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A global synthesis of high-resolution stable isotope data from benthic foraminifera of the last deglaciation.
Juan Muglia, Stefan Mulitza, Janne Repschläger, Andreas Schmittner, Lester Lembke-Jene, Lorraine Lisiecki, Alan Mix, Rajeev Saraswat, Elizabeth Sikes, Claire Waelbroeck, Julia Gottschalk, Jörg Lippold, David Lund, Gema Martinez-Mendez, Elisabeth Michel, Francesco Muschitiello, Sushant Naik, Yusuke Okazaki, Lowell Stott, Antje Voelker, Ning Zhao
Apr 11, 2023
We present the first version of the Ocean Circulation and Carbon Cycling (OC3) working group database, of oxygen and carbon stable isotope ratios from benthic foraminifera in deep ocean sediment cores from the Last Glacial...
Published by: Scientific data
A global synthesis of high-resolution stable isotope data from benthic foraminifera of the last deglaciation.
Juan Muglia, Stefan Mulitza, Janne Repschläger, Andreas Schmittner, Lester Lembke-Jene, Lorraine Lisiecki, Alan Mix, Rajeev Saraswat, Elizabeth Sikes, Claire Waelbroeck, Julia Gottschalk, Jörg Lippold, David Lund, Gema Martinez-Mendez, Elisabeth Michel, Francesco Muschitiello, Sushant Naik, Yusuke Okazaki, Lowell Stott, Antje Voelker, Ning Zhao
Mar 10, 2023
Running coupling and power corrections in nonlinear evolution at the high-energy limit.
A main feature of high-energy scattering in QCD is saturation in the number density of gluons.
This phenomenon is described by non-linear evolution equations, JIMWLK and BK, which have
been derived at leading logarithmic...
Cryo-EM structure of ssDNA bacteriophage ΦCjT23 provides insight into early virus evolution.
Nejc Kejzar, Elina Laanto, Ilona Rissanen, Vahid Abrishami, Muniyandi Selvaraj, Sylvain Moineau, Janne Ravantti, Lotta-Riina Sundberg, Juha T Huiskonen
Jan 04, 2023
The origin of viruses remains an open question. While lack of detectable sequence similarity hampers the analysis of distantly related viruses, structural biology investigations of conserved capsid protein structures facilitate...
Physical Activity and Abdominal Fat Distribution in Greenland.
Inger Katrine Dahl-Petersen, Søren Brage, Peter Bjerregaard, Janne Schurmann Tolstrup, Marit Eika Jørgensen
Nov 23, 2017
PURPOSE: We examined how total volume of physical activity and reallocation of time spent at various objectively measured intensities of physical activity (PA) were associated with overall and abdominal fat distribution in adult...
Shear Alignment of Bola-Amphiphilic Arginine-Coated Peptide Nanotubes.
Ian W Hamley, Samuel Burholt, Jessica Hutchinson, Valeria Castelletto, Emerson Rodrigo da Silva, Wendel Alves, Philipp Gutfreund, Lionel Porcar, Rajeev Dattani, Daniel Hermida-Merino, Gemma Newby, Mehedi Reza, Janne Ruokolainen, Joanna Stasiak
May 16, 2019
The bola-amphiphilic arginine-capped peptide RFL4RF self-assembles into nanotubes in aqueous solution. The nanostructure and rheology are probed by in situ simultaneous rheology/small-angle scattering experiments including...
Ecological networks of dissolved organic matter and microorganisms under global change.
Ang Hu, Mira Choi, Andrew J Tanentzap, Jinfu Liu, Kyoung-Soon Jang, Jay T Lennon, Yongqin Liu, Janne Soininen, Xiancai Lu, Yunlin Zhang, Ji Shen, Jianjun Wang
Jul 24, 2022
Microbes regulate the composition and turnover of organic matter. Here we developed a framework called Energy-Diversity-Trait integrative Analysis to quantify how dissolved organic matter and microbes interact along global...
Ecological networks of dissolved organic matter and microorganisms under global change.
Ang Hu, Mira Choi, Andrew Tanentzap, Jinfu Liu, Kyoung-Soon Jang, Jay T Lennon, Yongqin Liu, Janne Soininen, Xiancai Lu, Yunlin Zhang, Ji Shen, Jianjun Wang
Jun 29, 2022
Microbes regulate the composition and turnover of organic matter. Here we developed a framework called Energy-Diversity-Trait integrative Analysis to quantify how dissolved organic matter and microbes interact along global...
Cryo-EM structure of ssDNA bacteriophage ΦCjT23 provides insight into early virus evolution.
Nejc Kejzar, Elina Laanto, Ilona Rissanen, Vahid Abrishami, Muniyandi Selvaraj, Sylvain Moineau, Janne Ravantti, Lotta-Riina Sundberg, Juha T Huiskonen
Dec 08, 2022
The origin of viruses remains an open question. While lack of detectable sequence similarity hampers the analysis of distantly related viruses, structural biology investigations of conserved capsid protein structures facilitate...
Impact of Adalimumab Treatment on Interleukin-17 and Interleukin-17 Receptor Expression in Skin and Synovium of Psoriatic Arthritis Patients with Mild Psoriasis.
Proteogenomics and Hi-C reveal transcriptional dysregulation in high hyperdiploid childhood acute lymphoblastic leukemia.
Minjun Yang, Mattias Vesterlund, Ioannis Siavelis, Larissa H Moura-Castro, Anders Castor, Thoas Fioretos, Rozbeh Jafari, Henrik Lilljebjörn, Duncan T Odom, Linda Olsson, Naveen Ravi, Eleanor L Woodward, Louise Harewood, Janne Lehtiö, Kajsa Paulsson
Jun 20, 2019
Hyperdiploidy, i.e. gain of whole chromosomes, is one of the most common genetic features of childhood acute lymphoblastic leukemia (ALL), but its pathogenetic impact is poorly understood. Here, we report a proteogenomic...
Adolescent Aneuploidy CCCTC-Binding Factor Cell Cycle Proteins Child Child Preschool Chromatin Chromosomal Proteins Non-Histone Chromosome Aberrations Core Binding Factor Alpha 2 Subunit Female Gene Dosage Gene Expression Profiling Gene Expression Regulation Leukemic Genome Human Genome-Wide Association Study Humans Infant Infant Newborn Male Precursor Cell Lymphoblastic Leukemia-Lymphoma Proteogenomics Proteome Proto-Oncogene Proteins c-ets Repressor Proteins Sequence Analysis RNA Transcription Genetic
Impact of Adalimumab Treatment on Interleukin-17 and Interleukin-17 Receptor Expression in Skin and Synovium of Psoriatic Arthritis Patients with Mild Psoriasis.
Janne W Bolt, Arno W van Kuijk, Marcel BM Teunissen, Dennis van der Coelen, Saïda Aarrass, Daniëlle M Gerlag, Paul P Tak, Marleen G van de Sande, Maria C Lebre, Lisa GM van Baarsen
Jan 30, 2022
Interleukin (IL)-17 and tumor necrosis factor-alpha (TNF)-α are key players in psoriatic arthritis (PsA) pathogenesis. While both cytokines can be therapeutically targeted with beneficial clinical outcome, it is unclear whether...
Fine-tuning autophagy maximises lifespan and is associated with changes in mitochondrial gene expression in Drosophila.
Ivana Bjedov, Helena M Cochemé, Andrea Foley, Daniela Wieser, Nathaniel S Woodling, Jorge Iván Castillo-Quan, Povilas Norvaisas, Celia Lujan, Jennifer C Regan, Janne M Toivonen, Michael P Murphy, Janet Thornton, Kerri J Kinghorn, Thomas P Neufeld, Filipe Cabreiro, Linda Partridge
Dec 07, 2020
Increased cellular degradation by autophagy is a feature of many interventions that delay ageing. We report here that increased autophagy is necessary for reduced insulin-like signalling (IIS) to extend lifespan in Drosophila...
Consistently dated Atlantic sediment cores over the last 40 thousand years
Claire Waelbroeck, Bryan C. Lougheed, Natalia Vazquez Riveiros, Lise Missiaen, Joel Pedro, Trond Dokken, Irka Hajdas, Lukas Wacker, Peter Abbott, Jean-Pascal Dumoulin, François Thil, Frédérique Eynaud, Linda Rossignol, Wiem Fersi, Ana Luiza Albuquerque, Helge Arz, William E. N. Austin, Rosemarie Came, Anders E. Carlson, James A. Collins, Bernard Dennielou, Stéphanie Desprat, Alex Dickson, Mary Elliot, Christa Farmer, Jacques Giraudeau, Julia Gottschalk, Jorijntje Henderiks, Konrad Hughen, Simon Jung, Paul Knutz, Susana Lebreiro, David C. Lund, Jean Lynch-Stieglitz, Bruno Malaizé, Thomas Marchitto, Gema Martínez-Méndez, Gesine Mollenhauer, Filipa Naughton, Silvia Nave, Dirk Nürnberg, Delia Oppo, Victoria Peck, Frank J. C. Peeters, Aurélie Penaud, Rodrigo da Costa Portilho-Ramos, Janne Repschläger, Jenny Roberts, Carsten Rühlemann, Emilia Salgueiro, Maria Fernanda Sanchez Goni, Joachim Schönfeld, Paolo Scussolini, Luke C. Skinner, Charlotte Skonieczny, David Thornalley, Samuel Toucanne, David Van Rooij, Laurence Vidal, Antje H. L. Voelker, Mélanie Wary, Syee Weldeab, Martin Ziegler
Sep 01, 2020
Abstract: Rapid changes in ocean circulation and climate have been observed in marine-sediment and ice cores over the last glacial period and deglaciation, highlighting the non-linear character of the climate system and...
Fine-tuning autophagy maximises lifespan and is associated with changes in mitochondrial gene expression in Drosophila
Ivana Bjedov, Helena M. Cochemé, Andrea Foley, Daniela Wieser, Nathaniel S. Woodling, Jorge Iván Castillo-Quan, Povilas Norvaisas, Celia Lujan, Jennifer C. Regan, Janne M. Toivonen, Michael P. Murphy, Janet Thornton, Kerri J. Kinghorn, Thomas P. Neufeld, Filipe Cabreiro, Linda Partridge
Dec 22, 2020
Increased cellular degradation by autophagy is a feature of many interventions that delay ageing. We report here that increased autophagy is necessary for reduced insulin-like signalling (IIS) to extend lifespan in Drosophila...
The international experience of in-situ recovery of the DCD heart
John Louca, Marco Öchsner, Ashish Shah, Jordan Hoffman, Francisco González Vilchez, Iris Garrido, Mario Royo-Villanova, Beatriz Domínguez-Gil, Deane Smith, Leslie James, Nader Moazami, Filip Rega, Janne Brouckaert, Johan Van Cleemput, Katrien Vandendriessche, Vincent Tchana-Sato, Diawara Bandiougou, Marian Urban, Alex Manara, Marius Berman, Simon Messer, Stephen Large
Apr 12, 2023
Background
Heart transplantation is an effective treatment offering the best recovery in both quality and quantity of life in those affected by refractory, severe heart failure. However, transplantation is limited by...
Cold storage Donation After Circulatory Determination Of Death Esmp Cs Dbd Dcd donation after brain death Non Heart Beating Donation Thoraco-Abdominal Nromothermic Regional Perfusion Donation After Neurological Death Heart Beating Donation Tanrp In-situ Perfusion Ex-situ Machine Perfusion
Published by: EClinicalMedicine
Consistently dated Atlantic sediment cores over the last 40 thousand years.
Claire Waelbroeck, Bryan C Lougheed, Natalia Vazquez Riveiros, Lise Missiaen, Joel Pedro, Trond Dokken, Irka Hajdas, Lukas Wacker, Peter Abbott, Jean-Pascal Dumoulin, François Thil, Frédérique Eynaud, Linda Rossignol, Wiem Fersi, Ana Luiza Albuquerque, Helge Arz, William EN Austin, Rosemarie Came, Anders E Carlson, James A Collins, Bernard Dennielou, Stéphanie Desprat, Alex Dickson, Mary Elliot, Christa Farmer, Jacques Giraudeau, Julia Gottschalk, Jorijntje Henderiks, Konrad Hughen, Simon Jung, Paul Knutz, Susana Lebreiro, David C Lund, Jean Lynch-Stieglitz, Bruno Malaizé, Thomas Marchitto, Gema Martínez-Méndez, Gesine Mollenhauer, Filipa Naughton, Silvia Nave, Dirk Nürnberg, Delia Oppo, Victoria Peck, Frank JC Peeters, Aurélie Penaud, Rodrigo da Costa Portilho-Ramos, Janne Repschläger, Jenny Roberts, Carsten Rühlemann, Emilia Salgueiro, Maria Fernanda Sanchez Goni, Joachim Schönfeld, Paolo Scussolini, Luke C Skinner, Charlotte Skonieczny, David Thornalley, Samuel Toucanne, David Van Rooij, Laurence Vidal, Antje HL Voelker, Mélanie Wary, Syee Weldeab, Martin Ziegler
Nov 20, 2019
Rapid changes in ocean circulation and climate have been observed in marine-sediment and ice cores over the last glacial period and deglaciation, highlighting the non-linear character of the climate system and underlining the...
Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells.
Mohamed-Sami Trabelsi, Mehdi Daoudi, Janne Prawitt, Sarah Ducastel, Véronique Touche, Sama I Sayin, Alessia Perino, Cheryl A Brighton, Yasmine Sebti, Jérôme Kluza, Olivier Briand, Hélène Dehondt, Emmanuelle Vallez, Emilie Dorchies, Grégory Baud, Valeria Spinelli, Nathalie Hennuyer, Sandrine Caron, Kadiombo Bantubungi, Robert Caiazzo, Frank Reimann, Philippe Marchetti, Philippe Lefebvre, Fredrik Bäckhed, Fiona M Gribble, Kristina Schoonjans, François Pattou, Anne Tailleux, Bart Staels, Sophie Lestavel
Jan 31, 2020
Bile acids are signalling molecules, which activate the transmembrane receptor TGR5 and the nuclear receptor FXR. BA sequestrants (BAS) complex bile acids in the intestinal lumen and decrease intestinal FXR activity. The BAS-BA...
Animals Anticholesteremic Agents Basic Helix-Loop-Helix Leucine Zipper Transcription Factors Bile Acids and Salts Blood Glucose Colesevelam Hydrochloride Colon Diet High-Fat Enteroendocrine Cells Glucagon-Like Peptide 1 Glycolysis Humans Ileum Insulin Insulin Secretion Insulin-Secreting Cells Intestinal Mucosa Intestines Jejunum Mice Mice Knockout Mice Obese Nuclear Proteins obesity Proglucagon RNA Messenger Receptors Cytoplasmic and Nuclear Receptors G-Protein-Coupled Sequestering Agents Signal Transduction Transcription Factors
Support systems to guide clinical decision-making in precision oncology
David Tamborero, Rodrigo Dienstmann, Maan Haj Rachid, Jorrit Boekel, Richard Baird, Irene Braña, Luigi De Petris, Jeffrey Yachnin, Christophe Massard, Frans L Opdam, Richard Schlenk, Claudio Vernieri, Elena Garralda, Michele Masucci, Xenia Villalobos, Elena Chavarria, Cancer Core Europe consortium, Fabien Calvo, Stefan Fröhling, Alexander Eggermont, Giovanni Apolone, Emile E Voest, Carlos Caldas, Josep Tabernero, Ingemar Ernberg, Jordi Rodon, Janne Lehtiö
Jul 08, 2020
To the editor: the optimal management of cancer patients is increasingly dependent on individualized treatments guided by tumor sequencing data. As comprehensive genomic tests become routine in many disease settings and academic...
The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology.
David Tamborero, Rodrigo Dienstmann, Maan Haj Rachid, Jorrit Boekel, Adria Lopez-Fernandez, Markus Jonsson, Ali Razzak, Irene Braña, Luigi De Petris, Jeffrey Yachnin, Richard D Baird, Yohann Loriot, Christophe Massard, Patricia Martin-Romano, Frans Opdam, Richard F Schlenk, Claudio Vernieri, Michele Masucci, Xenia Villalobos, Elena Chavarria, Cancer Core Europe consortium, Judith Balmaña, Giovanni Apolone, Carlos Caldas, Jonas Bergh, Ingemar Ernberg, Stefan Fröhling, Elena Garralda, Claes Karlsson, Josep Tabernero, Emile Voest, Jordi Rodon, Janne Lehtiö
Feb 28, 2022
There is a growing need for systems that efficiently support the work of medical teams at the precision-oncology point of care. Here, we present the implementation of the Molecular Tumor Board Portal (MTBP), an academic clinical...
Paneth cells as a site of origin for intestinal inflammation.
Timon E Adolph, Michal F Tomczak, Lukas Niederreiter, Hyun-Jeong Ko, Janne Böck, Eduardo Martinez-Naves, Jonathan N Glickman, Markus Tschurtschenthaler, John Hartwig, Shuhei Hosomi, Magdalena B Flak, Jennifer L Cusick, Kenji Kohno, Takao Iwawaki, Susanne Billmann-Born, Tim Raine, Richa Bharti, Ralph Lucius, Mi-Na Kweon, Stefan J Marciniak, Augustine Choi, Susan J Hagen, Stefan Schreiber, Philip Rosenstiel, Arthur Kaser, Richard S Blumberg
May 18, 2018
The recognition of autophagy related 16-like 1 (ATG16L1) as a genetic risk factor has exposed the critical role of autophagy in Crohn's disease. Homozygosity for the highly prevalent ATG16L1 risk allele, or murine hypomorphic...
Animals Autophagy Autophagy-Related Proteins Carrier Proteins Cell Line DNA-Binding Proteins Endoplasmic reticulum stress Inflammation Intestinal Diseases Intestinal Mucosa Mice Paneth Cells Regulatory Factor X Transcription Factors Signal Transduction Transcription Factors Unfolded Protein Response X-Box Binding Protein 1 eIF-2 Kinase
Serum neurofilament light chain in genetic frontotemporal dementia
Emma L van der Ende, Lieke H Meeter, Jackie M Poos, Jessica L Panman, Lize C Jiskoot, Elise GP Dopper, Janne M Papma, Frank Jan de Jong, Inge MW Verberk, Charlotte Teunissen, Dimitris Rizopoulos, Carolin Heller, Rhian S Convery, Katrina M Moore, Martina Bocchetta, Mollie Neason, David M Cash, Barbara Borroni, Daniela Galimberti, Raquel Sanchez-Valle, Robert Laforce, Fermin Moreno, Matthis Synofzik, Caroline Graff, Mario Masellis, Maria Carmela Tartaglia, James B Rowe, Rik Vandenberghe, Elizabeth Finger, Fabrizio Tagliavini, Alexandre de Mendonça, Isabel Santana, Chris Butler, Simon Ducharme, Alex Gerhard, Adrian Danek, Johannes Levin, Markus Otto, Giovanni B Frisoni, Stefano Cappa, Yolande AL Pijnenburg, Jonathan D Rohrer, John C van Swieten, Genetic Frontotemporal dementia Initiative (GENFI)
May 26, 2020
Impairment of episodic memory in genetic frontotemporal dementia
Jackie M Poos, Lucy L Russell, Georgia Peakman, Martina Bocchetta, Caroline V Greaves, Lize C Jiskoot, Emma L van der Ende, Harro Seelaar, Janne M Papma, Esther van den Berg, Yolande A L Pijnenburg, Barbara Borroni, Raquel Sanchez-Valle, Fermin Moreno, Robert Laforce, Caroline Graff, Matthias Synofzik, Daniela Galimberti, James B Rowe, Mario Masellis, Carmela Tartaglia, Elizabeth Finger, Rik Vandenberghe, Alexandre de Medonça, Fabrizio Tagliavini, Chris R Butler, Isabel Santana, Isabelle Le Ber, Alex Gerhard, Simon Ducharme, Johannes Levin, Adrian Danek, Markus Otto, Sandro Sorbi, Florence Pasquier, John C van Swieten, Jonathan D Rohrer
Jun 24, 2021
Introduction
We aimed to assess episodic memory in genetic frontotemporal dementia (FTD) with the Free and Cued Selective Reminding Test (FCSRT).Methods
The FCSRT was administered in 417 presymptomatic and...
Impairment of episodic memory in genetic frontotemporal dementia
Jackie M. Poos, Lucy L. Russell, Georgia Peakman, Martina Bocchetta, Caroline V. Greaves, Lize C. Jiskoot, Emma L. van der Ende, Harro Seelaar, Janne M. Papma, Esther van den Berg, Yolande A.L. Pijnenburg, Barbara Borroni, Raquel Sanchez‐Valle, Fermin Moreno, Robert Laforce, Caroline Graff, Matthias Synofzik, Daniela Galimberti, James B. Rowe, Mario Masellis, Carmela Tartaglia, Elizabeth Finger, Rik Vandenberghe, Alexandre de Medonça, Fabrizio Tagliavini, Chris R. Butler, Isabel Santana, Isabelle Le Ber, Alex Gerhard, Simon Ducharme, Johannes Levin, Adrian Danek, Markus Otto, Sandro Sorbi, Florence Pasquier, John C. van Swieten, Jonathan D. Rohrer, GENF the Genetic FTD Initiative
May 20, 2021
Abstract: Introduction: We aimed to assess episodic memory in genetic frontotemporal dementia (FTD) with the Free and Cued Selective Reminding Test (FCSRT). Methods: The FCSRT was administered in 417 presymptomatic and...
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