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Results: 39
Identification of genes preventing transgenerational transmission of stress-induced epigenetic states.
DNA Methylation chromatin regulation ATPases Associated with Diverse Cellular Activities Arabidopsis Arabidopsis Proteins DNA Methylation DNA-Binding Proteins Epigenesis Genetic Gene Expression Regulation Plant Hot Temperature Inheritance Patterns Mutation Nuclear Proteins Plants Genetically Modified Reverse Transcriptase Polymerase Chain Reaction Stress Physiological Transcription Factors Transcription Genetic
Developmental Restriction of Retrotransposition Activated in Arabidopsis by Environmental Stress.
Retrotransposons (RTs) can rapidly increase in copy number due to periodic bursts of transposition. Such bursts are mutagenic and thus potentially deleterious. However, certain transposition-induced gain-of-function or...
Mobilization of Pack-CACTA transposons in Arabidopsis suggests the mechanism of gene shuffling.
Pack-TYPE transposons are a unique class of potentially mobile non-autonomous elements that can capture, merge and relocate fragments of chromosomal DNA. It has been postulated that their activity accelerates the evolution of...
Environmental and epigenetic regulation of Rider retrotransposons in tomato.
Matthias Benoit, Hajk-Georg Drost, Marco Catoni, Quentin Gouil, Sara Lopez-Gomollon, David Baulcombe, Jerzy Paszkowski
Oct 29, 2019
Transposable elements in crop plants are the powerful drivers of phenotypic variation that has been selected during domestication and breeding programs. In tomato, transpositions of the LTR (long terminal repeat) retrotransposon...
Online or Offline Services for Urban Neighbourhoods?
Services originally developed as natural concentrations of human activity, reflecting the Christallerian hierarchy of central places. Today, those natural mechanisms are challenged by strong competition from online facilities....
Published by: IGI Global Scientific Publishing
Environmental proxies of antigen exposure explain variation in immune investment better than indices of pace of life.
Nicholas PC Horrocks, Arne Hegemann, Stéphane Ostrowski, Henry Ndithia, Mohammed Shobrak, Joseph B Williams, Kevin D Matson, BI Tieleman
Mar 20, 2015
Are antimicrobial defences in bird eggs related to climatic conditions associated with risk of trans-shell microbial infection?
Nicholas PC Horrocks, Kathryn Hine, Arne Hegemann, Henry K Ndithia, Mohammed Shobrak, Stéphane Ostrowski, Joseph B Williams, Kevin D Matson, B Irene Tieleman
Aug 23, 2021
INTRODUCTION: All bird eggs are exposed to microbes in the environment, which if transmitted to the developing embryo, could cause hatching failure. However, the risk of trans-shell infection varies with environmental conditions...
High-frequency recombination between members of an LTR retrotransposon family during transposition bursts.
Retrotransposons containing long terminal repeats (LTRs) form a substantial fraction of eukaryotic genomes. The timing of past transposition can be estimated by quantifying the accumulation of mutations in initially identical...
Implications of Oxidative Stress in Glioblastoma Multiforme Following Treatment with Purine Derivatives.
Marta Orlicka-Płocka, Agnieszka Fedoruk-Wyszomirska, Dorota Gurda-Woźna, Paweł Pawelczak, Patrycja Krawczyk, Małgorzata Giel-Pietraszuk, Grzegorz Framski, Tomasz Ostrowski, Eliza Wyszko
Jun 13, 2021
Recently, small compound-based therapies have provided new insights into the treatment of glioblastoma multiforme (GBM) by inducing oxidative impairment. Kinetin riboside (KR) and newly designed derivatives (8-azaKR, 7-deazaKR)...
A Thyroid Hormone-Independent Molecular Fingerprint of 3,5-Diiodothyronine Suggests a Strong Relationship with Coffee Metabolism in Humans.
Maik Pietzner, Josef Köhrle, Ina Lehmphul, Kathrin Budde, Gabi Kastenmüller, Georg Brabant, Henry Völzke, Anna Artati, Jerzy Adamski, Uwe Völker, Matthias Nauck, Nele Friedrich, Georg Homuth
Jan 10, 2020
Background: In numerous studies based predominantly on rodent models, administration of 3,5-diiodo-L-thyronine (3,5-T2), a metabolite of the thyroid hormones (TH) thyroxine (T4) and triiodo-L-thyronine (T3), was reported to...
3 5-diiodothyronine caffeine metabolism Metabolomics Thyroid thyrotoxicosis Adult caffeine Coffee DNA Fingerprinting Diiodothyronines Female Healthy Volunteers Humans Magnetic Resonance Spectroscopy Male Mass Spectrometry Metabolomics Middle Aged Reference Values Thyroid Function Tests Thyroid Hormones Thyrotoxicosis Thyrotropin Thyroxine
Comprehensive metabolic profiling of chronic low-grade inflammation among generally healthy individuals.
Maik Pietzner, Anne Kaul, Ann-Kristin Henning, Gabi Kastenmüller, Anna Artati, Markus M Lerch, Jerzy Adamski, Matthias Nauck, Nele Friedrich
Nov 16, 2020
BACKGROUND: Inflammation occurs as an immediate protective response of the immune system to a harmful stimulus, whether locally confined or systemic. In contrast, a persisting, i.e., chronic, inflammatory state, even at a...
C-Reactive Protein Fibrinogen Inflammation Mass Spectrometry Metabolomics nuclear magnetic resonance spectroscopy White blood cell count Adult Atherosclerosis Biomarkers C-Reactive Protein Cardiovascular Diseases Female Humans Inflammation Inflammation Mediators Male Mass Spectrometry Metabolomics Middle Aged Nuclear Magnetic Resonance Biomolecular Risk Factors
The mitochondrial transporter SLC25A25 links ciliary TRPP2 signaling and cellular metabolism.
Alexis Hofherr, Claudia Seger, Fiona Fitzpatrick, Tilman Busch, Elisabeth Michel, Jingting Luan, Lea Osterried, Frieder Linden, Albrecht Kramer-Zucker, Barbara Wakimoto, Conny Schütze, Nils Wiedemann, Anna Artati, Jerzy Adamski, Gerd Walz, Edmund RS Kunji, Craig Montell, Terry Watnick, Michael Köttgen
Nov 09, 2018
Cilia are organelles specialized in movement and signal transduction. The ciliary transient receptor potential ion channel polycystin-2 (TRPP2) controls elementary cilia-mediated physiological functions ranging from male...
The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes
Robert W. Koivula, Naeimeh Atabaki-Pasdar, Giuseppe N. Giordano, Tom White, Jerzy Adamski, Jimmy D. Bell, Joline Beulens, Søren Brage, Søren Brunak, Federico De Masi, Emmanouil T. Dermitzakis, Ian M. Forgie, Gary Frost, Torben Hansen, Tue H. Hansen, Andrew Hattersley, Tarja Kokkola, Azra Kurbasic, Markku Laakso, Andrea Mari, Timothy J. McDonald, Oluf Pedersen, Femke Rutters, Jochen M. Schwenk, Harriet J. A. Teare, E. Louise Thomas, Ana Vinuela, Anubha Mahajan, Mark I. McCarthy, Hartmut Ruetten, Mark Walker, Ewan Pearson, Imre Pavo, Paul W. Franks
Jun 06, 2020
Abstract: Aims/hypothesis: It is well established that physical activity, abdominal ectopic fat and glycaemic regulation are related but the underlying structure of these relationships is unclear. The previously proposed...
The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes
Robert W Koivula, Naeimeh Atabaki-Pasdar, Giuseppe N Giordano, Tom White, Jerzy Adamski, Jimmy D Bell, Joline Beulens, Søren Brage, Søren Brunak, Federico De Masi, Emmanouil T Dermitzakis, Ian M Forgie, Gary Frost, Torben Hansen, Tue H Hansen, Andrew Hattersley, Tarja Kokkola, Azra Kurbasic, Markku Laakso, Andrea Mari, Timothy J McDonald, Oluf Pedersen, Femke Rutters, Jochen M Schwenk, Harriet JA Teare, E Louise Thomas, Ana Vinuela, Anubha Mahajan, Mark I McCarthy, Hartmut Ruetten, Mark Walker, Ewan Pearson, Imre Pavo, Paul W Franks, IMI DIRECT Consortium
Jan 29, 2021
Beta cell function ectopic fat glycaemic control insulin sensitivity physical activity Prediabetes structural equation modelling Type 2 diabetes Aged Blood Glucose Cohort Studies Cross-Sectional Studies Denmark Diabetes mellitus Type 2 Energy Metabolism Exercise Female Finland Glucose Tolerance Test glycemic control Homeostasis Humans Insulin Resistance Male Middle Aged Netherlands Sweden
Reproducibility of Molecular Phenotypes after Long-Term Differentiation to Human iPSC-Derived Neurons
Viola Volpato, James Smith, Cynthia Sandor, Janina S Ried, Anna Baud, Adam Handel, Sarah E Newey, Frank Wessely, Moustafa Attar, Emma Whiteley, Satyan Chintawar, An Verheyen, Thomas Barta, Majlinda Lako, Lyle Armstrong, Caroline Muschet, Anna Artati, Carlo Cusulin, Klaus Christensen, Christoph Patsch, Eshita Sharma, Jerome Nicod, Philip Brownjohn, Victoria Stubbs, Wendy E Heywood, Paul Gissen, Roberta De Filippis, Katharina Janssen, Peter Reinhardt, Jerzy Adamski, Ines Royaux, Pieter J Peeters, Georg C Terstappen, Martin Graf, Frederick J Livesey, Colin J Akerman, Kevin Mills, Rory Bowden, George Nicholson, Caleb Webber, M Zameel Cader, Viktor Lakics
Feb 01, 2019
cortical neurons cross-site experimental variation gene expression profile induced pluripotent stem cell molecular profiling proteomic profiles public-private partnership reproducibility Single-cell sequencing stembancc Cell Differentiation Cell Line Factor Analysis Statistical Gene Expression Regulation Genotype Humans Induced Pluripotent Stem Cells Neurons Phenotype Proteomics Reproducibility of Results Transcriptome
The blood metabolome of incident kidney cancer
Florence Guida, Vanessa Y Tan, Laura J Corbin, Karl Smith-Byrne, Karine Alcala, Claudia Langenberg, Isobel D Stewart, Adam S Butterworth, Praveen Surendran, David Achaintre, Jerzy Adamski, Pilar Amiano Exezarreta, Manuela M Bergmann, Caroline J Bull, Christina C Dahm, Audrey Gicquiau, Graham G Giles, Marc J Gunter, Toomas Haller, Arnulf Langhammer, Tricia L Larose, Börje Ljungberg, Andres Metspalu, Roger L Milne, David C Muller, Therese H Nøst, Elin Pettersen Sørgjerd, Cornelia Prehn, Elio Riboli, Sabina Rinaldi, Joseph A Rothwell, Augustin Scalbert, Julie A Schmidt, Gianluca Severi, Sabina Sieri, Roel Vermeulen, Emma E Vincent, Melanie Waldenberger, Nicholas J Timpson, Mattias Johansson
Oct 18, 2021
BACKGROUND: Excess bodyweight and related metabolic perturbations have been implicated in kidney cancer aetiology, but the specific molecular mechanisms underlying these relationships are poorly understood. In this study, we...
The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes
Robert W. Koivula, Naeimeh Atabaki-Pasdar, Giuseppe N. Giordano, Tom White, Jerzy Adamski, Jimmy D. Bell, Joline Beulens, Søren Brage, Søren Brunak, Federico De Masi, Emmanouil T. Dermitzakis, Ian M. Forgie, Gary Frost, Torben Hansen, Tue H. Hansen, Andrew Hattersley, Tarja Kokkola, Azra Kurbasic, Markku Laakso, Andrea Mari, Timothy J. McDonald, Oluf Pedersen, Femke Rutters, Jochen M. Schwenk, Harriet J. A. Teare, E. Louise Thomas, Ana Vinuela, Anubha Mahajan, Mark I. McCarthy, Hartmut Ruetten, Mark Walker, Ewan Pearson, Imre Pavo, Paul W. Franks
Nov 13, 2020
Abstract: Aims/hypothesis: It is well established that physical activity, abdominal ectopic fat and glycaemic regulation are related but the underlying structure of these relationships is unclear. The previously proposed...
The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes
Robert W. Koivula, Naeimeh Atabaki-Pasdar, Giuseppe N. Giordano, Tom White, Jerzy Adamski, Jimmy D. Bell, Joline Beulens, Søren Brage, Søren Brunak, Federico De Masi, Emmanouil T. Dermitzakis, Ian M. Forgie, Gary Frost, Torben Hansen, Tue H. Hansen, Andrew Hattersley, Tarja Kokkola, Azra Kurbasic, Markku Laakso, Andrea Mari, Timothy J. McDonald, Oluf Pedersen, Femke Rutters, Jochen M. Schwenk, Harriet J. A. Teare, E. Louise Thomas, Ana Vinuela, Anubha Mahajan, Mark I. McCarthy, Hartmut Ruetten, Mark Walker, Ewan Pearson, Imre Pavo, Paul W. Franks
Dec 04, 2020
Abstract: Aims/hypothesis: It is well established that physical activity, abdominal ectopic fat and glycaemic regulation are related but the underlying structure of these relationships is unclear. The previously proposed...
The blood metabolome of incident kidney cancer
Florence Guida, Vanessa Y Tan, Laura J Corbin, Karl Smith-Byrne, Karine Alcala, Claudia Langenberg, Isobel D Stewart, Adam S Butterworth, Praveen Surendran, David Achaintre, Jerzy Adamski, Pilar Amiano, Manuela M Bergmann, Caroline J Bull, Christina C Dahm, Audrey Gicquiau, Graham G Giles, Marc J Gunter, Toomas Haller, Arnulf Langhammer, Tricia L Larose, Börje Ljungberg, Andres Metspalu, Roger L Milne, David C Muller, Therese H Nøst, Elin Pettersen Sørgjerd, Cornelia Prehn, Elio Riboli, Sabina Rinaldi, Joseph A Rothwell, Augustin Scalbert, Julie A Schmidt, Gianluca Severi, Sabina Sieri, Roel Vermeulen, Emma E Vincent, Melanie Waldenberger, Nicholas J Timpson, Mattias Johansson
Oct 21, 2021
Background
Excess bodyweight and related metabolic perturbations have been implicated in kidney cancer aetiology, but the specific molecular mechanisms underlying these relationships are poorly understood. In this study...
Published by: PLoS Medicine
Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes
Robert W Koivula, Ian M Forgie, Azra Kurbasic, Ana Viñuela, Alison Heggie, Giuseppe N Giordano, Tue H Hansen, Michelle Hudson, Anitra DM Koopman, Femke Rutters, Maritta Siloaho, Kristine H Allin, Søren Brage, Caroline A Brorsson, Adem Y Dawed, Federico De Masi, Christopher J Groves, Tarja Kokkola, Anubha Mahajan, Mandy H Perry, Simone P Rauh, Martin Ridderstråle, Harriet JA Teare, E Louise Thomas, Andrea Tura, Henrik Vestergaard, Tom White, Jerzy Adamski, Jimmy D Bell, Joline W Beulens, Søren Brunak, Emmanouil T Dermitzakis, Philippe Froguel, Gary Frost, Ramneek Gupta, Torben Hansen, Andrew Hattersley, Bernd Jablonka, Jane Kaye, Markku Laakso, Timothy J McDonald, Oluf Pedersen, Jochen M Schwenk, Imre Pavo, Andrea Mari, Mark I McCarthy, Hartmut Ruetten, Mark Walker, Ewan Pearson, Paul W Franks, IMI DIRECT Consortium
Apr 26, 2019
AIMS/HYPOTHESIS: Here, we describe the characteristics of the Innovative Medicines Initiative (IMI) Diabetes Research on Patient Stratification (DIRECT) epidemiological cohorts at baseline and follow-up examinations (18, 36 and...
Diet ectopic fat Genome glycaemic control Insulin Secretion insulin sensitivity Personalised medicine physical activity Prediabetes Type 2 diabetes Aged Biomarkers Blood Glucose Cohort Studies Diabetes mellitus Type 2 Female Glucose Glucose Tolerance Test Humans Male Metformin Middle Aged Prediabetic State Prospective Studies
Dietary metabolite profiling brings new insight into the relationship between nutrition and metabolic risk
Rebeca Eriksen, Isabel Garcia Perez, Joram M. Posma, Mark Haid, Sapna Sharma, Cornelia Prehn, Louise E. Thomas, Robert W. Koivula, Roberto Bizzotto, Andrea Mari, Giuseppe N. Giordano, Imre Pavo, Jochen M. Schwenk, Federico De Masi, Konstantinos D. Tsirigos, Søren Brunak, Ana Viñuela, Anubha Mahajan, Timothy J. McDonald, Tarja Kokkola, Femke Rutter, Harriet Teare, Tue H. Hansen, Juan Fernandez, Angus Jones, Chris Jennison, Mark Walker, Mark I. McCarthy, Oluf Pedersen, Hartmut Ruetten, Ian Forgie, Jimmy D. Bell, Ewan R. Pearson, Paul W. Franks, Jerzy Adamski, Elaine Holmes, Gary Frost
Aug 01, 2020
Background: Dietary advice remains the cornerstone of prevention and management of type 2 diabetes (T2D). However, understanding the efficacy of dietary interventions is confounded by the challenges inherent in assessing free...
Dietary metabolite profiling brings new insight into the relationship between nutrition and metabolic risk
Rebeca Eriksen, Isabel Garcia Perez, Joram M. Posma, Mark Haid, Sapna Sharma, Cornelia Prehn, Louise E. Thomas, Robert W. Koivula, Roberto Bizzotto, Andrea Mari, Giuseppe N. Giordano, Imre Pavo, Jochen M. Schwenk, Federico De Masi, Konstantinos D. Tsirigos, Søren Brunak, Ana Viñuela, Anubha Mahajan, Timothy J. McDonald, Tarja Kokkola, Femke Rutter, Harriet Teare, Tue H. Hansen, Juan Fernandez, Angus Jones, Chris Jennison, Mark Walker, Mark I. McCarthy, Oluf Pedersen, Hartmut Ruetten, Ian Forgie, Jimmy D. Bell, Ewan R. Pearson, Paul W. Franks, Jerzy Adamski, Elaine Holmes, Gary Frost
Aug 01, 2020
Background: Dietary advice remains the cornerstone of prevention and management of type 2 diabetes (T2D). However, understanding the efficacy of dietary interventions is confounded by the challenges inherent in assessing free...
The blood metabolome of incident kidney cancer
Florence Guida, Vanessa Y. Tan, Laura J. Corbin, Karl Smith-Byrne, Karine Alcala, Claudia Langenberg, Isobel D. Stewart, Adam S. Butterworth, Praveen Surendran, David Achaintre, Jerzy Adamski, Pilar Amiano, Manuela M. Bergmann, Caroline J. Bull, Christina C. Dahm, Audrey Gicquiau, Graham G. Giles, Marc J. Gunter, Toomas Haller, Arnulf Langhammer, Tricia L. Larose, Börje Ljungberg, Andres Metspalu, Roger L. Milne, David C. Muller, Therese H. Nøst, Elin Pettersen Sørgjerd, Cornelia Prehn, Elio Riboli, Sabina Rinaldi, Joseph A. Rothwell, Augustin Scalbert, Julie A. Schmidt, Gianluca Severi, Sabina Sieri, Roel Vermeulen, Emma E. Vincent, Melanie Waldenberger, Nicholas J. Timpson, Mattias Johansson
Oct 07, 2021
Background: Excess bodyweight and related metabolic perturbations have been implicated in kidney cancer aetiology, but the specific molecular mechanisms underlying these relationships are poorly understood. In this study, we...
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