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Interview with Janet Cotter
Janet Alexander Cotter
Jan 01, 0001
Interview with Janet Cotter, member of the South Carolina Mother of the Year Selection Committee.
Published by: Winthrop University
Janet Gray Selected as Recipient of Kinard Award
Winthrop University
Jan 01, 0001
During the 11 a.m. ceremony at Winthrop Coliseum, the university will award 279 degrees to graduating seniors and an honorary degree of Doctor of Humane Letters to Charlotte, N.C., businessman and philanthropist Irwin "Ike"...
Published by: Winthrop University
Evidence for biased agonists and antagonists at the endothelin receptors.
Janet J Maguire
Feb 18, 2016
Apelin, Elabela/Toddler, and biased agonists as novel therapeutic agents in the cardiovascular system.
Advances in therapeutic peptides targeting G protein-coupled receptors.
Anthony P Davenport, Conor CG Scully, Chris de Graaf, Alastair JH Brown, Janet J Maguire
Jan 22, 2020
Genes encoding ACE2, TMPRSS2 and related proteins mediating SARS-CoV-2 viral entry are upregulated with age in human cardiomyocytes.
Emma L Robinson, Kanar Alkass, Olaf Bergmann, Janet J Maguire, H Llewelyn Roderick, Anthony P Davenport
Aug 20, 2020
Age (>70 years), case fatality rate (CFR,10.2%) and coexisting conditions, particularly cardiovascular disease (CFR,10.5%) and hypertension (CFR,6.0%), are independent predictors of adverse outcome for 45,000 COVID-19 patients...
angiotensin apelin Bradykinin covid-19 Human cardiomyocytes RNA-sequencing SARS-CoV-2 aging Angiotensin-Converting Enzyme 2 Angiotensins apelin Betacoronavirus Bradykinin covid-19 Cathepsin B Cathepsin L Coronavirus Infections Humans Myocardium Myocytes Cardiac Pandemics Peptidyl-Dipeptidase A Pneumonia Viral SARS-CoV-2 Serine Endopeptidases Virus Attachment Virus Internalization
In vitro metabolism of synthetic Elabela/Toddler (ELA-32) peptide in human plasma and kidney homogenates analyzed with mass spectrometry and validation of endogenous peptide quantification in tissues by ELISA.
Duuamene Nyimanu, Richard G Kay, Rhoda E Kuc, Alastair JH Brown, Fiona M Gribble, Janet J Maguire, Anthony P Davenport
Sep 01, 2021
Expanding the apelin receptor pharmacological toolbox using novel fluorescent ligands.
Thomas L Williams, Robyn GC Macrae, Rhoda E Kuc, Alastair JH Brown, Janet J Maguire, Anthony P Davenport
Mar 23, 2023
The therapeutic potential of apelin in kidney disease.
Fiona A Chapman, Duuamene Nyimanu, Janet J Maguire, Anthony P Davenport, David E Newby, Neeraj Dhaun
Sep 14, 2021
Chronic kidney disease (CKD) is a leading cause of global morbidity and mortality and is independently associated with cardiovascular disease. The mainstay of treatment for CKD is blockade of the renin-angiotensin-aldosterone...
Published by: Nature reviews. Nephrology
Design, characterization, and first-in-human study of the vascular actions of a novel biased apelin receptor agonist.
Aimee L Brame, Janet J Maguire, Peiran Yang, Alex Dyson, Rubben Torella, Joseph Cheriyan, Mervyn Singer, Robert C Glen, Ian B Wilkinson, Anthony P Davenport
Apr 29, 2015
[Pyr1]apelin-13 pulmonary arterial hypertension β-arrestin G-protein coupled receptors Animals Antipyretics Apelin Receptors Disease Models Animal GTP-Binding Proteins Humans Hypertension Pulmonary Intercellular Signaling Peptides and Proteins Male Rats Rats Wistar Receptors G-Protein-Coupled Research Design Saphenous Vein Vasodilation
The G Protein Biased Small Molecule Apelin Agonist CMF-019 is Disease Modifying in Endothelial Cell Apoptosis In Vitro and Induces Vasodilatation Without Desensitisation In Vivo.
Cai Read, Duuamene Nyimanu, Peiran Yang, Rhoda E Kuc, Thomas L Williams, Christopher M Fitzpatrick, Richard Foster, Robert C Glen, Janet J Maguire, Anthony P Davenport
Dec 04, 2020
Signaling through the apelin receptor is beneficial for a number of diseases including pulmonary arterial hypertension. The endogenous small peptides, apelin and elabela/toddler, are downregulated in pulmonary arterial...
The G Protein Biased Small Molecule Apelin Agonist CMF-019 is Disease Modifying in Endothelial Cell Apoptosis In Vitro and Induces Vasodilatation Without Desensitisation In Vivo
Cai Read, Duuamene Nyimanu, Peiran Yang, Rhoda E. Kuc, Thomas L. Williams, Christopher M. Fitzpatrick, Richard Foster, Robert C. Glen, Janet J. Maguire, Anthony P. Davenport
Mar 10, 2021
Signaling through the apelin receptor is beneficial for a number of diseases including pulmonary arterial hypertension. The endogenous small peptides, apelin and elabela/toddler, are downregulated in pulmonary arterial...
Trans-myocardial Extraction of Endothelin-1 Correlates with Increased Microcirculatory Resistance following Percutaneous Coronary Intervention.
George R Abraham, Duuamene Nyimanu, Rhoda E Kuc, Janet J Maguire, Anthony P Davenport, Stephen P Hoole
Nov 19, 2022
OBJECTIVE: Coronary microvascular dysfunction (CMD) can complicate successful percutaneous coronary intervention (PCI). The potent endogenous vasoconstrictor peptide Endothelin-1 (ET-1) may be an important mediator. To...
The CCR5 chemokine receptor mediates vasoconstriction and stimulates intimal hyperplasia in human vessels in vitro.
Janet J Maguire, Katie L Jones, Rhoda E Kuc, Murray CH Clarke, Martin R Bennett, Anthony P Davenport
Aug 18, 2014
Apelin-36-[L28A] and Apelin-36-[L28C(30kDa-PEG)] peptides that improve diet induced obesity are G protein biased ligands at the apelin receptor.
Duuamene Nyimanu, Rhoda E Kuc, Thomas L Williams, Maria Bednarek, Philip Ambery, Lutz Jermutus, Janet J Maguire, Anthony P Davenport
Aug 29, 2019
apelin apelin receptor Biased ligands cardiovascular disease GPCR human heart METABOLIC DISEASE Receptor affinity Adult Animals apelin Apelin Receptors Binding Competitive CHO Cells Colforsin Complex Mixtures Cricetulus Cyclic AMP Female Heart Ventricles Humans Ligands Male Middle Aged Peptides Protein Binding Rats Rats Sprague-Dawley beta-Arrestins
Differential expression in humans of the viral entry receptor ACE2 compared with the short deltaACE2 isoform lacking SARS-CoV-2 binding sites.
Thomas L Williams, Gregory Strachan, Robyn GC Macrae, Rhoda E Kuc, Duuamene Nyimanu, Anna L Paterson, Sanjay Sinha, Janet J Maguire, Anthony P Davenport
Jan 05, 2022
Plasma levels of apelin are reduced in patients with liver fibrosis and cirrhosis but are not correlated with circulating levels of bone morphogenetic protein 9 and 10.
Nicola E Owen, Duuamene Nyimanu, Rhoda E Kuc, Paul D Upton, Nicholas W Morrell, Graeme J Alexander, Janet J Maguire, Anthony P Davenport
Nov 03, 2020
Development and validation of an LC-MS/MS method for detection and quantification of in vivo derived metabolites of [Pyr1]apelin-13 in humans.
Duuamene Nyimanu, Richard G Kay, Petra Sulentic, Rhoda E Kuc, Philip Ambery, Lutz Jermutus, Frank Reimann, Fiona M Gribble, Joseph Cheriyan, Janet J Maguire, Anthony P Davenport
Dec 05, 2019
[Pyr1]apelin-13 is the predominant apelin peptide isoform in the human cardiovascular system and plasma. To date, few studies have investigated [Pyr1]apelin-13 metabolism in vivo in rats with no studies examining its stability...
Development and validation of an LC-MS/MS method for detection and quantification of in vivo derived metabolites of [Pyr 1 ]apelin-13 in humans
Duuamene Nyimanu, Richard G. Kay, Petra Sulentic, Rhoda E. Kuc, Philip Ambery, Lutz Jermutus, Frank Reimann, Fiona M. Gribble, Joseph Cheriyan, Janet J. Maguire, Anthony P. Davenport
Dec 26, 2020
Abstract: [Pyr1]apelin-13 is the predominant apelin peptide isoform in the human cardiovascular system and plasma. To date, few studies have investigated [Pyr1]apelin-13 metabolism in vivo in rats with no studies examining its...
Apelin is expressed throughout the human kidney, is elevated in chronic kidney disease & associates independently with decline in kidney function.
Duuamene Nyimanu, Fiona A Chapman, Peter J Gallacher, Rhoda E Kuc, Thomas L Williams, David E Newby, Janet J Maguire, Anthony P Davenport, Neeraj Dhaun
Jul 20, 2022
AIMS: Chronic kidney disease (CKD) is common and cardiovascular disease (CVD) is its commonest complication. The apelin system is a potential therapeutic target for CVD but data relating to apelin in CKD are limited. We examined...
The G Protein Biased Small Molecule Apelin Agonist CMF-019 is Disease Modifying in Endothelial Cell Apoptosis In Vitro and Induces Vasodilatation Without Desensitisation In Vivo
Cai Read, Duuamene Nyimanu, Peiran Yang, Rhoda E. Kuc, Thomas L. Williams, Christopher M. Fitzpatrick, Richard Foster, Robert C. Glen, Janet J. Maguire, Anthony P. Davenport
Feb 04, 2021
Signaling through the apelin receptor is beneficial for a number of diseases including pulmonary arterial hypertension. The endogenous small peptides, apelin and elabela/toddler, are downregulated in pulmonary arterial...
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