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Results: 35
Strategy for identifying dendritic cell-processed CD4+ T cell epitopes from the HIV Gag p24 protein
Mass Spectrometry (MS) is becoming a preferred method to identify class I and class II peptides presented on major histocompability complexes (MHC) on antigen presenting cells (APC). We describe a combined computational and MS...
Published by: Rockefeller University
Cortical microtubule nucleation can organise the cytoskeleton of Drosophila oocytes to define the anteroposterior axis.
Philipp Khuc Trong, Hélène Doerflinger, Jörn Dunkel, Daniel St Johnston, Raymond E Goldstein
Oct 01, 2015
A predictive account of how novelty influences declarative memory.
A rich body of studies in the human and non-human literature has examined the question how novelty influences memory. For a variety of different stimuli, ranging from simple objects and words to vastly complex scenarios, the...
Mode Selection in Compressible Active Flow Networks.
Coherent, large-scale dynamics in many nonequilibrium physical, biological, or information transport networks are driven by small-scale local energy input. Here, we introduce and explore an analytically tractable nonlinear model...
Elevated circulating Sclerostin concentrations in individuals with high bone mass, with and without LRP5 mutations.
Celia L Gregson, Kenneth ES Poole, Eugene V McCloskey, Emma L Duncan, Jörn Rittweger, William D Fraser, George Davey Smith, Jonathan H Tobias
Oct 06, 2015
Adaptor Proteins Signal Transducing Adult Aged Aged 80 and over Bone Density Bone Morphogenetic Proteins Case-Control Studies Female Genetic Markers Humans Hyperostosis Low Density Lipoprotein Receptor-Related Protein-5 Male Middle Aged Mutation Osteochondrodysplasias Syndactyly United Kingdom Young Adult
NICER/NuSTAR Characterization of 4U 1957+11
Abstract
4U 1957+11 is a black hole candidate system that has been in a soft X-ray spectral state since its discovery. We present analyses of recent joint NICER and NuSTAR spectra...
Erin Barillier, Victoria Grinberg, David Horn, Michael A Nowak, Ronald A Remillard, James F Steiner, Dominic J Walton, Jörn Wilms
Feb 22, 2023
Identification of tissue-specific and common methylation quantitative trait loci in healthy individuals using MAGAR.
Michael Scherer, Gilles Gasparoni, Souad Rahmouni, Tatiana Shashkova, Marion Arnoux, Edouard Louis, Arina Nostaeva, Diana Avalos, Emmanouil T Dermitzakis, Yurii S Aulchenko, Thomas Lengauer, Paul A Lyons, Michel Georges, Jörn Walter
Oct 18, 2021
Background
Understanding the influence of genetic variants on DNA methylation is fundamental for the interpretation of epigenomic data in the context of disease. There is a need for systematic approaches not only for...
Published by: Epigenetics & chromatin
Cellulose Nanocrystal-Templated Tin Dioxide Thin Films for Gas Sensing.
Alesja Ivanova, Bruno Frka-Petesic, Andrej Paul, Thorsten Wagner, Askhat N Jumabekov, Yury Vilk, Johannes Weber, Jörn Schmedt Auf der Günne, Silvia Vignolini, Michael Tiemann, Dina Fattakhova-Rohlfing, Thomas Bein
Jan 15, 2020
Porous tin dioxide is an important low-cost semiconductor applied in electronics, gas sensors, and biosensors. Here, we present a versatile template-assisted synthesis of nanostructured tin dioxide thin films using cellulose...
Development and validation of Gaucher disease type 1 (GD1)-specific patient-reported outcome measures (PROMs) for clinical monitoring and for clinical trials.
Deborah Elstein, Nadia Belmatoug, Patrick Deegan, Özlem Göker-Alpan, Derralynn A Hughes, Ida Vanessa D Schwartz, Neal Weinreb, Nicola Bonner, Charlotte Panter, Donna Fountain, Andrew Lenny, Louise Longworth, Rachael Miller, Koonal Shah, Jörn Schenk, Rohini Sen, Ari Zimran
Feb 09, 2022
BACKGROUND: Disease-specific patient-reported outcome measures (PROMs) are fundamental to understanding the impact on, and expectations of, patients with genetic disorders, and can facilitate constructive and educated...
Development and validation of Gaucher disease type 1 (GD1)-specific patient-reported outcome measures (PROMs) for clinical monitoring and for clinical trials.
Deborah Elstein, Nadia Belmatoug, Patrick Deegan, Özlem Göker-Alpan, Derralynn A Hughes, Ida Vanessa D Schwartz, Neal Weinreb, Nicola Bonner, Charlotte Panter, Donna Fountain, Andrew Lenny, Louise Longworth, Rachael Miller, Koonal Shah, Jörn Schenk, Rohini Sen, Ari Zimran
Jan 10, 2022
Identification of tissue-specific and common methylation quantitative trait loci in healthy individuals using MAGAR.
Michael Scherer, Gilles Gasparoni, Souad Rahmouni, Tatiana Shashkova, Marion Arnoux, Edouard Louis, Arina Nostaeva, Diana Avalos, Emmanouil T Dermitzakis, Yurii S Aulchenko, Thomas Lengauer, Paul A Lyons, Michel Georges, Jörn Walter
Sep 27, 2021
BACKGROUND: Understanding the influence of genetic variants on DNA methylation is fundamental for the interpretation of epigenomic data in the context of disease. There is a need for systematic approaches not only for...
Surveillance of SARS-CoV-2 in Frankfurt am Main from October to December 2020 Reveals High Viral Diversity Including Spike Mutation N501Y in B.1.1.70 and B.1.1.7.
Marek Widera, Barbara Mühlemann, Victor M Corman, Tuna Toptan, Jörn Beheim-Schwarzbach, Niko Kohmer, Julia Schneider, Annemarie Berger, Talitha Veith, Christiane Pallas, Tobias Bleicker, Udo Goetsch, Julia Tesch, Rene Gottschalk, Terry C Jones, Sandra Ciesek, Christian Drosten
May 03, 2021
BACKGROUND: International travel is a major driver of the introduction and spread of SARS-CoV-2. AIM: To investigate SARS-CoV-2 genetic diversity in the region of a major transport hub in Germany, we characterized the viral...
MERVL/Zscan4 Network Activation Results in Transient Genome-wide DNA Demethylation of mESCs.
Mélanie A Eckersley-Maslin, Valentine Svensson, Christel Krueger, Thomas M Stubbs, Pascal Giehr, Felix Krueger, Ricardo J Miragaia, Charalampos Kyriakopoulos, Rebecca V Berrens, Inês Milagre, Jörn Walter, Sarah A Teichmann, Wolf Reik
May 16, 2019
Mouse embryonic stem cells are dynamic and heterogeneous. For example, rare cells cycle through a state characterized by decondensed chromatin and expression of transcripts, including the Zscan4 cluster and MERVL endogenous...
DNA Methylation MERVL Zscan4 Chromatin Embryonic Stem Cell Endogenous retrovirus imprint preimplantation reprogramming Animals Cell Cycle Cellular Reprogramming Chromatin DNA Methylation DNA Modification Methylases endogenous retroviruses Epigenesis Genetic Genome Genomic Imprinting Induced Pluripotent Stem Cells Mice Mouse embryonic stem cells Multigene Family RNA Messenger Single-Cell Analysis Transcription Factors Transcriptional Activation Transcriptome
Identification of tissue-specific and common methylation quantitative trait loci in healthy individuals using MAGAR
Metabolic signatures across the full spectrum of non-alcoholic fatty liver disease.
Aidan J McGlinchey, Olivier Govaere, Dawei Geng, Vlad Ratziu, Michael Allison, Jerome Bousier, Salvatore Petta, Claudia de Oliviera, Elisabetta Bugianesi, Jörn M Schattenberg, Ann K Daly, Tuulia Hyötyläinen, Quentin M Anstee, Matej Orešič
May 18, 2022
2-HB 2-hydroxybutanoic acid 3-HB 3-hydroxybutanoic acid ALT alanine aminotransferase AST aspartate aminotransferase Ce cholesterol ester Cer ceramide FFA free fatty acid FLIP Fatty Liver Inhibition of Progression Fibrosis GC gas chromatography HCC hepatocellular carcinoma HSD honest significant difference LC lipid cluster LDL low-density lipoprotein LM lipid and metabolite LMC lipid metabolite and clinical variable LPC lysophosphatidylcholine lipidomics Mass Spectrometry Metabolomics NAFL non-alcoholic fatty liver NAFLD non-alcoholic fatty liver disease NAS NASH activity score NASH non-alcoholic steatohepatitis NIDDK NASH-CRN National Institute of Digestive Diseases and Kidney NASH Clinical Research Network NRR non-rejection rate Non-alcoholic steatohepatitis PC(O) ether PC PC phosphatidylcholine PCA principal component analysis PE phosphatidylethanolamine QTOFMS quadrupole-time-of-flight mass spectrometry ROC receiving operator characteristic SAF steatosis activity and fibrosis SM sphingomyelin T2DM type 2 diabetes mellitus TG triacylglycerol UHPLC ultrahigh-performance liquid chromatography
Estimating infectiousness throughout SARS-CoV-2 infection course.
Terry C Jones, Guido Biele, Barbara Mühlemann, Talitha Veith, Julia Schneider, Jörn Beheim-Schwarzbach, Tobias Bleicker, Julia Tesch, Marie Luisa Schmidt, Leif Erik Sander, Florian Kurth, Peter Menzel, Rolf Schwarzer, Marta Zuchowski, Jörg Hofmann, Andi Krumbholz, Angela Stein, Anke Edelmann, Victor Max Corman, Christian Drosten
May 31, 2021
Two elementary parameters for quantifying viral infection and shedding are viral load and whether samples yield a replicating virus isolate in cell culture. We examined 25,381 cases of severe acute respiratory syndrome...
Quantitative modeling of human liver reveals dysregulation of glycosphingolipid pathways in nonalcoholic fatty liver disease.
Partho Sen, Olivier Govaere, Tim Sinioja, Aidan McGlinchey, Dawei Geng, Vlad Ratziu, Elisabetta Bugianesi, Jörn M Schattenberg, Antonio Vidal-Puig, Michael Allison, Simon Cockell, Ann K Daly, Tuulia Hyötyläinen, Quentin M Anstee, Matej Orešič
Oct 06, 2022
Nonalcoholic fatty liver disease (NAFLD) is an increasingly prevalent disease that is associated with multiple metabolic disturbances, yet the metabolic pathways underlying its progression are poorly understood. Here, we studied...
Synergism of anisotropic and computational NMR methods reveals the likely configuration of phormidolide A.
Ikenna E Ndukwe, Xiao Wang, Nelson YS Lam, Kristaps Ermanis, Kelsey L Alexander, Matthew J Bertin, Gary E Martin, Garrett Muir, Ian Paterson, Robert Britton, Jonathan M Goodman, Eric JN Helfrich, Jörn Piel, William H Gerwick, R Thomas Williamson
Jun 09, 2020
Characterization of the complex molecular scaffold of the marine polyketide natural product phormidolide A represents a challenge that has persisted for nearly two decades. In light of discordant results arising from recent...
Longitudinal multi-omics analysis identifies early blood-based predictors of anti-TNF therapy response in inflammatory bowel disease.
Neha Mishra, Konrad Aden, Johanna I Blase, Nathan Baran, Dora Bordoni, Florian Tran, Claudio Conrad, Diana Avalos, Charlot Jaeckel, Michael Scherer, Signe B Sørensen, Silja H Overgaard, Berenice Schulte, Susanna Nikolaus, Guillaume Rey, Gilles Gasparoni, Paul A Lyons, Joachim L Schultze, Jörn Walter, Vibeke Andersen, SYSCID Consortium, Emmanouil T Dermitzakis, Stefan Schreiber, Philip Rosenstiel
Oct 25, 2022
BACKGROUND AND AIMS: Treatment with tumor necrosis factor α (TNFα) antagonists in IBD patients suffers from primary non-response rates of up to 40%. Biomarkers for early prediction of therapy success are missing. We investigated...
Longitudinal multi-omics analysis identifies early blood-based predictors of anti-TNF therapy response in inflammatory bowel disease.
Neha Mishra, Konrad Aden, Johanna I Blase, Nathan Baran, Dora Bordoni, Florian Tran, Claudio Conrad, Diana Avalos, Charlot Jaeckel, Michael Scherer, Signe B Sørensen, Silja H Overgaard, Berenice Schulte, Susanna Nikolaus, Guillaume Rey, Gilles Gasparoni, Paul A Lyons, Joachim L Schultze, Jörn Walter, Vibeke Andersen, SYSCID Consortium, Emmanouil T Dermitzakis, Stefan Schreiber, Philip Rosenstiel
Sep 25, 2022
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