, Dagmara Korona, Clara I Mata, Harriet T Parsons, Michael J Deery, Maarten LATM Hertog, Bart M Nicolaï, Steven Russell, Kathryn S Lilley
Apr 04, 2018
Quantitative proteomics methods have emerged as powerful tools for measuring protein expression changes at the proteome level. Using MS-based approaches, it is now possible to routinely quantify thousands of proteins. However...
Comparison of Drosophila melanogaster Embryo and Adult Proteome by SWATH-MS Reveals Differential Regulation of Protein Synthesis, Degradation Machinery, and Metabolism Modules.
Bertrand Fabre, Dagmara Korona, Jonathan G Lees, Ikrame Lazar, Ido Livneh, Manon Brunet, Christine A Orengo, Steven Russell, Kathryn S Lilley
May 13, 2019
Analysis of Drosophila melanogaster proteome dynamics during embryonic development by a combination of label-free proteomics approaches.
Bertrand Fabre, Dagmara Korona, Arnoud Groen, Jakob Vowinckel, Laurent Gatto, Michael J Deery, Markus Ralser, Steven Russell, Kathryn S Lilley
Apr 13, 2016
Concordance for clonal hematopoiesis is limited in elderly twins.
Margarete A Fabre, Thomas McKerrell, Maximillian Zwiebel, MS Vijayabaskar, Naomi Park, Philippa M Wells, Roland Rad, Panagiotis Deloukas, Kerrin Small, Claire J Steves, George S Vassiliou
Dec 17, 2019
Although acquisition of leukemia-associated somatic mutations by 1 or more hematopoietic stem cells is inevitable with advancing age, its consequences are highly variable, ranging from clinically silent clonal hematopoiesis (CH)...
In Depth Exploration of the Alternative Proteome of Drosophila melanogaster.
Bertrand Fabre, Sebastien A Choteau, Carine Duboé, Carole Pichereaux, Audrey Montigny, Dagmara Korona, Michael J Deery, Mylène Camus, Christine Brun, Odile Burlet-Schiltz, Steven Russell, Jean-Philippe Combier, Kathryn S Lilley, Serge Plaza
Jul 20, 2022
Recent studies have shown that hundreds of small proteins were occulted when protein-coding genes were annotated. These proteins, called alternative proteins, have failed to be annotated notably due to the short length of their...
Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis.
Selective EGF-Receptor Inhibition in CD4+ T Cells Induces Anergy and Limits Atherosclerosis.
Lynda Zeboudj, Mikael Maître, Lea Guyonnet, Ludivine Laurans, Jeremie Joffre, Jeremie Lemarie, Simon Bourcier, Wared Nour-Eldine, Coralie Guérin, Jonas Friard, Abdelilah Wakkach, Elizabeth Fabre, Alain Tedgui, Ziad Mallat, Pierre-Louis Tharaux, Hafid Ait-Oufella
Jun 20, 2018
BACKGROUND: Several epidermal growth factor receptor (EGFR) inhibitors have been successfully developed for the treatment of cancer, limiting tumor growth and metastasis. EGFR is also expressed by leukocytes, but little is...
Ethylene Receptors, CTRs and EIN2 Target Protein Identification and Quantification Through Parallel Reaction Monitoring During Tomato Fruit Ripening.
Clara I Mata, Bertrand Fabre, Harriet T Parsons, Maarten LATM Hertog, Geert Van Raemdonck, Geert Baggerman, Bram Van de Poel, Kathryn S Lilley, Bart M Nicolaï
Feb 07, 2019
Ethylene, the plant ripening hormone of climacteric fruit, is perceived by ethylene receptors which is the first step in the complex ethylene signal transduction pathway. Much progress has been made in elucidating the mechanism...
In Depth Exploration of the Alternative Proteome of Drosophila melanogaster.
Bertrand Fabre, Sebastien A Choteau, Carine Duboé, Carole Pichereaux, Audrey Montigny, Dagmara Korona, Michael Deery, Mylène Camus, Christine Brun, Odile Burlet-Schiltz, Steve Russell, Jean-Philippe Combier, Kathryn S Lilley, Serge Plaza
Jun 17, 2022
Recent studies have shown that hundreds of small proteins were occulted when protein-coding genes were annotated. These proteins, called alternative proteins, have failed to be annotated notably due to the short length of their...
Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis.
Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis.
Siddhartha P Kar, Pedro M Quiros, Muxin Gu, Tao Jiang, Jonathan Mitchell, Ryan Langdon, Vivek Iyer, Clea Barcena, MS Vijayabaskar, Margarete A Fabre, Paul Carter, Slavé Petrovski, Stephen Burgess, George S Vassiliou
Aug 14, 2022
The longitudinal dynamics and natural history of clonal haematopoiesis.
Margarete A Fabre, José Guilherme de Almeida, Edoardo Fiorillo, Emily Mitchell, Aristi Damaskou, Justyna Rak, Valeria Orrù, Michele Marongiu, Michael Spencer Chapman, MS Vijayabaskar, Joanna Baxter, Claire Hardy, Federico Abascal, Nicholas Williams, Jyoti Nangalia, Iñigo Martincorena, Peter J Campbell, Eoin F McKinney, Francesco Cucca, Moritz Gerstung, George Vassiliou
Jun 09, 2022
Clonal expansions driven by somatic mutations become pervasive across human tissues with age, including in the haematopoietic system, where the phenomenon is termed clonal haematopoiesis1-4. The understanding of how and when...
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