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Facing one’s implicit biases
Expanding on conflicting theoretical conceptualizations of implicit bias, 6 studies tested the effectiveness of different procedures to increase acknowledgment of harboring biases against minorities. Participants who predicted...
Single-Molecule Studies of CFTR Gating and Pharmacology
Jesper Bøegh Levring
Jan 01, 0001
The cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride channel expressed in the apical membrane of epithelial tissues. Alterations in CFTR that disrupt activity cause cystic fibrosis, a fatal disease which...
Published by: Rockefeller University
Facing one’s implicit biases
Expanding on conflicting theoretical conceptualizations of implicit bias, 6 studies tested the effectiveness of different procedures to increase acknowledgment of harboring biases against minorities. Participants who predicted...
Contribution of allelic imbalance to colorectal cancer.
Kimmo Palin, Esa Pitkänen, Mikko Turunen, Biswajyoti Sahu, Päivi Pihlajamaa, Teemu Kivioja, Eevi Kaasinen, Niko Välimäki, Ulrika A Hänninen, Tatiana Cajuso, Mervi Aavikko, Sari Tuupanen, Outi Kilpivaara, Linda van den Berg, Johanna Kondelin, Tomas Tanskanen, Riku Katainen, Marta Grau, Heli Rauanheimo, Roosa-Maria Plaketti, Aurora Taira, Päivi Sulo, Tuomo Hartonen, Kashyap Dave, Bernhard Schmierer, Sandeep Botla, Maria Sokolova, Anna Vähärautio, Kornelia Gladysz, Halit Ongen, Emmanouil Dermitzakis, Jesper Bertram Bramsen, Torben Falck Ørntoft, Claus Lindbjerg Andersen, Ari Ristimäki, Anna Lepistö, Laura Renkonen-Sinisalo, Jukka-Pekka Mecklin, Jussi Taipale, Lauri A Aaltonen
Jun 04, 2019
Point mutations in cancer have been extensively studied but chromosomal gains and losses have been more challenging to interpret due to their unspecific nature. Here we examine high-resolution allelic imbalance (AI) landscape in...
Allelic Imbalance CRISPR-Cas Systems Chromosome Aberrations Chromosomes Human Pair 8 Colorectal Neoplasms DNA Copy Number Variations Denmark Gene Expression Profiling Genetic Predisposition to Disease Genomics Genotype Humans Loss of Heterozygosity Microsatellite Repeats Phenotype Point Mutation Proto-Oncogene Proteins p21(ras) RNA Small Interfering Transcription Factors Tumor Suppressor Protein p53 whole genome sequencing
Equilibria of an anisotropic nonlocal interaction equation
In this paper, we study the equilibria of an anisotropic, nonlocal aggregation equation with nonlinear diffusion which does not possess a gradient flow structure. Here, the anisotropy is induced by an underlying tensor field....
Finite volume methods Nonlinear diffusion Nonlocal aggregation pattern formation Stationary states /dk/atira/pure/subjectarea/asjc/2600/2603 name=Analysis /dk/atira/pure/subjectarea/asjc/2600/2607 name=Discrete Mathematics and Combinatorics /dk/atira/pure/subjectarea/asjc/2600/2604 name=Applied Mathematics
Equilibria of an anisotropic nonlocal interaction equation
In this paper, we study the equilibria of an anisotropic, nonlocal aggregation equation with nonlinear diffusion which does not possess a gradient flow structure. Here, the anisotropy is induced by an underlying tensor field....
Finite volume methods Nonlinear diffusion Nonlocal aggregation pattern formation Stationary states /dk/atira/pure/subjectarea/asjc/2600/2603 name=Analysis /dk/atira/pure/subjectarea/asjc/2600/2607 name=Discrete Mathematics and Combinatorics /dk/atira/pure/subjectarea/asjc/2600/2604 name=Applied Mathematics
Freedom as Ariadne’s Thread through the Interpretation of Life
Jesper L. Rasmussen
Aug 29, 2018
According to Schelling’s 1806 Aphorisms as an Introduction to Naturphilosophie, the aim of philosophy should be nothing less than a sort of excitation of further developments of an eternal poem (Gedicht) (SW VII: 145f). This...
Published by: Memorial University Libraries
Freedom as Ariadne’s Thread through the Interpretation of Life
Jesper L. Rasmussen
Aug 29, 2018
According to Schelling’s 1806 Aphorisms as an Introduction to Naturphilosophie, the aim of philosophy should be nothing less than a sort of excitation of further developments of an eternal poem (Gedicht) (SW VII: 145f). This...
Published by: Memorial University Libraries
The impact of hypertonic saline on cerebrovascular reactivity and compensatory reserve in traumatic brain injury
Logan Froese, Joshua Dian, Carleen Batson, Alwyn Gomez, Bertram Unger, Frederick A Zeiler
Oct 23, 2020
BACKGROUND: Intravenous hypertonic saline is utilized commonly in critical care for treatment of acute or refractory elevations of intracranial pressure (ICP) in traumatic brain injury (TBI) patients. Though there is a clear...
Cerebrovascular Circulation cerebrovascular response Hypertonic saline Intracranial Pressure pressure reactivity index Sodium Chloride Adult Arterial Pressure Brain Injuries Traumatic Cerebrovascular Circulation Female Hemodynamics Humans Intracranial Hypertension Intracranial Pressure Male Middle Aged Retrospective Studies Saline Solution Hypertonic Young Adult
The function of BCL9 in Wnt/beta-catenin signaling and colorectal cancer cells.
Stability analysis of line patterns of an anisotropic interaction model
Motivated by the formation of fingerprint patterns, we consider a class of interacting particle models with anisotropic, repulsive-attractive interaction forces whose orientations depend on an underlying tensor field. This...
Pattern formation of a nonlocal, anisotropic interaction model
Martin Burger, Bertram Düring, Lisa Maria Kreusser, Peter A. Markowich, Carola Bibiane Schönlieb
Mar 01, 2018
We consider a class of interacting particle models with anisotropic, repulsive-attractive interaction forces whose orientations depend on an underlying tensor field. An example of this class of models is the so-called...
Cloning, mapping and molecular characterization of porcine progesterone receptor membrane component 2 (PGRMC2) gene.
Congying Chen, Carole Sargent, Claire Quilter, Zhuqing Yang, Jun Ren, Nabeel Affara, Bertram Brenig, Lusheng Huang
Jun 22, 2020
Progesterone plays an important role in sow reproduction by stimulating classic genomic pathways via nuclear receptors and non-genomic pathways via membrane receptors such a progesterone receptor membrane component 2 (PGRMC2)....
Towards resolving the presynaptic NMDA receptor debate.
In the classical view, postsynaptic NMDA receptors (NMDARs) trigger Hebbian plasticity via Ca2+ influx. However, unconventional presynaptic NMDARs (preNMDARs) which regulate both long-term and short-term plasticity at several...
Stability analysis of line patterns of an anisotropic interaction model
Motivated by the formation of fingerprint patterns, we consider a class of interacting particle models with anisotropic, repulsive-attractive interaction forces whose orientations depend on an underlying tensor field. This...
An anisotropic interaction model for simulating fingerprints.
Bertram Düring, Carsten Gottschlich, Stephan Huckemann, Lisa Maria Kreusser, Carola-Bibiane Schönlieb
Feb 18, 2019
Evidence suggests that both the interaction of so-called Merkel cells and the epidermal stress distribution play an important role in the formation of fingerprint patterns during pregnancy. To model the formation of fingerprint...
Cerebrovascular Response to Phenylephrine in Traumatic Brain Injury
Intravenous phenylephrine (PE) is utilized commonly in critical care for cardiovascular support. Its impact on the cerebrovasculature is unclear and its use may have important implications during states of critical neurological...
Pattern formation of a nonlocal, anisotropic interaction model
Martin Burger, Bertram Düring, Lisa Maria Kreusser, Peter A. Markowich, Carola Bibiane Schönlieb
Mar 01, 2018
We consider a class of interacting particle models with anisotropic, repulsive-attractive interaction forces whose orientations depend on an underlying tensor field. An example of this class of models is the so-called...
Comparison of high versus low frequency cerebral physiology for cerebrovascular reactivity assessment in traumatic brain injury
Eric P. Thelin, Rahul Raj, Bo-Michael Bellander, David Nelson, Anna Piippo-Karjalainen, Jari Siironen, Päivi Tanskanen, Gregory Hawryluk, Mohammed Hasen, Bertram Unger, Frederick A. Zeiler
Sep 30, 2020
Abstract: Current accepted cerebrovascular reactivity indices suffer from the need of high frequency data capture and export for post-acquisition processing. The role for minute-by-minute data in cerebrovascular reactivity...
Computer Vision for Continuous Bedside Pharmacological Data Extraction
Logan Froese, Joshua Dian, Carleen Batson, Alwyn Gomez, Amanjyot Singh Sainbhi, Bertram Unger, Frederick A Zeiler
Sep 10, 2021
Introduction: As real time data processing is integrated with medical care for traumatic brain injury (TBI) patients, there is a requirement for devices to have digital output. However, there are still many devices that fail to...
Oesophageal cancer.
Elizabeth C Smyth, Jesper Lagergren, Rebecca C Fitzgerald, Florian Lordick, Manish A Shah, Pernilla Lagergren, David Cunningham
Sep 05, 2018
Oesophageal cancer is the sixth most common cause of cancer-related death worldwide and is therefore a major global health challenge. The two major subtypes of oesophageal cancer are oesophageal squamous cell carcinoma (OSCC)...
Adenocarcinoma Africa Eastern Aged Aged 80 and over Antineoplastic Agents Immunological Carcinoma Squamous Cell Chemoradiotherapy endoscopy Digestive System Esophageal Neoplasms Esophageal Squamous Cell Carcinoma Female Humans Male Middle Aged Prognosis Receptor ErbB-2 South America Survival Rate Trastuzumab Treatment Outcome
Published by: Nat Rev Dis Primers
Tunable Anion-Selective Transport through Monolayer Graphene and Hexagonal Boron Nitride.
Mustafa Caglar, Inese Silkina, Bertram T Brown, Alice L Thorneywork, Oliver J Burton, Vitaliy Babenko, Stephen Matthew Gilbert, Alex Zettl, Stephan Hofmann, Ulrich F Keyser
Jan 06, 2020
Membranes that selectively filter for both anions and cations are central to technological applications from clean energy generation to desalination devices. 2D materials have immense potential as these ion-selective membranes...
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