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Functional movements of the GABA type A receptor.
We have performed a parallel tempering crankshaft motion Monte Carlo simulation on a model of the GABA type A receptor with the aim of exploring a wide variety of local conformational space. We develop a novel method to analyse...
Prediction of GABARAP interaction with the GABA type A receptor.
We have performed docking simulations on GABARAP interacting with the GABA type A receptor using SwarmDock. We have also used a novel method to study hydration sites on the surface of these two proteins; this method identifies...
Temporal Dynamics of GABA and Glx in the Visual Cortex.
Reuben Rideaux
Jul 06, 2020
Magnetic resonance spectroscopy (MRS) can be used in vivo to quantify neurometabolite concentration and provide evidence for the involvement of different neurotransmitter systems (e.g., inhibitory and excitatory) in sensory and...
Jane Smith and Jennifer Disney Capture Faculty Awards
Winthrop University
Jan 01, 0001
Faculty members Jane Smith, English, and Jennifer Disney, political science, were named Distinguished Professor and Outstanding Junior Professor. The awards were presented May 5 during spring commencement.
Published by: Winthrop University
Hippocampal GABA enables inhibitory control over unwanted thoughts.
Taylor W Schmitz, Marta M Correia, Catarina S Ferreira, Andrew P Prescot, Michael C Anderson
Apr 06, 2018
Intrusive memories, images, and hallucinations are hallmark symptoms of psychiatric disorders. Although often attributed to deficient inhibitory control by the prefrontal cortex, difficulty in controlling intrusive thoughts is...
GABA promotes gastrin-releasing peptide secretion in NE/NE-like cells
Susana R Solorzano, Ivan Imaz-Rosshandler, Ignacio Camacho-Arroyo, Pilar García-Tobilla, Gustavo Morales-Montor, Patricia Salazar, Ma Leticia Arena-Ortiz, Mauricio Rodríguez-Dorantes
Sep 20, 2018
In prostate cancer (PCa), neuroendocrine cells (NE) have been associated with the progression of the disease due to the secretion of neuropeptides that are capable of diffusing and influence surrounding cells. The GABAergic...
Symptom improvement in children with autism spectrum disorder following bumetanide administration is associated with decreased GABA/glutamate ratios.
Lingli Zhang, Chu-Chung Huang, Yuan Dai, Qiang Luo, Yiting Ji, Kai Wang, Shining Deng, Juehua Yu, Mingyu Xu, Xiujuan Du, Yun Tang, Chun Shen, Jianfeng Feng, Barbara J Sahakian, Ching-Po Lin, Fei Li
Feb 28, 2020
Bumetanide has been reported to alter synaptic excitation-inhibition (E-I) balance by potentiating the action of γ-aminobutyric acid (GABA), thereby attenuating the severity of autism spectrum disorder (ASD) in animal models....
GABA, not BOLD, reveals dissociable learning-dependent plasticity mechanisms in the human brain.
Experience and training have been shown to facilitate our ability to extract and discriminate meaningful patterns from cluttered environments. Yet, the human brain mechanisms that mediate our ability to learn by suppressing...
brain plasticity Functional MRI human Magnetic Resonance Spectroscopy neuroscience visual learning Adult Female GABAergic Neurons Humans learning Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Male Neural Inhibition Neuronal Plasticity Occipital Lobe Perception Temporal Lobe Young Adult gamma-Aminobutyric Acid
Developmental excitatory-to-inhibitory GABA-polarity switch is disrupted in 22q11.2 deletion syndrome
Individuals with 22q11.2 microdeletion syndrome (22q11.2 DS) show cognitive and behavioral dysfunctions, developmental delays in childhood and risk of developing schizophrenia and autism. Despite extensive previous studies in...
GABA-ergic Dynamics in Human Frontotemporal Networks Confirmed by Pharmaco-Magnetoencephalography.
Natalie E Adams, Laura E Hughes, Holly N Phillips, Alexander D Shaw, Alexander G Murley, David Nesbitt, Thomas E Cope, W Richard Bevan-Jones, Luca Passamonti, James B Rowe
Jan 08, 2020
To bridge the gap between preclinical cellular models of disease and in vivo imaging of human cognitive network dynamics, there is a pressing need for informative biophysical models. Here we assess dynamic causal models (DCM) of...
‘Working on a rocky shore’
Susanne Gannon, Carol Taylor, Gill Adams, Helen Donaghue, Stephanie Hannam-Swain, Jean Harris-Evans, Joan Healey, Patricia Moore
May 01, 2019
Neoliberal ideologies, marketization and performative regimes associated with recent reforms in universities have exerted considerable pressure on academic working conditions and subjects in recent years. While analysing these...
Excitatory/inhibitory imbalance in autism
Viola Hollestein, Geert Poelmans, Natalie J Forde, Christian F Beckmann, Christine Ecker, Caroline Mann, Tim Schäfer, Carolin Moessnang, Sarah Baumeister, Tobias Banaschewski, Thomas Bourgeron, Eva Loth, Flavio Dell'Acqua, Declan GM Murphy, Nicolaas A Puts, Julian Tillmann, Tony Charman, Emily JH Jones, Luke Mason, Sara Ambrosino, Rosemary Holt, Sven Bölte, Jan K Buitelaar, Jilly Naaijen
Feb 21, 2023
The excitatory/inhibitory (E/I) imbalance hypothesis posits that imbalance between excitatory (glutamatergic) and inhibitory (GABAergic) mechanisms underlies the behavioral characteristics of autism. However, how E/I imbalance...
Ethosuximide modifies network excitability in the rat entorhinal cortex via an increase in GABA release
Stuart D Greenhill, Nicola H Morgan, Peter V Massey, Gavin L Woodhall, Roland S G Jones
Feb 01, 2012
Ethosuximide is the drug of choice for treating generalized absence seizures, but its mechanism of action is still a matter of debate. It has long been thought to act by disrupting a thalamic focus via blockade of T-type...
Ethosuximide modifies network excitability in the rat entorhinal cortex via an increase in GABA release
Stuart D Greenhill, Nicola H Morgan, Peter V Massey, Gavin L Woodhall, Roland S G Jones
Feb 01, 2012
Ethosuximide is the drug of choice for treating generalized absence seizures, but its mechanism of action is still a matter of debate. It has long been thought to act by disrupting a thalamic focus via blockade of T-type...
‘Working on a rocky shore’
Susanne Gannon, Carol Taylor, Gill Adams, Helen Donaghue, Stephanie Hannam-Swain, Jean Harris-Evans, Joan Healey, Patricia Moore
May 01, 2019
Neoliberal ideologies, marketization and performative regimes associated with recent reforms in universities have exerted considerable pressure on academic working conditions and subjects in recent years. While analysing these...
Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice.
Andrea Slezia, Christopher M Proctor, Attila Kaszas, George G Malliaras, Adam Williamson
Jul 09, 2019
Epilepsy is a group of neurological disorders which affects millions of people worldwide. Although treatment with medication is helpful in 70% of the cases, serious side effects affect the quality of life of patients. Moreover...
GnRH pulse generator frequency is modulated by kisspeptin and GABA-glutamate interactions in the posterodorsal medial amygdala in female mice.
Geffen Lass, Xiao Feng Li, Margaritis Voliotis, Ellen Wall, Ross A de Burgh, Deyana Ivanova, Caitlin McIntyre, Xian-Hua Lin, William H Colledge, Stafford L Lightman, Krasimira Tsaneva-Atanasova, Kevin T O'Byrne
Oct 28, 2022
Kisspeptin neurons in the arcuate nucleus of the hypothalamus generate gonadotrophin-releasing hormone (GnRH) pulses, and act as critical initiators of functional gonadotrophin secretion and reproductive competency. However...
Highway to Hell? Images of the American Road in Kelly Reichardt's<i>Old Joy</i>,<i>Wendy and Lucy</i>, and<i>Meek's Cutoff</i>
This article examines representations of the road in the work of independent Florida-born film director Kelly Reichardt. Reading Reichardt's so-called Oregon trilogy,Old...
DIARMUID HESTER
Dec 10, 2018
Investigating How Corridor Cell Migration is Influenced by GABA
Samantha White
Jan 01, 0001
Fetal alcohol spectrum disorders (FASD) result in many developmental abnormalities, including sensation and perception, which are detrimental to life. These abnormalities can result from thalamocortical axon (TCA) misguidance....
thalamocortical axons GABA corridor cells Migration fetal alcohol spectrum disorders Life Sciences Neuroscience and Neurobiology
Published by: Ursinus College
The length of uninterrupted CAG repeats in stem regions of repeat disease associated hairpins determines the amount of short CAG oligonucleotides that are toxic to cells through RNA interference
Abstract Extended CAG trinucleotide repeats (TNR) in the genes huntingtin (HTT ) and androgen receptor (AR ) are the cause of two progressive...
Andrea E Murmann, Monal Patel, Si-Yeon Jeong, Elizabeth T Bartom, A Jennifer Morton, Marcus E Peter
Jan 04, 2023
A Comparison of Your Better Life Index and Its Antecedents Across Two Chinese Cultures
Jennifer Gao
Jul 01, 2021
OECD identified 11 topics in Your Better Life Index (YBLI). YBLI is generally accepted as an essential indicator of material living conditions and quality of life. This study compared YBLI in two predominantly Chinese regions...
Published by: IGI Global Scientific Publishing
The RNA-binding proteins Zfp36l1 and Zfp36l2 act redundantly in myogenesis.
Hema Bye-A-Jee, Dhamayanthi Pugazhendhi, Samuel Woodhouse, Patrick Brien, Rachel Watson, Martin Turner, Jennifer Pell
Jun 24, 2019
BACKGROUND: Members of the ZFP36 family of RNA-binding proteins regulate gene expression post-transcriptionally by binding to AU-rich elements in the 3'UTR of mRNA and stimulating mRNA degradation. The proteins within this...
Injury RNA RNA-Binding Proteins Regeneration satellite cells Skeletal muscle stem cells Zfp36L1 Zfp36L2 Animals Butyrate Response Factor 1 Cell Differentiation Cells Cultured Female Male Mice Mice Inbred C57BL Muscle Development Muscle Skeletal Nuclear Proteins PAX7 Transcription Factor RNA Messenger RNA-Binding Proteins satellite cells Skeletal Muscle Tristetraprolin
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