Search
Results: 679
Chlorambucil targets BRCA1/2-deficient tumours and counteracts PARP inhibitor resistance.
Eliana MC Tacconi, Sophie Badie, Giuliana De Gregoriis, Timo Reisländer, Xianning Lai, Manuela Porru, Cecilia Folio, John Moore, Arnaud Kopp, Júlia Baguña Torres, Deborah Sneddon, Marcus Green, Simon Dedic, Jonathan W Lee, Ankita Sati Batra, Oscar M Rueda, Alejandra Bruna, Carlo Leonetti, Carlos Caldas, Bart Cornelissen, Laurent Brino, Anderson Ryan, Annamaria Biroccio, Madalena Tarsounas
Jul 31, 2019
BRCA1 BRCA2 DNA damage responses alkylating agents cisplatin Animals BRCA1 Protein BRCA2 Protein Cell Line Tumor Chlorambucil Cricetinae Drug Delivery Systems Drug Resistance Neoplasm Humans Leukemia Lymphocytic Chronic B-Cell Male Mice Mice SCID Peroxisome Proliferator-Activated Receptors Phthalazines Piperazines Xenograft Model Antitumor Assays
Review: Torres Cacoullos and Travis. 2018. Bilingualism in the Community: Code-switching and Grammars in Contact. Cambridge
Li Nguyen
Sep 10, 2019
Torres Cacoullos and Travis's ‘Bilingualism in the Community: Code-switching and Grammars in Contact’ is a comprehensive study of language contact in New Mexico – a well-established bilingual community in the Southwest of the...
Explosion in weighted hyperbolic random graphs and geometric inhomogeneous random graphs
In this paper we study weighted distances in scale-free spatial network models: hyperbolic random graphs, geometric inhomogeneous random graphs and scale-free percolation. In hyperbolic random graphs...
First passage percolation Hyperbolic random graphs Scale-free property Small world property Spatial network models Typical distances /dk/atira/pure/subjectarea/asjc/2600/2613 name=Statistics and Probability /dk/atira/pure/subjectarea/asjc/2600/2611 name=Modelling and Simulation /dk/atira/pure/subjectarea/asjc/2600/2604 name=Applied Mathematics
Explosion in weighted hyperbolic random graphs and geometric inhomogeneous random graphs
In this paper we study weighted distances in scale-free spatial network models: hyperbolic random graphs, geometric inhomogeneous random graphs and scale-free percolation. In hyperbolic random graphs...
First passage percolation Hyperbolic random graphs Scale-free property Small world property Spatial network models Typical distances /dk/atira/pure/subjectarea/asjc/2600/2613 name=Statistics and Probability /dk/atira/pure/subjectarea/asjc/2600/2611 name=Modelling and Simulation /dk/atira/pure/subjectarea/asjc/2600/2604 name=Applied Mathematics
How Do Magnetic Field Models Affect Astrophysical Limits on Light Axion-like Particles? An X-Ray Case Study with NGC 1275
James H. Matthews, Christopher S. Reynolds, M. C. David Marsh, Júlia Sisk-Reynés, Payton E. Rodman
May 09, 2022
Abstract: Axion-like particles (ALPs) are a well-motivated extension to the standard model of particle physics, and X-ray observations of cluster-hosted AGN currently place the most stringent constraints on the ALP coupling to...
Dorsal and ventral striatal dopamine D1 and D2 receptors differentially modulate distinct phases of serial visual reversal learning.
Júlia Sala-Bayo, Leanne Fiddian, Simon RO Nilsson, Mona E Hervig, Colin McKenzie, Alexis Mareschi, Maria Boulos, Peter Zhukovsky, Janet Nicholson, Jeffrey W Dalley, Johan Alsiö, Trevor W Robbins
Jan 03, 2020
Impaired cognitive flexibility in visual reversal-learning tasks has been observed in a wide range of neurological and neuropsychiatric disorders. Although both human and animal studies have implicated striatal D2-like and...
Dorsal and ventral striatal dopamine D1 and D2 receptors differentially modulate distinct phases of serial visual reversal learning
Dopamine D2-like receptor stimulation blocks negative feedback in visual and spatial reversal learning in the rat
Johan Alsiö, Benjamin U Phillips, Júlia Sala-Bayo, Simon RO Nilsson, Teresa C Calafat-Pla, Arazo Rizwand, Jessica M Plumbridge, Laura López-Cruz, Jeffrey W Dalley, Rudolf N Cardinal, Adam C Mar, Trevor W Robbins
Jun 17, 2019
Cognition Cognitive flexibility Computational modelling Dopamine Dopamine D1 receptor Dopamine D2 receptor Hierarchical Bayesian analysis rat reinforcement learning Reversal Learning Animals Dopamine Dopamine Agonists Dopamine Antagonists Dopamine D2 Receptor Antagonists Feedback Physiological Male Photic Stimulation Rats Receptors Dopamine D1 Receptors Dopamine D2 Reversal Learning Space Perception Visual Perception
Withdrawal from escalated cocaine self-administration impairs reversal learning by disrupting the effects of negative feedback on reward exploitation
Peter Zhukovsky, Mickael Puaud, Bianca Jupp, Júlia Sala-Bayo, Johan Alsiö, Jing Xia, Lydia Searle, Zoe Morris, Aryan Sabir, Chiara Giuliano, Barry J Everitt, David Belin, Trevor W Robbins, Jeffrey W Dalley
Apr 05, 2019
Reprogramming of Trypanosoma cruzi metabolism triggered by parasite interaction with the host cell extracellular matrix.
Eliciane C Mattos, Gisele Canuto, Nubia C Manchola, Rubens DM Magalhães, Thomas WM Crozier, Douglas J Lamont, Marina FM Tavares, Walter Colli, Michael AJ Ferguson, Maria Júlia M Alves
Mar 19, 2019
Trypanosoma cruzi, the etiological agent of Chagas' disease, affects 8 million people predominantly living in socioeconomic underdeveloped areas. T. cruzi trypomastigotes (Ty), the classical infective stage, interact with the...
Deterministic programming of human pluripotent stem cells into microglia facilitates studying their role in health and disease.
Anna M Speicher, Lisanne Korn, Júlia Csatári, Laura Gonzalez-Cano, Michael Heming, Christian Thomas, Christina B Schroeter, David Schafflick, Xiaolin Li, Lukas Gola, Alexander Engler, Thilo Kaehne, Ludovic Vallier, Sven G Meuth, Gerd Meyer Zu Hörste, Stjepana Kovac, Heinz Wiendl, Hans R Schöler, Matthias Pawlowski
Nov 17, 2022
Microglia, the resident immune cells of the central nervous system (CNS), are derived from yolk-sac macrophages that populate the developing CNS during early embryonic development. Once established, the microglia population is...
Ambidexterity, performance and environmental dynamism
Purpose - This research examines the relationship between organizational ambidexterity, the ability of companies to explore new and to exploit existing processes simultaneously, and manufacturing performance as represented by...
Reverse engineering of ceramic anthropomorphic figurines from the Tumaco archaeological tradition in southwest Colombia.
Traditional studies of archaeological ceramics in Colombia have been largely based on visual and stylistic analyses. Here we introduce frameworks and concepts of reverse engineering as a complementary strategy to develop...
Reverse engineering of ceramic anthropomorphic figurines from the Tumaco archaeological tradition in southwest Colombia.
Traditional studies of archaeological ceramics in Colombia have been largely based on visual and stylistic analyses. Here we introduce frameworks and concepts of reverse engineering as a complementary strategy to develop...
Published by: PLOS ONE
Ambidexterity, performance and environmental dynamism
Purpose - This research examines the relationship between organizational ambidexterity, the ability of companies to explore new and to exploit existing processes simultaneously, and manufacturing performance as represented by...
NF-κB activation is a turn on for vaccinia virus phosphoprotein A49 to turn off NF-κB activation.
innate immunity nuclear factor kappa B vaccinia virus virus immune evasion Feedback Physiological Humans I-kappa B Kinase I-kappa B Proteins Molecular Mimicry NF-kappa B Phosphoproteins Phosphorylation Signal Transduction Ubiquitin-Protein Ligases Ubiquitination vaccinia virus Viral Proteins Virulence beta-Transducin Repeat-Containing Proteins
What Can Data Tell Us?
Researchers have found that student engagement has an impact on student learning, retention, motivation, and persistence in higher education. However, faculty often experience challenges in maintaining high levels of student...
Published by: IGI Global Scientific Publishing
Modulating Vaccinia Virus Immunomodulators to Improve Immunological Memory.
The increasing frequency of monkeypox virus infections, new outbreaks of other zoonotic orthopoxviruses and concern about the re-emergence of smallpox have prompted research into developing antiviral drugs and better vaccines...
Genetic Engineering Immune Evasion immunological memory orthopoxviruses smallpox vaccine vaccinia virus Animals Communicable Diseases Emerging Cytokines Genetic Engineering Humans Immunity Immunogenicity Vaccine Immunologic Memory immunomodulation Inflammation Mediators smallpox smallpox vaccine vaccinia virus Viral Vaccines Zoonoses
|
|< |
< |
1 |