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Results: 43
Gastrointestinal worms and bacteria
A plethora of studies, both experimental and epidemiological, have indicated the occurrence of associations between infections by gastrointestinal (GI) helminths and the composition and function of the host gut microbiota. Given...
Helminths, hosts, and their microbiota
INTRODUCTION: Evidence is emerging of complex interactions occurring between gastrointestinal (GI) parasites of ruminants and the resident gut flora, with likely implications for the pathophysiology of worm infection and...
The impact of testing and infection prevention and control strategies on within-hospital transmission dynamics of COVID-19 in English hospitals
Stephanie Evans, Emily Agnew, Emilia Vynnycky, James Stimson, Alex Bhattacharya, Christopher Rooney, Ben Warne, Julie Robotham
May 31, 2021
Nosocomial transmission of SARS-CoV-2 is a key concern, and evaluating the effect of testing and infection prevention and control strategies is essential for guiding policy in this area. Using a within-hospital SEIR transition...
Vaccination against the brown stomach worm, Teladorsagia circumcincta, followed by parasite challenge, induces inconsistent modifications in gut microbiota composition of lambs
James Rooney, Alba Cortés, Riccardo Scotti, Daniel R. G. Price, Yvonne Bartley, Karen Fairlie-Clarke, Tom N. McNeilly, Alasdair J. Nisbet, Cinzia Cantacessi
Apr 07, 2021
Engineering bacteriocin-mediated resistance against the plant pathogen Pseudomonas syringae.
William M Rooney, Rhys W Grinter, Annapaula Correia, Julian Parkhill, Daniel C Walker, Joel J Milner
Mar 07, 2020
The plant pathogen, Pseudomonas syringae (Ps), together with related Ps species, infects and attacks a wide range of agronomically important crops, including tomato, kiwifruit, pepper, olive and soybean, causing economic losses....
The CATFISH study protocol
Michaela Goodwin, Richard Emsley, Michael Kelly, Eric Rooney, Matthew Sutton, Martin Tickle, Rebecca Wagstaff, Tanya Walsh, William Whittaker, Iain A Pretty
Sep 29, 2016
Abstract
Background
Tooth decay is the commonest disease of childhood. We have known for over 90 years that fluoride can prevent tooth decay; it is present in nearly all toothpastes...
The impact of testing and infection prevention and control strategies on within-hospital transmission dynamics of COVID-19 in English hospitals.
Stephanie Evans, Emily Agnew, Emilia Vynnycky, James Stimson, Alex Bhattacharya, Christopher Rooney, Ben Warne, Julie Robotham
May 31, 2021
Nosocomial transmission of SARS-CoV-2 is a key concern, and evaluating the effect of testing and infection prevention and control strategies is essential for guiding policy in this area. Using a within-hospital SEIR transition...
The impact of testing and infection prevention and control strategies on within-hospital transmission dynamics of COVID-19 in English hospitals.
Stephanie Evans, Emily Agnew, Emilia Vynnycky, James Stimson, Alex Bhattacharya, Christopher Rooney, Ben Warne, Julie Robotham
Dec 15, 2021
Nosocomial transmission of SARS-CoV-2 is a key concern, and evaluating the effect of testing and infection prevention and control strategies is essential for guiding policy in this area. Using a within-hospital SEIR transition...
The researchers' role in knowledge translation
Jon Banks, Lesley Wye, Nicola Hall, James Rooney, Fiona Walter, Willie Hamilton, Ardiana Gjini, Greg Rubin
Jan 10, 2018
BACKGROUND: In examining an initiative to develop and implement new cancer diagnostic pathways in two English localities, this paper evaluates 'what works' and examines the role of researchers in facilitating knowledge...
Published by: Health Res Policy Syst
Baseline Gut Microbiota Composition Is Associated With Schistosoma mansoni Infection Burden in Rodent Models.
Alba Cortés, Simon Clare, Alice Costain, Alexandre Almeida, Catherine McCarthy, Katherine Harcourt, Cordelia Brandt, Charlotte Tolley, James Rooney, Matthew Berriman, Trevor Lawley, Andrew S MacDonald, Gabriel Rinaldi, Cinzia Cantacessi
Oct 22, 2020
In spite of growing evidence supporting the occurrence of complex interactions between Schistosoma and gut bacteria in mice and humans, no data is yet available on whether worm-mediated changes in microbiota composition are...
Schistosoma mansoni Dysbiosis gut microbial diversity helminth-gut microbiota interactions human-microbiota associated mouse models immune-modulation Animals Antibodies Protozoan Bacteria Biodiversity Computational Biology Disease Models Animal Dysbiosis Feces Gastrointestinal Microbiome host-parasite interactions immunomodulation Metagenomics Mice Parasite Load RNA Ribosomal 16S Schistosoma Schistosomiasis mansoni
Large magnetoelectric coupling in multiferroic oxide heterostructures assembled via epitaxial lift-off
D. Pesquera, E. Khestanova, M. Ghidini, S. Zhang, A. P. Rooney, F. Maccherozzi, P. Riego, S. Farokhipoor, J. Kim, X. Moya, M. E. Vickers, N. A. Stelmashenko, S. J. Haigh, S. S. Dhesi, N. D. Mathur
Jun 24, 2021
Abstract: Epitaxial films may be released from growth substrates and transferred to structurally and chemically incompatible substrates, but epitaxial films of transition metal perovskite oxides have not been transferred to...
Evolutionary loss of inflammasomes in the Carnivora and implications for the carriage of zoonotic infections.
Zsofi Digby, Panagiotis Tourlomousis, James Rooney, Joseph P Boyle, Betsaida Bibo-Verdugo, Robert J Pickering, Steven J Webster, Thomas P Monie, Lee J Hopkins, Nobuhiko Kayagaki, Guy S Salvesen, Soren Warming, Lucy Weinert, Clare E Bryant
Aug 06, 2021
Zoonotic pathogens, such as COVID-19, reside in animal hosts before jumping species to infect humans. The Carnivora, like mink, carry many zoonoses, yet how diversity in host immune genes across species affect pathogen carriage...
Carnivora NLRC4 NLRP3 Caspase 1 caspase 11 caspase 4 inflammasome Animals Carnivora Caspase 1 Caspase 8 Caspases Initiator Cell Death Cell Line evolution Molecular Humans Inflammasomes Interleukin-1beta Lipopolysaccharides MACROPHAGES Mice Mice Inbred C57BL NLR proteins Recombinant Fusion Proteins Recombinant Proteins Salmonella typhi Zoonoses
Combining comparative proteomics and molecular genetics uncovers regulators of synaptic and axonal stability and degeneration in vivo.
Thomas M Wishart, Timothy M Rooney, Douglas J Lamont, Ann K Wright, A Jennifer Morton, Mandy Jackson, Marc R Freeman, Thomas H Gillingwater
Feb 13, 2020
Degeneration of synaptic and axonal compartments of neurons is an early event contributing to the pathogenesis of many neurodegenerative diseases, but the underlying molecular mechanisms remain unclear. Here, we demonstrate the...
Aldehyde Dehydrogenase Animals Axons Brain Injuries Calbindin 2 Drosophila Drosophila Proteins HSP40 Heat-Shock Proteins Huntington Disease Mice Molecular Chaperones Mutation Nerve Degeneration Proteomics S100 Calcium Binding Protein G Spinocerebellar Ataxias Synapses Thiolester Hydrolases Wallerian degeneration rho-Associated Kinases
Excretory-secretory products from the brown stomach worm, Teladorsagia circumcincta, exert antimicrobial activity in in vitro growth assays
James Rooney, Timothy L Williams, Holly M Northcote, Fiona E Karet Frankl, Daniel RG Price, Alasdair J Nisbet, Russell M Morphew, Cinzia Cantacessi
Oct 02, 2022
Vaccination against the brown stomach worm, Teladorsagia circumcincta, followed by parasite challenge, induces inconsistent modifications in gut microbiota composition of lambs.
James Rooney, Alba Cortés, Riccardo Scotti, Daniel RG Price, Yvonne Bartley, Karen Fairlie-Clarke, Tom N McNeilly, Alasdair J Nisbet, Cinzia Cantacessi
Mar 15, 2021
BACKGROUND: Growing evidence points towards a role of gastrointestinal (GI) helminth parasites of ruminants in modifying the composition of the host gut flora, with likely repercussions on the pathophysiology of worm infection...
Gastrointestinal helminth Microbiome Prevotella spp. Ruminant Teladorsagia circumcincta vaccine Animals Antibodies Helminth Bacteria Feces Gastrointestinal Microbiome Intestinal Diseases Parasitic Ostertagia Parasite Egg Count RNA Ribosomal 16S Reproducibility of Results Sheep Sheep Diseases Trichostrongyloidiasis Vaccination
Vaccination against the brown stomach worm, Teladorsagia circumcincta, followed by parasite challenge, induces inconsistent modifications in gut microbiota composition of lambs
James Rooney, Alba Cortés, Riccardo Scotti, Daniel R. G. Price, Yvonne Bartley, Karen Fairlie-Clarke, Tom N. McNeilly, Alasdair J. Nisbet, Cinzia Cantacessi
Nov 12, 2021
Cross-discipline evidence principles for sustainability policy.
Edward T Game, Heather Tallis, Lydia Olander, Steven M Alexander, Jonah Busch, Nancy Cartwright, Elizabeth L Kalies, Yuta J Masuda, Anne-Christine Mupepele, Jiangxiao Qiu, Andrew Rooney, Erin Sills, William J Sutherland
Nov 22, 2018
Evidence-based approaches to sustainability challenges must draw on knowledge from the environment, development and health communities. To be practicable, this requires an approach to evidence that is broader and less...
Large magnetoelectric coupling in multiferroic oxide heterostructures assembled via epitaxial lift-off
D. Pesquera, E. Khestanova, M. Ghidini, S. Zhang, A. P. Rooney, F. Maccherozzi, P. Riego, S. Farokhipoor, J. Kim, X. Moya, M. E. Vickers, N. A. Stelmashenko, S. J. Haigh, S. S. Dhesi, N. D. Mathur
Jun 24, 2020
Abstract: Epitaxial films may be released from growth substrates and transferred to structurally and chemically incompatible substrates, but epitaxial films of transition metal perovskite oxides have not been transferred to...
Baseline Gut Microbiota Composition Is Associated With Schistosoma mansoni Infection Burden in Rodent Models
Alba Cortés, Simon Clare, Alice Costain, Alexandre Almeida, Catherine McCarthy, Katherine Harcourt, Cordelia Brandt, Charlotte Tolley, James Rooney, Matthew Berriman, Trevor Lawley, Andrew S. MacDonald, Gabriel Rinaldi, Cinzia Cantacessi
Dec 02, 2020
In spite of growing evidence supporting the occurrence of complex interactions between Schistosoma and gut bacteria in mice and humans, no data is yet available on whether worm-mediated changes in microbiota composition are...
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