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Results: 55
Neural stem cell temporal patterning and brain tumour growth rely on oxidative phosphorylation.
D. melanogaster Warburg effect brain tumours developmental biology Neural Stem Cells Oxidative Phosphorylation Regenerative Medicine Stem Cells temporal patterning tumour heterogeneity Animals Brain Neoplasms Cell Differentiation Cell Proliferation Disease Models Animal Drosophila Glycolysis Neural Stem Cells Oxidative Phosphorylation
TaDa! Analysing cell type-specific chromatin in vivo with Targeted DamID.
The emergence of neuronal diversity during development of the nervous system relies on dynamic changes in the epigenetic landscape of neural stem cells and their progeny. Targeted DamID (TaDa) is proving invaluable in...
A carrier-assisted ChIP-seq method for estrogen receptor-chromatin interactions from breast cancer core needle biopsy samples.
Wilbert Zwart, Rutger Koornstra, Jelle Wesseling, Emiel Rutgers, Sabine Linn, Jason S Carroll
May 02, 2019
BACKGROUND: The Estrogen Receptor alpha (ERα) is the key transcriptional regulator in luminal breast cancer and is therefore the main target for adjuvant treatment of this subtype. Luminal gene signatures are dictated by the...
Mitochondrial Diseases
Katherine R Schon, Thiloka Ratnaike, Jelle van den Ameele, Rita Horvath, Patrick F Chinnery
Jun 24, 2020
Mitochondrial disorders have emerged as a common cause of inherited disease, but are traditionally viewed as being difficult to diagnose clinically, and even more difficult to comprehensively characterize at the molecular level....
Genomic analysis of methicillin-resistant Staphylococcus aureus clonal complex 239 isolated from Danish patients with and without an international travel history.
Cortical Neurogenesis Requires Bcl6-Mediated Transcriptional Repression of Multiple Self-Renewal-Promoting Extrinsic Pathways.
Jerome Bonnefont, Luca Tiberi, Jelle van den Ameele, Delphine Potier, Zachary B Gaber, Xionghui Lin, Angéline Bilheu, Adèle Herpoel, Fausto D Velez Bravo, François Guillemot, Stein Aerts, Pierre Vanderhaeghen
Aug 02, 2019
During neurogenesis, progenitors switch from self-renewal to differentiation through the interplay of intrinsic and extrinsic cues, but how these are integrated remains poorly understood. Here, we combine whole-genome...
Bcl6 FGF signaling notch signaling Shh signaling Wnt signaling brain development Cyclins Neurogenesis stemness Transcription Animals Cell Self Renewal Epigenetic Repression Fibroblast Growth Factors Gene Expression Profiling Hedgehog Proteins Histone Code Histones Mice Neural Stem Cells Neurogenesis Proto-Oncogene Proteins c-bcl-6 RNA-seq Receptors Notch Signal Transduction Sirtuin 1 Wnt Signaling Pathway
MitoPhen database
Thiloka E Ratnaike, Daniel Greene, Wei Wei, Alba Sanchis-Juan, Katherine R Schon, Jelle van den Ameele, Lucy Raymond, Rita Horvath, Ernest Turro, Patrick F Chinnery
Aug 09, 2021
Diagnosing mitochondrial disorders remains challenging. This is partly because the clinical phenotypes of patients overlap with those of other sporadic and inherited disorders. Although the widespread availability of genetic...
Teenage-onset progressive myoclonic epilepsy due to a familial C9orf72 repeat expansion.
Jelle van den Ameele, Ivana Jedlickova, Anna Pristoupilova, Anne Sieben, Sara Van Mossevelde, Chantal Ceuterick-de Groote, Helena Hůlková, Radoslav Matej, Alfred Meurs, Christine Van Broeckhoven, Samuel F Berkovic, Patrick Santens, Stanislav Kmoch, Bart Dermaut
Dec 11, 2019
BACKGROUND: The progressive myoclonic epilepsies (PME) are a heterogeneous group of disorders in which a specific diagnosis cannot be made in a subset of patients, despite exhaustive investigation. C9orf72 repeat expansions are...
Genomic analysis of methicillin-resistant Staphylococcus aureus clonal complex 239 isolated from Danish patients with and without an international travel history
Jasmine Coppens, Basil Britto Xavier, Jelle Vlaeminck, Jesper Larsen, Christine Lammens, Sandra Van Puyvelde, Herman Goossens, Anders Rhod Larsen, Surbhi Malhotra-Kumar
Jan 11, 2023
Introduction
International travel has been a major determinant for the introduction of pathogens such as methicillin-resistant Staphylococcus aureus (MRSA) into naïve geographic areas. MRSA clonal complex 239 (CC239) is...
Published by: Frontiers in microbiology
Ductal carcinoma in situ
Maartje van Seijen, Esther H. Lips, Alastair M. Thompson, Serena Nik-Zainal, Andrew Futreal, E. Shelley Hwang, Ellen Verschuur, Joanna Lane, Jos Jonkers, Daniel W. Rea, Jelle Wesseling
Jul 08, 2020
Abstract: Ductal carcinoma in situ (DCIS) now represents 20–25% of all ‘breast cancers’ consequent upon detection by population-based breast cancer screening programmes. Currently, all DCIS lesions are treated, and treatment...
Targeted DamID reveals differential binding of mammalian pluripotency factors.
Seth W Cheetham, Wolfram H Gruhn, Jelle van den Ameele, Robert Krautz, Tony D Southall, Toshihiro Kobayashi, M Azim Surani, Andrea H Brand
Oct 03, 2018
The precise control of gene expression by transcription factor networks is crucial to organismal development. The predominant approach for mapping transcription factor-chromatin interactions has been chromatin...
Genetic Risk as a Marker of Amyloid-β and Tau Burden in Cerebrospinal Fluid.
Nicola Voyle, Hamel Patel, Amos Folarin, Stephen Newhouse, Caroline Johnston, Pieter Jelle Visser, Richard JB Dobson, Steven J Kiddle, EDAR and DESCRIPA study groups and the Alzheimer’s Disease Neuroimaging Initiative
May 21, 2018
Alzheimer’s disease biomarker Blood multi-modal polygenic risk score Tau Aged Aged 80 and over Alzheimer Disease Amyloid beta-Peptides Apolipoproteins E Biomarkers Cohort Studies Databases Factual Early Diagnosis Female Humans Logistic Models Male Oligonucleotide Array Sequence Analysis Polymorphism Single Nucleotide Positron-Emission Tomography tau Proteins
A robust human norovirus replication model in zebrafish larvae.
Jana Van Dycke, Annelii Ny, Nádia Conceição-Neto, Jan Maes, Myra Hosmillo, Arno Cuvry, Ian Goodfellow, Tatiane C Nogueira, Erik Verbeken, Jelle Matthijnssens, Peter de Witte, Johan Neyts, Joana Rocha-Pereira
Oct 28, 2019
Human noroviruses (HuNoVs) are the most common cause of foodborne illness, with a societal cost of $60 billion and 219,000 deaths/year. The lack of robust small animal models has significantly hindered the understanding of...
Chronic pain is common in mitochondrial disease.
Jelle van den Ameele, Joshua Fuge, Robert DS Pitceathly, Sarah Berry, Zoe McIntyre, Michael G Hanna, Michael Lee, Patrick F Chinnery
Feb 26, 2020
ESUR/ESUI consensus statements on multi-parametric MRI for the detection of clinically significant prostate cancer
Maarten de Rooij, Bas Israël, Marcia Tummers, Hashim U. Ahmed, Tristan Barrett, Francesco Giganti, Bernd Hamm, Vibeke Løgager, Anwar Padhani, Valeria Panebianco, Philippe Puech, Jonathan Richenberg, Olivier Rouvière, Georg Salomon, Ivo Schoots, Jeroen Veltman, Geert Villeirs, Jochen Walz, Jelle O. Barentsz
Sep 07, 2020
Amyloid-β and APOE genotype predict memory decline in cognitively unimpaired older individuals independently of Alzheimer's disease polygenic risk score.
Jori Tomassen, Anouk den Braber, Sven J van der Lee, Lianne M Reus, Elles Konijnenberg, Stephen F Carter, Maqsood Yaqub, Bart NM van Berckel, Lyduine E Collij, Dorret I Boomsma, Eco JC de Geus, Philip Scheltens, Karl Herholz, Betty M Tijms, Pieter Jelle Visser
Dec 15, 2022
BACKGROUND: What combination of risk factors for Alzheimer's disease (AD) are most predictive of cognitive decline in cognitively unimpaired individuals remains largely unclear. We studied associations between APOE genotype...
APOE genotype Amyloid-β cognitive decline Longitudinal design neuropsychology polygenic risk score Preclinical Alzheimer’s disease Female Humans Male Alzheimer Disease Amyloid beta-Peptides Cognitive Dysfunction Genotype Apolipoproteins E Memory Disorders Risk Factors Positron-Emission Tomography Apolipoprotein E4
Epigenetic remodelling licences adult cholangiocytes for organoid formation and liver regeneration.
Luigi Aloia, Mikel Alexander McKie, Grégoire Vernaz, Lucía Cordero-Espinoza, Niya Aleksieva, Jelle van den Ameele, Francesco Antonica, Berta Font-Cunill, Alexander Raven, Riccardo Aiese Cigliano, German Belenguer, Richard L Mort, Andrea H Brand, Magdalena Zernicka-Goetz, Stuart J Forbes, Eric A Miska, Meritxell Huch
Oct 21, 2019
Adaptor Proteins Signal Transducing Animals Bile Ducts Cell Cycle Proteins DNA Methylation DNA-Binding Proteins Epigenesis Genetic epigenome Epithelial Cells Female Gene Expression Profiling Hippo Signaling Pathway Liver Liver Regeneration Male Mice Transgenic Organoids Primary Cell Culture Protein Serine-Threonine Kinases Proto-Oncogene Proteins Signal Transduction Transcriptome YAP-Signaling Proteins
High prevalence of focal and multi-focal somatic genetic variants in the human brain.
Michael J Keogh, Wei Wei, Juvid Aryaman, Lauren Walker, Jelle van den Ameele, Jon Coxhead, Ian Wilson, Matthew Bashton, Jon Beck, John West, Richard Chen, Christian Haudenschild, Gabor Bartha, Shujun Luo, Chris M Morris, Nick S Jones, Johannes Attems, Patrick F Chinnery
Nov 13, 2018
Somatic mutations during stem cell division are responsible for several cancers. In principle, a similar process could occur during the intense cell proliferation accompanying human brain development, leading to the accumulation...
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