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Results: 47
Plant responses to fertilization experiments in lowland, species-rich, tropical forests.
S Joseph Wright, Benjamin L Turner, Joseph B Yavitt, Kyle E Harms, Michael Kaspari, Edmund VJ Tanner, Jelena Bujan, Eric A Griffin, Jordan R Mayor, Sarah C Pasquini, Merlin Sheldrake, Milton N Garcia
Nov 01, 2018
We present a meta-analysis of plant responses to fertilization experiments conducted in lowland, species-rich, tropical forests. We also update a key result and present the first species-level analyses of tree growth rates for a...
Identifying targets of the Sox domain protein Dichaete in the Drosophila CNS via targeted expression of dominant negative proteins.
Time-resolved open-circuit conductive atomic force microscopy for direct electromechanical characterisation.
Yonatan Calahorra, Wonjong Kim, Jelena Vukajlovic-Plestina, Anna Fontcuberta I Morral, Sohini Kar-Narayan
Jun 09, 2020
Studying nanomaterial piezoelectricity and triboelectricity is attractive for energy and sensing applications. However, quantitative characterisation of electromechanical effects in nanomaterials is challenging due to practical...
Association Between Risk-of-Bias Assessments and Results of Randomized Trials in Cochrane Reviews
Jelena Savovic, Rebecca M Turner, David Mawdsley, Hayley E Jones, Rebecca Beynon, Julian PT Higgins, Jonathan AC Sterne
Oct 10, 2018
Flaws in the design of randomized trials may bias intervention effect estimates and increase between-trial heterogeneity. Empirical evidence suggests that these problems are greatest for subjectively assessed outcomes. For the...
The role of Dichaete in transcriptional regulation during Drosophila embryonic development.
Animals Binding Sites Central Nervous System Drosophila Drosophila Proteins Embryonic Development Gene Expression Profiling Gene Expression Regulation Developmental Mutation Neural Plate Nucleotide Motifs Position-Specific Scoring Matrices Protein Binding SOX Transcription Factors Signal Transduction Transcription Genetic
Between-trial heterogeneity in meta-analyses may be partially explained by reported design characteristics.
Kirsty M Rhodes, Rebecca M Turner, Jelena Savović, Hayley E Jones, David Mawdsley, Julian PT Higgins
Jun 18, 2018
OBJECTIVE: We investigated the associations between risk of bias judgments from Cochrane reviews for sequence generation, allocation concealment and blinding, and between-trial heterogeneity. STUDY DESIGN AND SETTING: Bayesian...
Patient flow within UK emergency departments
Syed Mohiuddin, John Busby, Jelena Savovic, Alison Richards, Kate Northstone, William Hollingworth, Jenny Donovan, Christos Vasilakis
May 01, 2017
Background: Overcrowding in the emergency department (ED) is common in the UK as in other countries worldwide. Computer simulation is one approach used for understanding the causes of ED overcrowding and assessing the likely...
Patient flow within UK emergency departments
Syed Mohiuddin, John Busby, Jelena Savovic, Alison Richards, Kate Northstone, William Hollingworth, Jenny Donovan, Christos Vasilakis
May 01, 2017
Background: Overcrowding in the emergency department (ED) is common in the UK as in other countries worldwide. Computer simulation is one approach used for understanding the causes of ED overcrowding and assessing the likely...
Barley Hv CIRCADIAN CLOCK ASSOCIATED 1 and Hv PHOTOPERIOD H1 Are Circadian Regulators That Can Affect Circadian Rhythms in Arabidopsis.
Jelena Kusakina, Zoe Rutterford, Sean Cotter, María C Martí, David A Laurie, Andy J Greenland, Anthony Hall, Alex AR Webb
Jun 01, 2015
Chromatin interaction maps identify Wnt responsive cis-regulatory elements coordinating Paupar-Pax6 expression in neuronal cells
Ioanna Pavlaki, Michael Shapiro, Giuseppina Pisignano, Steph Jones, Jelena Telenius, Silvia Munoz-Descalzo, Robert J Williams, Jim R. Hughes, Keith Vance
Jun 16, 2022
Central nervous system-expressed long non-coding RNAs (lncRNAs) are often located in the genome close to protein coding genes involved in transcriptional control. Such lncRNA-protein coding gene pairs are frequently temporally...
mRNA 3' uridylation and poly(A) tail length sculpt the mammalian maternal transcriptome.
Marcos Morgan, Christian Much, Monica DiGiacomo, Chiara Azzi, Ivayla Ivanova, Dimitrios M Vitsios, Jelena Pistolic, Paul Collier, Pedro N Moreira, Vladimir Benes, Anton J Enright, Dónal O'Carroll
Jun 12, 2018
A fundamental principle in biology is that the program for early development is established during oogenesis in the form of the maternal transcriptome. How the maternal transcriptome acquires the appropriate content and dosage...
Shallow Whole-Genome Sequencing from Plasma Identifies FGFR1 Amplified Breast Cancers and Predicts Overall Survival.
Chantal Bourrier, Jean-Yves Pierga, Laura Xuereb, Hélène Salaun, Charlotte Proudhon, Michael R Speicher, Jelena Belic, Ellen Heitzer, Brian Paul Lockhart, Nolwen Guigal-Stephan
Jun 07, 2020
Background: Focal amplification of fibroblast growth factor receptor 1 (FGFR1) defines a subgroup of breast cancers with poor prognosis and high risk of recurrence. We sought to demonstrate the potential of circulating cell-free...
Stem cell function and stress response are controlled by protein synthesis.
Sandra Blanco, Roberto Bandiera, Martyna Popis, Shobbir Hussain, Patrick Lombard, Jelena Aleksic, Abdulrahim Sajini, Hinal Tanna, Rosana Cortés-Garrido, Nikoletta Gkatza, Sabine Dietmann, Michaela Frye
May 05, 2016
Longitudinal monitoring of disease burden and response using ctDNA from dried blood spots in xenograft models.
Carolin M Sauer, Katrin Heider, Jelena Belic, Samantha E Boyle, James A Hall, Dominique-Laurent Couturier, Angela An, Aadhitthya Vijayaraghavan, Marika Av Reinius, Karen Hosking, Maria Vias, Nitzan Rosenfeld, James D Brenton
Jun 13, 2022
Whole-genome sequencing (WGS) of circulating tumour DNA (ctDNA) is now a clinically important biomarker for predicting therapy response, disease burden and disease progression. However, the translation of ctDNA monitoring into...
Chromatin interaction maps identify Wnt responsive cis-regulatory elements coordinating Paupar-Pax6 expression in neuronal cells
Ioanna Pavlaki, Michael Shapiro, Giuseppina Pisignano, Steph Jones, Jelena Telenius, Silvia Munoz-Descalzo, Robert J Williams, Jim R. Hughes, Keith Vance
Jun 16, 2022
Central nervous system-expressed long non-coding RNAs (lncRNAs) are often located in the genome close to protein coding genes involved in transcriptional control. Such lncRNA-protein coding gene pairs are frequently temporally...
The Role of DNA Methylation and Histone Modifications in Neurodegenerative Diseases
Ke-Xin Wen, Jelena Miliç, Bassem El-Khodor, Klodian Dhana, Jana Nano, Tammy Pulido, Bledar Kraja, Asija Zaciragic, Wichor M Bramer, John Troup, Rajiv Chowdhury, M Arfam Ikram, Abbas Dehghan, Taulant Muka, Oscar H Franco
Nov 20, 2017
IMPORTANCE: Epigenetic modifications of the genome, such as DNA methylation and histone modifications, have been reported to play a role in neurodegenerative diseases (ND) such as Alzheimer's disease (AD) and Parkinson's disease...
Primary post-transplant lymphoproliferative disorder of the central nervous system
Mary M Taj, Britta Maecker-Kolhoff, Rebecca Ling, Simon Bomken, Birgit Burkhardt, Alan KS Chiang, Monika Csoka, Anna Füreder, Stéphanie Haouy, Jelena Lazic, Natalia Miakova, Veronique Minard-Colin, Suzanne D Turner, Anne Uyttebroeck, Andishe Attarbaschi, the international Berlin-Frankfurt-Münster (i-BFM) Study Group European Intergroup for Childhood Non-Hodgkin’s Lymphoma (EICNHL)
Feb 17, 2021
Primary central nervous system (CNS) post-transplant lymphoproliferative disorder (PTLD) in childhood is rare. Twenty-five patients were retrieved from nine European Intergroup for Childhood Non-Hodgkin's Lymphoma and/or...
Central Nervous System outcome post-transplant lymphoproliferative disorder transplant Treatment Adolescent Adult Allografts Brain Neoplasms Child Child Preschool Disease-Free Survival Female Hematopoietic Stem Cell Transplantation Humans Infant Injections Spinal Lymphoproliferative Disorders Male Organ Transplantation Rituximab Survival Rate
Neanderthals on the Lower Danube
Dušan Borić, Emanuela Cristiani, Rachel Hopkins, Jean‐Luc Schwenninger, Katarina Gerometta, Charly A. I. French, Giuseppina Mutri, Jelena Ćalić, Vesna Dimitrijević, Ana B. Marín‐Arroyo, Jennifer R. Jones, Rhiannon Stevens, Alana Masciana, Kevin Uno, Kristine Korzow Richter, Dragana Antonović, Karol Wehr, Christine Lane, Dustin White
Aug 26, 2021
SPECIAL ISSUE ARTICLE Special Issue Articles Cryptotephra Danube Gorges OSL dating Palaeolithic radiocarbon dating ZooMS
Published by: Journal of Quaternary Science
Thyroid Hormone Receptor Beta in the Ventromedial Hypothalamus Is Essential for the Physiological Regulation of Food Intake and Body Weight.
Saira Hameed, Michael Patterson, Waljit S Dhillo, Sofia A Rahman, Yue Ma, Christopher Holton, Apostolos Gogakos, Giles SH Yeo, Brian YH Lam, Joseph Polex-Wolf, Wiebke Fenske, Jimmy Bell, Jelena Anastasovska, Jacques Samarut, Stephen R Bloom, JH Duncan Bassett, Graham R Williams, James V Gardiner
Aug 18, 2017
The obesity epidemic is a significant global health issue. Improved understanding of the mechanisms that regulate appetite and body weight will provide the rationale for the design of anti-obesity therapies. Thyroid hormones...
Circadian Entrainment in Arabidopsis by the Sugar-Responsive Transcription Factor bZIP63.
Alexander Frank, Cleverson C Matiolli, Américo JC Viana, Timothy J Hearn, Jelena Kusakina, Fiona E Belbin, David Wells Newman, Aline Yochikawa, Dora L Cano-Ramirez, Anupama Chembath, Kester Cragg-Barber, Michael J Haydon, Carlos T Hotta, Michel Vincentz, Alex AR Webb, Antony N Dodd
Sep 20, 2018
On-treatment measurements of circulating tumor DNA during FOLFOX therapy in patients with colorectal cancer.
Tina Moser, Julie Waldispuehl-Geigl, Jelena Belic, Sabrina Weber, Qing Zhou, Samantha O Hasenleithner, Ricarda Graf, Jasmin Alia Terzic, Florian Posch, Heinz Sill, Sigurd Lax, Karl Kashofer, Gerald Hoefler, Helmut Schoellnast, Ellen Heitzer, Jochen B Geigl, Thomas Bauernhofer, Michael R Speicher
Nov 13, 2020
We addressed a significant unknown feature of circulating tumor DNA (ctDNA), i.e., how ctDNA levels change during chemotherapy, by serially monitoring ctDNA in patients with colorectal cancer during the 48-h application of...
Phenotypic screening reveals TNFR2 as a promising target for cancer immunotherapy.
Geoffrey S Williams, Bina Mistry, Sandrine Guillard, Jane Coates Ulrichsen, Alan M Sandercock, Jun Wang, Andrea González-Muñoz, Julie Parmentier, Chelsea Black, Jo Soden, Jim Freeth, Jelena Jovanović, Rebecca Leyland, Rafia S Al-Lamki, Andrew J Leishman, Steven J Rust, Ross Stewart, Lutz Jermutus, John R Bradley, Vahe Bedian, Viia Valge-Archer, Ralph Minter, Robert W Wilkinson
Jul 20, 2018
TNFR2 cancer immunotherapy Drug Discovery phenotypic screening Regulatory T cell Animals Antineoplastic Agents Cell Line Tumor Drug Screening Assays Antitumor Female HEK293 Cells Humans Immunotherapy Jurkat Cells Mice Inbred BALB C NF-kappa B Neoplasms Neoplasms Experimental Phenotype Receptors Tumor Necrosis Factor Type II Signal Transduction T-Lymphocytes Regulatory
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