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Results: 42
Electron cryo-tomography reveals the subcellular architecture of growing axons in human brain organoids.
Patrick C Hoffmann, Stefano L Giandomenico, Iva Ganeva, Michael R Wozny, Magdalena Sutcliffe, Madeline A Lancaster, Wanda Kukulski
Oct 28, 2021
Nanostructure in Amphiphile-Based Deep Eutectic Solvents
Deep eutectic solvents (DESs) are an emerging class of modern, often “green” solvents with unique properties. Recently, a deep eutectic system based on amphiphilic surfactant N-alkyl-N,N-dimethyl-3-ammonio-1-propanesulfonate...
Global Scale Dissemination of ST93
Sebastiaan J van Hal, Eike J Steinig, Patiyan Andersson, Matthew TG Holden, Simon R Harris, Graeme R Nimmo, Deborah A Williamson, Helen Heffernan, SR Ritchie, Angela M Kearns, Matthew J Ellington, Elizabeth Dickson, Herminia de Lencastre, Geoffrey W Coombs, Stephen D Bentley, Julian Parkhill, Deborah C Holt, Phillip M Giffard, Steven YC Tong
Sep 06, 2019
Background: In Australia, community-associated methicillin-resistant Staphylococcus aureus (MRSA) lineage sequence type (ST) 93 has rapidly risen to dominance since being described in the early 1990s. We examined 459 ST93 genome...
Nanostructure in Amphiphile-Based Deep Eutectic Solvents
Deep eutectic solvents (DESs) are an emerging class of modern, often “green” solvents with unique properties. Recently, a deep eutectic system based on amphiphilic surfactant N-alkyl-N,N-dimethyl-3-ammonio-1-propanesulfonate...
Differential viral accessibility (DIVA) identifies alterations in chromatin architecture through large-scale mapping of lentiviral integration sites.
Alterations in chromatin structure play a major role in the epigenetic regulation of gene expression. Here, we describe a step-by-step protocol for differential viral accessibility (DIVA), a method for identifying changes in...
Variations in the magnetic properties of meteoritic cloudy zone
Claire IO Nichols, James FJ Bryson, Roberts Blukis, Julia Herrero‐Albillos, Florian Kronast, Rudolf Rüffer, Aleksandr I Chumakov, Richard J Harrison
Feb 03, 2020
Iron and stony‐iron meteorites form the Widmanstätten pattern during slow cooling. This pattern is composed of several microstructures whose length‐scale, composition and magnetic properties are dependent upon cooling rate. Here...
Position-effect variegation revisited
HUSH complex haploid genetic screen Heterochromatin POSITION-EFFECT VARIEGATION retroviral silencing Animals Antigens Neoplasm Biological Evolution Cell Line Tumor Chromosomal Position Effects Drosophila melanogaster Gene Silencing Genetic Testing HIV-1 Haploidy Heterochromatin Histones Humans Mice Nuclear Proteins Phosphoproteins Virus Latency
Genetic dissection of mammalian ERAD through comparative haploid and CRISPR forward genetic screens.
Richard T Timms, Sam A Menzies, Iva A Tchasovnikarova, Lea C Christensen, James C Williamson, Robin Antrobus, Gordon Dougan, Lars Ellgaard, Paul J Lehner
Apr 07, 2016
Animals CRISPR-Cas Systems Endoplasmic Reticulum-Associated Degradation Fluorescent Dyes Genes Reporter Genetic Testing Glycoproteins HEK293 Cells Haploidy HeLa Cells Histocompatibility Antigens Class I Humans Mammals Oxidation-Reduction Protein Binding Protein Domains Thioredoxins alpha-Glucosidases
ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex.
ATF7IP H3K9me3 HUSH complex SETDB1 epigenetic silencing Heterochromatin histone methylation ubiquitin-mediated degradation Cell Nucleus Enzyme Stability Epigenesis Genetic Gene Deletion Gene Silencing HeLa Cells Heterochromatin Histone-Lysine N-Methyltransferase Histones Humans Lysine Methylation Multiprotein Complexes Proteasome Endopeptidase Complex Protein Binding Protein Methyltransferases Proteolysis Repressor Proteins Transcription Factors Transcriptome
GENE SILENCING. Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells.
Iva A Tchasovnikarova, Richard T Timms, Nicholas J Matheson, Kim Wals, Robin Antrobus, Berthold Göttgens, Gordon Dougan, Mark A Dawson, Paul J Lehner
Jun 11, 2015
Animals Antigens Neoplasm Chromosomal Position Effects Conserved Sequence Drosophila melanogaster evolution Molecular Gene Silencing Genes Reporter Genetic Loci Green Fluorescent Proteins HeLa Cells Heterochromatin Histone-Lysine N-Methyltransferase Histones Humans Immunoprecipitation Multiprotein Complexes Nuclear Proteins Phosphoproteins Protein Methyltransferases
The HUSH complex cooperates with TRIM28 to repress young retrotransposons and new genes.
Luisa Robbez-Masson, Christopher HC Tie, Lucia Conde, Hale Tunbak, Connor Husovsky, Iva A Tchasovnikarova, Richard T Timms, Javier Herrero, Paul J Lehner, Helen M Rowe
Jul 09, 2018
Periphilin self-association underpins epigenetic silencing by the HUSH complex.
Daniil M Prigozhin, Christopher H Douse, Laura E Farleigh, Anna Albecka, Iva A Tchasovnikarova, Richard T Timms, Shun-Ichiro Oda, Frank Adolf, Stefan MV Freund, Sarah Maslen, Paul J Lehner, Yorgo Modis
Sep 08, 2020
TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control.
Christopher H Douse, Iva A Tchasovnikarova, Richard T Timms, Anna V Protasio, Marta Seczynska, Daniil M Prigozhin, Anna Albecka, Jane Wagstaff, James C Williamson, Stefan MV Freund, Paul J Lehner, Yorgo Modis
Sep 14, 2020
Amino Acid Sequence Antigens Neoplasm Binding Sites DNA Transposable Elements Epigenesis Genetic Exons Genome HEK293 Cells HeLa Cells Histones Humans Lysine Magnetic Resonance Spectroscopy Methylation Multiprotein Complexes NAD Nuclear Proteins Phosphoproteins Poly(ADP-ribose) Polymerases Protein Binding Protein Domains RNA RNA processing Post-Transcriptional Transcription Genetic
TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control
Christopher H. Douse, Iva A. Tchasovnikarova, Richard T. Timms, Anna V. Protasio, Marta Seczynska, Daniil M. Prigozhin, Anna Albecka, Jane Wagstaff, James C. Williamson, Stefan M. V. Freund, Paul J. Lehner, Yorgo Modis
Oct 02, 2020
Abstract: The HUSH complex represses retroviruses, transposons and genes to maintain the integrity of vertebrate genomes. HUSH regulates deposition of the epigenetic mark H3K9me3, but how its three core subunits — TASOR, MPP8...
MicroRNA profiling of the pubertal mouse mammary gland identifies miR-184 as a candidate breast tumour suppressor gene.
Yu Wei Phua, Akira Nguyen, Daniel L Roden, Benjamin Elsworth, Niantao Deng, Iva Nikolic, Jessica Yang, Andrea McFarland, Roslin Russell, Warren Kaplan, Mark J Cowley, Radhika Nair, Elena Zotenko, Sandra O'Toole, Shi-Xiong Tan, David E James, Susan J Clark, Hosein Kouros-Mehr, Alexander Swarbrick
May 07, 2019
INTRODUCTION: The study of mammalian development has offered many insights into the molecular aetiology of cancer. We previously used analysis of mammary morphogenesis to discover a critical role for GATA-3 in mammary...
Animals Breast Neoplasms Cell Line Tumor Cell Proliferation Cell Transformation Neoplastic Cluster Analysis Epigenesis Genetic Female Gene Expression Profiling Gene Expression Regulation Neoplastic Gene Silencing Genes Tumor Suppressor Humans Mammary Glands Animal Mice MicroRNAs Neoplasm Metastasis Prognosis Proto-Oncogene Proteins c-akt RNA Interference Sexual Maturation TOR Serine-Threonine Kinases
TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control
Christopher H. Douse, Iva A. Tchasovnikarova, Richard T. Timms, Anna V. Protasio, Marta Seczynska, Daniil M. Prigozhin, Anna Albecka, Jane Wagstaff, James C. Williamson, Stefan M. V. Freund, Paul J. Lehner, Yorgo Modis
Oct 02, 2021
Abstract: The HUSH complex represses retroviruses, transposons and genes to maintain the integrity of vertebrate genomes. HUSH regulates deposition of the epigenetic mark H3K9me3, but how its three core subunits — TASOR, MPP8...
Prognostic significance of MRI-based late-course tumor volume in locoregionally advanced nasopharyngeal carcinoma.
Ge Yan, Yan Feng, Mingyao Wu, Chao Li, Yiran Wei, Li Hua, Guoqi Zhao, Zhekai Hu, Shengyu Yao, Lingtong Hou, Xuming Chen, Qianqian Liu, Qian Huang
Jun 29, 2022
BACKGROUND: To validate tumor volume-based imaging markers for predicting local recurrence-free survival (LRFS) in locoregionally advanced nasopharyngeal carcinoma patients, who underwent induction chemotherapy followed by...
Late-course volume (LCV) Local recurrence-free survival (LRFS) Locoregionally advanced nasopharyngeal carcinoma (LA-NPC) TNM staging system Volume regression rate (VRR) Carcinoma Disease-Free Survival Humans Magnetic Resonance Imaging Nasopharyngeal Carcinoma Nasopharyngeal Neoplasms Neoplasm Staging Prognosis Radiotherapy Intensity-Modulated Retrospective Studies Tumor Burden
Spatial multiomics map of trophoblast development in early pregnancy.
Anna Arutyunyan, Kenny Roberts, Kevin Troulé, Frederick CK Wong, Megan A Sheridan, Ilia Kats, Luz Garcia-Alonso, Britta Velten, Regina Hoo, Elias R Ruiz-Morales, Carmen Sancho-Serra, Jarrod Shilts, Louis-Francois Handfield, Luca Marconato, Elizabeth Tuck, Lucy Gardner, Cecilia Icoresi Mazzeo, Qian Li, Iva Kelava, Gavin J Wright, Elena Prigmore, Sarah A Teichmann, Omer Ali Bayraktar, Ashley Moffett, Oliver Stegle, Margherita Y Turco, Roser Vento-Tormo
Apr 05, 2023
Proteogenomic analysis of Inhibitor of Differentiation 4 (ID4) in basal-like breast cancer.
Laura A Baker, Holly Holliday, Daniel Roden, Christoph Krisp, Sunny Z Wu, Simon Junankar, Aurelien A Serandour, Hisham Mohammed, Radhika Nair, Geetha Sankaranarayanan, Andrew MK Law, Andrea McFarland, Peter T Simpson, Sunil Lakhani, Eoin Dodson, Christina Selinger, Lyndal Anderson, Goli Samimi, Neville F Hacker, Elgene Lim, Christopher J Ormandy, Matthew J Naylor, Kaylene Simpson, Iva Nikolic, Sandra O'Toole, Warren Kaplan, Mark J Cowley, Jason S Carroll, Mark Molloy, Alexander Swarbrick
Aug 21, 2020
BACKGROUND: Basal-like breast cancer (BLBC) is a poorly characterised, heterogeneous disease. Patients are diagnosed with aggressive, high-grade tumours and often relapse with chemotherapy resistance. Detailed understanding of...
Breast Cancer DNA Damage Helix-loop-helix Transcription factor Animals Apoptosis Breast Neoplasms Carcinoma Basal Cell Cell Differentiation Cell Line Tumor Cell Proliferation Chromatin DNA Damage Female Heterografts Humans Inhibitor of Differentiation Proteins Mice Mice Inbred NOD Mice SCID Prognosis Proteogenomics Tumor Cells Cultured
Copy number, linkage disequilibrium and disease association in the FCGR locus.
Heather A Niederer, Lisa C Willcocks, Tim F Rayner, Wanling Yang, Yu Lung Lau, Thomas N Williams, J Anthony G Scott, Britta C Urban, Norbert Peshu, Sarah J Dunstan, Tran Tinh Hien, Nguyen Hoan Phu, Leonid Padyukov, Iva Gunnarsson, Elisabet Svenungsson, Caroline O Savage, Richard A Watts, Paul A Lyons, David G Clayton, Kenneth GC Smith
Sep 05, 2018
The response of a leukocyte to immune complexes (ICs) is modulated by receptors for the Fc region of IgG (FcgammaRs), and alterations in their affinity or function have been associated with risk of autoimmune diseases, including...
Alleles Asian People Black People Chi-Square Distribution China GPI-Linked Proteins Gene Dosage Gene Frequency Genetic Predisposition to Disease Genotype Humans Kenya Linkage Disequilibrium Lupus Erythematosus Systemic Polymorphism Single Nucleotide Receptors IgG Sweden United Kingdom Vietnam White People
Spatial multiomics map of trophoblast development in early pregnancy.
Anna Arutyunyan, Kenny Roberts, Kevin Troulé, Frederick C K Wong, Megan A Sheridan, Ilia Kats, Luz Garcia-Alonso, Britta Velten, Regina Hoo, Elias R Ruiz-Morales, Carmen Sancho-Serra, Jarrod Shilts, Louis-Francois Handfield, Luca Marconato, Elizabeth Tuck, Lucy Gardner, Cecilia Icoresi Mazzeo, Qian Li, Iva Kelava, Gavin J Wright, Elena Prigmore, Sarah A Teichmann, Omer Ali Bayraktar, Ashley Moffett, Oliver Stegle, Margherita Y Turco, Roser Vento-Tormo
Apr 17, 2023
The relationship between the human placenta-the extraembryonic organ made by the fetus, and the decidua-the mucosal layer of the uterus, is essential to nurture and protect the fetus during pregnancy. Extravillous trophoblast...
Myometrium Decidua Organoids Stem Cells Trophoblasts Placenta Humans Transcription Factors maternal-fetal relations Cell Communication Cell Differentiation Cell Movement Pregnancy Pregnancy Trimester First Female Single-Cell Analysis Transcriptome multiomics
Published by: Nature
VGEA
Paul E Oluniyi, Fehintola Ajogbasile, Judith Oguzie, Jessica Uwanibe, Adeyemi Kayode, Anise Happi, Alphonsus Ugwu, Testimony Olumade, Olusola Ogunsanya, Philomena Ehiaghe Eromon, Onikepe Folarin, Simon DW Frost, Jonathan Heeney, Christian T Happi
Nov 09, 2021
Next generation sequencing (NGS)-based studies have vastly increased our understanding of viral diversity. Viral sequence data obtained from NGS experiments are a rich source of information, these data can be used to study their...
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
Caroline S Fox, Yongmei Liu, Charles C White, Mary Feitosa, Albert V Smith, Nancy Heard-Costa, Kurt Lohman, GIANT Consortium, MAGIC Consortium, GLGC Consortium, Andrew D Johnson, Meredith C Foster, Danielle M Greenawalt, Paula Griffin, Jinghong Ding, Anne B Newman, Fran Tylavsky, Iva Miljkovic, Stephen B Kritchevsky, Lenore Launer, Melissa Garcia, Gudny Eiriksdottir, J Jeffrey Carr, Vilmunder Gudnason, Tamara B Harris, L Adrienne Cupples, Ingrid B Borecki
Mar 21, 2018
Body fat distribution, particularly centralized obesity, is associated with metabolic risk above and beyond total adiposity. We performed genome-wide association of abdominal adipose depots quantified using computed tomography...
Adult Aged Alpha-Ketoglutarate-Dependent Dioxygenase FTO Body Mass Index Cytokines Female Genome-Wide Association Study HapMap Project Humans Intra-Abdominal Fat Lysophospholipase Male Middle Aged Phenotype Polymorphism Single Nucleotide Proteins Sex Characteristics Subcutaneous Fat Abdominal White People
Genome-wide Association Study of Change in Fasting Glucose over time in 13,807 non-diabetic European Ancestry Individuals.
Ching-Ti Liu, Jordi Merino, Denis Rybin, Daniel DiCorpo, Kelly S Benke, Jennifer L Bragg-Gresham, Mickaël Canouil, Tanguy Corre, Harald Grallert, Aaron Isaacs, Zoltan Kutalik, Jari Lahti, Letizia Marullo, Carola Marzi, Laura J Rasmussen-Torvik, Ghislain Rocheleau, Rico Rueedi, Chiara Scapoli, Niek Verweij, Nicole Vogelzangs, Sara M Willems, Loïc Yengo, Stephan JL Bakker, John Beilby, Jennie Hui, Eero Kajantie, Martina Müller-Nurasyid, Wolfgang Rathmann, Beverley Balkau, Sven Bergmann, Johan G Eriksson, Jose C Florez, Philippe Froguel, Tamara Harris, Joseph Hung, Alan L James, Maryam Kavousi, Iva Miljkovic, Arthur W Musk, Lyle J Palmer, Annette Peters, Ronan Roussel, Pim van der Harst, Cornelia M van Duijn, Peter Vollenweider, Inês Barroso, Inga Prokopenko, Josée Dupuis, James B Meigs, Nabila Bouatia-Naji
Jul 18, 2019
Type 2 diabetes (T2D) affects the health of millions of people worldwide. The identification of genetic determinants associated with changes in glycemia over time might illuminate biological features that precede the development...
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