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Effectiveness of the Viet Nam produced, mouse brain-derived, inactivated Japanese encephalitis vaccine in Northern Viet Nam.
Florian Marks, Thi Thu Yen Nguyen, Nhu Duong Tran, Minh Hong Nguyen, Hai Ha Vu, Christian G Meyer, Young Ae You, Frank Konings, Wei Liu, Thomas F Wierzba, Zhi-Yi Xu
Feb 19, 2019
BACKGROUND: Japanese encephalitis (JE) is a flaviviral disease of public health concern in many parts of Asia. JE often occurs in large epidemics, has a high case-fatality ratio and, among survivors, frequently causes persistent...
Dynamics of Japanese encephalitis virus transmission among pigs in Northwest Bangladesh and the potential impact of pig vaccination.
Salah Uddin Khan, Henrik Salje, A Hannan, Md Atiqul Islam, AA Mamun Bhuyan, Md Ariful Islam, M Ziaur Rahman, Nazmun Nahar, M Jahangir Hossain, Stephen P Luby, Emily S Gurley
Feb 15, 2021
BACKGROUND: Japanese encephalitis (JE) virus infection can cause severe disease in humans, resulting in death or permanent neurologic deficits among survivors. Studies indicate that the incidence of JE is high in northwestern...
A model immunization programme to control Japanese encephalitis in Viet Nam.
Nguyen Thu Yen, Wei Liu, Hoang Duc Hanh, Na Yoon Chang, Tran Nhu Duong, Robert V Gibbons, Florian Marks, Nghiem Anh Thu, Nguyen Minh Hong, Jin Kyung Park, Pham Anh Tuan, Ananda Nisalak, John D Clemens, Zhi-Yi Xu
Aug 01, 2019
In Viet Nam, an inactivated, mouse brain-derived vaccine for Japanese encephalitis (JE) has been given exclusively to ≤ 5 years old children in 3 paediatric doses since 1997. However, JE incidence remained high, especially among...
Demonstration project Effectiveness study Immunization Japanese encephalitis vaccines Child Child Preschool Encephalitis Japanese Feasibility Studies Female Humans Immunization Programs Incidence Infant Japanese Encephalitis Vaccines Male vaccines Inactivated Vietnam
Published by: J Health Popul Nutr
Kinetic interplay between droplet maturation and coalescence modulates shape of aged protein condensates.
Biomolecular condensates formed by the process of liquid-liquid phase separation (LLPS) play diverse roles inside cells, from spatiotemporal compartmentalisation to speeding up chemical reactions. Upon maturation, the...
The Lantern Vol. 50, No. 2, Spring 1984
Mark W. Wingel, Ellen M. Walsh, Kenneth C. Taylor, Andrew P. Wack, Angela L. Russek, Trisha L. Carvelli, Ronald J. Carter, Diane Grace Fries, Elizabeth P. Harp, Brian E. Kelley, Jacqueline Crahalla, Matt Fagan, Jerome F. Frasier, III, Walter S. Keehn, Thomas G. Egner, Sara D. Seese, Jeremy Landersfield, Timothy S. Weible, Michael Macron, Rosemary J. Wuenschel, Dorene M. Pasekoff, Beth A. Long, Tom Feeney
Jan 01, 0001
The Storm Je ne sais pas The Ghetious Blastious An Empty Cradle The Playing Hands Battle Hymn A Limerick Parting Thoughts The River Miss You De la Tristeza Two So Special Time of the Unicorn The...
Ursinus College Collegeville Pennsylvania Lantern Literary Magazine poetry fiction Creative Nonfiction Arts and Humanities Creative Writing fiction illustration Nonfiction poetry
Published by: Ursinus College
Business Intelligence Readiness Assessment for a Shopping Mall
This case takes place at SCC, a recognized shopping mall located in Cali, Colombia. In March 2018, Javier Ortiz, CEO of SCC, contacted a group of researchers to identify the key success factors before the implementation of...
Published by: IGI Global Scientific Publishing
Rekindling Nature
Juan Felipe Guevara-Aristizabal
Apr 05, 2022
In the Freedom Essay, before formulating what he considers to be the central philosophical problem concerning human freedom—the capacity for good and evil—Schelling unpacks some remarks about logic and the uses of the copula as...
Published by: Memorial University Libraries
Targeted modulation of protein liquid-liquid phase separation by evolution of amino-acid sequence.
Rationally and efficiently modifying the amino-acid sequence of proteins to control their ability to undergo liquid-liquid phase separation (LLPS) on demand is not only highly desirable, but can also help to elucidate which...
Rekindling Nature
Juan Felipe Guevara-Aristizabal
Apr 05, 2022
In the Freedom Essay, before formulating what he considers to be the central philosophical problem concerning human freedom—the capacity for good and evil—Schelling unpacks some remarks about logic and the uses of the copula as...
Published by: Memorial University Libraries
Zola’s “champ limité de la réalisation”
Nicholas White
Dec 07, 2020
Émile Zola explains the inclusion of the Paris Commune of 1871 in his novel, La Débâcle (1892) in terms of his Naturalist epistemophilia: “Je veux tout mettre, je suis toujours désespéré du champ limité de la réalisation.” But...
NAFlex
Adam Hospital, Ignacio Faustino, Rosana Collepardo-Guevara, Carlos González, Josep Lluis Gelpí, Modesto Orozco
Mar 25, 2021
We present NAFlex, a new web tool to study the flexibility of nucleic acids, either isolated or bound to other molecules. The server allows the user to incorporate structures from protein data banks, completing gaps and removing...
Targeted modulation of protein liquid-liquid phase separation by evolution of amino-acid sequence.
Rationally and efficiently modifying the amino-acid sequence of proteins to control their ability to undergo liquid-liquid phase separation (LLPS) on demand is not only highly desirable, but can also help to elucidate which...
Published by: PLoS computational biology
Crucial role of dynamic linker histone binding and divalent ions for DNA accessibility and gene regulation revealed by mesoscale modeling of oligonucleosomes.
Monte Carlo simulations of a mesoscale model of oligonucleosomes are analyzed to examine the role of dynamic-linker histone (LH) binding/unbinding in high monovalent salt with divalent ions, and to further interpret noted...
Protein disorder-to-order transition enhances the nucleosome-binding affinity of H1.
Intrinsically disordered proteins are crucial elements of chromatin heterogenous organization. While disorder in the histone tails enables a large variation of inter-nucleosome arrangements, disorder within the chromatin-binding...
Expansion of Intrinsically Disordered Proteins Increases the Range of Stability of Liquid-Liquid Phase Separation.
Proteins containing intrinsically disordered regions (IDRs) are ubiquitous within biomolecular condensates, which are liquid-like compartments within cells formed through liquid-liquid phase separation (LLPS). The sequence of...
A. V. Dicey and English Constitutionalism
JE KIRBY
Sep 05, 2018
The jurist A. V. Dicey’s study of the Law of the Constitution (1885) has been since its publication the dominant analysis of the British constitution and the source of orthodoxy on such subjects as parliamentary sovereignty and...
Investor Diligence in Investment Arbitration
JE Vinuales
Mar 07, 2017
Most contemporary observers of international investment law will likely share with the author of these lines the impression that the criticism expressed by many commentators over the last decade with respect to the operation of...
Valency and Binding Affinity Variations Can Regulate the Multilayered Organization of Protein Condensates with Many Components
Ignacio Sanchez-Burgos, Jorge R. Espinosa, Jerelle A. Joseph, Rosana Collepardo-Guevara
Feb 15, 2021
Biomolecular condensates, which assemble via the process of liquid–liquid phase separation (LLPS), are multicomponent compartments found ubiquitously inside cells. Experiments and simulations have shown that biomolecular...
Nucleosome plasticity is a critical element of chromatin liquid-liquid phase separation and multivalent nucleosome interactions.
Stephen E Farr, Esmae J Woods, Jerelle A Joseph, Adiran Garaizar, Rosana Collepardo-Guevara
Jun 18, 2021
Liquid-liquid phase separation (LLPS) is an important mechanism that helps explain the membraneless compartmentalization of the nucleus. Because chromatin compaction and LLPS are collective phenomena, linking their modulation to...
Chromatin Nucleosomes Histones DNA Nucleic Acid Conformation Algorithms Models Genetic Computer Simulation Molecular Dynamics Simulation
Published by: Nature Communications
Dynamic condensation of linker histone C-terminal domain regulates chromatin structure.
The basic and intrinsically disordered C-terminal domain (CTD) of the linker histone (LH) is essential for chromatin compaction. However, its conformation upon nucleosome binding and its impact on chromatin organization remain...
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