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A phase 1, single-dose study of fresolimumab, an anti-TGF-β antibody, in treatment-resistant primary focal segmental glomerulosclerosis.
Howard Trachtman, Fernando C Fervenza, Debbie S Gipson, Peter Heering, David RW Jayne, Harm Peters, Stefano Rota, Giuseppe Remuzzi, L Christian Rump, Lorenz K Sellin, Jeremy PW Heaton, James B Streisand, Marjie L Hard, Steven R Ledbetter, Flavio Vincenti
Nov 24, 2020
Primary focal segmental glomerulosclerosis (FSGS) is a disease with poor prognosis and high unmet therapeutic need. Here, we evaluated the safety and pharmacokinetics of single-dose infusions of fresolimumab, a human monoclonal...
Adult Antibodies Monoclonal Antibodies Monoclonal Humanized Biomarkers Biopsy Creatinine Dose-Response Relationship Drug Europe Female Glomerular Filtration Rate Glomerulosclerosis Focal Segmental Humans Infusions Parenteral Kidney Male Middle Aged Proteinuria Transforming Growth Factor beta Treatment Outcome United States Young Adult
Modeling arterial pulse waves in healthy aging
Peter H Charlton, Jorge Mariscal Harana, Samuel Vennin, Ye Li, Phil Chowienczyk, Jordi Alastruey
Sep 11, 2020
The arterial pulse wave (PW) is a rich source of information on cardiovascular (CV) health. It is widely measured by both consumer and clinical devices. However, the physical determinants of the PW are not yet fully understood...
IPR Policy Brief - Mentally disordered offenders' perspectives on their risk assessment plans
Jeremy Dixon
Feb 01, 2014
Research carried out by Dr Jeremy Dixon (University of Bath) examined mentally disordered offenders’ views of their risk assessment and management plans.
The research took place between March 2009 and September 2011...
The research took place between March 2009 and September 2011...
/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Published by: University of Bath
IPR Policy Brief - Mentally disordered offenders' perspectives on their risk assessment plans
Jeremy Dixon
Feb 01, 2014
Research carried out by Dr Jeremy Dixon (University of Bath) examined mentally disordered offenders’ views of their risk assessment and management plans.
The research took place between March 2009 and September 2011...
The research took place between March 2009 and September 2011...
/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Published by: University of Bath
To Press, Or Not to Press the Button?
Timo Kivimaki
Oct 22, 2015
This article looks at the interpretative foundations of nuclear deterrence and interprets the statement by Jeremy Corbryn, related to UK's nuclear weapons.
To Press, Or Not to Press the Button?
Timo Kivimaki
Oct 22, 2015
This article looks at the interpretative foundations of nuclear deterrence and interprets the statement by Jeremy Corbryn, related to UK's nuclear weapons.
Hybrid and Virtual Educational Simulation Games (vESGs) for the Remote Learning Era
Virtual educational simulation games (vESGs) promote unique combinations of learning interactions and affordances to create environments with which students can engage to effectively learn about complex phenomena and processes...
Educational Technologies Education Teacher Education Media and Communications Computer Science and Information Technology
Published by: IGI Global Scientific Publishing
Developing Written Argumentation Skills With an Educational Simulation Game (ESG)
In this chapter, the authors present the case of GlobalEd, a virtual educational simulation game (ESG) that focuses on the development of student written argumentation and socio-scientific literacy skills over the course of...
Web-Based Teaching & Learning Education Curriculum Development and Instructional Design Library and Information Science Computer Science and Information Technology
Published by: IGI Global Scientific Publishing
Defining and Designing Responsive Online Professional Development (ROPD)
Teacher professional development programs typically do not meet teachers' ongoing, long-term needs that arise. In this chapter, the authors forward a systematic framework called responsive online professional development (ROPD)...
Educational Technologies Education Educational Technologies Computer Science and Information Technology
Published by: IGI Global Scientific Publishing
Enhancing Student Affect From Multi-Classroom Simulation Games via Teacher Professional Development
Educational simulations often require players to maintain a high degree of engagement for play in the simulation to continue. Student motivation and engagement is tied to affective factors, such as interest and self-efficacy. As...
Published by: IGI Global Scientific Publishing
The political realism of Jeremy Bentham
James Vitali
Feb 25, 2023
The Ontological Structure of the Hermeneutic Circle
In his recent review of a book by Fred Lawrence, Jeremy Wilkins remarked that the author left undeveloped his claim that Lonergan’s functional specialties “thematize the ontological structure of the hermeneutic circle.” Why, he...
Published by: Memorial University of Newfoundland
The Cambridge Crime Harm Index
The logic of simply summing crimes of all kind into a single total has long been challenged as misleading. All crimes are not created equal. Counting them as if they are fosters distortion of risk assessments, resource...
Linear response of east Greenland's tidewater glaciers to ocean/atmosphere warming.
Predicting the retreat of tidewater outlet glaciers forms a major obstacle to forecasting the rate of mass loss from the Greenland Ice Sheet. This reflects the challenges of modeling the highly dynamic, topographically complex...
The Grizzly, April 28, 2011
Katie Callahan, Allison Nichols, Liz Kilmer, Taylor Sparks, Lisa Jobe, Sara Hourwitz, Laura Faith, Ryan Sullivan, Jeff Centafont, Sarah Bollert, Brooke Haley, Sara Sherr, Kyu Chul Shin, Nick Pane
Jan 01, 0001
New U Hosts "Spring Into Wellness" Month College Campuses are a Hotbed for Theft Take a Little Break with Activities from Around Collegeville Relay for Life Benefits American Cancer Society Active Minds Hosts Art Festival ...
Ursinus College Collegeville Pennsylvania newspaper Wellness Theft Relay for Life Active Minds Ahnenerbe Sierra Guerin Jeremy Garavel cross country track team cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Analysis and design for constant current/constant voltage multi-coil wireless power transfer system with high EMF reduction
Abstract: The investigation on the constant current (CC)/constant voltage (CV) charging for the electric vehicle wireless power transfer (WPT) system has been widely conducted. However, the CC/CV performance under misalignment...
Essential Genes for In Vitro Growth of the Endophyte Herbaspirillum seropedicae SmR1 as Revealed by Transposon Insertion Site Sequencing.
A High-Quality De novo Genome Assembly from a Single Mosquito Using PacBio Sequencing.
Sarah B Kingan, Haynes Heaton, Juliana Cudini, Christine C Lambert, Primo Baybayan, Brendan D Galvin, Richard Durbin, Jonas Korlach, Mara Kn Lawniczak
Apr 09, 2019
A high-quality reference genome is a fundamental resource for functional genetics, comparative genomics, and population genomics, and is increasingly important for conservation biology. PacBio Single Molecule, Real-Time (SMRT)...
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