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Loss of ap4s1 in zebrafish leads to neurodevelopmental defects resembling spastic paraplegia 52.
Angelica D'Amore, Alessandra Tessa, Valentina Naef, Maria Teresa Bassi, Andrea Citterio, Romina Romaniello, Gianluca Fichi, Daniele Galatolo, Serena Mero, Roberta Battini, Giulia Bertocci, Jacopo Baldacci, Federico Sicca, Federica Gemignani, Ivana Ricca, Anna Rubegni, Jennifer Hirst, Maria Marchese, Mustafa Sahin, Darius Ebrahimi-Fakhari, Filippo M Santorelli
May 18, 2020
Autosomal recessive spastic paraplegia 52 is caused by biallelic mutations in AP4S1 which encodes a subunit of the adaptor protein complex 4 (AP-4). Using next-generation sequencing, we identified three novel unrelated SPG52...
Modularity and stability in ecological communities
Networks composed of distinct, densely connected subsystems are called modular. In ecology, it has been posited that a modular organization of species interactions would benefit the dynamical stability of communities, even...
Effect of population abundances on the stability of large random ecosystems
Random matrix theory successfully connects the structure of interactions of large ecological communities to their ability to respond to perturbations. One of the most debated aspects of this approach is that so far studies...
Effect of population abundances on the stability of large random ecosystems
Random matrix theory successfully connects the structure of interactions of large ecological communities to their ability to respond to perturbations. One of the most debated aspects of this approach is that so far studies...
Modularity and stability in ecological communities
Networks composed of distinct, densely connected subsystems are called modular. In ecology, it has been posited that a modular organization of species interactions would benefit the dynamical stability of communities, even...
Guest-Modulated Circularly Polarized Luminescence by Ligand-to-Ligand Chirality Transfer in Heteroleptic PdII Coordination Cages.
Multicomponent metallo-supramolecular assembly allows the rational combination of different building blocks. Discrete multifunctional hosts with an accessible cavity can be prepared in a non-statistical fashion. We employ our...
Abundant serendipitous emission line sources with JWST/NIRSpec
Abstract
The James Webb Space Telescope will provide observational capabilities that far exceed those of current ground- or space-based instrumentation. In particular, the...
Extraction and Integration of Genetic Networks from Short-Profile Omic Data Sets
Mass spectrometry technologies are widely used in the fields of ionomics and metabolomics to simultaneously profile the intracellular concentrations of, e.g., amino acids or elements in genome-wide mutant libraries. These...
Coherent backscattering of light by an anisotropic biological network.
Gianni Jacucci, Olimpia D Onelli, Antonio De Luca, Jacopo Bertolotti, Riccardo Sapienza, Silvia Vignolini
Jan 07, 2019
The scattering strength of a random medium relies on the geometry and spatial distribution of its components as well as on their refractive index. Anisotropy can, therefore, play a major role in the optimization of the...
Extraction and Integration of Genetic Networks from Short-Profile Omic Data Sets.
Mass spectrometry technologies are widely used in the fields of ionomics and metabolomics to simultaneously profile the intracellular concentrations of, e.g., amino acids or elements in genome-wide mutant libraries. These...
Hybrid Fly Ash-Based Geopolymeric Foams
Giuseppina roviello, Laura Ricciotti, Antonio Jacopo Molino, Constantino Menna, Claudio Ferone, Domenico Asprone, Raffaele Cioffi, Veronica Ferrandiz-Mas, Pietro Russo, Oreste Tarallo
Jun 29, 2020
This research investigates the preparation and characterization of new organic–inorganic geopolymeric foams obtained by simultaneously reacting coal fly ash and an alkali silicate solution with polysiloxane oligomers. Foaming...
Hybrid Fly Ash-Based Geopolymeric Foams
Giuseppina roviello, Laura Ricciotti, Antonio Jacopo Molino, Constantino Menna, Claudio Ferone, Domenico Asprone, Raffaele Cioffi, Veronica Ferrandiz-Mas, Pietro Russo, Oreste Tarallo
Jun 29, 2020
This research investigates the preparation and characterization of new organic–inorganic geopolymeric foams obtained by simultaneously reacting coal fly ash and an alkali silicate solution with polysiloxane oligomers. Foaming...
Rapid Atlantification along the Fram Strait at the beginning of the 20th century.
Tommaso Tesi, Francesco Muschitiello, Gesine Mollenhauer, Stefano Miserocchi, Leonardo Langone, Chiara Ceccarelli, Giuliana Panieri, Jacopo Chiggiato, Alessio Nogarotto, Jens Hefter, Gianmarco Ingrosso, Federico Giglio, Patrizia Giordano, Lucilla Capotondi
Jan 07, 2022
The recent expansion of Atlantic waters into the Arctic Ocean represents undisputable evidence of the rapid changes occurring in this region. Understanding the past variability of this “Atlantification” is thus crucial in...
Simulating lattice gauge theories within quantum technologies
Mari Carmen Bañuls, Rainer Blatt, Jacopo Catani, Alessio Celi, Juan Ignacio Cirac, Marcello Dalmonte, Leonardo Fallani, Karl Jansen, Maciej Lewenstein, Simone Montangero, Christine A. Muschik, Benni Reznik, Enrique Rico, Luca Tagliacozzo, Karel Van Acoleyen, Frank Verstraete, Uwe-Jens Wiese, Matthew Wingate, Jakub Zakrzewski, Peter Zoller
Aug 04, 2020
Abstract: Lattice gauge theories, which originated from particle physics in the context of Quantum Chromodynamics (QCD), provide an important intellectual stimulus to further develop quantum information technologies. While one...
3D super-resolution deep-tissue imaging in living mice.
Mary Grace M Velasco, Mengyang Zhang, Jacopo Antonello, Peng Yuan, Edward S Allgeyer, Dennis May, Ons M'Saad, Phylicia Kidd, Andrew ES Barentine, Valentina Greco, Jaime Grutzendler, Martin J Booth, Joerg Bewersdorf
Aug 11, 2021
Stimulated emission depletion (STED) microscopy enables the three-dimensional (3D) visualization of dynamic nanoscale structures in living cells, offering unique insights into their organization. However, 3D-STED imaging deep...
25 Jahre retikuläre Chemie
Ralph Freund, Stefano Canossa, Seth M Cohen, Wei Yan, Hexiang Deng, Vincent Guillerm, Mohamed Eddaoudi, David G Madden, David Fairen‐Jimenez, Hao Lyu, Lauren K Macreadie, Zhe Ji, Yuanyuan Zhang, Bo Wang, Frederik Haase, Christof Wöll, Orysia Zaremba, Jacopo Andreo, Stefan Wuttke, Christian S Diercks
Aug 04, 2021
25 Years of Reticular Chemistry.
Ralph Freund, Stefano Canossa, Seth M Cohen, Wei Yan, Hexiang Deng, Vincent Guillerm, Mohamed Eddaoudi, David G Madden, David Fairen-Jimenez, Hao Lyu, Lauren K Macreadie, Zhe Ji, Yuanyuan Zhang, Bo Wang, Frederik Haase, Christof Wöll, Orysia Zaremba, Jacopo Andreo, Stefan Wuttke, Christian S Diercks
Aug 04, 2021
At its core, reticular chemistry has translated the precision and expertise of organic and inorganic synthesis to the solid state. While initial excitement over metal-organic frameworks (MOFs) and covalent organic frameworks...
Simulating lattice gauge theories within quantum technologies
Mari Carmen Bañuls, Rainer Blatt, Jacopo Catani, Alessio Celi, Juan Ignacio Cirac, Marcello Dalmonte, Leonardo Fallani, Karl Jansen, Maciej Lewenstein, Simone Montangero, Christine A. Muschik, Benni Reznik, Enrique Rico, Luca Tagliacozzo, Karel Van Acoleyen, Frank Verstraete, Uwe-Jens Wiese, Matthew Wingate, Jakub Zakrzewski, Peter Zoller
Aug 11, 2021
Abstract: Lattice gauge theories, which originated from particle physics in the context of Quantum Chromodynamics (QCD), provide an important intellectual stimulus to further develop quantum information technologies. While one...
α-Synuclein is a Novel Microtubule Dynamase.
Daniele Cartelli, Alessandro Aliverti, Alberto Barbiroli, Carlo Santambrogio, Enzio M Ragg, Francesca VM Casagrande, Francesca Cantele, Silvia Beltramone, Jacopo Marangon, Carmelita De Gregorio, Vittorio Pandini, Marco Emanuele, Evelina Chieregatti, Stefano Pieraccini, Staffan Holmqvist, Luigi Bubacco, Laurent Roybon, Gianni Pezzoli, Rita Grandori, Isabelle Arnal, Graziella Cappelletti
Jun 01, 2020
α-Synuclein is a presynaptic protein associated to Parkinson's disease, which is unstructured when free in the cytoplasm and adopts α helical conformation when bound to vesicles. After decades of intense studies, α-Synuclein...
Continuous population-level monitoring of SARS-CoV-2 seroprevalence in a large European metropolitan region.
Marc Emmenegger, Elena De Cecco, David Lamparter, Raphaël PB Jacquat, Julien Riou, Dominik Menges, Tala Ballouz, Daniel Ebner, Matthias M Schneider, Itzel Condado Morales, Berre Doğançay, Jingjing Guo, Anne Wiedmer, Julie Domange, Marigona Imeri, Rita Moos, Chryssa Zografou, Leyla Batkitar, Lidia Madrigal, Dezirae Schneider, Chiara Trevisan, Andres Gonzalez-Guerra, Alessandra Carrella, Irina L Dubach, Catherine K Xu, Georg Meisl, Vasilis Kosmoliaptsis, Tomas Malinauskas, Nicola Burgess-Brown, Ray Owens, Stephanie Hatch, Juthathip Mongkolsapaya, Gavin R Screaton, Katharina Schubert, John D Huck, Feimei Liu, Florence Pojer, Kelvin Lau, David Hacker, Elsbeth Probst-Müller, Carlo Cervia, Jakob Nilsson, Onur Boyman, Lanja Saleh, Katharina Spanaus, Arnold von Eckardstein, Dominik J Schaer, Nenad Ban, Ching-Ju Tsai, Jacopo Marino, Gebhard FX Schertler, Nadine Ebert, Volker Thiel, Jochen Gottschalk, Beat M Frey, Regina R Reimann, Simone Hornemann, Aaron M Ring, Tuomas PJ Knowles, Milo A Puhan, Christian L Althaus, Ioannis Xenarios, David I Stuart, Adriano Aguzzi
Feb 09, 2023
Effective public health measures against SARS-CoV-2 require granular knowledge of population-level immune responses. We developed a Tripartite Automated Blood Immunoassay (TRABI) to assess the IgG response against three...
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