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Results: 417
Circulating peroxiredoxin 4 and type 2 diabetes risk
Ali Abbasi, Eva Corpeleijn, Ron T Gansevoort, Rijk OB Gans, Joachim Struck, Janin Schulte, Hans L Hillege, Pim van der Harst, Ronald P Stolk, Gerjan Navis, Stephan JL Bakker
Jul 03, 2014
Protein phase separation hotspots at the presynapse.
Janin Lautenschläger
Mar 13, 2022
Fundamental discoveries have shaped our molecular understanding of presynaptic processes, such as neurotransmitter release, active zone organization and mechanisms of synaptic vesicle (SV) recycling. However, certain regulatory...
Protein phase separation hotspots at the presynapse.
Janin Lautenschläger
Feb 09, 2022
Fundamental discoveries have shaped our molecular understanding of presynaptic processes, such as neurotransmitter release, active zone organization and mechanisms of synaptic vesicle (SV) recycling. However, certain regulatory...
Protein phase separation hotspots at the presynapse
Janin Lautenschläger
Mar 04, 2022
Fundamental discoveries have shaped our molecular understanding of presynaptic processes, such as neurotransmitter release, active zone organization and mechanisms of synaptic vesicle (SV) recycling. However, certain regulatory...
Mitochondrial degradation of amyloidogenic proteins - A new perspective for neurodegenerative diseases.
This perspective article outlines mechanisms of mitochondrial import and protein degradation and how these have been linked to alpha-synuclein and Amyloid beta (Aβ) homeostasis. Our aim is to underpin and stimulate the debate on...
Modulation of antigen presenting cell functions during chronic HPV infection.
High-risk human papillomaviruses (HR-HPV) infect basal keratinocytes, where in some individuals they evade host immune responses and persist. Persistent HR-HPV infection of the cervix causes precancerous neoplasia that can...
An Easy-to-Implement Protocol for Preparing Postnatal Ventral Mesencephalic Cultures.
Janin Lautenschläger, Eugene V Mosharov, Ellen Kanter, David Sulzer, Gabriele S Kaminski Schierle
Apr 19, 2018
Postnatally derived cultures of ventral mesencephalic neurons offer several crucial advantages over embryonic ventral mesencephalic cultures, including a higher content of TH-positive cells and the ability to derive cells from...
The biological and clinical significance of emerging SARS-CoV-2 variants.
Kaiming Tao, Philip L Tzou, Janin Nouhin, Ravindra K Gupta, Tulio de Oliveira, Sergei L Kosakovsky Pond, Daniela Fera, Robert W Shafer
Oct 19, 2021
The past several months have witnessed the emergence of SARS-CoV-2 variants with novel spike protein mutations that are influencing the epidemiological and clinical aspects of the COVID-19 pandemic. These variants can increase...
Intramitochondrial proteostasis is directly coupled to α-synuclein and amyloid β1-42 pathologies.
Janin Lautenschläger, Sara Wagner-Valladolid, Amberley D Stephens, Ana Fernández-Villegas, Colin Hockings, Ajay Mishra, James D Manton, Marcus J Fantham, Meng Lu, Eric J Rees, Clemens F Kaminski, Gabriele S Kaminski Schierle
Jun 02, 2020
HtrA serine peptidase 2 HtrA2/Omi Lon peptidase 1 mitochondrial Lon protease Parkinson Disease amyloid-β (AB) amyloid-β (Aβ ) Mitochondria neurodegeneration Neurodegenerative disease protein aggregation Protein homeostasis α-synuclein α-synuclein (a-synuclein) Amyloid beta-Peptides Animals Cell Line Tumor Female High-Temperature Requirement A Serine Peptidase 2 Humans Mitochondria Nerve Tissue Proteins Parkinson Disease Peptide Fragments Proteostasis Rats Rats Sprague-Dawley Serine-Arginine Splicing Factors ALPHA-SYNUCLEIN
The effect of gadolinium-based contrast agent administration on magnetic resonance fingerprinting-based T 1 relaxometry in patients with prostate cancer
Nikita Sushentsev, Joshua D. Kaggie, Guido Buonincontri, Rolf F. Schulte, Martin J. Graves, Vincent J. Gnanapragasam, Tristan Barrett
Nov 24, 2020
Abstract: Magnetic resonance fingerprinting (MRF) is a rapidly developing fast quantitative mapping technique able to produce multiple property maps with reduced sensitivity to motion. MRF has shown promise in improving the...
The Association Between Food Addiction and Weight Status in School-Age Children and Adolescents.
BACKGROUND: The association between food addiction (FA) and weight status in children and adolescents remains poorly understood. This study aimed to elucidate the association between FA and weight status using the validated...
A rapid intrinsic heart rate resetting response with thermal acclimation in rainbow trout, Oncorhynchus mykiss.
Rachel L Sutcliffe, Shaorong Li, Matthew JH Gilbert, Patricia M Schulte, Kristi M Miller, Anthony P Farrell
Apr 28, 2020
Linking Diversity and Mental Health
Niklas Schulte, Friedrich M Götz, Fabienne Partsch, Tim Goldmann, Lea Smidt, Bertolt Meyer
Jul 14, 2020
Diversity and psychological health issues at the workplace are pressing issues in today's organizations. However, research linking two fields is scant. To bridge this gap, drawing from team faultline research, social...
High-throughput surface marker screen on primary human breast tissues reveals further cellular heterogeneity.
BACKGROUND: Normal human breast tissues are a heterogeneous mix of epithelial and stromal subtypes in different cell states. Delineating the spectrum of cellular heterogeneity will provide new insights into normal cellular...
Diagnostic uncertainty in pediatric chronic pain
Alexandra Neville, Abbie Jordan, Tamar Pincus, Cara Nania, Fiona Schulte, Keith Yeates, Melanie Noel
Nov 30, 2020
Introduction: Diagnostic uncertainty (DU), which is the perception that a label or explanation for a patient’s health problem is missing or inaccurate, has been linked to distress, anxiety, and difficulty coping among adults...
Diagnostic uncertainty in pediatric chronic pain
Alexandra Neville, Abbie Jordan, Tamar Pincus, Cara Nania, Fiona Schulte, Keith Yeates, Melanie Noel
Nov 30, 2020
Introduction: Diagnostic uncertainty (DU), which is the perception that a label or explanation for a patient’s health problem is missing or inaccurate, has been linked to distress, anxiety, and difficulty coping among adults...
The effect of gadolinium-based contrast agent administration on magnetic resonance fingerprinting-based T1 relaxometry in patients with prostate cancer.
Nikita Sushentsev, Joshua D Kaggie, Guido Buonincontri, Rolf F Schulte, Martin J Graves, Vincent J Gnanapragasam, Tristan Barrett
Nov 04, 2020
Index sorting resolves heterogeneous murine hematopoietic stem cell populations.
Reiner Schulte, Nicola K Wilson, Janine CM Prick, Chiara Cossetti, Michal K Maj, Berthold Gottgens, David G Kent
Jun 09, 2015
The Association Between Food Addiction and Weight Status in School-Age Children and Adolescents.
Background: The association between food addiction (FA) and weight status in children and adolescents remains poorly understood. This study aimed to elucidate the association between FA and weight status using the validated...
Characterization and correction of center-frequency effects in X-nuclear eddy current compensations on a clinical MR system.
Mary A McLean, R Scott Hinks, Joshua D Kaggie, Ramona Woitek, Frank Riemer, Martin J Graves, Dominick JO McIntyre, Ferdia A Gallagher, Rolf F Schulte
Oct 30, 2020
C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction.
Janin Lautenschläger, Amberley D Stephens, Giuliana Fusco, Florian Ströhl, Nathan Curry, Maria Zacharopoulou, Claire H Michel, Romain Laine, Nadezhda Nespovitaya, Marcus Fantham, Dorothea Pinotsi, Wagner Zago, Paul Fraser, Anurag Tandon, Peter St George-Hyslop, Eric Rees, Jonathan J Phillips, Alfonso De Simone, Clemens F Kaminski, Gabriele S Kaminski Schierle
Jul 31, 2018
Alpha-synuclein is known to bind to small unilamellar vesicles (SUVs) via its N terminus, which forms an amphipathic alpha-helix upon membrane interaction. Here we show that calcium binds to the C terminus of alpha-synuclein...
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