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Regioselective Transition-Metal-Catalyzed C–H Functionalization of Anilines

Anilines are a vital synthetic core of pharmaceuticals, agrochemicals, natural products and building blocks. Metal-catalyzed C–H functionalization has emerged as a powerful tool to derivatize biologically relevant molecules....

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Regioselective Transition-Metal-Catalyzed C–H Functionalization of Anilines

Anilines are a vital synthetic core of pharmaceuticals, agrochemicals, natural products and building blocks. Metal-catalyzed C–H functionalization has emerged as a powerful tool to derivatize biologically relevant molecules....

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Beyond C2 and C3
The indole scaffold will continue to play a vital part in the future of drug discovery and agrochemical development. Because of this, the necessity for elegant techniques to enable selective C–H functionalization is vast. Early...
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Beyond C2 and C3
The indole scaffold will continue to play a vital part in the future of drug discovery and agrochemical development. Because of this, the necessity for elegant techniques to enable selective C–H functionalization is vast. Early...
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Board Unanimously Votes to Terminate Contract of Suspended President Jamie Comstock Williamson
Winthrop University
Jan 01, 0001
Winthrop University Board of Trustees members voted unanimously to terminate the contract of suspended President Jamie Comstock Williamson during a June 26 board meeting. Provost Debra Boyd has been appointed Acting President.
Published by: Winthrop University
Ruthenium(II)-Catalyzed C–H Functionalization Using the Oxazolidinone Heterocycle as a Weakly Coordinating Directing Group
Herein, we report the ruthenium-catalyzed ortho C–H alkenylation of a wide range of N-aryloxazolidinone scaffolds. Alkenylation was achieved with complete monoselectivity with a scope of 27 examples in 2-MeTHF. Yields ranged...
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Ruthenium(II)-Catalyzed C–H Functionalization Using the Oxazolidinone Heterocycle as a Weakly Coordinating Directing Group
Herein, we report the ruthenium-catalyzed ortho C–H alkenylation of a wide range of N-aryloxazolidinone scaffolds. Alkenylation was achieved with complete monoselectivity with a scope of 27 examples in 2-MeTHF. Yields ranged...
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Ruthenium catalyzed remote C4-selective C–H functionalisation of carbazoles via σ-activation
We report the C4-selective C–H alkylation of carbazole derivatives furnished with a pyrimidine directing group at N9. This was realized using ruthenium catalyzed r-activation methodology, whereby C–H activation at C1 enables the...
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Resilient High Catalytic Performance of Platinum Nanocatalysts with Porous Graphene Envelope.
Despite the innumerable developments of nanosized and well dispersed noble metal catalysts, the degradation of metal nanoparticle catalysts has proven to be a significant obstacle for the commercialization of the hydrogen fuel...
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Ruthenium-Catalyzed para-Selective C−H Alkylation of Aniline Derivatives
The para-selective C−H alkylation of aniline derivatives furnished with a pyrimidine auxiliary is herein reported. This reaction is proposed to take place via an N−H-activated cyclometalate formed in situ. Experimental and DFT...
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Ruthenium-Catalyzed para-Selective C−H Alkylation of Aniline Derivatives
The para-selective C−H alkylation of aniline derivatives furnished with a pyrimidine auxiliary is herein reported. This reaction is proposed to take place via an N−H-activated cyclometalate formed in situ. Experimental and DFT...
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Ruthenium catalyzed remote C4-selective C–H functionalisation of carbazoles via σ-activation
We report the C4-selective C–H alkylation of carbazole derivatives furnished with a pyrimidine directing group at N9. This was realized using ruthenium catalyzed r-activation methodology, whereby C–H activation at C1 enables the...
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Remote C6-Selective Ruthenium-Catalyzed C-H Alkylation of Indole Derivatives via σ-Activation

The site-selective functionalization of an indole template offers exciting possibilities for the derivatization of molecules with useful biological properties. Herein, we report the remote C6-selective C-H alkylation of...

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Remote C6-Selective Ruthenium-Catalyzed C-H Alkylation of Indole Derivatives via σ-Activation

The site-selective functionalization of an indole template offers exciting possibilities for the derivatization of molecules with useful biological properties. Herein, we report the remote C6-selective C-H alkylation of...

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Interview with W. H. Winborne
W. H. Winborne
Jan 01, 0001
In his July 1984 interview with Michael Cooke, W. H. Winborne described his work with the Orangeburg Area Sickle Cell Anemia Foundation, the Family Health Center, and the outreach programs related to the foundation. Winborne...
Published by: Winthrop University
Enantioselective S‐H Insertion Reactions of α‐Carbonyl Sulfoxonium Ylides
The first example of enantioselective S‐H insertion reactions of sulfoxonium ylides is reported. Under the influence of thiourea catalysis, excellent levels of enantiocontrol (up to 95% ee) and yields (up to 97%) are achieved...
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Enantioselective S‐H Insertion Reactions of α‐Carbonyl Sulfoxonium Ylides
The first example of enantioselective S‐H insertion reactions of sulfoxonium ylides is reported. Under the influence of thiourea catalysis, excellent levels of enantiocontrol (up to 95% ee) and yields (up to 97%) are achieved...
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Constraints on the evolution of the relationship between H i mass and halo mass in the last 12 Gyr
H Padmanabhan, G Kulkarni
Jul 26, 2017
The neutral hydrogen (H I) content of dark matter haloes forms an intermediate state in the baryon cycle that connects the hot shock-heated gas and cold star-forming gas in haloes. Measurement of the relationship between H I...
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