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Results: 29
Randomized Trial of C5a Receptor Inhibitor Avacopan in ANCA-Associated Vasculitis.
David RW Jayne, Annette N Bruchfeld, Lorraine Harper, Matthias Schaier, Michael C Venning, Patrick Hamilton, Volker Burst, Franziska Grundmann, Michel Jadoul, István Szombati, Vladimír Tesař, Mårten Segelmark, Antonia Potarca, Thomas J Schall, Pirow Bekker, CLEAR Study Group
May 13, 2019
Alternative C activation is involved in the pathogenesis of ANCA-associated vasculitis. However, glucocorticoids used as treatment contribute to the morbidity and mortality of vasculitis. We determined whether avacopan (CCX168)...
ANCA ANCA-associated vasculitis avacopan complement complement 5a complement 5a receptor Adult Aged Aniline Compounds Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis cyclophosphamide Double-Blind Method Drug Therapy Combination Female Glucocorticoids Humans Immunosuppressive Agents Male Middle Aged Nipecotic Acids prednisone Receptor Anaphylatoxin C5a Rituximab Severity of Illness Index
Sexual conflict and consistency of offspring desertion in Eurasian penduline tit Remiz pendulinus
Background: The trade-off between current and future parental investment is often different between males and females. This difference may lead to sexual conflict between parents over care provisioning in animals that breed with...
Leading exponential finite size corrections for non-diagonal form factors
Abstract
We derive the leading exponential finite volume corrections in two dimensional integrable models for non-diagonal form factors in diagonally...
Planning activity for internally generated reward goals in monkey amygdala neurons.
The best rewards are often distant and can only be achieved by planning and decision-making over several steps. We designed a multi-step choice task in which monkeys followed internal plans to save rewards toward self-defined...
Sexual conflict and consistency of offspring desertion in Eurasian penduline tit Remiz pendulinus
Background: The trade-off between current and future parental investment is often different between males and females. This difference may lead to sexual conflict between parents over care provisioning in animals that breed with...
Toward Understanding CB[7]-Based Supramolecular Diels-Alder Catalysis.
Cucurbiturils (CBs) are robust and versatile macrocyclic compounds, often used as molecular hosts in complex supramolecular systems. In previous work, remarkable catalytic activity has been observed for asymmetric cycloadditions...
Toward Understanding CB[7]-Based Supramolecular Diels-Alder Catalysis
Cucurbiturils (CBs) are robust and versatile macrocyclic compounds, often used as molecular hosts in complex supramolecular systems. In previous work, remarkable catalytic activity has been observed for asymmetric cycloadditions...
Constraints and entropy in a model of network evolution
Barabási–Albert’s “Scale Free” model is the starting point for much of the accepted theory of the evolution of real world communication networks. Careful comparison of the theory with a wide range of real world networks...
Constraints and entropy in a model of network evolution
Barabási–Albert’s “Scale Free” model is the starting point for much of the accepted theory of the evolution of real world communication networks. Careful comparison of the theory with a wide range of real world networks...
Room-Temperature Optical Picocavities below 1 nm3 Accessing Single-Atom Geometries.
Cloudy Carnegie, Jack Griffiths, Bart de Nijs, Charlie Readman, Rohit Chikkaraddy, William M Deacon, Yao Zhang, István Szabó, Edina Rosta, Javier Aizpurua, Jeremy J Baumberg
Dec 20, 2018
Reproducible confinement of light on the nanoscale is essential for the ability to observe and control chemical reactions at the single-molecule level. Here we reliably form millions of identical nanocavities and show that the...
Anomalously Large Spectral Shifts near the Quantum Tunnelling Limit in Plasmonic Rulers with Subatomic Resolution.
Charlie Readman, Bart de Nijs, István Szabó, Angela Demetriadou, Ryan Greenhalgh, Colm Durkan, Edina Rosta, Oren A Scherman, Jeremy J Baumberg
Feb 15, 2019
The resonance wavelength of a coupled plasmonic system is extremely sensitive to the distance between its metallic surfaces, resulting in "plasmon rulers". We explore this behavior in the subnanometer regime using self-assembled...
Controlling the structure and photophysics of fluorophore dimers using multiple cucurbit[8]uril clampings.
Guanglu Wu, Youn Jue Bae, Magdalena Olesińska, Daniel Antón-García, István Szabó, Edina Rosta, Michael R Wasielewski, Oren A Scherman
Jul 28, 2021
A modular strategy has been employed to develop a new class of fluorescent molecules, which generates discrete, dimeric stacked fluorophores upon complexation with multiple cucurbit[8]uril macrocycles. The multiple constraints...
Published by: Chemical science
Feeding Immunity
Sarah A Budischak, Christina B Hansen, Quentin Caudron, Romain Garnier, Tyler R Kartzinel, István Pelczer, Clayton E Cressler, Anieke van Leeuwen, Andrea L Graham
Mar 21, 2018
Resources are a core currency of species interactions and ecology in general (e.g., think of food webs or competition). Within parasite-infected hosts, resources are divided among the competing demands of host immunity and...
Inhibiting Analyte Theft in Surface-Enhanced Raman Spectroscopy Substrates
Bart de Nijs, Cloudy Carnegie, István Szabó, David-Benjamin Grys, Rohit Chikkaraddy, Marlous Kamp, Steven J Barrow, Charlie A Readman, Marie-Elena Kleemann, Oren A Scherman, Edina Rosta, Jeremy J Baumberg
Oct 03, 2019
SERS THC drug detection Nanoparticles Self-assembly SPICE synthetic cannabinoids tetrahydrocannabinol Bridged-Ring Compounds Dronabinol gold Imidazoles Indoles Limit of Detection Metal Nanoparticles Molecular Dynamics Simulation Paraquat principal component analysis Psychotropic Drugs Reproducibility of Results Spectrum Analysis Raman
The fall of the summer truffle
Brian S Steidinger, Ulf Büntgen, Uli Stobbe, Willy Tegel, Ludger Sproll, Matthias Haeni, Barbara Moser, István Bagi, José-Antonio Bonet, Marc Buée, Benjamin Dauphin, Fernando Martínez-Peña, Virginie Molinier, Roman Zweifel, Simon Egli, Martina Peter
Oct 06, 2022
Global warming is pushing populations outside their range of physiological tolerance. According to the environmental envelope framework, the most vulnerable populations occur near the climatic edge of their species'...
Host-Guest Chemistry Meets Electrocatalysis
Andreas Wagner, Khoa H Ly, Nina Heidary, István Szabó, Tamás Földes, Khaleel I Assaf, Steven J Barrow, Kamil Sokołowski, Mohamed Al-Hada, Nikolay Kornienko, Moritz F Kuehnel, Edina Rosta, Ingo Zebger, Werner M Nau, Oren A Scherman, Erwin Reisner
Feb 14, 2020
The rational control of forming and stabilizing reaction intermediates to guide specific reaction pathways remains to be a major challenge in electrocatalysis. In this work, we report a surface active-site engineering approach...
Published by: ACS catalysis
Host-Guest Chemistry Meets Electrocatalysis
Andreas Wagner, Khoa H Ly, Nina Heidary, István Szabó, Tamás Földes, Khaleel I Assaf, Steven J Barrow, Kamil Sokołowski, Mohamed Al-Hada, Nikolay Kornienko, Moritz F Kuehnel, Edina Rosta, Ingo Zebger, Werner M Nau, Oren A Scherman, Erwin Reisner
Nov 25, 2019
Differential signal sensitivities can contribute to the stability of multispecies bacterial communities.
BACKGROUND: Bacterial species present in multispecies microbial communities often react to the same chemical signal but at vastly different concentrations. The existence of different response thresholds with respect to the same...
Understanding 6th-century barbarian social organization and migration through paleogenomics.
Carlos Eduardo G Amorim, Stefania Vai, Cosimo Posth, Alessandra Modi, István Koncz, Susanne Hakenbeck, Maria Cristina La Rocca, Balazs Mende, Dean Bobo, Walter Pohl, Luisella Pejrani Baricco, Elena Bedini, Paolo Francalacci, Caterina Giostra, Tivadar Vida, Daniel Winger, Uta von Freeden, Silvia Ghirotto, Martina Lari, Guido Barbujani, Johannes Krause, David Caramelli, Patrick J Geary, Krishna R Veeramah
Nov 21, 2018
Complement lectin pathway activation is associated with COVID-19 disease severity, independent of MBL2 genotype subgroups
Lisa Hurler, Ágnes Szilágyi, Federica Mescia, Laura Bergamaschi, Blanka Mező, György Sinkovits, Marienn Réti, Veronika Müller, Zsolt Iványi, János Gál, László Gopcsa, Péter Reményi, Beáta Szathmáry, Botond Lakatos, János Szlávik, Ilona Bobek, Zita Z Prohászka, Zsolt Förhécz, Dorottya Csuka, Erika Kajdácsi, László Cervenak, Petra Kiszel, Tamás Masszi, István Vályi-Nagy, Reinhard Würzner, Paul A Lyons, Erik JM Toonen, Zoltán Prohászka
Apr 10, 2023
ONEST (Observers Needed to Evaluate Subjective Tests) Analysis of Stromal Tumour-Infiltrating Lymphocytes (sTILs) in Breast Cancer and Its Limitations.
Bálint Cserni, Darren Kilmartin, Mark O'Loughlin, Xavier Andreu, Zsuzsanna Bagó-Horváth, Simonetta Bianchi, Ewa Chmielik, Paulo Figueiredo, Giuseppe Floris, Maria Pia Foschini, Anikó Kovács, Päivi Heikkilä, Janina Kulka, Anne-Vibeke Laenkholm, Inta Liepniece-Karele, Caterina Marchiò, Elena Provenzano, Peter Regitnig, Angelika Reiner, Aleš Ryška, Anna Sapino, Elisabeth Specht Stovgaard, Cecily Quinn, Vasiliki Zolota, Mark Webber, Sharon A Glynn, Rita Bori, Erika Csörgő, Orsolya Oláh-Németh, Tamás Pancsa, Anita Sejben, István Sejben, András Vörös, Tamás Zombori, Tibor Nyári, Grace Callagy, Gábor Cserni
Mar 06, 2023
ONEST (Observers Needed to Evaluate Subjective Tests) Analysis of Stromal Tumour-Infiltrating Lymphocytes (sTILs) in Breast Cancer and Its Limitations.
Bálint Cserni, Darren Kilmartin, Mark O'Loughlin, Xavier Andreu, Zsuzsanna Bagó-Horváth, Simonetta Bianchi, Ewa Chmielik, Paulo Figueiredo, Giuseppe Floris, Maria Pia Foschini, Anikó Kovács, Päivi Heikkilä, Janina Kulka, Anne-Vibeke Laenkholm, Inta Liepniece-Karele, Caterina Marchiò, Elena Provenzano, Peter Regitnig, Angelika Reiner, Aleš Ryška, Anna Sapino, Elisabeth Specht Stovgaard, Cecily Quinn, Vasiliki Zolota, Mark Webber, Sharon A Glynn, Rita Bori, Erika Csörgő, Orsolya Oláh-Németh, Tamás Pancsa, Anita Sejben, István Sejben, András Vörös, Tamás Zombori, Tibor Nyári, Grace Callagy, Gábor Cserni
Mar 28, 2023
Tumour-infiltrating lymphocytes (TILs) reflect antitumour immunity. Their evaluation of histopathology specimens is influenced by several factors and is subject to issues of reproducibility. ONEST (Observers Needed to Evaluate...
reproducibility Breast Cancer TILs triple-negative Tumour-infiltrating lymphocytes sTILs ONEST international immuno-oncology biomarker working group European Working Group for Breast Screening Pathology observers needed to evaluate subjective tests
Published by: Cancers
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