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Results: 1206
A suboptimal maternal diet combined with accelerated postnatal growth results in an altered aging profile in the thymus of male rats.
Jane L Tarry-Adkins, Catherine E Aiken, Thomas J Ashmore, Denise S Fernandez-Twinn, Jian-Hua Chen, Susan E Ozanne
Sep 05, 2018
Reduced fetal nutrition and rapid postnatal growth accelerates the aging phenotype in many organ systems; however, effects on the immune system are unclear. We addressed this by studying the thymus from a rat model of...
Telomere Length Analysis
Accelerated cellular aging is known to play an important role in the etiology of phenotypes associated with developmental programming, such as cardiovascular disease and type 2 diabetes. Telomere length analysis is a powerful...
Nutrition in early life and age-associated diseases.
Age-associated disease developmental programming MECHANISM Oxidative Stress Sub-optimal nutrition aging Animals Cardiovascular Diseases Cellular Senescence Chronic Disease Diabetes mellitus Type 2 Epigenesis Genetic Female Humans Models Animal Nutritional Status obesity Pregnancy prenatal exposure delayed effects
Impact of metformin treatment during pregnancy on maternal outcomes
Abstract: We systematically assessed the impact of metformin treatment on maternal pregnancy outcomes. PubMed, Ovid Embase, Medline, Web of Science, ClinicalTrials.gov and Cochrane databases were systematically searched...
Insulin-signalling dysregulation and inflammation is programmed trans-generationally in a female rat model of poor maternal nutrition.
Developmental programming phenotypes can be recapitulated in subsequent generations not directly exposed to the initial suboptimal intrauterine environment. A maternal low-protein diet during pregnancy and postnatal catch-up...
Maternal protein restriction affects postnatal growth and the expression of key proteins involved in lifespan regulation in mice.
We previously reported that maternal protein restriction in rodents influenced the rate of growth in early life and ultimately affected longevity. Low birth weight caused by maternal protein restriction followed by catch-up...
Interview with Jane West
Jane West
Jan 01, 0001
In her July 15, 2013 interview with Martha Manning, Jane West details her time at Winthrop as a Biology major in the 1960s. Briefly, West discusses student life and Winthrop traditions, but she provides insight into her life...
Published by: Winthrop University
Exploring Telomere Dynamics in Aging Male Rat Tissues
Jane L Tarry-Adkins, Catherine E Aiken, Laura Dearden, Denise S Fernandez-Twinn, Susan Ozanne
Sep 28, 2020
INTRODUCTION: Due to increasing lifespan, global aging rates are rising rapidly and age-associated diseases are increasing. To ensure that health span is concomitant with life span, a greater understanding of cellular mechanisms...
Interview with Jane Rawls
Jane Rawls
Jan 01, 0001
In her August 1, 2013 interview, Jane Rawls shares stories of her life as a student at Winthrop Training School in the 1960s and as "day student" in 1974. In particular, Rawls discusses life as a child and student in the 1960s....
Winthrop Training School Winthrop College kindergarten May Day Civil Rights Segregation Coeducation Oral History
Published by: Winthrop University
Efficacy and Side Effect Profile of Different Formulations of Metformin
Jane L. Tarry-Adkins, Imogen D. Grant, Susan E. Ozanne, Rebecca M. Reynolds, Catherine E. Aiken
Jul 28, 2021
Abstract: Introduction: Metformin is among the most frequently prescribed drugs worldwide for a variety of indications. Although metformin has several important advantages, for example being easy to store and administer, it is...
Decreased ovarian reserve, dysregulation of mitochondrial biogenesis, and increased lipid peroxidation in female mouse offspring exposed to an obesogenic maternal diet.
developmental programming lipoxygenase primordial follicle reproductive potential Animals Body Weight Diet High-Fat Female Gene Expression Profiling Lipid Peroxidation Maternal Nutritional Physiological Phenomena Mice Inbred C57BL Mitochondria Organ Size Ovarian Reserve Ovary Pregnancy prenatal exposure delayed effects Reverse Transcriptase Polymerase Chain Reaction
Maternal antioxidant treatment protects adult offspring against memory loss and hippocampal atrophy in a rodent model of developmental hypoxia
Emily J. Camm, Christine M. Cross, Andrew D. Kane, Jane L. Tarry‐Adkins, Susan E. Ozanne, Dino A. Giussani
Apr 23, 2021
Abstract: Chronic fetal hypoxia is one of the most common outcomes in complicated pregnancy in humans. Despite this, its effects on the long‐term health of the brain in offspring are largely unknown. Here, we investigated in...
Published by: The FASEB Journal
Interview with Jane H. Adams - OH 241
Jane H. Adams
Jan 01, 0001
In her 1996 interview with Ron Chepesiuk, Jane Adams described her time as a 1960s radical. She covered various topics, including bohemians, socialism, beatniks, civil rights, women's liberation and consciousness, the Vietnam...
University school Socialism bohemians beatniks (beats) Student Peace Union (SPU) Freedom Summer SNCC (Student Nonviolent Coordinating Committee) Jim Crow Herbert Lee Civil Rights women's consciousness COFO (Jackson County of Federated Organizations) Fidel Castro Vietnam War SDS (Students for a Democratic Society) YPSL (Young People Socialist League) Clark Kissinger Régis Debray Ché Guevara Revolution in the Revolution Progressive Labor (PL) prairie populist Dave Dellinger Bernardine Dohrn feminism Women's Liberation Anita Hill-Clarence Thomas psychedelics counterculture World War II ERAP (Economic Research and Action Project) LSD (lysergic acid diethylamide) Democratic Convention of 1968 Weathermen James Chaney Andrew Goodman Michael Schwerner Oral History
Published by: Winthrop University
Poor maternal nutrition and accelerated postnatal growth induces an accelerated aging phenotype and oxidative stress in skeletal muscle of male rats
Jane L Tarry-Adkins, Denise S Fernandez-Twinn, Jian Hua Chen, Iain P Hargreaves, Viruna Neergheen, Catherine E Aiken, Susan E Ozanne
Apr 05, 2018
developmental programming Mitochondria Oxidative Stress Skeletal muscle aging Animals antioxidants Biomarkers DNA Damage Diet Female Growth and Development Inflammation Male Maternal Nutritional Physiological Phenomena Muscle Skeletal NF-kappa B Oxidants Oxidative Stress Phenotype Rats Wistar Telomere Shortening
Coenzyme Q10 Prevents Insulin Signaling Dysregulation and Inflammation Prior to Development of Insulin Resistance in Male Offspring of a Rat Model of Poor Maternal Nutrition and Accelerated Postnatal Growth.
Jane L Tarry-Adkins, Denise S Fernandez-Twinn, Ralitsa Madsen, Jian-Hua Chen, Asha Carpenter, Iain P Hargreaves, Josie M McConnell, Susan E Ozanne
Aug 03, 2015
Transgenerational Developmental Programming of Ovarian Reserve.
Maternal diet-induced obesity programs cardiovascular dysfunction in adult male mouse offspring independent of current body weight.
Heather L Blackmore, Youguo Niu, Denise S Fernandez-Twinn, Jane L Tarry-Adkins, Dino A Giussani, Susan E Ozanne
Mar 20, 2015
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