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Results: 26
Preserved sensory processing but hampered conflict detection when stimulus input is task-irrelevant
Stijn Adriaan Nuiten, Andrés Canales-Johnson, Lola Beerendonk, Nutsa Nanuashvili, Johannes Jacobus Fahrenfort, Tristan Bekinschtein, Simon van Gaal
Jul 28, 2021
Conflict detection in sensory input is central to adaptive human behavior. Perhaps unsurprisingly, past research has shown that conflict may even be detected in the absence of conflict awareness, suggesting that conflict...
Preserved sensory processing but hampered conflict detection when stimulus input is task-irrelevant.
Stijn Adriaan Nuiten, Andrés Canales-Johnson, Lola Beerendonk, Nutsa Nanuashvili, Johannes Jacobus Fahrenfort, Tristan Bekinschtein, Simon van Gaal
Jun 18, 2021
Conflict detection in sensory input is central to adaptive human behavior. Perhaps unsurprisingly, past research has shown that conflict may even be detected in the absence of conflict awareness, suggesting that conflict...
Clinical Features, Inpatient Trajectories and Frailty in Older Inpatients with COVID-19
Christopher N. Osuafor, Catriona Davidson, Alistair J. Mackett, Marie Goujon, Lelane Van Der Poel, Vince Taylor, Jacobus Preller, Robert J. B. Goudie, Victoria L. Keevil
Feb 02, 2021
Introduction: We describe the clinical features and inpatient trajectories of older adults hospitalized with COVID-19 and explore relationships with frailty. Methods: This retrospective observational study included older adults...
Development and validation of a dynamic 48-hour in-hospital mortality risk stratification for COVID-19 in a UK teaching hospital
Development and validation of a dynamic 48-hour in-hospital mortality risk stratification for COVID-19 in a UK teaching hospital
Martin Wiegand, Sarah L Cowan, Claire S Waddington, David J Halsall, Victoria L Keevil, Brian DM Tom, Vince Taylor, Effrossyni Gkrania-Klotsas, Jacobus Preller, Robert JB Goudie
Feb 23, 2023
The Prognostic and Discriminatory Utility of the Clinical Frailty Scale and Modified Frailty Index Compared to Age.
Ben Carter, Victoria L Keevil, Atul Anand, Christopher N Osuafor, Robert JB Goudie, Jacobus Preller, Matthew Lowry, Sarah Clunie, Susan D Shenkin, Kathryn McCarthy, Jonathan Hewitt, Terence J Quinn
Aug 25, 2022
Background: There is no consensus on the optimal method for the assessment of frailty. We compared the prognostic utility of two approaches (modified Frailty Index [mFI], Clinical Frailty Scale [CFS]) in older adults (≥65 years)...
Factors Associated with Significant Weight Loss in Hospitalised Patients with COVID-19
Dimitra Zannidi, Pinal S Patel, Eleni Leventea, Jessica Paciepnik, Frances Dobson, Caroline Heyes, Robert JB Goudie, Linda M Oude Griep, Jacobus Preller, Lynsey N Spillman
Nov 16, 2022
Specifically neuropathic Gaucher's mutations accelerate cognitive decline in Parkinson's.
Ganqiang Liu, Brendon Boot, Joseph J Locascio, Iris E Jansen, Sophie Winder-Rhodes, Shirley Eberly, Alexis Elbaz, Alexis Brice, Bernard Ravina, Jacobus J van Hilten, Florence Cormier-Dequaire, Jean-Christophe Corvol, Roger A Barker, Peter Heutink, Johan Marinus, Caroline H Williams-Gray, Clemens R Scherzer, International Genetics of Parkinson Disease Progression (IGPP) Consortium
May 16, 2018
OBJECTIVE: We hypothesized that specific mutations in the β-glucocerebrosidase gene (GBA) causing neuropathic Gaucher's disease (GD) in homozygotes lead to aggressive cognitive decline in heterozygous Parkinson's disease (PD)...
The Prognostic and Discriminatory Utility of the Clinical Frailty Scale and Modified Frailty Index Compared to Age.
Ben Carter, Victoria L Keevil, Atul Anand, Christopher N Osuafor, Robert JB Goudie, Jacobus Preller, Matthew Lowry, Sarah Clunie, Susan D Shenkin, Kathryn McCarthy, Jonathan Hewitt, Terence J Quinn
Oct 24, 2022
Background: There is no consensus on the optimal method for the assessment of frailty. We compared the prognostic utility of two approaches (modified Frailty Index [mFI], Clinical Frailty Scale [CFS]) in older adults (≥65 years)...
Analyses of germline variants associated with ovarian cancer survival identify functional candidates at the 1q22 and 19p12 outcome loci.
Dylan M Glubb, Sharon E Johnatty, Michael CJ Quinn, Tracy A O'Mara, Jonathan P Tyrer, Bo Gao, Peter A Fasching, Matthias W Beckmann, Diether Lambrechts, Ignace Vergote, Digna R Velez Edwards, Alicia Beeghly-Fadiel, Javier Benitez, Maria J Garcia, Marc T Goodman, Pamela J Thompson, Thilo Dörk, Matthias Dürst, Francesmary Modungo, Kirsten Moysich, Florian Heitz, Andreas du Bois, Jacobus Pfisterer, Peter Hillemanns, AGO Study Group, Beth Y Karlan, Jenny Lester, Ellen L Goode, Julie M Cunningham, Stacey J Winham, Melissa C Larson, Bryan M McCauley, Susanne Krüger Kjær, Allan Jensen, Joellen M Schildkraut, Andrew Berchuck, Daniel W Cramer, Kathryn L Terry, Helga B Salvesen, Line Bjorge, Penny M Webb, Peter Grant, Tanja Pejovic, Melissa Moffitt, Claus K Hogdall, Estrid Hogdall, James Paul, Rosalind Glasspool, Marcus Bernardini, Alicia Tone, David Huntsman, Michelle Woo, Aocs Group, Anna DeFazio, Catherine J Kennedy, Paul DP Pharoah, Stuart MacGregor, Georgia Chenevix-Trench
Nov 22, 2018
Genetic risk of Parkinson disease and progression:
Hirotaka Iwaki, Cornelis Blauwendraat, Hampton L Leonard, Ganqiang Liu, Jodi Maple-Grødem, Jean-Christophe Corvol, Lasse Pihlstrøm, Marlies van Nimwegen, Samantha J Hutten, Khanh-Dung H Nguyen, Jacqueline Rick, Shirley Eberly, Faraz Faghri, Peggy Auinger, Kirsten M Scott, Ruwani Wijeyekoon, Vivianna M Van Deerlin, Dena G Hernandez, Aaron G Day-Williams, Alexis Brice, Guido Alves, Alastair J Noyce, Ole-Bjørn Tysnes, Jonathan R Evans, David P Breen, Karol Estrada, Claire E Wegel, Fabrice Danjou, David K Simon, Bernard Ravina, Mathias Toft, Peter Heutink, Bastiaan R Bloem, Daniel Weintraub, Roger A Barker, Caroline H Williams-Gray, Bart P van de Warrenburg, Jacobus J van Hilten, Clemens R Scherzer, Andrew B Singleton, Mike A Nalls
May 03, 2019
Common pitfalls and recommendations for using machine learning to detect and prognosticate for COVID-19 using chest radiographs and CT scans
Michael Roberts, Derek Driggs, Matthew Thorpe, Julian Gilbey, Michael Yeung, Stephan Ursprung, Angelica I. Aviles-Rivero, Christian Etmann, Cathal McCague, Lucian Beer, Jonathan R. Weir-McCall, Zhongzhao Teng, Effrossyni Gkrania-Klotsas, James H. F. Rudd, Evis Sala, Carola-Bibiane Schönlieb, Alessandro Ruggiero, Anna Korhonen, Emily Jefferson, Emmanuel Ako, Georg Langs, Ghassem Gozaliasl, Guang Yang, Helmut Prosch, Jacobus Preller, Jan Stanczuk, Jing Tang, Johannes Hofmanninger, Judith Babar, Lorena Escudero Sánchez, Muhunthan Thillai, Paula Martin Gonzalez, Philip Teare, Xiaoxiang Zhu, Mishal Patel, Conor Cafolla, Hojjat Azadbakht, Joseph Jacob, Josh Lowe, Kang Zhang, Kyle Bradley, Marcel Wassin, Markus Holzer, Kangyu Ji, Maria Delgado Ortet, Tao Ai, Nicholas Walton, Pietro Lio, Samuel Stranks, Tolou Shadbahr, Weizhe Lin, Yunfei Zha, Zhangming Niu
Mar 18, 2021
Abstract: Machine learning methods offer great promise for fast and accurate detection and prognostication of coronavirus disease 2019 (COVID-19) from standard-of-care chest radiographs (CXR) and chest computed tomography (CT)...
Cognitive training and remediation interventions for substance use disorders
Antonio Verdejo-Garcia, Tara Rezapour, Emily Giddens, Arash Khojasteh Zonoozi, Parnian Rafei, Jamie Berry, Alfonso Caracuel, Marc L Copersino, Matt Field, Eric L Garland, Valentina Lorenzetti, Leandro Malloy-Diniz, Victoria Manning, Ely M Marceau, David L Pennington, Justin C Strickland, Reinout Wiers, Rahia Fairhead, Alexandra Anderson, Morris Bell, Wouter J Boendermaker, Samantha Brooks, Raimondo Bruno, Salvatore Campanella, Janna Cousijn, W Miles Cox, Andrew C Dean, Karen D Ersche, Ingmar Franken, Brett Froeliger, Pedro Gamito, Thomas E Gladwin, Priscila D Goncalves, Katrijn Houben, Joanna Jacobus, Andrew Jones, Anne M Kaag, Johannes Lindenmeyer, Elly McGrath, Talia Nardo, Jorge Oliveira, Charlotte R Pennington, Kelsey Perrykkad, Hugh Piercy, Claudia I Rupp, Mieke HJ Schulte, Lindsay M Squeglia, Petra Staiger, Dan J Stein, Jeff Stein, Maria Stein, William W Stoops, Mary Sweeney, Katie Witkiewitz, Steven P Woods, Richard Yi, Min Zhao, Hamed Ekhtiari
Jan 04, 2023
AIMS: Substance use disorders (SUD) are associated with cognitive deficits that are not always addressed in current treatments, and this hampers recovery. Cognitive training and remediation interventions are well suited to fill...
Differences in the Presentation and Progression of Parkinson's Disease by Sex.
Hirotaka Iwaki, Cornelis Blauwendraat, Hampton L Leonard, Mary B Makarious, Jonggeol J Kim, Ganqiang Liu, Jodi Maple-Grødem, Jean-Christophe Corvol, Lasse Pihlstrøm, Marlies van Nimwegen, Luba Smolensky, Ninad Amondikar, Samantha J Hutten, Mark Frasier, Khanh-Dung H Nguyen, Jacqueline Rick, Shirley Eberly, Faraz Faghri, Peggy Auinger, Kirsten M Scott, Ruwani Wijeyekoon, Vivianna M Van Deerlin, Dena G Hernandez, Raphael J Gibbs, Aaron G Day-Williams, Alexis Brice, Guido Alves, Alastair J Noyce, Ole-Bjørn Tysnes, Jonathan R Evans, David P Breen, Karol Estrada, Claire E Wegel, Fabrice Danjou, David K Simon, Ole A Andreassen, Bernard Ravina, Mathias Toft, Peter Heutink, Bastiaan R Bloem, Daniel Weintraub, Roger A Barker, Caroline H Williams-Gray, Bart P van de Warrenburg, Jacobus J van Hilten, Clemens R Scherzer, Andrew B Singleton, Mike A Nalls
Aug 11, 2020
The association between frailty and MRI features of cerebral small vessel disease
Ilse M. J. Kant, Henri J. M. M. Mutsaerts, Simone J. T. van Montfort, Myriam G. Jaarsma-Coes, Theodoor D. Witkamp, Georg Winterer, Claudia D. Spies, Jeroen Hendrikse, Arjen J. C. Slooter, Jeroen de Bresser, Franz Paul Armbruster, Axel Böcher, Diana Boraschi, Friedrich Borchers, Giacomo Della Camera, Edwin van Dellen, Ina Diehl, Thomas Bernd Dschietzig, Insa Feinkohl, Ariane Fillmer, Jürgen Gallinat, Bettina Hafen, Katarina Hartmann, Karsten Heidtke, Anja Helmschrodt, Paola Italiani, Bernd Ittermann, Roland Krause, Marion Kronabel, Simone Kühn, Gunnar Lachmann, Daniela Melillo, David K. Menon, Laura Moreno-López, Rudolf Mörgeli, Peter Nürnberg, Kwaku Ofosu, Maria Olbert, Malte Pietzsch, Tobias Pischon, Jacobus Preller, Jana Ruppert, Reinhard Schneider, Emmanuel A. Stamatakis, Simon Weber, Marius Weyer, Stefan Winzeck, Alissa Wolf, Fatima Yürek, Norman Zacharias
Aug 04, 2020
Abstract: Frailty is a common syndrome in older individuals that is associated with poor cognitive outcome. The underlying brain correlates of frailty are unclear. The aim of this study was to investigate the association between...
Genome-wide survival study identifies a novel synaptic locus and polygenic score for cognitive progression in Parkinson's disease.
Ganqiang Liu, Jiajie Peng, Zhixiang Liao, Joseph J Locascio, Jean-Christophe Corvol, Frank Zhu, Xianjun Dong, Jodi Maple-Grødem, Meghan C Campbell, Alexis Elbaz, Suzanne Lesage, Alexis Brice, Graziella Mangone, John H Growdon, Albert Y Hung, Michael A Schwarzschild, Michael T Hayes, Anne-Marie Wills, Todd M Herrington, Bernard Ravina, Ira Shoulson, Pille Taba, Sulev Kõks, Thomas G Beach, Florence Cormier-Dequaire, Guido Alves, Ole-Bjørn Tysnes, Joel S Perlmutter, Peter Heutink, Sami S Amr, Jacobus J van Hilten, Meike Kasten, Brit Mollenhauer, Claudia Trenkwalder, Christine Klein, Roger A Barker, Caroline H Williams-Gray, Johan Marinus, International Genetics of Parkinson Disease Progression (IGPP) Consortium, Clemens R Scherzer
Apr 19, 2022
A key driver of patients' well-being and clinical trials for Parkinson's disease (PD) is the course that the disease takes over time (progression and prognosis). To assess how genetic variation influences the progression of PD...
Apolipoprotein E4 Cognition Cognition Disorders Disease Progression Genetic Loci Genetic Predisposition to Disease Genome-Wide Association Study Glucosylceramidase Humans Longitudinal Studies Multifactorial Inheritance Mutation Parkinson Disease Proportional Hazards Models Risk Factors Survival Analysis Synapses
A critical analysis of the potential for EU Common Agricultural Policy measures to support wild pollinators on farmland.
Lorna J Cole, David Kleijn, Lynn V Dicks, Jane C Stout, Simon G Potts, Matthias Albrecht, Mario V Balzan, Ignasi Bartomeus, Penelope J Bebeli, Danilo Bevk, Jacobus C Biesmeijer, Róbert Chlebo, Anželika Dautartė, Nikolaos Emmanouil, Chris Hartfield, John M Holland, Andrea Holzschuh, Nieke TJ Knoben, Anikó Kovács-Hostyánszki, Yael Mandelik, Heleni Panou, Robert J Paxton, Theodora Petanidou, Miguel AA Pinheiro de Carvalho, Maj Rundlöf, Jean-Pierre Sarthou, Menelaos C Stavrinides, Maria Jose Suso, Hajnalka Szentgyörgyi, Bernard E Vaissière, Androulla Varnava, Montserrat Vilà, Romualdas Zemeckis, Jeroen Scheper
Mar 13, 2020
Agricultural intensification and associated loss of high-quality habitats are key drivers of insect pollinator declines. With the aim of decreasing the environmental impact of agriculture, the 2014 EU Common Agricultural Policy...
Clonal hematopoiesis is not significantly associated with COVID-19 disease severity.
Yifan Zhou, Ruba Shalhoub, Stephanie N Rogers, Shiqin Yu, Muxin Gu, Margarete A Fabre, Pedro M Quiros, Tae-Hoon Shin, Arch Diangson, Wenhan Deng, Shubha Anand, Wenhua Lu, Matthew Cullen, Anna L Godfrey, Jacobus Preller, Jerome Hadjadj, Emmanuelle Jouanguy, Aurélie Cobat, Laurent Abel, Frederic Rieux-Laucat, Benjamin Terrier, Alain Fischer, Lara Novik, Ingelise J Gordon, Larisa Strom, Martin R Gaudinski, Andrea Lisco, Irini Sereti, Thomas J Gniadek, Andrea Biondi, Paolo Bonfanti, Luisa Imberti, Clifton L Dalgard, Yu Zhang, Kerry Dobbs, Helen C Su, Luigi D Notarangelo, Colin O Wu, Peter JM Openshaw, Malcolm G Semple, Ziad Mallat, Kenneth Baillie, Cynthia E Dunbar, George S Vassiliou
Aug 16, 2022
Threats to an ecosystem service
Adam J Vanbergen, Mathilde Baude, Jacobus C Biesmeijer, Nicholas F Britton, Mark J F Brown, John Bryden, Giles E Budge, James C Bull, Claire Carvell, Andrew J Challinor, Christopher N Connolly, David J Evans, Edward J Feil, Mike P Garratt, Mark K Greco, Matthew S Heard, Vincent A A Jansen, M J Keeling, William E Kunin, Gay C Marris, Jane Memmott, James T Murray, Susan W Nicolson, Juliet L Osborne, Robert J Paxton, Christian W W Pirk, Chiara Polce, S G Potts, Nicholas K Priest, Nigel E Raine, S Roberts, Eugene V Ryabov, Sharoni Shafir, Mark D F Shirley, Stephen J Simpson, Philip C Stevenson, Graham N Stone, Mette Termansen, Geraldine A Wright
Jun 01, 2013
Insect pollinators of crops and wild plants are under threat globally and their decline or loss could have profound economic and environmental consequences. Here, we argue that multiple anthropogenic pressures - including...
/dk/atira/pure/sustainabledevelopmentgoals/zero_hunger name=SDG 2 - Zero Hunger /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being /dk/atira/pure/sustainabledevelopmentgoals/climate_action name=SDG 13 - Climate Action /dk/atira/pure/sustainabledevelopmentgoals/life_on_land name=SDG 15 - Life on Land
Threats to an ecosystem service
Adam J Vanbergen, Mathilde Baude, Jacobus C Biesmeijer, Nicholas F Britton, Mark J F Brown, John Bryden, Giles E Budge, James C Bull, Claire Carvell, Andrew J Challinor, Christopher N Connolly, David J Evans, Edward J Feil, Mike P Garratt, Mark K Greco, Matthew S Heard, Vincent A A Jansen, M J Keeling, William E Kunin, Gay C Marris, Jane Memmott, James T Murray, Susan W Nicolson, Juliet L Osborne, Robert J Paxton, Christian W W Pirk, Chiara Polce, S G Potts, Nicholas K Priest, Nigel E Raine, S Roberts, Eugene V Ryabov, Sharoni Shafir, Mark D F Shirley, Stephen J Simpson, Philip C Stevenson, Graham N Stone, Mette Termansen, Geraldine A Wright
Jun 01, 2013
Insect pollinators of crops and wild plants are under threat globally and their decline or loss could have profound economic and environmental consequences. Here, we argue that multiple anthropogenic pressures - including...
/dk/atira/pure/sustainabledevelopmentgoals/zero_hunger name=SDG 2 - Zero Hunger /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being /dk/atira/pure/sustainabledevelopmentgoals/climate_action name=SDG 13 - Climate Action /dk/atira/pure/sustainabledevelopmentgoals/life_on_land name=SDG 15 - Life on Land
Genomewide association study of Parkinson's disease clinical biomarkers in 12 longitudinal patients' cohorts.
Hirotaka Iwaki, Cornelis Blauwendraat, Hampton L Leonard, Jonggeol J Kim, Ganqiang Liu, Jodi Maple-Grødem, Jean-Christophe Corvol, Lasse Pihlstrøm, Marlies van Nimwegen, Samantha J Hutten, Khanh-Dung H Nguyen, Jacqueline Rick, Shirley Eberly, Faraz Faghri, Peggy Auinger, Kirsten M Scott, Ruwani Wijeyekoon, Vivianna M Van Deerlin, Dena G Hernandez, J Raphael Gibbs, International Parkinson's Disease Genomics Consortium, Kumaraswamy Naidu Chitrala, Aaron G Day-Williams, Alexis Brice, Guido Alves, Alastair J Noyce, Ole-Bjørn Tysnes, Jonathan R Evans, David P Breen, Karol Estrada, Claire E Wegel, Fabrice Danjou, David K Simon, Ole Andreassen, Bernard Ravina, Mathias Toft, Peter Heutink, Bastiaan R Bloem, Daniel Weintraub, Roger A Barker, Caroline H Williams-Gray, Bart P van de Warrenburg, Jacobus J van Hilten, Clemens R Scherzer, Andrew B Singleton, Mike A Nalls
Jul 29, 2019
Apolipoprotein E GBA Parkinson's Disease genomewide association study Adult Aged Aged 80 and over Antigens CD Biomarkers Cognitive Dysfunction Cohort Studies Cross-Sectional Studies Disease Progression Female Genome-Wide Association Study Glucosylceramidase Humans Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Longitudinal Studies Male Middle Aged Organic Cation Transport Proteins Parkinson Disease Phenotype Risk Assessment
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