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Results: 16
A reliable technique to fabricate superconducting joints between single grain, Y–Ba–Cu–O bulk superconductors
Abstract: The production of large (RE)Ba–Cu–O single grains ((RE)BCO), where RE = Y, Gd or Sm, of complex geometries is presently limited by the intrinsic slowness of the grain growth process. Additionally, the shapes achievable...
A reliable technique to fabricate superconducting joints between single grain, Y–Ba–Cu–O bulk superconductors
Abstract: The production of large (RE)Ba–Cu–O single grains ((RE)BCO), where RE = Y, Gd or Sm, of complex geometries is presently limited by the intrinsic slowness of the grain growth process. Additionally, the shapes achievable...
Characterisation of the mechanical failure and fracture mechanisms of single grain Y–Ba–Cu–O bulk superconductors
Jasmin V J Congreve, Yunhua Shi, Kai Yuan Huang, Anthony R Dennis, John H Durrell, David A Cardwell
Dec 11, 2019
Abstract: The widespread use of melt processed, single grain (RE)–Ba–Cu–O bulk superconductors [(RE)BCO], where RE = Y, Gd or Sm, is limited predominantly by the poor mechanical properties of these inherently brittle...
Acetylcholine prioritises direct synaptic inputs from entorhinal cortex to CA1 by differential modulation of feedforward inhibitory circuits.
Jon Palacios-Filardo, Matt Udakis, Giles A Brown, Benjamin G Tehan, Miles S Congreve, Pradeep J Nathan, Alastair JH Brown, Jack R Mellor
Jan 04, 2022
Acetylcholine release in the hippocampus plays a central role in the formation of new memory representations. An influential but largely untested theory proposes that memory formation requires acetylcholine to enhance responses...
Acetylcholine prioritises direct synaptic inputs from entorhinal cortex to CA1 by differential modulation of feedforward inhibitory circuits
Jon Palacios-Filardo, Matt Udakis, Giles A. Brown, Benjamin G. Tehan, Miles S. Congreve, Pradeep J. Nathan, Alastair J. H. Brown, Jack R. Mellor
Sep 16, 2021
Abstract: Acetylcholine release in the hippocampus plays a central role in the formation of new memory representations. An influential but largely untested theory proposes that memory formation requires acetylcholine to enhance...
Acetylcholine prioritises direct synaptic inputs from entorhinal cortex to CA1 by differential modulation of feedforward inhibitory circuits.
Jon Palacios-Filardo, Matt Udakis, Giles A Brown, Benjamin G Tehan, Miles S Congreve, Pradeep J Nathan, Alastair JH Brown, Jack R Mellor
Dec 24, 2021
Acetylcholine release in the hippocampus plays a central role in the formation of new memory representations. An influential but largely untested theory proposes that memory formation requires acetylcholine to enhance responses...
A phase 1b/2a multicenter study of the safety and preliminary pharmacodynamic effects of selective muscarinic M1 receptor agonist HTL0018318 in patients with mild-to-moderate Alzheimer's disease.
Pradeep J Nathan, S Babli Millais, Alex Godwood, Odile Dewit, David M Cross, Janet Liptrot, Bharat Ruparelia, Stephen Paul Jones, Geor Bakker, Paul T Maruff, Gregory A Light, Alastair JH Brown, Malcolm Peter Weir, Miles Congreve, Tim Tasker
Feb 23, 2022
Safety, pharmacokinetics and pharmacodynamics of HTL0009936, a selective muscarinic M1 -acetylcholine receptor agonist
Charlotte Bakker, Samantha Prins, Jan Liptrot, Ellen P Hart, Erica S Klaassen, Giles A Brown, Alastair Brown, Miles Congreve, Malcolm Weir, Fiona H Marshall, Jasper Stevens, David M Cross, Tim Tasker, Pradeep J Nathan, Geert Jan Groeneveld
May 08, 2021
AIMS: HTL0009936 is a selective M1 muscarinic receptor agonist in development for cognitive dysfunction in Alzheimer's disease. Safety, tolerability and pharmacokinetics and exploratory pharmacodynamic effects of HTL0009936...
Improved trapped field performance of single grain Y‐Ba‐Cu‐O bulk superconductors containing artificial holes
Kai Yuan Huang, Tomáš Hlásek, Devendra Kumar Namburi, Anthony R. Dennis, Yunhua Shi, Mark D. Ainslie, Jasmin V. J. Congreve, Vladimir Plecháček, Jan Plecháček, David A. Cardwell, John H. Durrell
Jul 28, 2021
Abstract: The intrinsic mechanical properties of single‐grain RE‐Ba‐Cu‐O bulk high‐temperature superconductors can be improved by employing a thin‐wall geometry. This is where the samples are melt‐processed with a predefined...
Original Article Original Articles brittle materials magnetic materials/properties mechanical properties superconductors yttrium/yttrium compounds
Published by: Journal of the American Ceramic Society
Safety, pharmacokinetics and exploratory pro-cognitive effects of HTL0018318, a selective M1 receptor agonist, in healthy younger adult and elderly subjects
Charlotte Bakker, Tim Tasker, Jan Liptrot, Ellen P Hart, Erica S Klaassen, Robert Jan Doll, Giles A Brown, Alastair Brown, Miles Congreve, Malcolm Weir, Fiona H Marshall, David M Cross, Geert Jan Groeneveld, Pradeep J Nathan
Apr 22, 2021
First-in-man study to investigate safety, pharmacokinetics and exploratory pharmacodynamics of HTL0018318, a novel M1 -receptor partial agonist for the treatment of dementias.
Charlotte Bakker, Tim Tasker, Jan Liptrot, Ellen P Hart, Erica S Klaassen, Samantha Prins, Thalia F van der Doef, Giles A Brown, Alastair Brown, Miles Congreve, Malcolm Weir, Fiona H Marshall, David M Cross, Geert Jan Groeneveld, Pradeep J Nathan
Jun 29, 2021