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Deconstructing a Hermeneutic Presupposition in Ricoeur’s The Symbolism of Evil
This paper critically analyzes Paul Ricoeurʼs presupposition that Plato’s philosophy was built on Orphism. In order to shed light on this central problematic issue in The Symbolism of Evil, this paper develops the following...
Macromolecular ab initio phasing enforcing secondary and tertiary structure.
Ab initio phasing of macromolecular structures, from the native intensities alone with no experimental phase information or previous particular structural knowledge, has been the object of a long quest, limited by two main...
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Long non-coding RNAs in the regulation of the immune response
J.A. Heward, M.A. Lindsay
Sep 01, 2014
It is increasingly clear that long non-coding RNAs (lncRNAs) regulate a variety biological responses, and that they do so by a diverse range of mechanisms. In the field of immunology, recent publications have shown widespread...
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Deconstructing a Hermeneutic Presupposition in Ricoeur’s The Symbolism of Evil
This paper critically analyzes Paul Ricoeurʼs presupposition that Plato’s philosophy was built on Orphism. In order to shed light on this central problematic issue in The Symbolism of Evil, this paper develops the following...
Structure of a 13-fold superhelix (almost) determined from first principles.
Nuclear hormone receptors are cytoplasm-based transcription factors that bind a ligand, translate to the nucleus and initiate gene transcription in complex with a co-activator such as TIF2 (transcriptional intermediary factor...
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Concordant and divergent strategies to improve postprandial glucose and lipid metabolism
Following ingestion of a mixed-macronutrient meal, blood glucose and triacylglycerol (TAG) concentrations are elevated for approximately 2 and 8 hours respectively, depending on factors such as the amount and type of food...
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Likelihood-based docking of models into cryo-EM maps.
Optimized docking of models into cryo-EM maps requires exploiting an understanding of the signal expected in the data to minimize the calculation time while maintaining sufficient signal. The likelihood-based rotation function...
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Likelihood-based signal and noise analysis for docking of models into cryo-EM maps.
Fast, reliable docking of models into cryo-EM maps requires understanding of the errors in the maps and the models. Likelihood-based approaches to errors have proven to be powerful and adaptable in experimental structural...
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ALIXE
Fragment-based molecular replacement exploits the use of very accurate yet incomplete search models. In the case of the ARCIMBOLDO programs, consistent phase sets produced from the placement and refinement of fragments with...
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Concordant and divergent strategies to improve postprandial glucose and lipid metabolism
Following ingestion of a mixed-macronutrient meal, blood glucose and triacylglycerol (TAG) concentrations are elevated for approximately 2 and 8 hours respectively, depending on factors such as the amount and type of food...
Published by:
Likelihood-based signal and noise analysis for docking of models into cryo-EM maps.
Fast, reliable docking of models into cryo-EM maps requires understanding of the errors in the maps and the models. Likelihood-based approaches to errors have proven to be powerful and adaptable in experimental structural...
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Towards an understanding of when non-climate frames can generate public support for climate change policy
There is a growing tendency for policy makers to frame climate change action in terms of non-climate benefits, raising important empirical questions regarding the utility of such approaches. Across three studies we explore...
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Likelihood-based docking of models into cryo-EM maps.
Optimized docking of models into cryo-EM maps requires exploiting an understanding of the signal expected in the data to minimize the calculation time while maintaining sufficient signal. The likelihood-based rotation function...
Published by:
Towards an understanding of when non-climate frames can generate public support for climate change policy
There is a growing tendency for policy makers to frame climate change action in terms of non-climate benefits, raising important empirical questions regarding the utility of such approaches. Across three studies we explore...
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Confinement in nonlocal interaction equations
We investigate some dynamical properties of nonlocal interaction equations. We consider sets of particles interacting pairwise via a potential W, as well as continuum descriptions of such systems. The typical potentials we...
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Long non-coding RNAs in the regulation of the immune response
J.A. Heward, M.A. Lindsay
Sep 01, 2014
It is increasingly clear that long non-coding RNAs (lncRNAs) regulate a variety biological responses, and that they do so by a diverse range of mechanisms. In the field of immunology, recent publications have shown widespread...
Published by:
ALEPH
The analysis of large structural databases reveals general features and relationships among proteins, providing useful insight. A different approach is required to characterize ubiquitous secondary-structure elements, where...
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Putting AlphaFold models to work with phenix.process_predicted_model and ISOLDE.
AlphaFold has recently become an important tool in providing models for experimental structure determination by X-ray crystallography and cryo-EM. Large parts of the predicted models typically approach the accuracy of...
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