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Primate amygdala neurons evaluate the progress of self-defined economic choice sequences.
The amygdala is a prime valuation structure yet its functions in advanced behaviors are poorly understood. We tested whether individual amygdala neurons encode a critical requirement for goal-directed behavior: the evaluation of...
Practical guidelines for the comprehensive analysis of ChIP-seq data.
Timothy Bailey, Pawel Krajewski, Istvan Ladunga, Celine Lefebvre, Qunhua Li, Tao Liu, Pedro Madrigal, Cenny Taslim, Jie Zhang
Jun 19, 2020
Mapping the chromosomal locations of transcription factors, nucleosomes, histone modifications, chromatin remodeling enzymes, chaperones, and polymerases is one of the key tasks of modern biology, as evidenced by the...
Transmembrane signal transduction by cofactor transport.
Information processing and cell signalling in biological systems relies on passing chemical signals across lipid bilayer membranes, but examples of synthetic systems that can achieve this process are rare. A synthetic transducer...
Published by: Chemical science
Modular supramolecular dimerization of optically tunable extended aryl viologens.
Magdalena Olesińska, Guanglu Wu, Silvia Gómez-Coca, Daniel Antón-García, Istvan Szabó, Edina Rosta, Oren A Scherman
Jan 06, 2020
Cucurbit[8]uril (CB[8]) mediated assembly of extended aryl viologens (EVs) into optically tunable dimers is reported for the first time. We show that the modular design and synthesis of a new class of π-conjugated viologen...
Identification of Natural Mutations Responsible for Altered Infection Phenotypes of Salmonella enterica Clinical Isolates by Using Cell Line Infection Screens.
Rafał Kolenda, Michał Burdukiewicz, Marcjanna Wimonć, Adrianna Aleksandrowicz, Aamir Ali, Istvan Szabo, Karsten Tedin, Josefin Bartholdson Scott, Derek Pickard, Peter Schierack
Dec 07, 2020
The initial steps of Salmonella pathogenesis involve adhesion to and invasion into host epithelial cells. While well-studied for Salmonella enterica serovar Typhimurium, the factors contributing to this process in other...
Insights into the Pathogenesis of Anaplastic Large-Cell Lymphoma through Genome-wide DNA Methylation Profiling.
Melanie R Hassler, Walter Pulverer, Ranjani Lakshminarasimhan, Elisa Redl, Julia Hacker, Gavin D Garland, Olaf Merkel, Ana-Iris Schiefer, Ingrid Simonitsch-Klupp, Lukas Kenner, Daniel J Weisenberger, Andreas Weinhaeusel, Suzanne D Turner, Gerda Egger
Oct 28, 2016
Structural insight into mitochondrial β-barrel outer membrane protein biogenesis
Kathryn A. Diederichs, Xiaodan Ni, Sarah E. Rollauer, Istvan Botos, Xiaofeng Tan, Martin S. King, Edmund R. S. Kunji, Jiansen Jiang, Susan K. Buchanan
Jul 03, 2020
Abstract: In mitochondria, β-barrel outer membrane proteins mediate protein import, metabolite transport, lipid transport, and biogenesis. The Sorting and Assembly Machinery (SAM) complex consists of three proteins that assemble...
Structural insight into mitochondrial β-barrel outer membrane protein biogenesis
Kathryn A. Diederichs, Xiaodan Ni, Sarah E. Rollauer, Istvan Botos, Xiaofeng Tan, Martin S. King, Edmund R. S. Kunji, Jiansen Jiang, Susan K. Buchanan
Jul 05, 2021
Abstract: In mitochondria, β-barrel outer membrane proteins mediate protein import, metabolite transport, lipid transport, and biogenesis. The Sorting and Assembly Machinery (SAM) complex consists of three proteins that assemble...
Structural insight into mitochondrial β-barrel outer membrane protein biogenesis.
Kathryn A Diederichs, Xiaodan Ni, Sarah E Rollauer, Istvan Botos, Xiaofeng Tan, Martin S King, Edmund RS Kunji, Jiansen Jiang, Susan K Buchanan
Jul 03, 2020
In mitochondria, β-barrel outer membrane proteins mediate protein import, metabolite transport, lipid transport, and biogenesis. The Sorting and Assembly Machinery (SAM) complex consists of three proteins that assemble as a...
Amino Acid Sequence Cryoelectron Microscopy detergents Fungal Proteins Mitochondria Mitochondrial Membrane Transport Proteins Mitochondrial Membranes Multiprotein Complexes Protein Biosynthesis Protein Conformation Protein Folding Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins Sequence Homology Amino Acid Sordariales
Mating-driven variability in olfactory local interneuron wiring.
Ya-Hui Chou, Chi-Jen Yang, Hao-Wei Huang, Nan-Fu Liou, Michael Raphael Panganiban, David Luginbuhl, Yijie Yin, Istvan Taisz, Liang Liang, Gregory SXE Jefferis, Liqun Luo
Mar 21, 2022
Variations in neuronal connectivity occur widely in nervous systems from invertebrates to mammals. Yet, it is unclear how neuronal variability originates, to what extent and at what time scales it exists, and what functional...
Synaptic Loss in Primary Tauopathies Revealed by [11 C]UCB-J Positron Emission Tomography.
Negin Holland, P Simon Jones, George Savulich, Julie K Wiggins, Young T Hong, Tim D Fryer, Roido Manavaki, Selena Milicevic Sephton, Istvan Boros, Maura Malpetti, Frank H Hezemans, Franklin I Aigbirhio, Jonathan P Coles, John O'Brien, James B Rowe
Jun 11, 2020
BACKGROUND: Synaptic loss is a prominent and early feature of many neurodegenerative diseases. OBJECTIVES: We tested the hypothesis that synaptic density is reduced in the primary tauopathies of progressive supranuclear palsy...
Crowdsourcing assessment of maternal blood multi-omics for predicting gestational age and preterm birth.
Adi L Tarca, Bálint Ármin Pataki, Roberto Romero, Marina Sirota, Yuanfang Guan, Rintu Kutum, Nardhy Gomez-Lopez, Bogdan Done, Gaurav Bhatti, Thomas Yu, Gaia Andreoletti, Tinnakorn Chaiworapongsa, DREAM Preterm Birth Prediction Challenge Consortium, Sonia S Hassan, Chaur-Dong Hsu, Nima Aghaeepour, Gustavo Stolovitzky, Istvan Csabai, James C Costello
Jun 25, 2021
Identification of pregnancies at risk of preterm birth (PTB), the leading cause of newborn deaths, remains challenging given the syndromic nature of the disease. We report a longitudinal multi-omics study coupled with a DREAM...
Aptamers collaborative competition human transcriptome arrays Machine Learning plasma proteomics predictive modeling preterm labor and delivery spontaneous preterm birth whole blood transcriptomics Adult Asymptomatic Diseases Biomarkers Blood Proteins Cell-Free Nucleic Acids Crowdsourcing Female Gestational Age Humans Infant Newborn Longitudinal Studies pre-eclampsia Pregnancy premature birth Proteomics ROC Curve Transcriptome
A Pharmacogenetic Approach to the Treatment of Patients With PPARG Mutations.
Maura Agostini, Erik Schoenmakers, Junaid Beig, Louise Fairall, Istvan Szatmari, Odelia Rajanayagam, Frederick W Muskett, Claire Adams, A David Marais, Stephen O'Rahilly, Robert K Semple, Laszlo Nagy, Amit R Majithia, John WR Schwabe, Dirk J Blom, Rinki Murphy, Krishna Chatterjee, David B Savage
Jun 28, 2018
Loss-of-function mutations in PPARG cause familial partial lipodystrophy type 3 (FPLD3) and severe metabolic disease in many patients. Missense mutations in PPARG are present in ∼1 in 500 people. Although mutations are often...
Adolescent Adult Amino Acid Substitution Binding Sites Female Gene Expression Regulation Genes Reporter HEK293 Cells Humans Hypoglycemic Agents Ligands lipodystrophy Familial Partial Models Molecular Molecular Conformation Molecular Docking Simulation Mutation Missense PPAR gamma Pharmacogenetics Pioglitazone Protein Conformation Recombinant Proteins Rosiglitazone Thiazolidinediones Young Adult
The pattern of amyloid accumulation in the brains of adults with Down syndrome.
Tiina Annus, Liam R Wilson, Young T Hong, Julio Acosta-Cabronero, Tim D Fryer, Arturo Cardenas-Blanco, Robert Smith, Istvan Boros, Jonathan P Coles, Franklin I Aigbirhio, David K Menon, Shahid H Zaman, Peter J Nestor, Anthony J Holland
Aug 18, 2015
Evaluating the Impact of Functional Genetic Variation on HIV-1 Control.
Paul J McLaren, Sara L Pulit, Deepti Gurdasani, Istvan Bartha, Patrick R Shea, Cristina Pomilla, Namrata Gupta, Effrossyni Gkrania-Klotsas, Elizabeth H Young, Norbert Bannert, Julia Del Amo, M John Gill, Jill Gilmour, Paul Kellam, Anthony D Kelleher, Anders Sönnerborg, Robert Zangerle, Frank A Post, Martin Fisher, David W Haas, Bruce D Walker, Kholoud Porter, David B Goldstein, Manjinder S Sandhu, Paul IW de Bakker, Jacques Fellay
Apr 05, 2019
Background: Previous genetic association studies of human immunodeficiency virus-1 (HIV-1) progression have focused on common human genetic variation ascertained through genome-wide genotyping. Methods: We sought to...
HIV host dependency factors HIV-1 control HIV-1 progression Exome Sequencing host genetics of infection Adult Female Genetic Predisposition to Disease genetic variation Genotype HIV Infections HIV-1 Host-Pathogen Interactions Humans Male Middle Aged Polymorphism Single Nucleotide Viral Load Whole exome sequencing
[11C]metomidate PET-CT versus adrenal vein sampling for diagnosing surgically curable primary aldosteronism
Xilin Wu, Russell Senanayake, Emily Goodchild, Waiel A Bashari, Jackie Salsbury, Claudia P Cabrera, Giulia Argentesi, Samuel M O'Toole, Matthew Matson, Brendan Koo, Laila Parvanta, Nick Hilliard, Vasilis Kosmoliaptsis, Alison Marker, Daniel M Berney, Wilson Tan, Roger Foo, Charles A Mein, Eva Wozniak, Emmanuel Savage, Anju Sahdev, Nicholas Bird, Kate Laycock, Istvan Boros, Stefan Hader, Victoria Warnes, Daniel Gillett, Anne Dawnay, Elizabeth Adeyeye, Alessandro Prete, Angela E Taylor, Wiebke Arlt, Anish N Bhuva, Franklin Aigbirhio, Charlotte Manisty, Alasdair McIntosh, Alexander McConnachie, J Kennedy Cruickshank, Heok Cheow, Mark Gurnell, William M Drake, Morris J Brown
Jan 25, 2023
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