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Key factors and challenges of research-informed policy making in ECEC
Abstract
In this commentary, we draw on examples from the thematic issue ‘Longitudinal studies in ECEC—challenges of translating research results into policy actions’ to discuss how research from longitudinal...
Protein Semi-Synthesis in Vivo
Izabela Giriat Stankiewicz
Jan 01, 0001
Incorporation of chemical probes into proteins is a powerful way to elucidate biological processes and to engineer novel function. This thesis describes the ligation of synthetic molecules to target proteins in an intracellular...
Published by: Rockefeller University
Social Protection Reforms in the Mena Region
The COVID-19 crisis revealed a significant gap in access to public services and highlighted significant issues with regards to government responsiveness to the immediate consequences of the pandemic. In the Middle East and North...
social protection social protection system mena Covid 19 pandemic /dk/atira/pure/sustainabledevelopmentgoals/no_poverty name=SDG 1 - No Poverty /dk/atira/pure/sustainabledevelopmentgoals/decent_work_and_economic_growth name=SDG 8 - Decent Work and Economic Growth
Published by: EU
An Open Label, Adaptive, Phase 1 Trial of High-Dose Oral Nitazoxanide in Healthy Volunteers
Lauren E Walker, Richard FitzGerald, Geoffrey Saunders, Rebecca Lyon, Michael Fisher, Karen Martin, Izabela Eberhart, Christie Woods, Sean Ewings, Colin Hale, Rajith KR Rajoli, Laura Else, Sujan Dilly-Penchala, Alieu Amara, David G Lalloo, Michael Jacobs, Henry Pertinez, Parys Hatchard, Robert Waugh, Megan Lawrence, Lucy Johnson, Keira Fines, Helen Reynolds, Timothy Rowland, Rebecca Crook, Emmanuel Okenyi, Kelly Byrne, Pavel Mozgunov, Thomas Jaki, Saye Khoo, Andrew Owen, Gareth Griffiths, Thomas E Fletcher, AGILE platform
Nov 22, 2021
Developmental relations between ADHD symptoms and bullying perpetration and victimization in adolescence.
It has previously been hypothesized that individuals with elevated attention deficit hyperactivity disorder (ADHD) symptoms are at greater risk of bullying perpetration and victimization. Using autoregressive latent trajectory...
An Open Label, Adaptive, Phase 1 Trial of High-Dose Oral Nitazoxanide in Healthy Volunteers
Lauren E Walker, Richard FitzGerald, Geoffrey Saunders, Rebecca Lyon, Michael Fisher, Karen Martin, Izabela Eberhart, Christie Woods, Sean Ewings, Colin Hale, Rajith KR Rajoli, Laura Else, Sujan Dilly-Penchala, Alieu Amara, David G Lalloo, Michael Jacobs, Henry Pertinez, Parys Hatchard, Robert Waugh, Megan Lawrence, Lucy Johnson, Keira Fines, Helen Reynolds, Timothy Rowland, Rebecca Crook, Emmanuel Okenyi, Kelly Byrne, Pavel Mozgunov, Thomas Jaki, Saye Khoo, Andrew Owen, Gareth Griffiths, Thomas E Fletcher, AGILE platform
Jan 06, 2022
Social Protection Reforms in the Mena Region
The COVID-19 crisis revealed a significant gap in access to public services and highlighted significant issues with regards to government responsiveness to the immediate consequences of the pandemic. In the Middle East and North...
social protection social protection system mena Covid 19 pandemic /dk/atira/pure/sustainabledevelopmentgoals/no_poverty name=SDG 1 - No Poverty /dk/atira/pure/sustainabledevelopmentgoals/decent_work_and_economic_growth name=SDG 8 - Decent Work and Economic Growth
Published by: EU
RAD sequencing sheds new light on the genetic structure and local adaptation of European scallops and resolves their demographic histories.
David LJ Vendrami, Michele De Noia, Luca Telesca, William Handal, Grégory Charrier, Pierre Boudry, Luke Eberhart-Phillips, Joseph I Hoffman
Mar 27, 2020
Recent developments in genomics are advancing our understanding of the processes shaping population structure in wild organisms. In particular, reduced representation sequencing has facilitated the generation of dense genetic...
A Longitudinal Study on Stability and Transitions Among Bullying Roles.
Izabela Zych, Maria M Ttofi, Vicente J Llorent, David P Farrington, Denis Ribeaud, Manuel P Eisner
Feb 12, 2019
Trajectories of stability and change in bullying roles were examined through a longitudinal prospective study of 916 school students followed up biannually from age 11 to 17. Perpetrators and victims had relatively stable...
AGILE: a seamless phase I/IIa platform for the rapid evaluation of candidates for COVID-19 treatment
Gareth O Griffiths, Richard FitzGerald, Thomas Jaki, Andrea Corkhill, Helen Reynolds, Sean Ewings, Susannah Condie, Emma Tilt, Lucy Johnson, Mike Radford, Catherine Simpson, Geoffrey Saunders, Sara Yeats, Pavel Mozgunov, Olana Tansley-Hancock, Karen Martin, Nichola Downs, Izabela Eberhart, Jonathan WB Martin, Cristiana Goncalves, Anna Song, Tom Fletcher, Kelly Byrne, David G Lalloo, Andrew Owen, Michael Jacobs, Lauren Walker, Rebecca Lyon, Christie Woods, Jennifer Gibney, Justin Chiong, Nomathemba Chandiwana, Shevin Jacob, Mohammed Lamorde, Catherine Orrell, Munir Pirmohamed, Saye Khoo, AGILE investigators
Jul 28, 2021
Gastric residual volume measurement in British neonatal intensive care units
Jon Dorling, Lyvonne Tume, Barbara Arch, Kerry Woolfall, Lynne Latten, Louise Roper, Elizabeth Deja, Nazima Pathan, Helen Eccleson, Helen Hickey, Michaela Brown, Anne Beissel, Izabela Andrzejewska, Frederic Valla, Chris Gale
Aug 11, 2020
Objective: Despite little evidence, the practice of routine gastric residual volume (GRV) measurement to guide enteral feeding in neonatal units is widespread. Due to increased interest in this practice, and to examine trial...
Pins is not required for spindle orientation in the Drosophila wing disc.
Dan T Bergstralh, Holly E Lovegrove, Izabela Kujawiak, Nicole S Dawney, Jinwei Zhu, Samantha Cooper, Rongguang Zhang, Daniel St Johnston
Jun 30, 2016
Ni2+-Assisted Hydrolysis May Affect the Human Proteome; Filaggrin Degradation Ex Vivo as an Example of Possible Consequences.
Ewa Izabela Podobas, Danuta Gutowska-Owsiak, Sébastien Moretti, Jarosław Poznański, Mariusz Kulińczak, Marcin Grynberg, Aleksandra Gruca, Arkadiusz Bonna, Dawid Płonka, Graham Ogg, Wojciech Bal
Mar 29, 2022
Deficiency in a principal epidermal barrier protein, filaggrin (FLG), is associated with multiple allergic manifestations, including atopic dermatitis and contact allergy to nickel. Toxicity caused by dermal and respiratory...
Optimal outcome measures for a trial of not routinely measuring gastric residual volume in neonatal care
Chris Gale, Jon Dorling, Barbara Arch, Kerry Woolfall, Elizabeth Deja, Louise Roper, Ashley P Jones, Lynne Latten, Helen Eccleson, Helen Hickey, Nazima Pathan, Jennifer Preston, Anne Beissel, Izabela Andrzejewska, Frederic Valla, Lyvonne Tume
Nov 03, 2020
Background: Routine measurement of gastric residual volume to guide feeding is widespread in neonatal units but not supported by high-quality evidence. Outcome selection is critical to trial design. Objective: To determine...
Can they stomach it? Parent and practitioner acceptability of a trial comparing gastric residual volume measurement versus no gastric residual volume in UK NNU and PICUs
Elizabeth Deja, Louise Roper, Lyvonne N. Tume, Jon Dorling, Chris Gale, Barbara Arch, Lynne Latten, Nazima Pathan, Helen Eccleson, Helen Hickey, Jenny Preston, Anne Beissel, Izabela Andrzejewska, Frédéric V. Valla, Kerry Woolfall
Feb 16, 2021
Abstract: Background: Routine measurement of gastric residual volume (GRV) to guide feeding in neonatal and paediatric intensive care is widespread. However, this practice is not evidence based and may cause harm. As part of a...
Ni2+-Assisted Hydrolysis May Affect the Human Proteome; Filaggrin Degradation Ex Vivo as an Example of Possible Consequences.
Ewa Izabela Podobas, Danuta Gutowska-Owsiak, Sébastien Moretti, Jarosław Poznański, Mariusz Kulińczak, Marcin Grynberg, Aleksandra Gruca, Arkadiusz Bonna, Dawid Płonka, Tomasz Frączyk, Graham Ogg, Wojciech Bal
Dec 26, 2022
Optimal outcome measures for a trial of not routinely measuring gastric residual volume in neonatal care
Chris Gale, Jon Dorling, Barbara Arch, Kerry Woolfall, Elizabeth Deja, Louise Roper, Ashley P Jones, Lynne Latten, Helen Eccleson, Helen Hickey, Nazima Pathan, Jennifer Preston, Anne Beissel, Izabela Andrzejewska, Frederic Valla, Lyvonne Tume
Nov 10, 2020
Background: Routine measurement of gastric residual volume to guide feeding is widespread in neonatal units but not supported by high-quality evidence. Outcome selection is critical to trial design. Objective: To determine...
Can they stomach it? Parent and practitioner acceptability of a trial comparing gastric residual volume measurement versus no gastric residual volume in UK NNU and PICUs
Elizabeth Deja, Louise Roper, Lyvonne N Tume, Jon Dorling, Chris Gale, Barbara Arch, Lynne Latten, Nazima Pathan, Helen Eccleson, Helen Hickey, Jenny Preston, Anne Beissel, Izabela Andrzejewska, Frédéric V Valla, Kerry Woolfall
Apr 19, 2021
BACKGROUND: Routine measurement of gastric residual volume (GRV) to guide feeding in neonatal and paediatric intensive care is widespread. However, this practice is not evidence based and may cause harm. As part of a feasibility...
Gastric residual volume measurement in British neonatal intensive care units
Jon Dorling, Lyvonne Tume, Barbara Arch, Kerry Woolfall, Lynne Latten, Louise Roper, Elizabeth Deja, Nazima Pathan, Helen Eccleson, Helen Hickey, Michaela Brown, Anne Beissel, Izabela Andrzejewska, Frederic Valla, Chris Gale
Sep 09, 2020
OBJECTIVE: Despite little evidence, the practice of routine gastric residual volume (GRV) measurement to guide enteral feeding in neonatal units is widespread. Due to increased interest in this practice, and to examine trial...
Optimal outcome measures for a trial of not routinely measuring gastric residual volume in neonatal care
Chris Gale, Jon Dorling, Barbara Arch, Kerry Woolfall, Elizabeth Deja, Louise Roper, Ashley P Jones, Lynne Latten, Helen Eccleson, Helen Hickey, Nazima Pathan, Jennifer Preston, Anne Beissel, Izabela Andrzejewska, Frederic Valla, Lyvonne Tume
Nov 16, 2020
BACKGROUND: Routine measurement of gastric residual volume to guide feeding is widespread in neonatal units but not supported by high-quality evidence. Outcome selection is critical to trial design. OBJECTIVE: To determine...
Data Collection Neonatology qualitative research Body Weights and Measures Consensus Delphi Technique Diagnostic Tests Routine Duration of Therapy Enteral nutrition Enterocolitis Necrotizing Humans Infant Newborn Intensive Care Neonatal Organ Size Outcome Assessment Health Care Parenteral nutrition Pneumonia Aspiration Procedures and Techniques Utilization Quality Improvement Stomach
Tumors induce de novo steroid biosynthesis in T cells to evade immunity
Bidesh Mahata, Jhuma Pramanik, Louise van der Weyden, Krzysztof Polanski, Gozde Kar, Angela Riedel, Xi Chen, Nuno A. Fonseca, Kousik Kundu, Lia S. Campos, Edward Ryder, Graham Duddy, Izabela Walczak, Klaus Okkenhaug, David J. Adams, Jacqueline D. Shields, Sarah A. Teichmann
Jul 17, 2020
Abstract: Tumors subvert immune cell function to evade immune responses, yet the complex mechanisms driving immune evasion remain poorly understood. Here we show that tumors induce de novo steroidogenesis in T lymphocytes to...
Cognitive Change in Schizophrenia and Other Psychoses in the Decade Following the First Episode.
Jolanta Zanelli, Josephine Mollon, Sven Sandin, Craig Morgan, Paola Dazzan, Izabela Pilecka, Tiago Reis Marques, Anthony S David, Kevin Morgan, Paul Fearon, Gillian A Doody, Peter B Jones, Robin M Murray, Abraham Reichenberg
Jun 27, 2019
Tumors induce de novo steroid biosynthesis in T cells to evade immunity
Bidesh Mahata, Jhuma Pramanik, Louise van der Weyden, Krzysztof Polanski, Gozde Kar, Angela Riedel, Xi Chen, Nuno A. Fonseca, Kousik Kundu, Lia S. Campos, Edward Ryder, Graham Duddy, Izabela Walczak, Klaus Okkenhaug, David J. Adams, Jacqueline D. Shields, Sarah A. Teichmann
Jul 28, 2021
Abstract: Tumors subvert immune cell function to evade immune responses, yet the complex mechanisms driving immune evasion remain poorly understood. Here we show that tumors induce de novo steroidogenesis in T lymphocytes to...
Neuropsychological function at first episode in treatment-resistant psychosis
Eugenia Kravariti, Arsime Demjaha, Jolanta Zanelli, Fowzia Ibrahim, Catherine Wise, James H MacCabe, Abraham Reichenberg, Izabela Pilecka, Kevin Morgan, Paul Fearon, Craig Morgan, Gillian A Doody, Kim Donoghue, Peter B Jones, Anil Şafak Kaçar, Paola Dazzan, Julia Lappin, Robin M Murray
Dec 03, 2018
cohort study first episode neuropsychological population-based Psychosis Schizophrenia treatment resistant Adolescent Adult Cross-Sectional Studies Drug Resistance Executive Function Female Follow-Up Studies Humans Intelligence Linear Models Male Middle Aged Neuropsychological Tests Psychotic Disorders Schizophrenia Spatial Memory United Kingdom Young Adult
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