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Results: 78771
Differential viral accessibility (DIVA) identifies alterations in chromatin architecture through large-scale mapping of lentiviral integration sites.
Alterations in chromatin structure play a major role in the epigenetic regulation of gene expression. Here, we describe a step-by-step protocol for differential viral accessibility (DIVA), a method for identifying changes in...
ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex.
ATF7IP H3K9me3 HUSH complex SETDB1 epigenetic silencing Heterochromatin histone methylation ubiquitin-mediated degradation Cell Nucleus Enzyme Stability Epigenesis Genetic Gene Deletion Gene Silencing HeLa Cells Heterochromatin Histone-Lysine N-Methyltransferase Histones Humans Lysine Methylation Multiprotein Complexes Proteasome Endopeptidase Complex Protein Binding Protein Methyltransferases Proteolysis Repressor Proteins Transcription Factors Transcriptome
Position-effect variegation revisited
HUSH complex haploid genetic screen Heterochromatin POSITION-EFFECT VARIEGATION retroviral silencing Animals Antigens Neoplasm Biological Evolution Cell Line Tumor Chromosomal Position Effects Drosophila melanogaster Gene Silencing Genetic Testing HIV-1 Haploidy Heterochromatin Histones Humans Mice Nuclear Proteins Phosphoproteins Virus Latency
Genetic dissection of mammalian ERAD through comparative haploid and CRISPR forward genetic screens.
Richard T Timms, Sam A Menzies, Iva A Tchasovnikarova, Lea C Christensen, James C Williamson, Robin Antrobus, Gordon Dougan, Lars Ellgaard, Paul J Lehner
Apr 07, 2016
Animals CRISPR-Cas Systems Endoplasmic Reticulum-Associated Degradation Fluorescent Dyes Genes Reporter Genetic Testing Glycoproteins HEK293 Cells Haploidy HeLa Cells Histocompatibility Antigens Class I Humans Mammals Oxidation-Reduction Protein Binding Protein Domains Thioredoxins alpha-Glucosidases
GENE SILENCING. Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells.
Iva A Tchasovnikarova, Richard T Timms, Nicholas J Matheson, Kim Wals, Robin Antrobus, Berthold Göttgens, Gordon Dougan, Mark A Dawson, Paul J Lehner
Jun 11, 2015
Animals Antigens Neoplasm Chromosomal Position Effects Conserved Sequence Drosophila melanogaster evolution Molecular Gene Silencing Genes Reporter Genetic Loci Green Fluorescent Proteins HeLa Cells Heterochromatin Histone-Lysine N-Methyltransferase Histones Humans Immunoprecipitation Multiprotein Complexes Nuclear Proteins Phosphoproteins Protein Methyltransferases
TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control.
Christopher H Douse, Iva A Tchasovnikarova, Richard T Timms, Anna V Protasio, Marta Seczynska, Daniil M Prigozhin, Anna Albecka, Jane Wagstaff, James C Williamson, Stefan MV Freund, Paul J Lehner, Yorgo Modis
Sep 14, 2020
Amino Acid Sequence Antigens Neoplasm Binding Sites DNA Transposable Elements Epigenesis Genetic Exons Genome HEK293 Cells HeLa Cells Histones Humans Lysine Magnetic Resonance Spectroscopy Methylation Multiprotein Complexes NAD Nuclear Proteins Phosphoproteins Poly(ADP-ribose) Polymerases Protein Binding Protein Domains RNA RNA processing Post-Transcriptional Transcription Genetic
The HUSH complex cooperates with TRIM28 to repress young retrotransposons and new genes.
Luisa Robbez-Masson, Christopher HC Tie, Lucia Conde, Hale Tunbak, Connor Husovsky, Iva A Tchasovnikarova, Richard T Timms, Javier Herrero, Paul J Lehner, Helen M Rowe
Jul 09, 2018
Periphilin self-association underpins epigenetic silencing by the HUSH complex.
Daniil M Prigozhin, Christopher H Douse, Laura E Farleigh, Anna Albecka, Iva A Tchasovnikarova, Richard T Timms, Shun-Ichiro Oda, Frank Adolf, Stefan MV Freund, Sarah Maslen, Paul J Lehner, Yorgo Modis
Sep 08, 2020
TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control
Christopher H. Douse, Iva A. Tchasovnikarova, Richard T. Timms, Anna V. Protasio, Marta Seczynska, Daniil M. Prigozhin, Anna Albecka, Jane Wagstaff, James C. Williamson, Stefan M. V. Freund, Paul J. Lehner, Yorgo Modis
Oct 02, 2020
Abstract: The HUSH complex represses retroviruses, transposons and genes to maintain the integrity of vertebrate genomes. HUSH regulates deposition of the epigenetic mark H3K9me3, but how its three core subunits — TASOR, MPP8...
TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control
Christopher H. Douse, Iva A. Tchasovnikarova, Richard T. Timms, Anna V. Protasio, Marta Seczynska, Daniil M. Prigozhin, Anna Albecka, Jane Wagstaff, James C. Williamson, Stefan M. V. Freund, Paul J. Lehner, Yorgo Modis
Oct 02, 2021
Abstract: The HUSH complex represses retroviruses, transposons and genes to maintain the integrity of vertebrate genomes. HUSH regulates deposition of the epigenetic mark H3K9me3, but how its three core subunits — TASOR, MPP8...
Global Scale Dissemination of ST93
Sebastiaan J van Hal, Eike J Steinig, Patiyan Andersson, Matthew TG Holden, Simon R Harris, Graeme R Nimmo, Deborah A Williamson, Helen Heffernan, SR Ritchie, Angela M Kearns, Matthew J Ellington, Elizabeth Dickson, Herminia de Lencastre, Geoffrey W Coombs, Stephen D Bentley, Julian Parkhill, Deborah C Holt, Phillip M Giffard, Steven YC Tong
Sep 06, 2019
Background: In Australia, community-associated methicillin-resistant Staphylococcus aureus (MRSA) lineage sequence type (ST) 93 has rapidly risen to dominance since being described in the early 1990s. We examined 459 ST93 genome...
Nanostructure in Amphiphile-Based Deep Eutectic Solvents
Deep eutectic solvents (DESs) are an emerging class of modern, often “green” solvents with unique properties. Recently, a deep eutectic system based on amphiphilic surfactant N-alkyl-N,N-dimethyl-3-ammonio-1-propanesulfonate...
High-flow nasal oxygen vs. standard oxygen therapy for patients undergoing transcatheter aortic valve replacement with conscious sedation
S Scheuermann, A Tan, P Govender, M Mckie, J Pack, G Martinez, F Falter, S George, A A. Klein
Apr 14, 2023
Nanostructure in Amphiphile-Based Deep Eutectic Solvents
Deep eutectic solvents (DESs) are an emerging class of modern, often “green” solvents with unique properties. Recently, a deep eutectic system based on amphiphilic surfactant N-alkyl-N,N-dimethyl-3-ammonio-1-propanesulfonate...
Achieving robustness to aleatoric uncertainty with heteroscedastic Bayesian optimisation
Ryan-Rhys Griffiths, Alexander A Aldrick, Miguel Garcia-Ortegon, Vidhi Lalchand, Alpha A Lee
Nov 23, 2021
Abstract: Bayesian optimisation is a sample-efficient search methodology that holds great promise for accelerating drug and materials discovery programs. A frequently-overlooked modelling consideration in Bayesian optimisation...
Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2
IA Tchasovnikarova, RT Timms, CH Douse, RC Roberts, G Dougan, RE Kingston, Y Modis, PJ Lehner
Jul 13, 2017
Adenosine Triphosphatases CRISPR-Cas Systems Charcot-Marie-Tooth disease Chromatin Assembly and Disassembly Epigenetic Repression Gene Silencing HeLa Cells Heterochromatin Histone Code Histone-Lysine N-Methyltransferase Histones Humans Lysine Methylation Multiprotein Complexes Mutation Missense Neurons Protein Domains Protein Interaction Mapping Protein Methyltransferases Protein Processing Post-Translational Transcription Factors Transgenes
Depression amongst interns working in a tertiary care teaching Hospital in Maharashtra
Background: Internship is a crucial stage of medical school regarding student stress which can affect the patient care negatively. Retrieving knowledge about presence of depression is therefore important in itself and if found...
Published by: IJHS Medical Association
A Model of Cloud Forensic Application With Assurance of Cloud Log
The key concepts of digital forensic investigation in cloud computing are examination and investigation. Cybercriminals target cloud-based web applications due to presence of vulnerabilities. Forensic investigation is a complex...
Published by: IGI Global Scientific Publishing
Variations in the magnetic properties of meteoritic cloudy zone
Claire IO Nichols, James FJ Bryson, Roberts Blukis, Julia Herrero‐Albillos, Florian Kronast, Rudolf Rüffer, Aleksandr I Chumakov, Richard J Harrison
Feb 03, 2020
Iron and stony‐iron meteorites form the Widmanstätten pattern during slow cooling. This pattern is composed of several microstructures whose length‐scale, composition and magnetic properties are dependent upon cooling rate. Here...
Depression amongst interns working in a tertiary care teaching Hospital in Maharashtra
Background: Internship is a crucial stage of medical school regarding student stress which can affect thepatient care negatively. Retrieving knowledge about presence of depression is therefore important in itself and iffound...
Published by: IJHS Medical Association
Sentiment Analysis on Movie Reviews Dataset Using Support Vector Machines and Ensemble Learning
The internet makes it easier for people to connect to each other and has become a platform to express ideas and share information with the world. The growth of the internet has indirectly led to the development of social...
Published by: IGI Global Scientific Publishing
Right sided eventration of diaphragm with clinodactyly
A. Sareen and K. Mahajan
Apr 21, 2015
Diaphragmatic hernia can be of two types-absence or deficiency of the diaphragm, or eventration resulting in elevation of a portion of the diaphragm as a result of incomplete muscularization. Complete eventration almost...
Published by: IJHS Medical Association
Knowledge and Attitude among High School Students towards HIV / AIDS in Rural areas of Belagavi–A Cross Sectional Study
Asha A. Bellad and Rajesh R Kulkarni
Mar 25, 2015
Introduction Since its emergence in 1981, the HIV/AIDS pandemic, which poses a serious challenge to mankind, without doubt, has become one of the most serious infectious diseases. Many adolescents around the world are sexually...
Published by: IJHS Medical Association
Knowledge and Attitude among High School Students towards HIV / AIDS in Rural areas of Belagavi–A Cross Sectional Study
Asha A. Bellad and Rajesh R Kulkarni
Mar 25, 2015
Introduction Since its emergence in 1981, the HIV/AIDS pandemic, which poses a serious challenge to mankind, without doubt, has become one of the most serious infectious diseases. Many adolescents around the world are sexually...
Published by: IJHS Medical Association
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