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Results: 885
Measuring single cell divisions in human tissues from multi-region sequencing data.
Benjamin Werner, Jack Case, Marc J Williams, Ketevan Chkhaidze, Daniel Temko, Javier Fernández-Mateos, George D Cresswell, Daniel Nichol, William Cross, Inmaculada Spiteri, Weini Huang, Ian PM Tomlinson, Chris P Barnes, Trevor A Graham, Andrea Sottoriva
Feb 24, 2021
Both normal tissue development and cancer growth are driven by a branching process of cell division and mutation accumulation that leads to intra-tissue genetic heterogeneity. However, quantifying somatic evolution in humans...
Clinical, Virological and Immunological Responses after Experimental Infection with African Horse Sickness Virus Serotype 9 in Immunologically Naïve and Vaccinated Horses.
Manuel Durán-Ferrer, Rubén Villalba, Paloma Fernández-Pacheco, Cristina Tena-Tomás, Miguel-Ángel Jiménez-Clavero, José-Antonio Bouzada, María-José Ruano, Jovita Fernández-Pinero, Marisa Arias, Javier Castillo-Olivares, Montserrat Agüero
Jul 19, 2022
This study described the clinical, virological, and serological responses of immunologically naïve and vaccinated horses to African horse sickness virus (AHSV) serotype 9. Naïve horses developed a clinical picture resembling the...
Writing 3D Nanomagnets Using Focused Electron Beams.
Amalio Fernández-Pacheco, Luka Skoric, José María De Teresa, JAVIER PABLO-NAVARRO, Michael Huth, Oleksandr V Dobrovolskiy
Aug 27, 2020
Focused electron beam induced deposition (FEBID) is a direct-write nanofabrication technique able to pattern three-dimensional magnetic nanostructures at resolutions comparable to the characteristic magnetic length scales. FEBID...
Clinical, Virological and Immunological Responses after Experimental Infection with African Horse Sickness Virus Serotype 9 in Immunologically Naïve and Vaccinated Horses.
Manuel Durán-Ferrer, Rubén Villalba, Paloma Fernández-Pacheco, Cristina Tena-Tomás, Miguel-Ángel Jiménez-Clavero, José-Antonio Bouzada, María-José Ruano, Jovita Fernández-Pinero, Marisa Arias, Javier Castillo-Olivares, Montserrat Agüero
Sep 02, 2022
This study described the clinical, virological, and serological responses of immunologically naïve and vaccinated horses to African horse sickness virus (AHSV) serotype 9. Naïve horses developed a clinical picture resembling the...
Survivors of Hell
UNLABELLED: Approximately half of the world's displaced population are children and a significant proportion of these are unaccompanied asylum-seeking children (UASC). UASC are the most vulnerable of all refugee populations. Up...
Polyploidy on Islands
Heidi M. Meudt, Dirk C. Albach, Andrew J. Tanentzap, Javier Igea, Sophie C. Newmarch, Angela J. Brandt, William G. Lee, Jennifer A. Tate
Mar 18, 2021
Whole genome duplication or polyploidy is widespread among floras globally, but traditionally has been thought to have played a minor role in the evolution of island biodiversity, based on the low proportion of polyploid taxa...
Polyploidy on Islands
Heidi M Meudt, Dirk C Albach, Andrew J Tanentzap, Javier Igea, Sophie C Newmarch, Angela J Brandt, William G Lee, Jennifer A Tate
Jun 08, 2021
Whole genome duplication or polyploidy is widespread among floras globally, but traditionally has been thought to have played a minor role in the evolution of island biodiversity, based on the low proportion of polyploid taxa...
LanB1 Cooperates With Kon-Tiki During Embryonic Muscle Migration in Drosophila.
Juan José Pérez-Moreno, Carmen Santa-Cruz Mateos, María Dolores Martín-Bermudo, Beatriz Estrada
Feb 20, 2022
Muscle development is a multistep process that involves cell specification, myoblast fusion, myotube migration, and attachment to the tendons. In spite of great efforts trying to understand the basis of these events, little is...
Psychological distress in refugees
Pascal Schlechter, Irene Mateos Rodriguez, Nexhmedin Morina, Judith Knausenberger, Paul O Wilkinson, Jens H Hellmann
Sep 02, 2021
Many refugees have been exposed to potentially traumatic events and report elevated levels of psychological distress. However, refugees vary greatly in the severity of mental health problems. Intra- and interpersonal factors...
Inhibition of profibrotic microRNA-21 affects platelets and their releasate.
Temo Barwari, Seda Eminaga, Ursula Mayr, Ruifang Lu, Paul C Armstrong, Melissa V Chan, Mahnaz Sahraei, Marta Fernández-Fuertes, Thomas Moreau, Javier Barallobre-Barreiro, Marc Lynch, Xiaoke Yin, Christian Schulte, Ferheen Baig, Raimund Pechlaner, Sarah R Langley, Anna Zampetaki, Peter Santer, Martin Weger, Roberto Plasenzotti, Markus Schosserer, Johannes Grillari, Stefan Kiechl, Johann Willeit, Ajay M Shah, Cedric Ghevaert, Timothy D Warner, Carlos Fernández-Hernando, Yajaira Suárez, Manuel Mayr
Jan 09, 2019
Fibrosis is a major contributor to organ disease for which no specific therapy is available. MicroRNA-21 (miR-21) has been implicated in the fibrogenetic response, and inhibitors of miR-21 are currently undergoing clinical...
Cardiology Cell Biology Fibrosis NONCODING RNAS platelets Aged Aged 80 and over Animals Blood Platelets Clinical Trials as Topic Extracellular Matrix Female FIBROBLASTS Fibrosis Humans Male Mice Mice Inbred C57BL MicroRNAs Middle Aged Myocardium Prospective Studies Proteomics RNA Untranslated Transforming Growth Factor beta1 Wiskott-Aldrich Syndrome Protein
Integrins regulate epithelial cell shape by controlling the architecture and mechanical properties of basal actomyosin networks.
Carmen Santa-Cruz Mateos, Andrea Valencia-Expósito, Isabel M Palacios, María D Martín-Bermudo
Dec 07, 2020
Forces generated by the actomyosin cytoskeleton are key contributors to many morphogenetic processes. The actomyosin cytoskeleton organises in different types of networks depending on intracellular signals and on cell-cell and...
The Impact of Dissonant Tie on Innovation Performance of Digital Transformation
The acquisition of innovation performance through social network relationship resources is a common behavior pattern of organizational members. Recent social network research suggests that negative ties may also have a positive...
Published by: IGI Global Scientific Publishing
Meta-analysis of Immunochip data of four autoimmune diseases reveals novel single-disease and cross-phenotype associations.
Ana Márquez, Martin Kerick, Alexandra Zhernakova, Javier Gutierrez-Achury, Wei-Min Chen, Suna Onengut-Gumuscu, Isidoro González-Álvaro, Luis Rodriguez-Rodriguez, Raquel Rios-Fernández, Miguel A González-Gay, Coeliac Disease Immunochip Consortium, Rheumatoid Arthritis Consortium International for Immunochip (RACI), International Scleroderma Group, Type 1 Diabetes Genetics Consortium, Maureen D Mayes, Soumya Raychaudhuri, Stephen S Rich, Cisca Wijmenga, Javier Martín
Feb 18, 2019
BACKGROUND: In recent years, research has consistently proven the occurrence of genetic overlap across autoimmune diseases, which supports the existence of common pathogenic mechanisms in autoimmunity. The objective of this...
Autoimmune Disease functional enrichment analysis Celiac disease Cross-disease meta-analysis Immunochip rheumatoid arthritis systemic sclerosis type 1 diabetes Arthritis Rheumatoid Autoimmune Diseases Celiac disease Diabetes mellitus Type 1 Genetic Predisposition to Disease Genome-Wide Association Study Humans Molecular Sequence Annotation Polymorphism Single Nucleotide Scleroderma Systemic
EGFR amplification and outcome in a randomised phase III trial of chemotherapy alone or chemotherapy plus panitumumab for advanced gastro-oesophageal cancers.
Elizabeth C Smyth, Georgios Vlachogiannis, Somaieh Hedayat, Alice Harbery, Sanna Hulkki-Wilson, Massimiliano Salati, Kyriakos Kouvelakis, Javier Fernandez-Mateos, George D Cresswell, Elisa Fontana, Therese Seidlitz, Clare Peckitt, Jens C Hahne, Andrea Lampis, Ruwaida Begum, David Watkins, Sheela Rao, Naureen Starling, Tom Waddell, Alicia Okines, Tom Crosby, Was Mansoor, Jonathan Wadsley, Gary Middleton, Matteo Fassan, Andrew Wotherspoon, Chiara Braconi, Ian Chau, Igor Vivanco, Andrea Sottoriva, Daniel E Stange, David Cunningham, Nicola Valeri
Nov 11, 2020
Gastric adenocarcinoma gastrointestinal cancer molecular oncology OESOPHAGEAL CANCER Adenocarcinoma Aged Antibiotics Antineoplastic Antineoplastic Agents Immunological Antineoplastic Combined Chemotherapy Protocols Biomarkers Tumor Epirubicin ErbB Receptors Esophageal Neoplasms Humans Male Middle Aged Panitumumab Stomach Neoplasms
Direct measurement of lensing amplification in Abell S1063 using a strongly lensed high redshift HII galaxy
Evolution of nectar spur length in a clade of Linaria reflects changes in cell division rather than in cell expansion.
BACKGROUND AND AIMS: Nectar spurs (tubular outgrowths of a floral organ which contain, or give the appearance of containing, nectar) are hypothesized to be a 'key innovation' which can lead to rapid speciation within a lineage...
Exact solution of several families of location-arc routing problems
We model and solve several families of location-arc routing problems on an undirected graph. These problems extend the multidepot rural postman problem to the case where the depots are not fixed. The aim is to select the...
Depletion of the RNA-binding protein RBP33 results in increased expression of silenced RNA polymerase II transcripts in Trypanosoma brucei.
Private agenda and re-election incentives
Javier Rivas
Apr 01, 2016
Consider a politician who has to take two sequential decisions during his term in office. For each decision, the politician faces a trade-off between taking what he believes to be the decision that generates a public benefit...
Using misleading online media articles to teach critical assessment of scientific findings about weight loss
Javier Gonzalez
Sep 01, 2018
In this paper, a teaching strategy that exploits misleading media articles covering peer-reviewed research is described. This task attempts to encourage university students to not take media articles on obesity physiology at...
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